CN103446540A - Pure Chinese medicine composition for treating chicken reticuloendotheliosis and preparation method thereof - Google Patents
Pure Chinese medicine composition for treating chicken reticuloendotheliosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicine composition for treating chicken reticuloendotheliosis. A preparation method of the pure Chinese medicine composition comprises the following steps: (1) respectively carrying out super-fine pulverization on various components in a formula, and then sieving by using a 700-mesh sieve; (2) weighting 15-35 parts of Chinese bulbul, 15-25 parts of cortex phellodendri, 10-35 parts of hawthorn, 15-30 parts of medicated leaven, 10-30 parts of curcuma aromatica, 10-30 parts of agrimonia pilosa and 15-35 parts of airpotato yam by weight, and mixing for 5 to 10 minutes until uniform; (3) weighting 15-45 parts of setose thistle, 10-35 parts of Chinese yam, 10-35 parts of astragalus root, 10-35 parts of epimedium, 10-35 parts of malaytea scurfpea fruit, 15-35 parts of sealwort and 15-35 parts of dodder by weight, and mixing for 5 to 10 minutes until uniform; and (4) combining compositions prepared in the step (2) and the step (3), and continuously mixing for 5 to 10 minutes until uniform. The pure Chinese medicine composition has the beneficial effects that the formula is reasonable, the preparation is simple, the pure Chinese medicine composition has no toxic or side effects, no medicine residues and no medicine resistance and has high biological availability due to super-fine pulverization and a very remarkable curative effect, and the special effect of the pure Chinese medicine composition for treating the chicken reticuloendotheliosis is clinically proven.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment chicken reticuloendotheliosis disease and preparation method thereof.
Background technology
Chicken reticuloendotheliosis disease is the one group of syndrome caused by chicken reticuloendotheliosis disease virus groups, comprises the chronic tumor that acute skein cell tumor formation, short and small syndrome and lymphoid tissue and its hetero-organization form.This disease is inhibitive ability of immunity and egg transmissibility infectious disease, and the chicken of the various length of time and kind all can infect, and mortality rate, generally lower than 20%, can affect growth and the egg laying performance of poultry.This disease all can occur throughout the year, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is chicken reticuloendotheliosis disease virus groups, and virus resistance to external world is very strong.This disease almost spreads all over the world all poultry country, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.
Therefore researching and developing a kind of drug residue free of chicken reticuloendotheliosis disease, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the pure Chinese medicine composition of the effective treatment chicken reticuloendotheliosis disease of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease, by following component by weight mixed preparing form: Radix Pulsatillae 15-35 part, Cortex Phellodendri 15-25 part, Fructus Crataegi 10-35 part, Massa Medicata Fermentata 15-30 part, Radix Curcumae 10-30 part, Herba Agrimoniae 10-30 part, Rhizoma Dioscoreae Bulbiferae 15-35 part, Radix Cirsii Japonici 15-45 part, Rhizoma Dioscoreae 10-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Fructus Psoraleae 10-35 part, Rhizoma Polygonati 15-35 part, Semen Cuscutae 15-35 part.
Described various component optimum ratio amount is: 25 parts of the Radix Pulsatillaes, 20 parts of Cortex Phellodendris, 20 parts of Fructus Crataegis, 20 parts of Massa Medicata Fermentata, 20 parts of Radix Curcumaes, 20 parts of Herba Agrimoniaes, 25 parts of Rhizoma Dioscoreae Bulbiferaes, 30 parts of Radix Cirsii Japonicis, 25 parts of Rhizoma Dioscoreaes, 25 parts of the Radixs Astragali, 25 parts of Herba Epimedii, 25 parts of Fructus Psoraleaes, 25 parts of Rhizoma Polygonatis, 25 parts of Semen Cuscutae.
A kind of preparation method for the treatment of the pure Chinese medicine composition of chicken reticuloendotheliosis disease, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight and get Radix Pulsatillae 15-35 part, Cortex Phellodendri 15-25 part, Fructus Crataegi 10-35 part, Massa Medicata Fermentata 15-30 part, Radix Curcumae 10-30 part, Herba Agrimoniae 10-30 part, Rhizoma Dioscoreae Bulbiferae 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Cirsii Japonici 15-45 part, Rhizoma Dioscoreae 10-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Fructus Psoraleae 10-35 part, Rhizoma Polygonati 15-35 part, Semen Cuscutae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Rhizoma Dioscoreae Bulbiferae: bitter, flat, GUIXIN, lung meridian, have the function of clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling; Cure mainly lung-heat cough with asthma, laryngopharynx swelling and pain, skin ulcer general edema with yellowish skin poison etc.
Rhizoma Polygonati: sweet, flat, return spleen, lung, kidney channel, there is the function of boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; Cure mainly weakness of the spleen and stomach, lassitude, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the greedy water of the deficiency of YIN etc.
Semen Cuscutae: hot, sweet, flat, return the liver,kidney,spleen warp, there is the function of nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; Curing mainly the spermatorrhea of suffering from a deficiency of the kidney, waist hip weakness, frequent micturition, frequent fetal movement, the halo vision of suffering from a deficiency of the kidney, spleen suffers from a deficiency of the kidney and rushes down etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Fructus Crataegi: sour, sweet, tepor, return stomach, spleen, Liver Channel, there is the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Massa Medicata Fermentata: sweet, hot, warm, return stomach, spleen channel, the function that there is invigorating the spleen and regulating the stomach, helps digestion in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Radix Curcumae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Cure mainly that distension and fullness of the chest and abdomen, intestinal Huang are had loose bowels, calentura coma, jaundice due to damp-heat etc.
Herba Agrimoniae: bitter, puckery, flat, return liver, heart channel, there is the function of astringing to arrest bleeding, dysentery relieving, removing toxic substances; Cure mainly have blood in stool, hematuria, haematemesis, epistaxis, dysentery, carbuncle sore tumefacting virus etc.
Radix Cirsii Japonici: bitter, sweet, cool, return liver, heart channel, there is the function of cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling; Cure mainly epistaxis, have blood in stool, hematuria, metrorrhagia, traumatic hemorrhage, the yellow furunculosis of skin ulcer etc.
Rhizoma Dioscoreae: sweet, flat, return spleen, stomach, lung meridian, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia cough with asthma, spermatorrhea etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Herba Epimedii: hot, sweet, warm, return liver, kidney channel, there is the function of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Cure mainly that sexual impotence, female animal non-estrus, waist hip are unable, rheumatic arthralgia etc.
Fructus Psoraleae: acrid, bitter, warm, return spleen, kidney channel, there is the function of warming the kidney to invigorate YANG, improving inspiration by invigorating kidney-QI antidiarrheal; Cure mainly sexual impotence, spermatorrhea, frequent micturition number, waist hip cold pain, the cold diarrhea of suffering from a deficiency of the kidney, suffer from a deficiency of the kidney and breathe heavily etc.
Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for clinical symptoms and the pathological change of chicken reticuloendotheliosis disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; The Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 14 flavor Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, to treatment, there is specially good effect in chicken reticuloendotheliosis disease, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight and get 150 parts of the Radix Pulsatillaes, 150 parts of Cortex Phellodendris, 100 parts of Fructus Crataegis, 150 parts of Massa Medicata Fermentata, 100 parts of Radix Curcumaes, 100 parts of Herba Agrimoniaes, 150 parts of Rhizoma Dioscoreae Bulbiferaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Cirsii Japonicis, 100 parts of Rhizoma Dioscoreaes, 100 parts of the Radixs Astragali, 100 parts of Herba Epimedii, 100 parts of Fructus Psoraleaes, 150 parts of Rhizoma Polygonatis, 150 parts of Semen Cuscutae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight and get 250 parts of the Radix Pulsatillaes, 200 parts of Cortex Phellodendris, 150 parts of Fructus Crataegis, 200 parts of Massa Medicata Fermentata, 200 parts of Radix Curcumaes, 200 parts of Herba Agrimoniaes, 250 parts of Rhizoma Dioscoreae Bulbiferaes, mix 5-10 minute to even;
(3) take by weight 300 parts of Radix Cirsii Japonicis, 150 parts of Rhizoma Dioscoreaes, 250 parts of the Radixs Astragali, 250 parts of Herba Epimedii, 250 parts of Fructus Psoraleaes, 250 parts of Rhizoma Polygonatis, 250 parts of Semen Cuscutae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight and get 350 parts of the Radix Pulsatillaes, 250 parts of Cortex Phellodendris, 350 parts of Fructus Crataegis, 300 parts of Massa Medicata Fermentata, 300 parts of Radix Curcumaes, 300 parts of Herba Agrimoniaes, 350 parts of Rhizoma Dioscoreae Bulbiferaes, mix 5-10 minute to even;
(3) take by weight 450 parts of Radix Cirsii Japonicis, 350 parts of Rhizoma Dioscoreaes, 350 parts of the Radixs Astragali, 350 parts of Herba Epimedii, 350 parts of Fructus Psoraleaes, 350 parts of Rhizoma Polygonatis, 350 parts of Semen Cuscutae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 50 ages in days, body weight at 0.9kg-1.0kg, the ill chicken that Laboratory Diagnosed is chicken reticuloendotheliosis disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; The blank group is left intact, and the medicine matched group is used treatment by institute's control drug by its description; Present composition group is product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill chicken of feeding, and a day dose is: 350 kilograms are fed or drunk water to 200 kilograms of every 100 gram present composition spices, every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is the experiment end.
Efficacy assessment standard:
Cure: spirit is normal, and the drinking-water of searching for food is normal, and growth promoter is normal, and motion etc. is normal, and bouncing cuts open the histoorgans such as inspection spleen, liver, muscle, intestinal normal, and thymus, fabricius bursa etc. are normal.
Symptom is arranged during end: clinical symptoms is not improved and is even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment chicken reticuloendotheliosis disease:
| Numbering | Group | Dead | Cure | Symptom is arranged during end |
| I | The blank group | 10 | 13 | 77 |
| II | The chicken reticuloendotheliosis disease group of faling apart | 7 | 68 | 25 |
| III | Chinese medicine composition group of the present invention | 5 | 78 | 17 |
This clinical effectiveness statistical analysis, the loose group of present composition group and chicken reticuloendotheliosis disease is being compared difference extremely significantly (P<0.01) aspect cure rate.
Safety testing:
Choose 60 of 20 age in days healthy chickens, according to 5 times of spices of the made pure Chinese medicine composition recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment chicken reticuloendotheliosis disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. a pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease, it is characterized in that by following component by weight mixed preparing form: Radix Pulsatillae 15-35 part, Cortex Phellodendri 15-25 part, Fructus Crataegi 10-35 part, Massa Medicata Fermentata 15-30 part, Radix Curcumae 10-30 part, Herba Agrimoniae 10-30 part, Rhizoma Dioscoreae Bulbiferae 15-35 part, Radix Cirsii Japonici 15-45 part, Rhizoma Dioscoreae 10-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Fructus Psoraleae 10-35 part, Rhizoma Polygonati 15-35 part, Semen Cuscutae 15-35 part.
2. pure Chinese medicine composition for the treatment of chicken reticuloendotheliosis disease according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of the Radix Pulsatillaes, 20 parts of Cortex Phellodendris, 20 parts of Fructus Crataegis, 20 parts of Massa Medicata Fermentata, 20 parts of Radix Curcumaes, 20 parts of Herba Agrimoniaes, 25 parts of Rhizoma Dioscoreae Bulbiferaes, 30 parts of Radix Cirsii Japonicis, 25 parts of Rhizoma Dioscoreaes, 25 parts of the Radixs Astragali, 25 parts of Herba Epimedii, 25 parts of Fructus Psoraleaes, 25 parts of Rhizoma Polygonatis, 25 parts of Semen Cuscutae.
3. the preparation method of the pure Chinese medicine composition of a treatment according to claim 1 and 2 chicken reticuloendotheliosis disease is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight and get Radix Pulsatillae 15-35 part, Cortex Phellodendri 15-25 part, Fructus Crataegi 10-35 part, Massa Medicata Fermentata 15-30 part, Radix Curcumae 10-30 part, Herba Agrimoniae 10-30 part, Rhizoma Dioscoreae Bulbiferae 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Cirsii Japonici 15-45 part, Rhizoma Dioscoreae 10-35 part, Radix Astragali 10-35 part, Herba Epimedii 10-35 part, Fructus Psoraleae 10-35 part, Rhizoma Polygonati 15-35 part, Semen Cuscutae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN102397529A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken reticuloendotheliosis and preparation method thereof |
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| CN102835594A (en) * | 2012-08-23 | 2012-12-26 | 青岛森源畜禽养殖有限公司 | Chinese medicinal epidemic prevention feed additive for chicken |
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2013
- 2013-08-29 CN CN201310400206.9A patent/CN103446540B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1765418A (en) * | 2005-07-29 | 2006-05-03 | 山东农业大学 | REV(reticuloendotheliosis virus) subunit vaccine and its production method |
| CN102397529A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken reticuloendotheliosis and preparation method thereof |
| CN102715360A (en) * | 2012-05-14 | 2012-10-10 | 东至县天野特种养殖农民专业合作社 | Health powder for feeding rare birds and preparation method thereof |
| CN102835594A (en) * | 2012-08-23 | 2012-12-26 | 青岛森源畜禽养殖有限公司 | Chinese medicinal epidemic prevention feed additive for chicken |
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