CN103328005A - 基于将到抗体的佐剂直接靶向抗原呈递细胞的新型疫苗佐剂 - Google Patents
基于将到抗体的佐剂直接靶向抗原呈递细胞的新型疫苗佐剂 Download PDFInfo
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| PCT/US2011/047633 WO2012021834A1 (en) | 2010-08-13 | 2011-08-12 | Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1109356A (zh) * | 1994-09-19 | 1995-10-04 | 中国医学科学院医药生物技术研究所 | 新型免疫佐剂 |
| WO2007103048A2 (en) * | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| WO2008118587A2 (en) * | 2007-02-23 | 2008-10-02 | Baylor Research Institute | Therapeutic applications of activation of human antigen-presenting cells through dectin-1 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200303759A (en) * | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
| US9259459B2 (en) * | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| EP2476432B1 (en) * | 2006-03-07 | 2015-08-19 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| MX2009008140A (es) * | 2007-02-02 | 2009-10-26 | Baylor Res Inst | Vacunas a base de antigeno dirigido a dcir expresado en celulas que presentan antigeno. |
| DK2224954T3 (en) * | 2007-11-07 | 2014-03-03 | Celldex Therapeutics Inc | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| WO2010009346A2 (en) * | 2008-07-16 | 2010-01-21 | Baylor Research Institute | Hiv vaccine based on targeting maximized gag and nef to dendritic cells |
| JP5883653B2 (ja) * | 2009-03-10 | 2016-03-15 | ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 抗原提示細胞ターゲティング抗ウイルスワクチン |
| CN108373509A (zh) * | 2009-03-10 | 2018-08-07 | 贝勒研究院 | 靶向抗原呈递细胞的抗病毒疫苗 |
| CA2754862C (en) * | 2009-03-10 | 2019-04-02 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
| CA2798616A1 (en) * | 2010-05-07 | 2011-11-10 | Baylor Research Institute | Dendritic cell immunoreceptors (dcir)-mediated crosspriming of human cd8+ t cells |
-
2011
- 2011-08-12 CN CN2011800489046A patent/CN103328005A/zh active Pending
- 2011-08-12 US US13/208,993 patent/US20120039916A1/en not_active Abandoned
- 2011-08-12 CA CA2807585A patent/CA2807585A1/en not_active Abandoned
- 2011-08-12 BR BR112013002940A patent/BR112013002940A2/pt not_active IP Right Cessation
- 2011-08-12 MX MX2013001527A patent/MX2013001527A/es not_active Application Discontinuation
- 2011-08-12 WO PCT/US2011/047633 patent/WO2012021834A1/en not_active Ceased
- 2011-08-12 AR ARP110102955A patent/AR082686A1/es not_active Application Discontinuation
- 2011-08-12 EP EP11817128.9A patent/EP2603235A4/en not_active Withdrawn
- 2011-08-12 KR KR1020137006354A patent/KR20130108295A/ko not_active Withdrawn
- 2011-08-12 TW TW100128970A patent/TWI506035B/zh not_active IP Right Cessation
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- 2011-08-12 AU AU2011289234A patent/AU2011289234B2/en not_active Ceased
-
2013
- 2013-02-06 ZA ZA2013/01013A patent/ZA201301013B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1109356A (zh) * | 1994-09-19 | 1995-10-04 | 中国医学科学院医药生物技术研究所 | 新型免疫佐剂 |
| WO2007103048A2 (en) * | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| WO2008118587A2 (en) * | 2007-02-23 | 2008-10-02 | Baylor Research Institute | Therapeutic applications of activation of human antigen-presenting cells through dectin-1 |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107098970B (zh) * | 2007-05-03 | 2021-11-23 | 新加坡科技研究局 | 结合细胞内prl-1多肽或prl-3多肽的抗体 |
| CN107098970A (zh) * | 2007-05-03 | 2017-08-29 | 新加坡科技研究局 | 结合细胞内prl‑1多肽或prl‑3多肽的抗体 |
| CN106170299A (zh) * | 2014-01-22 | 2016-11-30 | 小利兰斯坦福大学托管委员会 | 用于抗体和抗体负载树突状细胞介导治疗的方法和组合物 |
| CN106456736A (zh) * | 2014-06-02 | 2017-02-22 | 贝勒研究院 | 用于治疗过敏和炎性疾病的方法和组合物 |
| CN104689313A (zh) * | 2015-03-04 | 2015-06-10 | 中国科学院海洋研究所 | 大菱鲆cd83分子作为疫苗佐剂的应用 |
| CN108430498A (zh) * | 2015-11-10 | 2018-08-21 | 耶鲁大学 | 用于治疗自身免疫疾病和癌症的组合物及方法 |
| US11110178B2 (en) | 2016-07-07 | 2021-09-07 | The Board Of Trustees Of The Leland Standford Junior University | Antibody adjuvant conjugates |
| US11547761B1 (en) | 2016-07-07 | 2023-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| CN108727503A (zh) * | 2017-04-18 | 2018-11-02 | 武汉博沃生物科技有限公司 | VZV重组gE-鞭毛素融合蛋白及其制备方法和应用 |
| CN111432833A (zh) * | 2017-11-29 | 2020-07-17 | 自适应噬菌体治疗公司 | 使用二十面体噬菌体的疫苗接种方法 |
| CN111801100A (zh) * | 2018-02-28 | 2020-10-20 | 豪夫迈·罗氏有限公司 | 用于治疗和预防肝癌的7-取代的磺亚氨酰基嘌呤酮化合物和衍生物 |
| CN111801100B (zh) * | 2018-02-28 | 2023-10-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防肝癌的7-取代的磺亚氨酰基嘌呤酮化合物和衍生物 |
| US11400164B2 (en) | 2019-03-15 | 2022-08-02 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting HER2 |
| CN113811547A (zh) * | 2019-03-27 | 2021-12-17 | 国家医疗保健研究所 | 具有cd40激活特性的重组蛋白 |
| CN113811547B (zh) * | 2019-03-27 | 2024-06-25 | 国家医疗保健研究所 | 具有cd40激活特性的重组蛋白 |
Also Published As
| Publication number | Publication date |
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| BR112013002940A2 (pt) | 2019-09-24 |
| US20120039916A1 (en) | 2012-02-16 |
| RU2013110889A (ru) | 2014-09-20 |
| AU2011289234B2 (en) | 2014-09-11 |
| JP2013535508A (ja) | 2013-09-12 |
| AU2011289234A1 (en) | 2013-02-21 |
| EP2603235A4 (en) | 2014-04-09 |
| AR082686A1 (es) | 2012-12-26 |
| ZA201301013B (en) | 2015-10-28 |
| EP2603235A1 (en) | 2013-06-19 |
| WO2012021834A1 (en) | 2012-02-16 |
| MX2013001527A (es) | 2013-04-24 |
| TW201208696A (en) | 2012-03-01 |
| TWI506035B (zh) | 2015-11-01 |
| KR20130108295A (ko) | 2013-10-02 |
| CA2807585A1 (en) | 2012-02-16 |
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Application publication date: 20130925 |