CA2826741C - High penetration antifungal compositions comprising an allylamine antifungal - Google Patents

High penetration antifungal compositions comprising an allylamine antifungal Download PDF

Info

Publication number
CA2826741C
CA2826741C CA2826741A CA2826741A CA2826741C CA 2826741 C CA2826741 C CA 2826741C CA 2826741 A CA2826741 A CA 2826741A CA 2826741 A CA2826741 A CA 2826741A CA 2826741 C CA2826741 C CA 2826741C
Authority
CA
Canada
Prior art keywords
acid
antifungal
amount
allylamine
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2826741A
Other languages
English (en)
French (fr)
Other versions
CA2826741A1 (en
Inventor
Ake Lindahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Moberg Pharma AB
Original Assignee
Moberg Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45581892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2826741(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Moberg Pharma AB filed Critical Moberg Pharma AB
Publication of CA2826741A1 publication Critical patent/CA2826741A1/en
Application granted granted Critical
Publication of CA2826741C publication Critical patent/CA2826741C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2826741A 2011-02-11 2012-02-10 High penetration antifungal compositions comprising an allylamine antifungal Active CA2826741C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1150107 2011-02-11
SE1150107-9 2011-02-11
PCT/EP2012/052327 WO2012107565A1 (en) 2011-02-11 2012-02-10 Novel antifungal composition

Publications (2)

Publication Number Publication Date
CA2826741A1 CA2826741A1 (en) 2012-08-16
CA2826741C true CA2826741C (en) 2016-03-29

Family

ID=45581892

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2826741A Active CA2826741C (en) 2011-02-11 2012-02-10 High penetration antifungal compositions comprising an allylamine antifungal

Country Status (24)

Country Link
US (3) US8952070B2 (enExample)
EP (1) EP2672962B1 (enExample)
JP (1) JP5883886B2 (enExample)
KR (1) KR101647545B1 (enExample)
CN (2) CN109453150A (enExample)
AU (1) AU2012215383B2 (enExample)
BR (1) BR112013020456B1 (enExample)
CA (1) CA2826741C (enExample)
CY (1) CY1116275T1 (enExample)
DK (1) DK2672962T3 (enExample)
ES (1) ES2535827T3 (enExample)
HR (1) HRP20150507T1 (enExample)
IL (1) IL227765A (enExample)
ME (1) ME02152B (enExample)
MX (1) MX335945B (enExample)
PL (1) PL2672962T3 (enExample)
PT (1) PT2672962E (enExample)
RS (1) RS53982B1 (enExample)
RU (1) RU2587064C2 (enExample)
SG (1) SG192615A1 (enExample)
SI (1) SI2672962T1 (enExample)
SM (1) SMT201500154B (enExample)
WO (1) WO2012107565A1 (enExample)
ZA (1) ZA201305891B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2672962T3 (pl) 2011-02-11 2015-08-31 Moberg Pharma Ab Nowa kompozycja przeciwgrzybicza
CN103415824B (zh) 2012-08-30 2015-04-08 华为终端有限公司 一种控制中央处理器的方法和装置
US10272054B2 (en) * 2015-10-07 2019-04-30 Exodos Life Sciences Lp Topical antifungal compositions
US10258560B1 (en) 2016-08-08 2019-04-16 Marlinz Pharma, LLC Composition for topical treatment of nail conditions
US10543276B2 (en) 2016-08-08 2020-01-28 Marlinz Pharma, LLC Topical compositions
EP3292758A1 (en) 2016-09-07 2018-03-14 Rottapharm S.p.A. Antimicrobial composition comprising a carboxylic acid and two diols
WO2019206389A1 (en) * 2018-04-27 2019-10-31 Unigroup Aps Kit of parts for nail fungus
US11576920B2 (en) 2019-03-18 2023-02-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
KR20230116911A (ko) * 2020-12-08 2023-08-04 모베르그 파르마 아베 알릴아민 항진균 조성물을 사용한 조갑진균증의 치료 요법

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525635A (en) 1986-02-04 1996-06-11 Moberg; Sven Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof
DE4337945A1 (de) * 1993-11-06 1995-05-11 Labtec Gmbh Pflaster zur Behandlung von Nagelmykosen
US6165484A (en) 1997-08-26 2000-12-26 Wake Forest University EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
AUPP146598A0 (en) * 1998-01-21 1998-02-12 Health And Hygiene International Pty Ltd Fruit and vegetable wash
DE19921794A1 (de) * 1999-05-11 2000-11-23 Hexal Ag Neue pharmazeutische Zusammensetzung
US7074392B1 (en) 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
JP4803511B2 (ja) * 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
CN1678277B (zh) * 2002-07-29 2010-05-05 艾克里麦德公司 治疗皮肤病的方法和组合物
JP2005538156A (ja) * 2002-09-05 2005-12-15 ガルデルマ・ソシエテ・アノニム 爪塗布用溶液
WO2006013963A1 (ja) * 2004-08-05 2006-02-09 Hisamitsu Pharmaceutical Co., Inc. 爪用外用剤
US20060078599A1 (en) 2004-10-12 2006-04-13 Mathew Ebmeier Pharmaceutical composition applicable to body tissue
JP4992181B2 (ja) * 2004-12-28 2012-08-08 大正製薬株式会社 外用剤組成物
WO2006103638A2 (en) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Topical pharmaceutical compositions of terbinafine and processes for their preparation
GB0511499D0 (en) * 2005-06-06 2005-07-13 Medpharm Ltd Topical ungual formulations
CN1939539A (zh) 2005-09-29 2007-04-04 瑞士商拜欧伊果公司 疣、指甲疾病、及指甲保养用之局部配方
AU2006332425A1 (en) 2006-01-02 2007-07-12 Tlt Medical Ltd. Pharmaceutical composition for the treatment of nail diseases
US20070243222A1 (en) * 2006-02-03 2007-10-18 Carl Lawyer Fungicidal formulation and method of use
WO2007094999A2 (en) * 2006-02-13 2007-08-23 Stiefel Laboratories, Inc. Ungual antifungal compositions
US20080038219A1 (en) 2006-08-07 2008-02-14 Calgenex Corporation Novel Composition for a Topical Skin Treatment Base and Medicated Applications Thereof
AU2007355106A1 (en) * 2006-11-29 2008-12-18 Foamix Ltd. Foamable waterless compositions with modulating agents
CN105125529A (zh) * 2007-02-05 2015-12-09 亲生物有限公司 烯丙胺药物化合物的增加的效力
WO2008121709A1 (en) 2007-03-30 2008-10-09 Transport Pharmaceuticals, Inc. Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug
WO2009140215A2 (en) 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
JP2011529038A (ja) * 2008-07-23 2011-12-01 ターゲッティド デリバリー テクノロジーズ リミテッド 真菌感染症の処置のための局所抗真菌製剤の投与方法
US8524258B2 (en) * 2008-12-22 2013-09-03 Johnson & Johnson Consumer Companies, Inc. Structured lotions
FR2942716B1 (fr) * 2009-03-06 2011-04-15 Galderma Res & Dev Methode de solubilisation d'agent antifongique et compositions a haute concentration en agent antifongique applicables sur l'ongle
BR112012003209A2 (pt) * 2009-08-13 2016-03-01 Moberg Derma Ab composições e métodos para tratar infecção fúngica da unha
AU2010336441B2 (en) * 2009-12-23 2015-02-05 Nuvo Research Inc. Highly permeating terbinafine formulation for treating onychomycosis
WO2012017371A1 (en) * 2010-08-02 2012-02-09 Sulur Subramaniam Vanangamudi A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, clobetasole propionate, terbinafine hydrochloride and a process to make it
PL2672962T3 (pl) 2011-02-11 2015-08-31 Moberg Pharma Ab Nowa kompozycja przeciwgrzybicza

Also Published As

Publication number Publication date
SG192615A1 (en) 2013-09-30
PT2672962E (pt) 2015-05-25
CY1116275T1 (el) 2017-02-08
SI2672962T1 (sl) 2015-06-30
SMT201500154B (it) 2015-09-07
JP5883886B2 (ja) 2016-03-15
JP2014508146A (ja) 2014-04-03
ZA201305891B (en) 2015-06-24
RU2587064C2 (ru) 2016-06-10
EP2672962A1 (en) 2013-12-18
US8952070B2 (en) 2015-02-10
RU2013136147A (ru) 2015-03-20
AU2012215383B2 (en) 2016-06-09
IL227765A (en) 2016-09-29
MX2013009245A (es) 2013-12-09
CN103384518A (zh) 2013-11-06
US20150250878A1 (en) 2015-09-10
EP2672962B1 (en) 2015-03-25
CA2826741A1 (en) 2012-08-16
ES2535827T3 (es) 2015-05-18
AU2012215383A1 (en) 2013-08-29
KR20140025341A (ko) 2014-03-04
CN109453150A (zh) 2019-03-12
CN103384518B (zh) 2018-10-26
KR101647545B1 (ko) 2016-08-10
MX335945B (es) 2016-01-04
ME02152B (me) 2015-10-20
US20170258914A1 (en) 2017-09-14
PL2672962T3 (pl) 2015-08-31
DK2672962T3 (en) 2015-04-20
RS53982B1 (sr) 2015-10-30
BR112013020456B1 (pt) 2020-01-21
WO2012107565A1 (en) 2012-08-16
US20140031430A1 (en) 2014-01-30
BR112013020456A2 (pt) 2016-10-18
US9561279B2 (en) 2017-02-07
HK1190944A1 (en) 2014-07-18
HRP20150507T1 (hr) 2015-06-19
IL227765A0 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
US9561279B2 (en) Antifungal composition
JP5184341B2 (ja) 外用の医薬組成物
JP5992324B2 (ja) 脂肪酸モノグリセリド組成物
MX2008015599A (es) Composiciones topicas.
US20120129942A1 (en) Compositions and methods for treating fungal infection of the nail
CN102227211A (zh) 包含双氯芬酸和羟基脂肪酸聚氧化烯烃酯的药物配制剂
JP5681883B2 (ja) 核酸を有効成分とする外用剤組成物
HK40008037A (en) Novel antifungal composition
HK1190944B (en) Novel antifungal composition
RU2457830C2 (ru) Композиции для местного применения

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150219

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241217

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241217

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241217

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD

Year of fee payment: 14

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251202

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251202