HRP20150507T1 - Novi antifungalni pripravak - Google Patents

Novi antifungalni pripravak Download PDF

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Publication number
HRP20150507T1
HRP20150507T1 HRP20150507TT HRP20150507T HRP20150507T1 HR P20150507 T1 HRP20150507 T1 HR P20150507T1 HR P20150507T T HRP20150507T T HR P20150507TT HR P20150507 T HRP20150507 T HR P20150507T HR P20150507 T1 HRP20150507 T1 HR P20150507T1
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HR
Croatia
Prior art keywords
amount
composition according
present
preparation
acid
Prior art date
Application number
HRP20150507TT
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English (en)
Inventor
Ake Lindahl
Original Assignee
Moberg Pharma Ab
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Publication date
Application filed by Moberg Pharma Ab filed Critical Moberg Pharma Ab
Publication of HRP20150507T1 publication Critical patent/HRP20150507T1/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Claims (13)

1. Farmaceutski pripravak za tretiranje fungalne zaraze nokta koji sadrži fungalni alilamin spoj prisutan u količini od više od 5%, organsku kiselinu ili njen ester, diol i odvajajuće sredstvo, koje odvajajuće sredstvo je aminoacetatna kiselina, pri čemu je spomenuti farmaceutski pripravak značajno bezvodan.
2. Pripravak prema zahtjevu 1, pri čemu je antifungalni alilamin spoj otopljen u pripravku.
3. Pripravak prema zahtjevu 1 ili 2, pri čemu je organska kiselina mliječna kiselina.
4. Pripravak prema bilo kojem od zahtjeva 1 do 3, pri čemu je organska kiselina ili njen ester prisutna u količini od 5% do 25%.
5. Pripravak prema bilo kojem od zahtjeva 1 do 4, pri čemu je diol izabran iz skupine koja se sastoji od propandiola, butandiola, pentandiola i heksandiola.
6. Pripravak prema bilo kojem od zahtjeva 1 do 5, pri čemu je diol prisutan u količini od više od 50%.
7. Pripravak prema bilo kojem od zahtjeva 1 do 6, pri čemu alilamin antifungalni spoj je terbinafin.
8. Pripravak prema bilo kojem od prethodnih zahtjeva, pri čemu je alilamin antifungalni spoj prisutan u količini od 5% do 12%.
9. Pripravak prema zahtjevu 8, pri čemu je alilamin antifungalni spoj prisutan u količini od 8% do 11.5%.
10. Pripravak prema bilo kojem od prethodnih zahtjeva, pri čemu je aminoacetatna kiselina etilendiamin-tetraoctena kiselina (EDTA).
11. Pripravak prema zahtjevu 1 ili 2 koji sadrži mliječnu kiselinu u količini od 5% do 25%; diol izabran od skupine koja se sastoji od propandiola, butandiola, pentandiola i heksandiola u količini od više od 50%; terbinafin u količini od 5% do 12%; i EDTA u količini između 0.03% i 1%.
12. Pripravak prema zahtjevu 1 ili 2 koji sadrži od oko 67.5% do oko 84% propandiola, od 8% do 20% mliječne kiseline, od 0.03% do 0.1% EDTA i od 8% do 12% terbinafina.
13. Farmaceutski pripravak prema bilo kojem od zahtjeva 1 do 12 za uporabu u postupku tretiranja fungalne zaraze nokta.
HRP20150507TT 2011-02-11 2015-05-13 Novi antifungalni pripravak HRP20150507T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1150107 2011-02-11
PCT/EP2012/052327 WO2012107565A1 (en) 2011-02-11 2012-02-10 Novel antifungal composition
EP12703537.6A EP2672962B1 (en) 2011-02-11 2012-02-10 Novel antifungal composition

Publications (1)

Publication Number Publication Date
HRP20150507T1 true HRP20150507T1 (hr) 2015-06-19

Family

ID=45581892

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20150507TT HRP20150507T1 (hr) 2011-02-11 2015-05-13 Novi antifungalni pripravak

Country Status (25)

Country Link
US (3) US8952070B2 (hr)
EP (1) EP2672962B1 (hr)
JP (1) JP5883886B2 (hr)
KR (1) KR101647545B1 (hr)
CN (2) CN109453150A (hr)
AU (1) AU2012215383B2 (hr)
BR (1) BR112013020456B1 (hr)
CA (1) CA2826741C (hr)
CY (1) CY1116275T1 (hr)
DK (1) DK2672962T3 (hr)
ES (1) ES2535827T3 (hr)
HK (1) HK1190944A1 (hr)
HR (1) HRP20150507T1 (hr)
IL (1) IL227765A (hr)
ME (1) ME02152B (hr)
MX (1) MX335945B (hr)
PL (1) PL2672962T3 (hr)
PT (1) PT2672962E (hr)
RS (1) RS53982B1 (hr)
RU (1) RU2587064C2 (hr)
SG (1) SG192615A1 (hr)
SI (1) SI2672962T1 (hr)
SM (1) SMT201500154B (hr)
WO (1) WO2012107565A1 (hr)
ZA (1) ZA201305891B (hr)

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PL2672962T3 (pl) 2011-02-11 2015-08-31 Moberg Pharma Ab Nowa kompozycja przeciwgrzybicza
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AU2021396584A1 (en) 2020-12-08 2023-07-20 Moberg Pharma Ab Treatment regimen for onchyomycosis using allylamine antifungal compositions

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Also Published As

Publication number Publication date
CN103384518B (zh) 2018-10-26
CN103384518A (zh) 2013-11-06
PL2672962T3 (pl) 2015-08-31
PT2672962E (pt) 2015-05-25
RU2013136147A (ru) 2015-03-20
US20170258914A1 (en) 2017-09-14
ME02152B (me) 2015-10-20
IL227765A (en) 2016-09-29
CA2826741C (en) 2016-03-29
JP2014508146A (ja) 2014-04-03
MX2013009245A (es) 2013-12-09
JP5883886B2 (ja) 2016-03-15
BR112013020456A2 (pt) 2016-10-18
EP2672962A1 (en) 2013-12-18
KR20140025341A (ko) 2014-03-04
US8952070B2 (en) 2015-02-10
RU2587064C2 (ru) 2016-06-10
AU2012215383B2 (en) 2016-06-09
US20140031430A1 (en) 2014-01-30
KR101647545B1 (ko) 2016-08-10
SG192615A1 (en) 2013-09-30
ZA201305891B (en) 2015-06-24
AU2012215383A1 (en) 2013-08-29
EP2672962B1 (en) 2015-03-25
SMT201500154B (it) 2015-09-07
US20150250878A1 (en) 2015-09-10
SI2672962T1 (sl) 2015-06-30
MX335945B (es) 2016-01-04
IL227765A0 (en) 2013-09-30
US9561279B2 (en) 2017-02-07
CA2826741A1 (en) 2012-08-16
WO2012107565A1 (en) 2012-08-16
DK2672962T3 (en) 2015-04-20
HK1190944A1 (en) 2014-07-18
BR112013020456B1 (pt) 2020-01-21
CN109453150A (zh) 2019-03-12
ES2535827T3 (es) 2015-05-18
CY1116275T1 (el) 2017-02-08
RS53982B1 (en) 2015-10-30

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