CN103384518B - 新的抗真菌组合物 - Google Patents

新的抗真菌组合物 Download PDF

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Publication number
CN103384518B
CN103384518B CN201280007874.9A CN201280007874A CN103384518B CN 103384518 B CN103384518 B CN 103384518B CN 201280007874 A CN201280007874 A CN 201280007874A CN 103384518 B CN103384518 B CN 103384518B
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China
Prior art keywords
terbinafine
amount
composition
acid
lactic acid
Prior art date
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Application number
CN201280007874.9A
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English (en)
Chinese (zh)
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CN103384518A (zh
Inventor
A·林达尔
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Moberg Pharma AB
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Moberg Derma AB
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Application filed by Moberg Derma AB filed Critical Moberg Derma AB
Priority to CN201811087157.7A priority Critical patent/CN109453150A/zh
Publication of CN103384518A publication Critical patent/CN103384518A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280007874.9A 2011-02-11 2012-02-10 新的抗真菌组合物 Active CN103384518B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811087157.7A CN109453150A (zh) 2011-02-11 2012-02-10 新的抗真菌组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1150107 2011-02-11
SE1150107-9 2011-02-11
PCT/EP2012/052327 WO2012107565A1 (en) 2011-02-11 2012-02-10 Novel antifungal composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811087157.7A Division CN109453150A (zh) 2011-02-11 2012-02-10 新的抗真菌组合物

Publications (2)

Publication Number Publication Date
CN103384518A CN103384518A (zh) 2013-11-06
CN103384518B true CN103384518B (zh) 2018-10-26

Family

ID=45581892

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280007874.9A Active CN103384518B (zh) 2011-02-11 2012-02-10 新的抗真菌组合物
CN201811087157.7A Pending CN109453150A (zh) 2011-02-11 2012-02-10 新的抗真菌组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811087157.7A Pending CN109453150A (zh) 2011-02-11 2012-02-10 新的抗真菌组合物

Country Status (24)

Country Link
US (3) US8952070B2 (enExample)
EP (1) EP2672962B1 (enExample)
JP (1) JP5883886B2 (enExample)
KR (1) KR101647545B1 (enExample)
CN (2) CN103384518B (enExample)
AU (1) AU2012215383B2 (enExample)
BR (1) BR112013020456B1 (enExample)
CA (1) CA2826741C (enExample)
CY (1) CY1116275T1 (enExample)
DK (1) DK2672962T3 (enExample)
ES (1) ES2535827T3 (enExample)
HR (1) HRP20150507T1 (enExample)
IL (1) IL227765A (enExample)
ME (1) ME02152B (enExample)
MX (1) MX335945B (enExample)
PL (1) PL2672962T3 (enExample)
PT (1) PT2672962E (enExample)
RS (1) RS53982B1 (enExample)
RU (1) RU2587064C2 (enExample)
SG (1) SG192615A1 (enExample)
SI (1) SI2672962T1 (enExample)
SM (1) SMT201500154B (enExample)
WO (1) WO2012107565A1 (enExample)
ZA (1) ZA201305891B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53982B1 (sr) 2011-02-11 2015-10-30 Moberg Pharma Ab Nove antigljivične kompozicije
CN103415824B (zh) * 2012-08-30 2015-04-08 华为终端有限公司 一种控制中央处理器的方法和装置
CN108135844A (zh) * 2015-10-07 2018-06-08 埃克索多斯生命科学有限合伙公司 局部用抗真菌组合物
US10206962B1 (en) 2016-08-08 2019-02-19 Marlinz Pharma, LLC Method for treating fungal infections in nails
US10543276B2 (en) 2016-08-08 2020-01-28 Marlinz Pharma, LLC Topical compositions
EP3292758A1 (en) 2016-09-07 2018-03-14 Rottapharm S.p.A. Antimicrobial composition comprising a carboxylic acid and two diols
WO2019206389A1 (en) * 2018-04-27 2019-10-31 Unigroup Aps Kit of parts for nail fungus
US11576920B2 (en) 2019-03-18 2023-02-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
EP4259116A1 (en) * 2020-12-08 2023-10-18 Moberg Pharma AB Treatment regimen for onchyomycosis using allylamine antifungal compositions

Family Cites Families (30)

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US5525635A (en) 1986-02-04 1996-06-11 Moberg; Sven Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof
DE4337945A1 (de) * 1993-11-06 1995-05-11 Labtec Gmbh Pflaster zur Behandlung von Nagelmykosen
WO1999009997A1 (en) 1997-08-26 1999-03-04 Board Of Regents, The University Of Texas System Edta and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
AUPP146598A0 (en) * 1998-01-21 1998-02-12 Health And Hygiene International Pty Ltd Fruit and vegetable wash
DE19921794A1 (de) 1999-05-11 2000-11-23 Hexal Ag Neue pharmazeutische Zusammensetzung
US7074392B1 (en) 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
JP4803511B2 (ja) * 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
CN1678277B (zh) * 2002-07-29 2010-05-05 艾克里麦德公司 治疗皮肤病的方法和组合物
PL373235A1 (en) * 2002-09-05 2005-08-22 Galderma S.A. Solution for ungual application
WO2006013963A1 (ja) * 2004-08-05 2006-02-09 Hisamitsu Pharmaceutical Co., Inc. 爪用外用剤
US20060078599A1 (en) 2004-10-12 2006-04-13 Mathew Ebmeier Pharmaceutical composition applicable to body tissue
JP4992181B2 (ja) 2004-12-28 2012-08-08 大正製薬株式会社 外用剤組成物
WO2006103638A2 (en) 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Topical pharmaceutical compositions of terbinafine and processes for their preparation
GB0511499D0 (en) * 2005-06-06 2005-07-13 Medpharm Ltd Topical ungual formulations
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MX2011000932A (es) * 2008-07-23 2011-05-19 Targeted Delivery Technologies Ltd Metodos para administrar formulaciones antifungicas topicas para el tratamiento de infecciones fungicas.
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RS53982B1 (sr) 2011-02-11 2015-10-30 Moberg Pharma Ab Nove antigljivične kompozicije

Also Published As

Publication number Publication date
AU2012215383B2 (en) 2016-06-09
BR112013020456B1 (pt) 2020-01-21
PT2672962E (pt) 2015-05-25
IL227765A0 (en) 2013-09-30
MX2013009245A (es) 2013-12-09
JP5883886B2 (ja) 2016-03-15
RU2013136147A (ru) 2015-03-20
KR101647545B1 (ko) 2016-08-10
AU2012215383A1 (en) 2013-08-29
KR20140025341A (ko) 2014-03-04
HRP20150507T1 (hr) 2015-06-19
SMT201500154B (it) 2015-09-07
MX335945B (es) 2016-01-04
SG192615A1 (en) 2013-09-30
US20150250878A1 (en) 2015-09-10
JP2014508146A (ja) 2014-04-03
RS53982B1 (sr) 2015-10-30
US8952070B2 (en) 2015-02-10
PL2672962T3 (pl) 2015-08-31
DK2672962T3 (en) 2015-04-20
HK1190944A1 (en) 2014-07-18
CA2826741A1 (en) 2012-08-16
BR112013020456A2 (pt) 2016-10-18
SI2672962T1 (sl) 2015-06-30
RU2587064C2 (ru) 2016-06-10
ME02152B (me) 2015-10-20
US9561279B2 (en) 2017-02-07
EP2672962B1 (en) 2015-03-25
US20170258914A1 (en) 2017-09-14
WO2012107565A1 (en) 2012-08-16
CN103384518A (zh) 2013-11-06
ZA201305891B (en) 2015-06-24
CY1116275T1 (el) 2017-02-08
EP2672962A1 (en) 2013-12-18
CN109453150A (zh) 2019-03-12
ES2535827T3 (es) 2015-05-18
IL227765A (en) 2016-09-29
US20140031430A1 (en) 2014-01-30
CA2826741C (en) 2016-03-29

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