CN103520581A - Pure traditional Chinese medicine composition for treating avian spirochetosis and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition for treating avian spirochetosis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a pure traditional Chinese medicine composition for treating avian spirochetosis. The preparation method comprises the following steps: (1) carrying out ultrafine pulverization on the components in the prescription and sieving through a 700 mesh; (2) weighing by weight 15-25 parts of dried orange peel, 15-25 parts of malt, 15-35 parts of bitter orange, 15-35 parts of herba cephalanoploris and 15-35 parts of pseudo-ginseng, and mixing for 5-10 min to reach a uniform state; (3) weighing according to the weight 10-30 parts of Rhizoma Corydalis, 10-30 parts of Codonopsis, 10-30 parts of root of membranous milk vetch, 10-40 parts of angelica and 10-40 parts of licorice, and mixing for 5-10 min to reach a uniform state; and (4) mixing the compositions obtained in the step (2) and step (3), and continuing to mix for 10-15 min to reach a uniform state. The invention has the following beneficial effects: reasonable prescription, simple preparation, no toxic side effect, no drug residue and no drug resistance of the pure traditional Chinese medicine composition, ultrafine pulverization, high bioavailability and obvious curative effect. Clinical application proves that the composition has special effects on the treatment of avian spirochetosis.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of avian spirochaetosis and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment avian spirochaetosis and preparation method thereof.
Background technology
Avian spirochaetosis is that various age in days poultry and season all can infect by a kind of birds septic infectious disease due to goose Bollinger body spirillum, take suffer from diarrhoea, heating, anorexia and head cyanosis be feature, mortality rate is very high, very harmful to poultry.
The pathogen of primary disease is goose Bollinger body spirillum, and this disease is widely distributed.At present, treat this disease the most frequently used be various antibacterials, as penicillin, florfenicol, kanamycin sulfate, ciprofloxacin etc.; Due to the prolonged and repeated use of antibacterials, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal body, its meat does not reach nuisanceless requirement, has affected the healthy of the outlet of poultry product and people.
Therefore researching and developing a kind of specific medicament for the treatment of avian spirochaetosis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment avian spirochaetosis of toxic and side effects and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of avian spirochaetosis, by following component by weight mixed preparing form: Pericarpium Citri Reticulatae 15-25 part, Fructus Hordei Germinatus 15-25 part, Fructus Aurantii Immaturus 15-35 part, Herba Cirsii 15-35 part, Radix Notoginseng 15-35 part, Rhizoma Corydalis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-40 part, Radix Glycyrrhizae 10-40 part.
Described various component optimum ratio amount is: 20 parts of Pericarpium Citri Reticulataes, 20 parts, Fructus Hordei Germinatus, 25 parts of Fructus Aurantii Immaturuss, 25 parts of Herba Cirsiis, 25 parts of Radix Notoginseng, 20 parts of Rhizoma Corydalis, 20 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Glycyrrhizae.
A preparation method for the pure Chinese medicine composition of avian spirochaetosis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Pericarpium Citri Reticulatae 15-25 part, Fructus Hordei Germinatus 15-25 part, Fructus Aurantii Immaturus 15-35 part, Herba Cirsii 15-35 part, Radix Notoginseng 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Corydalis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-40 part, Radix Glycyrrhizae 10-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Fructus Hordei Germinatus: sweet, flat, return stomach, spleen channel, the function that there is strengthening the spleen to promote digestion, parasite killing, galactopoiesis, expedites the emergence of; Cure mainly that weakness of the spleen and stomach, grass of last year do not disappear, malnutrition due to parasitic infestation etc.
Fructus Aurantii Immaturus: bitter, acid, cold, return stomach, spleen channel, there is the function of dispelling the stagnated QI alleviating distention in middle-JIAO, the logical intestinal of removing food stagnancy; Cure mainly and hinder material, combined symptoms, dyspepsia etc.
Herba Cirsii: bitter, sweet, cool, GUIXIN, Liver Channel, have the function of cooling blood for hemostasis, removing blood stasis to reduce swelling; Cure mainly epistaxis, hematuria, carbuncle sore tumefacting virus etc.
Radix Notoginseng: bitter, sweet, warm, GUIXIN, liver, stomach warp, have the function of hemostasis promoting the circulation of blood, subduing swelling and relieving pain; In curing mainly, injure traumatic hemorrhage, have blood in stool, hematuria, epistaxis, traumatic injury, blood stasis etc.
Rhizoma Corydalis: bitter, pungent, warm, GUIXIN, Liver Channel, have the function of blood-activating and qi-promoting, pain relieving; Cure mainly all pains of breast abdomen, traumatic injury, stagnation of QI and blood, dysentery stomachache etc.
Radix Codonopsis: sweet, flat, return lung, spleen channel, there is the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down de-etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Radix Angelicae Sinensis: sweet, pungent, warm, return liver, the heart, spleen channel, there is the function of blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, moistening dryness for relaxing bowels; Cure mainly blood deficiency impairment caused by overstrain, blood stasis pain, too fat to move skin infection, dryness of the intestine constipation, tire and produce all diseases etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the clinical symptoms of avian spirochaetosis, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment avian spirochaetosis is had to specially good effect.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Pericarpium Citri Reticulataes, 150 parts, Fructus Hordei Germinatus, 150 parts of Fructus Aurantii Immaturuss, 150 parts of Herba Cirsiis, 150 parts of Radix Notoginseng, mix 5-10 minute to even;
(3) take by weight 100 parts of Rhizoma Corydalis, 100 parts of Radix Codonopsis, 100 parts of the Radixs Astragali, 100 parts of Radix Angelicae Sinensis, 100 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 200 parts of Pericarpium Citri Reticulataes, 200 parts, Fructus Hordei Germinatus, 250 parts of Fructus Aurantii Immaturuss, 250 parts of Herba Cirsiis, 250 parts of Radix Notoginseng, mix 5-10 minute to even;
(3) take by weight 200 parts of Rhizoma Corydalis, 200 parts of Radix Codonopsis, 200 parts of the Radixs Astragali, 250 parts of Radix Angelicae Sinensis, 250 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Pericarpium Citri Reticulataes, 250 parts, Fructus Hordei Germinatus, 350 parts of Fructus Aurantii Immaturuss, 350 parts of Herba Cirsiis, 350 parts of Radix Notoginseng, mix 5-10 minute to even;
(3) take by weight 300 parts of Rhizoma Corydalis, 300 parts of Radix Codonopsis, 300 parts of the Radixs Astragali, 400 parts of Radix Angelicae Sinensis, 400 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-30 age in days, body weight at 1.2kg-1.5kg, the ill broiler that Laboratory Diagnosed is fowl spirochetosis.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment with " dysentery health is loose " by specification; Chinese medicine composition group of the present invention is by the ill poultry of product embodiments 2 feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 200kg feeds, and drinking-water 350kg, is used in conjunction 3-5 day at every day 2-3 time; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Result (testing the 7th day) when following table is experiment end.
Efficacy assessment standard:
Cure: spiritual normal, the drinking-water of searching for food is normal, and feces is normal, breathes normally, and head is normal, bouncing cuts open inspection liver, heart, intestinal etc. normal.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment avian spirochaetosis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 21 | 33 | 46 |
| II | The dysentery health group of faling apart | 7 | 81 | 12 |
| III | Chinese medicine composition group of the present invention | 4 | 91 | 5 |
This clinical effectiveness statistical analysis, Chinese medicine composition group of the present invention is compared difference extremely significantly (P < 0.01) with the loose group of dysentery health.
Safety testing:
Choose 60 of the healthy broiler of 20 ages in days, according to 10 times of spices of the made Chinese medicine composition recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment avian spirochaetosis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for avian spirochaetosis, it is characterized in that by following component by weight mixed preparing form: Pericarpium Citri Reticulatae 15-25 part, Fructus Hordei Germinatus 15-25 part, Fructus Aurantii Immaturus 15-35 part, Herba Cirsii 15-35 part, Radix Notoginseng 15-35 part, Rhizoma Corydalis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-40 part, Radix Glycyrrhizae 10-40 part.
2. the pure Chinese medicine composition for the treatment of avian spirochaetosis according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of Pericarpium Citri Reticulataes, 20 parts, Fructus Hordei Germinatus, 25 parts of Fructus Aurantii Immaturuss, 25 parts of Herba Cirsiis, 25 parts of Radix Notoginseng, 20 parts of Rhizoma Corydalis, 20 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Glycyrrhizae.
3. a preparation method for the pure Chinese medicine composition for the treatment of avian spirochaetosis according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Pericarpium Citri Reticulatae 15-25 part, Fructus Hordei Germinatus 15-25 part, Fructus Aurantii Immaturus 15-35 part, Herba Cirsii 15-35 part, Radix Notoginseng 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Corydalis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-40 part, Radix Glycyrrhizae 10-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Citations (5)
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| CN1145248A (en) * | 1996-09-10 | 1997-03-19 | 康寿昆 | Physiological balancing agent for livestock and fowls |
| CN1254516A (en) * | 1999-11-11 | 2000-05-31 | 刘定国 | Natural plant feed additive |
| CN101028039A (en) * | 2006-03-02 | 2007-09-05 | 唐广平 | Feed without public nuisance |
| CN101653589A (en) * | 2008-08-22 | 2010-02-24 | 崔志常 | Chinese medicinal additive for livestock and poultry feeds and preparation method thereof |
| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
-
2013
- 2013-09-27 CN CN201310473325.7A patent/CN103520581A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145248A (en) * | 1996-09-10 | 1997-03-19 | 康寿昆 | Physiological balancing agent for livestock and fowls |
| CN1254516A (en) * | 1999-11-11 | 2000-05-31 | 刘定国 | Natural plant feed additive |
| CN101028039A (en) * | 2006-03-02 | 2007-09-05 | 唐广平 | Feed without public nuisance |
| CN101653589A (en) * | 2008-08-22 | 2010-02-24 | 崔志常 | Chinese medicinal additive for livestock and poultry feeds and preparation method thereof |
| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 乔颜良等: "家禽螺旋体病", 《中国兽医科技》 * |
| 宋清明: "禽螺旋体病", 《国外畜牧科技》 * |
| 李希林: "禽肠道螺旋体病再度流行", 《国外畜牧学》 * |
| 雷凡东: "禽螺旋体病", 《上海畜牧兽医通讯》 * |
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Application publication date: 20140122 |
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