CN103492365A - 取代的联苯衍生物 - Google Patents

取代的联苯衍生物 Download PDF

Info

Publication number
CN103492365A
CN103492365A CN201280016088.5A CN201280016088A CN103492365A CN 103492365 A CN103492365 A CN 103492365A CN 201280016088 A CN201280016088 A CN 201280016088A CN 103492365 A CN103492365 A CN 103492365A
Authority
CN
China
Prior art keywords
groups
alkyl
hydrogen
solvates
oso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280016088.5A
Other languages
English (en)
Chinese (zh)
Inventor
亨氏·福斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovation Treatment Co Ltd
Original Assignee
Innovation Treatment Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovation Treatment Co Ltd filed Critical Innovation Treatment Co Ltd
Publication of CN103492365A publication Critical patent/CN103492365A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/38—2,3-Dihydro derivatives, e.g. isoflavanones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280016088.5A 2011-03-16 2012-03-12 取代的联苯衍生物 Pending CN103492365A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011014087 2011-03-16
DE102011014087.5 2011-03-16
PCT/DE2012/000258 WO2012122969A1 (de) 2011-03-16 2012-03-12 Substituierte diphenylderivate

Publications (1)

Publication Number Publication Date
CN103492365A true CN103492365A (zh) 2014-01-01

Family

ID=46201039

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280016088.5A Pending CN103492365A (zh) 2011-03-16 2012-03-12 取代的联苯衍生物

Country Status (15)

Country Link
US (1) US9409859B2 (https=)
EP (1) EP2686298B1 (https=)
JP (1) JP2014515734A (https=)
KR (1) KR20140011383A (https=)
CN (1) CN103492365A (https=)
AU (1) AU2012228755B2 (https=)
BR (1) BR112013023316B1 (https=)
CA (1) CA2829998C (https=)
EA (1) EA024381B1 (https=)
ES (1) ES2683306T3 (https=)
IL (1) IL228431A (https=)
MX (1) MX346097B (https=)
SG (1) SG193443A1 (https=)
WO (1) WO2012122969A1 (https=)
ZA (1) ZA201306794B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015008631A1 (de) 2014-10-30 2016-05-04 Creative Therapeutics Gmbh Arzneimittel für die Krebstherapie
CN109293661A (zh) * 2018-10-22 2019-02-01 武汉华星光电半导体显示技术有限公司 近红外光热激活延迟荧光材料及其制备方法、显示装置
DE102020125641A1 (de) 2020-09-25 2022-03-31 Creative Therapeutics Gmbh Wirkstoffe und Arzneimittel für die Therapie von Viruserkrankungen, insbesondere Corona-Infektionen, insbesondere COVID-19
CN115582027B (zh) * 2022-09-09 2024-07-19 天津工业大学 一种不同长度烷基链修饰的共价有机框架有机溶剂纳滤膜制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2648660A (en) * 1953-08-11 Process fob
GB1282757A (en) * 1968-08-03 1972-07-26 Bayer Ag New triazene derivatives and pharmaceutical compositions thereof
GB1371969A (en) * 1971-09-24 1974-10-30 Bayer Ag Triazene derivatives their production and their medicinal use
CN1835964A (zh) * 2003-05-30 2006-09-20 TriN股份有限公司 性器官肿瘤的靶向化学疗法
CN101796020A (zh) * 2007-07-04 2010-08-04 三N药品有限责任公司 用于癌症治疗的新型三氮烯化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB691410A (en) * 1950-03-25 1953-05-13 Cfmc Process for the preparation of diazoamino compounds and water-insoluble azodyestuffs on fibres
DE4334823C2 (de) 1993-10-09 1998-09-17 Schering Ag Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
DE10052333A1 (de) 2000-10-24 2002-05-02 Boehringer Ingelheim Pharma Neue Sulfooxybenzamide
RS51189B (sr) 2004-07-28 2010-10-31 Janssen Pharmaceutica N.V. Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze
AR057579A1 (es) 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
WO2008003378A1 (de) 2006-07-05 2008-01-10 Merck Patent Gmbh Sulfamat-benzothiophen-derivate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2648660A (en) * 1953-08-11 Process fob
GB1282757A (en) * 1968-08-03 1972-07-26 Bayer Ag New triazene derivatives and pharmaceutical compositions thereof
GB1371969A (en) * 1971-09-24 1974-10-30 Bayer Ag Triazene derivatives their production and their medicinal use
CN1835964A (zh) * 2003-05-30 2006-09-20 TriN股份有限公司 性器官肿瘤的靶向化学疗法
CN101796020A (zh) * 2007-07-04 2010-08-04 三N药品有限责任公司 用于癌症治疗的新型三氮烯化合物

Also Published As

Publication number Publication date
KR20140011383A (ko) 2014-01-28
EP2686298A1 (de) 2014-01-22
IL228431A (en) 2016-10-31
EA201391335A1 (ru) 2014-01-30
EA024381B1 (ru) 2016-09-30
CA2829998C (en) 2019-07-23
BR112013023316B1 (pt) 2021-12-14
EP2686298B1 (de) 2018-05-09
MX2013010401A (es) 2014-02-28
MX346097B (es) 2017-03-07
AU2012228755B2 (en) 2017-03-23
ZA201306794B (en) 2014-07-30
SG193443A1 (en) 2013-10-30
JP2014515734A (ja) 2014-07-03
US20140005149A1 (en) 2014-01-02
IL228431A0 (en) 2013-12-31
BR112013023316A2 (pt) 2016-12-06
WO2012122969A1 (de) 2012-09-20
CA2829998A1 (en) 2012-09-20
ES2683306T3 (es) 2018-09-26
US9409859B2 (en) 2016-08-09
AU2012228755A1 (en) 2013-09-12

Similar Documents

Publication Publication Date Title
OA12938A (en) Indole derivatives as beta-2 agonists.
JP2000053635A (ja) ベンゾスルホン誘導体
CA2007117A1 (en) Beta-adrenergic agonists
JP2003528046A (ja) フェノキシプロパノールアミン類、それらの製造および治療的使用
CA2404439A1 (en) Diphenyl ether compounds useful in therapy
EP4095132A1 (en) Isoindoline derivative, and pharmaceutical composition and use thereof
CN103492365A (zh) 取代的联苯衍生物
WO2023091565A1 (en) Nsd2-targeted chemical degraders and compositions and methods of use thereof
Baldwin et al. . beta.-Adrenergic blocking agents with acute antihypertensive activity
EP1392280A2 (en) Arylsulfonamide ethers, and methods of use thereof
EP0190367B1 (en) Benzo adh bdcinnoline compounds, process for their preparation, and mecidinal composition containing them
WO1998043943A1 (fr) Derives de 2-phenoxyaniline
KR20020061636A (ko) 항-비만 및 항-당뇨 특성을 갖는 아릴에탄올아민 유도체의제조 방법
JP3468729B2 (ja) ５−リポキシゲナーゼ阻害剤を製造するための方法及び中間体
HK1187330A (en) Substituted diphenyl derivatives
CN105061267A (zh) 蓓萨罗丁的no供体n-羟基胍类衍生物及其制备方法
WO2012142698A1 (en) Alkylurea derivatives active against cancer cells
US4514573A (en) Isoprenylamine derivatives
JPS5995257A (ja) インド−ル誘導体、その製法及び該化合物を含有する抗癌作用を有する医薬組成物
JPS63239273A (ja) フエニルイミダゾ−ル誘導体
US4562200A (en) 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
US4521606A (en) 5-Indolyl substituted aminoethanols
CY1521A (en) Substituted 1-pyridyloxy-3-indolylalkylamino-2-propanols,preparation and use thereof
US7145014B2 (en) Process for the preparation of quinoline derivatives
CN105440023A (zh) Epz-6438的合成方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1187330

Country of ref document: HK

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140101

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1187330

Country of ref document: HK