CN1034810C - 1，3-氧硫杂环戊烷核苷类似物 - Google Patents

1，3-氧硫杂环戊烷核苷类似物 Download PDF

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Publication number
CN1034810C
CN1034810C CN92108995A CN92108995A CN1034810C CN 1034810 C CN1034810 C CN 1034810C CN 92108995 A CN92108995 A CN 92108995A CN 92108995 A CN92108995 A CN 92108995A CN 1034810 C CN1034810 C CN 1034810C
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China
Prior art keywords
enantiomorph
oxathiolane
compound
pharmaceutically acceptable
methylol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN92108995A
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English (en)
Chinese (zh)
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CN1070191A (zh
Inventor
G·迪翁
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Shire Canada Inc
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Biochem Pharma Inc
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Application filed by Biochem Pharma Inc filed Critical Biochem Pharma Inc
Publication of CN1070191A publication Critical patent/CN1070191A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN92108995A 1991-08-01 1992-08-01 1，3-氧硫杂环戊烷核苷类似物 Expired - Lifetime CN1034810C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919116601A GB9116601D0 (en) 1991-08-01 1991-08-01 1,3-oxathiolane nucleoside analogues
GB9116601.7 1991-08-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN95118741A Division CN1074924C (zh) 1991-08-01 1995-11-03 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法

Publications (2)

Publication Number Publication Date
CN1070191A CN1070191A (zh) 1993-03-24
CN1034810C true CN1034810C (zh) 1997-05-07

Family

ID=10699340

Family Applications (5)

Application Number Title Priority Date Filing Date
CN92108995A Expired - Lifetime CN1034810C (zh) 1991-08-01 1992-08-01 1，3-氧硫杂环戊烷核苷类似物
CNA2006100999092A Pending CN101074228A (zh) 1991-08-01 1992-08-01 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CNA2006100999088A Pending CN101066970A (zh) 1991-08-01 1992-08-01 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CN95118741A Expired - Lifetime CN1074924C (zh) 1991-08-01 1995-11-03 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CNB001179012A Expired - Lifetime CN100542535C (zh) 1991-08-01 2000-05-26 含有1,3-氧硫杂环戊烷核苷类似物的药物组合物的制备方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
CNA2006100999092A Pending CN101074228A (zh) 1991-08-01 1992-08-01 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CNA2006100999088A Pending CN101066970A (zh) 1991-08-01 1992-08-01 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CN95118741A Expired - Lifetime CN1074924C (zh) 1991-08-01 1995-11-03 含有1,3－氧硫杂环戊烷核苷类似物的药物组合物的制备方法
CNB001179012A Expired - Lifetime CN100542535C (zh) 1991-08-01 2000-05-26 含有1,3-氧硫杂环戊烷核苷类似物的药物组合物的制备方法

Country Status (41)

Country Link
US (2) US5538975A (ru)
EP (2) EP1155695B1 (ru)
JP (1) JP2960778B2 (ru)
KR (1) KR100242454B1 (ru)
CN (5) CN1034810C (ru)
AP (1) AP321A (ru)
AT (2) ATE227720T1 (ru)
AU (1) AU659668B2 (ru)
BG (1) BG61693B1 (ru)
CA (2) CA2682254C (ru)
CZ (1) CZ283765B6 (ru)
DE (2) DE69232845T2 (ru)
DK (2) DK0526253T3 (ru)
EE (1) EE03002B1 (ru)
EG (1) EG20193A (ru)
ES (2) ES2335968T3 (ru)
FI (1) FI940435A0 (ru)
GB (1) GB9116601D0 (ru)
GE (1) GEP20002094B (ru)
HK (2) HK1008672A1 (ru)
HN (1) HN1997000118A (ru)
HU (2) HUT70030A (ru)
IL (1) IL102616A (ru)
MA (1) MA22919A1 (ru)
MD (1) MD1434C2 (ru)
MX (1) MX9204474A (ru)
NO (3) NO300842B1 (ru)
NZ (1) NZ243637A (ru)
OA (1) OA09883A (ru)
PH (1) PH30983A (ru)
PT (2) PT526253E (ru)
RS (1) RS49993B (ru)
RU (1) RU2126405C1 (ru)
SG (1) SG68541A1 (ru)
SK (1) SK280131B6 (ru)
TJ (1) TJ244R3 (ru)
TN (1) TNSN92070A1 (ru)
TW (2) TW366347B (ru)
WO (1) WO1993003027A1 (ru)
YU (1) YU49259B (ru)
ZA (1) ZA925668B (ru)

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Also Published As

Publication number Publication date
IL102616A0 (en) 1993-01-14
NZ243637A (en) 1995-03-28
ATE227720T1 (de) 2002-11-15
CZ20394A3 (en) 1994-07-13
CN101066970A (zh) 2007-11-07
AU2340892A (en) 1993-03-02
ATE448787T1 (de) 2009-12-15
GB9116601D0 (en) 1991-09-18
YU74992A (sh) 1995-12-04
CA2114221C (en) 2009-12-22
OA09883A (en) 1994-09-15
BG98616A (bg) 1995-03-31
US5538975A (en) 1996-07-23
NO300842B1 (no) 1997-08-04
PH30983A (en) 1997-12-23
EG20193A (en) 1997-10-30
PT1155695E (pt) 2010-02-02
US5618820A (en) 1997-04-08
CN101074228A (zh) 2007-11-21
CN1074924C (zh) 2001-11-21
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