CN103476428A - 用于诊断上皮源性癌症的血液标志物及单克隆抗体 - Google Patents

用于诊断上皮源性癌症的血液标志物及单克隆抗体 Download PDF

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Publication number
CN103476428A
CN103476428A CN2010800688416A CN201080068841A CN103476428A CN 103476428 A CN103476428 A CN 103476428A CN 2010800688416 A CN2010800688416 A CN 2010800688416A CN 201080068841 A CN201080068841 A CN 201080068841A CN 103476428 A CN103476428 A CN 103476428A
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antibody
cancer
fragment
antigen
monoclonal antibody
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CN103476428B (zh
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沈恩允
宋扬
任世奇
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Mountgate Group Co ltd
Beijing Cotimes Biotech Co Ltd
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Mountgate Group Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4742—Keratin; Cytokeratin

Abstract

本发明提供细胞角蛋白片段作为诊断上皮源性癌症的标志物的用途。本发明提供细胞角蛋白的癌症相关表位及特异识别该袁位的单克隆抗体。本发明还提供对受试者中的上皮源性癌症进行早期筛查、诊断或预后评估的方法，评估相关药物或疗法的治疗效果的方法，以及用于实施该方法的试剂盒。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201080068841.6A 2010-09-09 2010-09-09 用于诊断上皮源性癌症的血液标志物及其单克隆抗体 Active CN103476428B (zh)

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CN201610922143.7A CN106706914B (zh) 2010-09-09 2010-09-09 用于诊断上皮源性癌症的血液标志物及单克隆抗体

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PCT/CN2010/001387 WO2012031374A1 (zh) 2010-09-09 2010-09-09 用于诊断上皮源性癌症的血液标志物及其单克隆抗体

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CN201610922143.7A Active CN106706914B (zh) 2010-09-09 2010-09-09 用于诊断上皮源性癌症的血液标志物及单克隆抗体

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CN111100905A (zh) * 2019-12-25 2020-05-05 安诺优达基因科技(北京)有限公司 缓冲液及其应用
CN113026114A (zh) * 2019-12-25 2021-06-25 安诺优达基因科技(北京)有限公司 缓冲液及其应用
CN117089529A (zh) * 2023-10-16 2023-11-21 深圳普门科技股份有限公司 杂交瘤细胞及其制备方法、单克隆抗体及试剂盒

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WO2012031374A1 (zh) * 2010-09-09 2012-03-15 北京同为时代生物技术有限公司 用于诊断上皮源性癌症的血液标志物及其单克隆抗体
BR112014032728A2 (pt) 2012-06-27 2017-11-28 Berg Llc uso de marcadores no diagnóstico e tratamento de câncer de próstata
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WO2015143277A1 (en) * 2014-03-20 2015-09-24 Wellstat Diagnostics, Llc Antibodies and methods for the detection of cell death
CN105572354B (zh) * 2014-10-17 2018-02-02 广州瑞博奥生物科技有限公司 一种检测早期胃癌的抗体芯片试剂盒
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
KR102384848B1 (ko) 2016-08-05 2022-04-08 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 방광암용 바이오마커로서의 케라틴 17
GB201701572D0 (en) * 2017-01-31 2017-03-15 Immunovia Ab Methods, arrays and uses thereof
CN110346569A (zh) * 2019-06-28 2019-10-18 安徽恩禾生物技术有限公司 一种胸苷激酶化学发光法检测试剂盒及其制备方法
CN112979810B (zh) * 2019-12-16 2023-03-14 广东菲鹏生物有限公司 Tag-72抗体-hrp稀释液及其应用
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JP2022128212A (ja) * 2021-02-22 2022-09-01 シスメックス株式会社 モノクローナル抗体、サイトケラチン１８フラグメントの測定試薬、試薬キットおよび測定方法
CN113219172A (zh) * 2021-04-25 2021-08-06 山东第一医科大学附属省立医院(山东省立医院) 一种检测肿瘤抗原ova12血清抗体的方法

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Cited By (5)

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Publication number Priority date Publication date Assignee Title
CN111100905A (zh) * 2019-12-25 2020-05-05 安诺优达基因科技(北京)有限公司 缓冲液及其应用
CN113026114A (zh) * 2019-12-25 2021-06-25 安诺优达基因科技(北京)有限公司 缓冲液及其应用
CN113026114B (zh) * 2019-12-25 2022-10-28 浙江安诺优达生物科技有限公司 缓冲液及其应用
CN117089529A (zh) * 2023-10-16 2023-11-21 深圳普门科技股份有限公司 杂交瘤细胞及其制备方法、单克隆抗体及试剂盒
CN117089529B (zh) * 2023-10-16 2024-03-15 深圳普门科技股份有限公司 杂交瘤细胞及其制备方法、单克隆抗体及试剂盒

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US9255142B2 (en) 2016-02-09
CN106706914A (zh) 2017-05-24
WO2012031374A1 (zh) 2012-03-15
US9840551B2 (en) 2017-12-12
US20160122423A1 (en) 2016-05-05
US20130260388A1 (en) 2013-10-03
CN106706914B (zh) 2018-10-19
CN103476428B (zh) 2016-10-26

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