CN103402536A - 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法 - Google Patents

用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法 Download PDF

Info

Publication number
CN103402536A
CN103402536A CN2011800619016A CN201180061901A CN103402536A CN 103402536 A CN103402536 A CN 103402536A CN 2011800619016 A CN2011800619016 A CN 2011800619016A CN 201180061901 A CN201180061901 A CN 201180061901A CN 103402536 A CN103402536 A CN 103402536A
Authority
CN
China
Prior art keywords
gip
glp
life
amino acid
agonist peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800619016A
Other languages
English (en)
Chinese (zh)
Inventor
路易斯·维格纳提
理查德·D·狄马区
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marcadia Biotech Inc
Original Assignee
Marcadia Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marcadia Biotech Inc filed Critical Marcadia Biotech Inc
Publication of CN103402536A publication Critical patent/CN103402536A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN2011800619016A 2010-12-22 2011-12-22 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法 Pending CN103402536A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061426338P 2010-12-22 2010-12-22
US61/426,338 2010-12-22
US201161500229P 2011-06-23 2011-06-23
US61/500,229 2011-06-23
PCT/US2011/066739 WO2012088379A2 (en) 2010-12-22 2011-12-22 Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides

Publications (1)

Publication Number Publication Date
CN103402536A true CN103402536A (zh) 2013-11-20

Family

ID=46314922

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800619016A Pending CN103402536A (zh) 2010-12-22 2011-12-22 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法

Country Status (14)

Country Link
US (2) US8975223B2 (enExample)
EP (1) EP2654774A4 (enExample)
JP (1) JP2014501762A (enExample)
KR (1) KR20140020851A (enExample)
CN (1) CN103402536A (enExample)
AR (1) AR084558A1 (enExample)
AU (1) AU2011348202A1 (enExample)
BR (1) BR112013015861A2 (enExample)
CA (1) CA2822617A1 (enExample)
MX (1) MX2013007327A (enExample)
NZ (1) NZ611878A (enExample)
RU (1) RU2013133803A (enExample)
SG (1) SG191252A1 (enExample)
WO (1) WO2012088379A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106414488A (zh) * 2014-04-07 2017-02-15 赛诺菲 衍生自毒蜥外泌肽‑4的肽类双重glp‑1/胰高血糖素受体激动剂
TWI582109B (zh) * 2015-01-09 2017-05-11 美國禮來大藥廠 Ｇｉｐ及ｇｌｐ－１共促效劑化合物
CN107106660A (zh) * 2014-09-16 2017-08-29 韩美药品株式会社 长效glp‑1/胰高血糖素受体双激动剂对于治疗非酒精性脂肪肝疾病的应用
CN108697769A (zh) * 2016-03-10 2018-10-23 免疫医疗有限公司 用于治疗肥胖症的胰高血糖素和glp-1共激动剂
CN109200273A (zh) * 2017-07-04 2019-01-15 中国药科大学 一种多肽用于制备预防或治疗脂肪肝病药物的用途
CN112512633A (zh) * 2018-07-23 2021-03-16 伊莱利利公司 使用gip/glp1共激动剂用于治疗的方法
WO2021083306A1 (zh) * 2019-10-31 2021-05-06 东莞市东阳光生物药研发有限公司 Glp-1/gcg双受体激动剂多肽
CN114617956A (zh) * 2020-12-10 2022-06-14 江苏中新医药有限公司 一种高效降糖的蛋白质药物
CN114891071A (zh) * 2020-12-08 2022-08-12 鸿绪生物科技(嘉善)有限公司 新型多肽及其治疗用途
WO2022257979A1 (en) * 2021-06-09 2022-12-15 The Scripps Research Institute Long-acting dual gip/glp-1 peptide conjugates and methods of use
CN116143884A (zh) * 2023-02-03 2023-05-23 江苏师范大学 一类长效GLP-1/glucagon/GIP受体三重激动剂及其应用

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2528618A4 (en) * 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
RU2739209C2 (ru) 2011-06-10 2020-12-21 Ханми Сайенс Ко., Лтд. Новые производные оксинтомодулина и содержащая их фармацевтическая композиция для лечения ожирения
SI2721062T1 (sl) 2011-06-17 2019-03-29 Hanmi Science Co., Ltd. Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega
WO2013006486A2 (en) 2011-07-01 2013-01-10 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
WO2013041678A1 (en) 2011-09-23 2013-03-28 Novo Nordisk A/S Novel glucagon analogues
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
KR101993393B1 (ko) 2012-11-06 2019-10-01 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
US9724420B2 (en) 2012-11-06 2017-08-08 Hanmi Pharm. Co., Ltd. Liquid formulation of protein conjugate comprising an oxyntomodulin derivative covalently linked to a non-peptidyl polymer to an immunoglobulin FC region
ES2828505T3 (es) 2012-11-28 2021-05-26 Ngm Biopharmaceuticals Inc Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
SG10202100667SA (en) 2012-12-27 2021-02-25 Ngm Biopharmaceuticals Inc Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
RU2683039C2 (ru) 2013-04-18 2019-03-26 Ново Нордиск А/С Стабильные совместные агонисты рецептора глюкагоноподобного пептида-1/глюкагона пролонгированного действия для медицинского применения
HUE057361T2 (hu) * 2013-05-28 2022-05-28 Takeda Pharmaceuticals Co Peptid vegyület
WO2015035419A1 (en) * 2013-09-09 2015-03-12 Hoffmann-La Roche Inc. Dosages of gip/glp-1 co-agonist peptides for human administration
CN105792851B (zh) * 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
EP3062881B1 (en) 2013-10-28 2019-10-02 NGM Biopharmaceuticals, Inc. Cancer models and associated methods
US10626156B2 (en) 2013-12-06 2020-04-21 Jie Han Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
AR098616A1 (es) 2013-12-18 2016-06-01 Lilly Co Eli Péptido para el tratamiento de hipoglicemia severa
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
NZ722377A (en) 2014-01-24 2022-09-30 Ngm Biopharmaceuticals Inc Binding proteins and methods of use thereof
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
JP2017525656A (ja) 2014-06-04 2017-09-07 ノヴォ ノルディスク アー／エス 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト
US10456449B2 (en) 2014-06-16 2019-10-29 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2016020119A1 (en) * 2014-08-06 2016-02-11 Nestec S.A. Biomarkers for predicting degree of weight loss
US10968266B2 (en) 2014-09-05 2021-04-06 University Of Copenhagen GIP peptide analogues
CN107108711B (zh) 2014-10-23 2021-11-23 恩格姆生物制药公司 包含肽变异体的药物组合物及其使用方法
MX382408B (es) 2014-10-24 2025-03-13 Merck Sharp & Dohme Llc Coagonistas de los receptores de glucagón y de glp-1.
WO2016073855A1 (en) 2014-11-07 2016-05-12 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
JP2018012644A (ja) * 2014-11-26 2018-01-25 武田薬品工業株式会社 ペプチド化合物
KR102418477B1 (ko) 2014-12-30 2022-07-08 한미약품 주식회사 글루카곤 유도체
KR101669140B1 (ko) 2015-04-28 2016-10-26 (주)케어젠 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
WO2017083276A1 (en) 2015-11-09 2017-05-18 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders
WO2017204219A1 (ja) 2016-05-24 2017-11-30 武田薬品工業株式会社 ペプチド化合物
EP3503882A4 (en) 2016-08-26 2020-07-29 NGM Biopharmaceuticals, Inc. METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
CN110691788B (zh) * 2017-05-31 2024-05-31 哥本哈根大学 长效gip肽类似物
US10470311B2 (en) * 2017-09-28 2019-11-05 Juniper Networks, Inc. Clearance size reduction for backdrilled differential vias
KR20200069316A (ko) 2017-10-12 2020-06-16 노보 노르디스크 에이/에스 의료 요법에서의 세마글루타이드
CN112074531B (zh) * 2018-05-04 2025-04-15 诺和诺德股份有限公司 Gip衍生物及其用途
KR20210102911A (ko) 2018-12-03 2021-08-20 안타그 테라퓨틱스 에이피에스 변형된 gip 펩티드 유사체
CN109379770B (zh) * 2018-12-11 2021-04-06 北京百瑞互联技术有限公司 蓝牙mesh网络的路径辅助候选节点的优选方法、装置及节点
WO2020143625A1 (zh) * 2019-01-07 2020-07-16 鸿绪生物医药科技（北京）有限公司 新型多肽及其治疗用途
AU2021304762B2 (en) * 2020-07-06 2024-05-02 Vitalixir (Beijing) Co., Ltd Novel polypeptide and therapeutic use thereof
TW202214679A (zh) * 2020-07-22 2022-04-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1及gip受體共促效劑
CN116157143A (zh) * 2020-07-22 2023-05-23 诺和诺德股份有限公司 适合于口服递送的glp-1和gip受体的共激动剂
MX2023001599A (es) * 2020-08-14 2023-03-07 Hanmi Pharmaceutical Co Ltd Composicion farmaceutica que comprende un conjugado de accion prolongada del triple agonista del receptor de glucagon/glp-1/gip.
KR20220050820A (ko) * 2020-10-16 2022-04-25 한미약품 주식회사 Glp-1/gip 이중작용제, 이의 지속형 결합체, 및 이를 포함하는 약학적 조성물
WO2022117056A1 (zh) * 2020-12-02 2022-06-09 南京明德新药研发有限公司 含内酰胺修饰的多肽类化合物
CA3220005A1 (en) 2021-05-13 2022-11-17 Carmot Therapeutics Inc. Modulators of g-protein coupled receptors
CN118103391A (zh) * 2021-11-12 2024-05-28 福建盛迪医药有限公司 Glp-1受体和gip受体双重激动剂的药物组合物及其用途
TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
WO2024226540A1 (en) * 2023-04-23 2024-10-31 Carmot Therapeutics Inc. Treatment of diabetes mellitus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010011439A2 (en) * 2008-06-17 2010-01-28 Indiana University Research And Technology Corporation Gip-based mixed agonists for treatment of metabolic disorders and obesity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846445B2 (en) 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
BRPI0815416A2 (pt) 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
JP2011511778A (ja) 2008-01-30 2011-04-14 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション エステルに基づいたペプチドプロドラッグ
CN102325539A (zh) 2008-12-19 2012-01-18 印第安纳大学研究及科技有限公司 基于酰胺的胰高血糖素超家族肽前药
CN102459325B (zh) 2009-06-16 2015-03-25 印第安纳大学科技研究有限公司 胃抑胜肽受体活化的胰高血糖素化合物
EP2528618A4 (en) 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
BR112013015389A2 (pt) 2010-12-22 2016-11-22 Univ Indiana Res & Tech Corp análogo de glucagon exibindo atividade de receptor gip

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010011439A2 (en) * 2008-06-17 2010-01-28 Indiana University Research And Technology Corporation Gip-based mixed agonists for treatment of metabolic disorders and obesity

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106414488A (zh) * 2014-04-07 2017-02-15 赛诺菲 衍生自毒蜥外泌肽‑4的肽类双重glp‑1/胰高血糖素受体激动剂
CN107106660B (zh) * 2014-09-16 2021-10-22 韩美药品株式会社 长效glp-1/胰高血糖素受体双激动剂对于治疗非酒精性脂肪肝疾病的应用
CN107106660A (zh) * 2014-09-16 2017-08-29 韩美药品株式会社 长效glp‑1/胰高血糖素受体双激动剂对于治疗非酒精性脂肪肝疾病的应用
TWI582109B (zh) * 2015-01-09 2017-05-11 美國禮來大藥廠 Ｇｉｐ及ｇｌｐ－１共促效劑化合物
CN107207576A (zh) * 2015-01-09 2017-09-26 伊莱利利公司 Gip和glp‑1共激动剂化合物
CN107207576B (zh) * 2015-01-09 2020-11-24 伊莱利利公司 Gip和glp-1共激动剂化合物
CN108697769A (zh) * 2016-03-10 2018-10-23 免疫医疗有限公司 用于治疗肥胖症的胰高血糖素和glp-1共激动剂
CN109200273A (zh) * 2017-07-04 2019-01-15 中国药科大学 一种多肽用于制备预防或治疗脂肪肝病药物的用途
CN109200273B (zh) * 2017-07-04 2021-02-19 中国药科大学 一种多肽用于制备预防或治疗脂肪肝病药物的用途
CN112512633A (zh) * 2018-07-23 2021-03-16 伊莱利利公司 使用gip/glp1共激动剂用于治疗的方法
WO2021083306A1 (zh) * 2019-10-31 2021-05-06 东莞市东阳光生物药研发有限公司 Glp-1/gcg双受体激动剂多肽
CN114891071A (zh) * 2020-12-08 2022-08-12 鸿绪生物科技(嘉善)有限公司 新型多肽及其治疗用途
CN114617956A (zh) * 2020-12-10 2022-06-14 江苏中新医药有限公司 一种高效降糖的蛋白质药物
CN114617956B (zh) * 2020-12-10 2023-10-03 江苏中新医药有限公司 一种高效降糖的蛋白质药物
WO2022257979A1 (en) * 2021-06-09 2022-12-15 The Scripps Research Institute Long-acting dual gip/glp-1 peptide conjugates and methods of use
CN116143884A (zh) * 2023-02-03 2023-05-23 江苏师范大学 一类长效GLP-1/glucagon/GIP受体三重激动剂及其应用
CN116143884B (zh) * 2023-02-03 2023-08-04 江苏师范大学 一类长效GLP-1/glucagon/GIP受体三重激动剂及其应用
CN116712530A (zh) * 2023-02-03 2023-09-08 江苏师范大学 一类长效GLP-1/glucagon/GIP受体三重激动剂及其应用
CN116712530B (zh) * 2023-02-03 2024-03-08 江苏师范大学 一类长效GLP-1/glucagon/GIP受体三重激动剂及其应用

Also Published As

Publication number Publication date
CA2822617A1 (en) 2012-06-28
US8975223B2 (en) 2015-03-10
SG191252A1 (en) 2013-07-31
WO2012088379A9 (en) 2012-11-08
US20140018291A1 (en) 2014-01-16
EP2654774A2 (en) 2013-10-30
US20160175400A1 (en) 2016-06-23
EP2654774A4 (en) 2015-07-01
AR084558A1 (es) 2013-05-22
AU2011348202A9 (en) 2016-03-24
KR20140020851A (ko) 2014-02-19
MX2013007327A (es) 2014-01-08
JP2014501762A (ja) 2014-01-23
WO2012088379A2 (en) 2012-06-28
NZ611878A (en) 2015-02-27
AU2011348202A1 (en) 2013-07-04
RU2013133803A (ru) 2015-01-27
BR112013015861A2 (pt) 2018-06-05

Similar Documents

Publication Publication Date Title
US8975223B2 (en) Methods for treating metabolic disorders and obesity with a peptide comprising the amino acid sequence of SEQ ID No. 146
JP7461997B2 (ja) 制御放出および持続的放出のためのｅｌｐ融合タンパク質
AU2003208945B2 (en) Method for administering GLP-1 molecules
KR102161177B1 (ko) 지속형 인슐린분비 펩타이드 결합체 액상 제제
JP4689833B2 (ja) グルカゴン様ペプチド−１の貯蔵安定性製剤
US20090186819A1 (en) Formulation of insulinotropic peptide conjugates
JP6755175B2 (ja) インスリン投薬レジメン
WO2011109787A1 (en) Methods of administering insulinotropic peptides
WO2021136302A1 (zh) 胰岛素衍生物
CN108904810A (zh) 治疗糖尿病的方法和组合物
EP4371577A1 (en) Composition for orally administered formulation containing glp-1 analogue
WO2024230819A1 (en) Pharmaceutical compositions and their uses, and methods for improving the storage stability of pharmaceutical compositions
ES2979305T3 (es) Composiciones y métodos para tratar enfermedades metabólicas
WO2015035419A1 (en) Dosages of gip/glp-1 co-agonist peptides for human administration
HK1191551A (en) Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides
TW201238972A (en) Methods for treating metabolic disorders and obesity with GIP and GLP-1 receptor-active glucagon-based peptides
US20250288650A1 (en) Therapeutic Regimens and Methods for Reducing Body Weight and/or Serum Lipids using a GLP-1R and GCGR Agonist

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1191551

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20131120

WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1191551

Country of ref document: HK