GB1282757A - New triazene derivatives and pharmaceutical compositions thereof - Google Patents
New triazene derivatives and pharmaceutical compositions thereofInfo
- Publication number
- GB1282757A GB1282757A GB37614/69A GB3761469A GB1282757A GB 1282757 A GB1282757 A GB 1282757A GB 37614/69 A GB37614/69 A GB 37614/69A GB 3761469 A GB3761469 A GB 3761469A GB 1282757 A GB1282757 A GB 1282757A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- pharmaceutically acceptable
- general formula
- alkyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1282757 Triazene derivatives FARBENFABRIKEN BAYER AG 25 July 1969 [3 Aug 1968] 37614/69 Heading C2C Novel triazene derivatives of the general formula wherein R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP> and R<SP>5</SP> are each a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, alkylsulphinyl or alkylsulphonyl group which may be substituted, or a nitro, cyano, -O(CH 2 ) n -COOY, -(CH 2 ) n COOY, -O(CH 2 ) n -CON(R<SP>1</SP>) 2 or -(CH 2 ) n CON(R<SP>1</SP>) 2 group (in which Y is a hydrogen atom or an optionally substituted alkyl group, or a cation such that the salt is pharmaceutically acceptable, n is 0 or an integer from 1 to 5 and R<SP>1</SP> is an aliphatic (two aliphatic R<SP>1</SP> groups together optionally completing a heterocyclic ring system) or cyclo-aliphatic radical; an SO 3 Y<SP>1</SP> or -O(CH 2 ) m N(R<SP>11</SP>) 2 group (in which Y<SP>1</SP> is a hydrogen atom or a cation such that the salt is pharmaceutically acceptable, m is 2, 3 or 4 and R<SP>11</SP> is a C 1-4 aliphatic radical) or an esterified carboxy (other than COOY), esterified sulpho, sulphamoyl, N - alkylsulphamoyl, N,N - dialkylsulphamoyl (the two alkyl groups optionally together completing a heterocyclic ring) or acyl group; R<SP>1</SP> also possibly being a group of the formula -N=N-NR<SP>6</SP>R<SP>7</SP> in the p-position with respect to X; R<SP>6</SP> and R<SP>7</SP> are each an alkyl or alkenyl group optionally substituted by a halogen atom; and X is a direct bond, an oxygen or sulphur atom, a carbonyl, sulphonyl sulphoxide, or azo group, an optionally substituted methylene, ethylene or vinylene group, or an ethynylene group; and pharmaceutically acceptable acid addition salts of those derivatives having basic groups are prepared by diazotization of an amine of the general formula and reaction of the product with a secondary amine of the general formula R<SP>6</SP>R<SP>7</SP>NH, followed optionally by salification of the product. Pharmaceutical compositions having a selective cell-damaging effect against malignant tumour cells comprise, as active ingredient, at least one triazine derivative of the first general formula above or acid addition salt as defined above, in admixture with a pharmaceutically acceptable diluent or carrier, and may be administered orally, parenterally or rectally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19681793115 DE1793115A1 (en) | 1968-08-03 | 1968-08-03 | New triazene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1282757A true GB1282757A (en) | 1972-07-26 |
Family
ID=5707581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB37614/69A Expired GB1282757A (en) | 1968-08-03 | 1969-07-25 | New triazene derivatives and pharmaceutical compositions thereof |
Country Status (11)
Country | Link |
---|---|
AT (1) | AT303000B (en) |
BE (1) | BE736959A (en) |
CH (1) | CH542187A (en) |
CS (1) | CS153526B2 (en) |
DE (1) | DE1793115A1 (en) |
ES (1) | ES370180A1 (en) |
FR (1) | FR2015031A1 (en) |
GB (1) | GB1282757A (en) |
IL (1) | IL32560A (en) |
NL (1) | NL6911774A (en) |
SE (1) | SE360855B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5114780A (en) * | 1990-04-17 | 1992-05-19 | Raychem Corporation | Electronic articles containing a fluorinated poly(arylene ether) dielectric |
US5155175A (en) * | 1989-12-08 | 1992-10-13 | Intellectual Property Law Dept. | Crosslinkable fluorinated polyarylene ether composition |
US5270453A (en) * | 1989-12-08 | 1993-12-14 | Raychem Corporation | Aromatic bistriazene compounds |
CN101796020A (en) * | 2007-07-04 | 2010-08-04 | 三N药品有限责任公司 | Novel triazine compounds for treatment of cancer |
WO2012130850A1 (en) * | 2011-03-31 | 2012-10-04 | Bayer Pharma Aktiengesellschaft | Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors |
EP2557075A1 (en) * | 2011-08-09 | 2013-02-13 | Trin Therapeutics GmbH | New triazene compounds for treating cancer |
CN103492365A (en) * | 2011-03-16 | 2014-01-01 | 创新治疗有限公司 | Substituted diphenyl derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2083148C (en) * | 1990-05-24 | 2002-01-01 | Christopher J. Michejda | Bistriazenes as chemotherapeutic agents |
-
1968
- 1968-08-03 DE DE19681793115 patent/DE1793115A1/en active Pending
-
1969
- 1969-07-04 CH CH1026769A patent/CH542187A/en not_active IP Right Cessation
- 1969-07-07 IL IL32560A patent/IL32560A/en unknown
- 1969-07-25 GB GB37614/69A patent/GB1282757A/en not_active Expired
- 1969-08-01 BE BE736959D patent/BE736959A/xx unknown
- 1969-08-01 NL NL6911774A patent/NL6911774A/xx unknown
- 1969-08-01 CS CS536969A patent/CS153526B2/cs unknown
- 1969-08-01 SE SE10848/69A patent/SE360855B/xx unknown
- 1969-08-02 ES ES370180A patent/ES370180A1/en not_active Expired
- 1969-08-04 FR FR6926729A patent/FR2015031A1/fr not_active Withdrawn
- 1969-08-04 AT AT747769A patent/AT303000B/en not_active IP Right Cessation
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5155175A (en) * | 1989-12-08 | 1992-10-13 | Intellectual Property Law Dept. | Crosslinkable fluorinated polyarylene ether composition |
US5270453A (en) * | 1989-12-08 | 1993-12-14 | Raychem Corporation | Aromatic bistriazene compounds |
US5114780A (en) * | 1990-04-17 | 1992-05-19 | Raychem Corporation | Electronic articles containing a fluorinated poly(arylene ether) dielectric |
CN101796020A (en) * | 2007-07-04 | 2010-08-04 | 三N药品有限责任公司 | Novel triazine compounds for treatment of cancer |
US8034797B2 (en) | 2007-07-04 | 2011-10-11 | Trin Therapeutics Gmbh | Triazene compounds for the treatment of cancer |
CN102424657A (en) * | 2007-07-04 | 2012-04-25 | 特林治疗有限责任公司 | Novel triazine compounds for treatment of cancer |
US8426390B2 (en) | 2007-07-04 | 2013-04-23 | Trin Therapeutics Gmbh | Triazene compounds for the treatment of cancer |
CN103492365A (en) * | 2011-03-16 | 2014-01-01 | 创新治疗有限公司 | Substituted diphenyl derivatives |
WO2012130850A1 (en) * | 2011-03-31 | 2012-10-04 | Bayer Pharma Aktiengesellschaft | Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors |
EP2557075A1 (en) * | 2011-08-09 | 2013-02-13 | Trin Therapeutics GmbH | New triazene compounds for treating cancer |
Also Published As
Publication number | Publication date |
---|---|
IL32560A0 (en) | 1969-09-25 |
AT303000B (en) | 1972-11-10 |
BE736959A (en) | 1970-02-02 |
NL6911774A (en) | 1970-02-05 |
CS153526B2 (en) | 1974-02-25 |
IL32560A (en) | 1973-10-25 |
DE1793115A1 (en) | 1972-02-03 |
CH542187A (en) | 1973-09-30 |
SE360855B (en) | 1973-10-08 |
ES370180A1 (en) | 1971-04-01 |
FR2015031A1 (en) | 1970-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |