CN103380133B - 化合物及其作为bace抑制剂的用途 - Google Patents

化合物及其作为bace抑制剂的用途 Download PDF

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CN103380133B
CN103380133B CN201180068285.7A CN201180068285A CN103380133B CN 103380133 B CN103380133 B CN 103380133B CN 201180068285 A CN201180068285 A CN 201180068285A CN 103380133 B CN103380133 B CN 103380133B
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mmol
methyl
indene
cyclohexane
mixture
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CN103380133A (zh
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G.斯杰伊克
S.卡尔斯特雷姆
A.科斯
K.科莫丁
M.内雷夫
L.奥伊伯格
L.拉科斯
L.桑德伯格
F.塞格梅布勒
P.塞德曼
B-M.斯瓦恩
S.冯伯格
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AstraZeneca AB
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CN201180068285.7A 2010-12-22 2011-12-21 化合物及其作为bace抑制剂的用途 Active CN103380133B (zh)

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US201061425852P 2010-12-22 2010-12-22
US61/425,852 2010-12-22
US61/425852 2010-12-22
US201161529620P 2011-08-31 2011-08-31
US61/529620 2011-08-31
US61/529,620 2011-08-31
PCT/SE2011/051555 WO2012087237A1 (en) 2010-12-22 2011-12-21 Compounds and their use as bace inhibitors

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US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
ES2566373T3 (es) 2011-10-10 2016-04-12 Astrazeneca Ab Inhibidores monofluoro beta-secretasa
US8779355B2 (en) 2011-12-28 2014-07-15 Quest Diagnostics Investments, Inc. Methods for detecting lacosamide by mass spectrometry
KR101669349B1 (ko) 2012-01-26 2016-10-25 에프. 호프만-라 로슈 아게 플루오로메틸-5,6-다이하이드로-4h-[1,3]옥사진
TWI557112B (zh) * 2012-03-05 2016-11-11 百靈佳殷格翰國際股份有限公司 β－分泌酶抑制劑
SG11201407796YA (en) 2012-05-30 2014-12-30 Comentis Inc Chromane compounds
US9000182B2 (en) * 2012-06-20 2015-04-07 Astrazeneca Ab 2H-imidazol-4-amine compounds and their use as BACE inhibitors
US9000183B2 (en) * 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
US9000184B2 (en) * 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
US9000185B2 (en) * 2012-06-20 2015-04-07 Astrazeneca Ab Cycloalkyl ether compounds and their use as BACE inhibitors
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