CA2833675C - Atmospheric pressure ion source by interacting high velocity spray with a target - Google Patents

Atmospheric pressure ion source by interacting high velocity spray with a target Download PDF

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Publication number
CA2833675C
CA2833675C CA2833675A CA2833675A CA2833675C CA 2833675 C CA2833675 C CA 2833675C CA 2833675 A CA2833675 A CA 2833675A CA 2833675 A CA2833675 A CA 2833675A CA 2833675 C CA2833675 C CA 2833675C
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CA
Canada
Prior art keywords
ion source
targets
droplets
ion
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2833675A
Other languages
English (en)
French (fr)
Other versions
CA2833675A1 (en
Inventor
Stevan Bajic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1106694.1A external-priority patent/GB201106694D0/en
Priority claimed from GBGB1204937.5A external-priority patent/GB201204937D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2833675A1 publication Critical patent/CA2833675A1/en
Application granted granted Critical
Publication of CA2833675C publication Critical patent/CA2833675C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2833675A 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target Active CA2833675C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1106694.1 2011-04-20
GBGB1106694.1A GB201106694D0 (en) 2011-04-20 2011-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target
US201161478725P 2011-04-25 2011-04-25
US61/478,725 2011-04-25
GBGB1204937.5A GB201204937D0 (en) 2012-03-21 2012-03-21 Atomspheric pressure ion source by interacting high velocity spray with a target
GB1204937.5 2012-03-21
US201261614734P 2012-03-23 2012-03-23
US61/614,734 2012-03-23
PCT/GB2012/050888 WO2012143737A1 (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Publications (2)

Publication Number Publication Date
CA2833675A1 CA2833675A1 (en) 2012-10-26
CA2833675C true CA2833675C (en) 2019-01-15

Family

ID=46261648

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2833675A Active CA2833675C (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Country Status (7)

Country Link
US (3) US8809777B2 (enExample)
EP (2) EP2700086B1 (enExample)
JP (1) JP6080311B2 (enExample)
CN (1) CN103597574B (enExample)
CA (1) CA2833675C (enExample)
GB (1) GB2499681B (enExample)
WO (1) WO2012143737A1 (enExample)

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EP3741303A3 (en) 2015-03-06 2020-12-30 Micromass UK Limited Chemically guided ambient ionisation mass spectrometry
WO2016142675A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Imaging guided ambient ionisation mass spectrometry
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
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CA2981085A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
GB2552602B (en) 2015-03-06 2020-12-30 Micromass Ltd Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
EP3265823B1 (en) 2015-03-06 2020-05-06 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
WO2016142693A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited In vivo endoscopic tissue identification tool
GB2553937B (en) * 2015-03-06 2022-06-08 Micromass Ltd Improved ionisation of gaseous samples
GB2551669B (en) 2015-03-06 2021-04-14 Micromass Ltd Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
US10777397B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
US11342170B2 (en) 2015-03-06 2022-05-24 Micromass Uk Limited Collision surface for improved ionisation
US11289320B2 (en) 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
DE102016007402A1 (de) 2015-06-23 2016-12-29 Dionex Corporation Verfahren und systeme zur erkennung von nichtflüchtigen gelösten stoffen
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
GB2563194B (en) 2016-04-21 2020-08-05 Waters Technologies Corp Dual mode ionization device
GB2567793B (en) * 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
GB201721700D0 (en) 2017-12-22 2018-02-07 Micromass Ltd Ion source
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
EP3951379B1 (en) * 2019-05-24 2023-11-22 National Institute Of Advanced Industrial Science And Technology Spray ionization device, analysis device, and surface coating device
EP3971564B1 (en) 2019-07-31 2024-04-24 National Institute Of Advanced Industrial Science and Technology Spray ionization device, analysis device, and surface coating device
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source
US20230063626A1 (en) * 2020-02-03 2023-03-02 National Institute Of Advanced Industrial Science And Technology Spray ionization device
WO2021181892A1 (ja) 2020-03-11 2021-09-16 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
CN113217247B (zh) * 2021-06-01 2022-04-29 哈尔滨工程大学 一种柴油机多次喷射喷雾贯穿距预测方法

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Also Published As

Publication number Publication date
US9082603B2 (en) 2015-07-14
EP3582251A1 (en) 2019-12-18
WO2012143737A1 (en) 2012-10-26
US20140151547A1 (en) 2014-06-05
CA2833675A1 (en) 2012-10-26
GB201207004D0 (en) 2012-06-06
EP2700086B1 (en) 2019-09-11
EP3582251B1 (en) 2020-12-16
GB2499681B (en) 2016-02-10
CN103597574A (zh) 2014-02-19
CN103597574B (zh) 2016-09-07
EP2700086A1 (en) 2014-02-26
US20140339420A1 (en) 2014-11-20
US8809777B2 (en) 2014-08-19
US8921777B2 (en) 2014-12-30
US20150155151A1 (en) 2015-06-04
GB2499681A (en) 2013-08-28
JP2014515831A (ja) 2014-07-03
JP6080311B2 (ja) 2017-02-15

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