CN103308497B - 用于研究生物细胞或细胞培养物的方法和酶标仪 - Google Patents
用于研究生物细胞或细胞培养物的方法和酶标仪 Download PDFInfo
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- CN103308497B CN103308497B CN201310177906.6A CN201310177906A CN103308497B CN 103308497 B CN103308497 B CN 103308497B CN 201310177906 A CN201310177906 A CN 201310177906A CN 103308497 B CN103308497 B CN 103308497B
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
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- Biomedical Technology (AREA)
- Zoology (AREA)
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- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Food Science & Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610647P | 2012-03-14 | 2012-03-14 | |
| CH00365/12A CH706326A2 (de) | 2012-03-14 | 2012-03-14 | Verfahren und Mikroplatten-Reader zum Untersuchung von biologischen Zellen oder Zellkulturen. |
| US61/610,647 | 2012-03-14 | ||
| CH00365/12 | 2012-03-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103308497A CN103308497A (zh) | 2013-09-18 |
| CN103308497B true CN103308497B (zh) | 2017-11-17 |
Family
ID=47901782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310177906.6A Active CN103308497B (zh) | 2012-03-14 | 2013-03-14 | 用于研究生物细胞或细胞培养物的方法和酶标仪 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10527550B2 (enExample) |
| EP (1) | EP2639292B2 (enExample) |
| JP (1) | JP6189611B2 (enExample) |
| CN (1) | CN103308497B (enExample) |
| CH (1) | CH706326A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9557217B2 (en) | 2007-02-13 | 2017-01-31 | Bti Holdings, Inc. | Universal multidetection system for microplates |
| JP6619544B2 (ja) * | 2014-03-19 | 2019-12-11 | 株式会社日立ハイテクノロジーズ | 検査装置 |
| JP6159486B2 (ja) * | 2014-06-12 | 2017-07-05 | アクシオン バイオシステムズ， インコーポレイテッド | 光学的刺激を有するマルチウェル微小電極アレイ |
| CN106471508A (zh) * | 2014-06-20 | 2017-03-01 | 康涅狄格儿童医疗中心 | 自动化细胞培养系统及对应的方法 |
| GB201600812D0 (en) * | 2016-01-15 | 2016-03-02 | Randox Lab Ltd | Chemiluminescence detector |
| JP6692660B2 (ja) | 2016-03-01 | 2020-05-13 | 株式会社Ｓｃｒｅｅｎホールディングス | 撮像装置 |
| JP6685148B2 (ja) | 2016-03-01 | 2020-04-22 | 株式会社Ｓｃｒｅｅｎホールディングス | 撮像装置および撮像方法 |
| JP6293186B2 (ja) * | 2016-03-10 | 2018-03-14 | 株式会社Ｓｃｒｅｅｎホールディングス | 撮像装置における撮像配置決定方法および撮像装置 |
| JP7316745B2 (ja) * | 2016-05-20 | 2023-07-28 | 株式会社リコー | 三次元組織体 |
| EP3301431B1 (en) * | 2016-09-29 | 2019-08-28 | Roche Diagniostics GmbH | Multi-chamber analysis device and method for analyzing |
| EP3615921A4 (en) * | 2017-04-27 | 2021-04-14 | Polybiomics, Inc. | ORTHOGONAL POLYBIO SENSORS AND IMAGING SYSTEMS |
| DE102017004567A1 (de) * | 2017-05-11 | 2018-11-15 | Innome Gmbh | Gerät zur Analyse von biologischen Proben |
| EP3404090A1 (de) | 2017-05-15 | 2018-11-21 | Eppendorf AG | Inkubator, system und verfahren für das überwachte zellwachstum |
| CN108048308A (zh) * | 2017-12-25 | 2018-05-18 | 广州汉腾生物科技有限公司 | 细胞培养物中细胞活力测定装置 |
| WO2020054561A1 (ja) * | 2018-09-11 | 2020-03-19 | ウシオ電機株式会社 | マイクロプレートリーダー |
| WO2020091732A1 (en) * | 2018-10-29 | 2020-05-07 | Hewlett-Packard Development Company, L.P. | Rotation and flat-form imaging for microscopic objects |
| DE102020128003A1 (de) | 2020-10-23 | 2020-12-31 | Bmg Labtech Gmbh | Mikroplatten-Lesegerät |
| KR20220135998A (ko) * | 2021-03-31 | 2022-10-07 | 주식회사 씨티셀즈 | 세포 선별 통합 장치 |
| CN113552337A (zh) * | 2021-07-19 | 2021-10-26 | 中山大学 | 一种全光谱高效率酶标仪系统 |
| KR102392754B1 (ko) * | 2021-11-16 | 2022-04-29 | (주)엘텍 | 복합 리더기 |
| CN114459859B (zh) * | 2022-02-16 | 2022-09-09 | 北京卢米斯生物科技有限公司 | 基于荧光素酶报告基因法的高通量二噁英自动检测装置 |
| CN120322564A (zh) | 2022-12-08 | 2025-07-15 | 贝克顿·迪金森公司 | 全自动dPCR系统及其使用方法 |
| CN120102449A (zh) * | 2023-12-06 | 2025-06-06 | 赛默飞世尔（上海）仪器有限公司 | 用于微孔板读取器的调节装置和微孔板读取器 |
Citations (2)
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| CN1301357A (zh) * | 1998-03-16 | 2001-06-27 | 普雷勒克斯公司 | 共焦显微镜成像系统 |
| CN101002083A (zh) * | 2004-07-26 | 2007-07-18 | 热内瓦韦公司 | 用于检测由多孔板的孔中的发色团基元发出的荧光的设备 |
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| JPH0230470B2 (ja) | 1981-10-09 | 1990-07-06 | Olympus Optical Co | Ryushigyoshupataankensahohooyobisochi |
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| JPH07209187A (ja) * | 1993-11-30 | 1995-08-11 | Omron Corp | レーザ走査式細胞分析装置 |
| US5784152A (en) | 1995-03-16 | 1998-07-21 | Bio-Rad Laboratories | Tunable excitation and/or tunable detection microplate reader |
| US5798263A (en) * | 1996-09-05 | 1998-08-25 | Promega Corporation | Apparatus for quantifying dual-luminescent reporter assays |
| US5885840A (en) * | 1997-02-10 | 1999-03-23 | Compucyte Corp. | Multiple assays of cell specimens |
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| JPH1137923A (ja) | 1997-07-18 | 1999-02-12 | Hitachi Koki Co Ltd | 凝集像判定方法 |
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| WO1999039184A1 (en) | 1998-01-29 | 1999-08-05 | Ribozyme Pharmaceuticals, Inc. | Image acquisition and image analysis of biological material |
| ATE225406T1 (de) * | 1998-10-30 | 2002-10-15 | Cellomics Inc | Ein screeningsystem auf zellbasis |
| GB9905954D0 (en) | 1999-03-16 | 1999-05-05 | Cambridge Imaging Ltd | Sample imaging |
| DE19916748A1 (de) * | 1999-04-14 | 2000-10-19 | Zeiss Carl Jena Gmbh | Anordnung und Auswertung von fluoreszenzbasierten Nachweisreaktionen |
| DE60023905T2 (de) * | 1999-08-05 | 2006-07-27 | Cellomics, Inc. | Optische Systemanalyse von Zellen |
| US6795189B2 (en) * | 2000-06-15 | 2004-09-21 | Packard Instrument Company | Universal microplate analyzer |
| US6673595B2 (en) | 2001-08-27 | 2004-01-06 | Biocrystal, Ltd | Automated cell management system for growth and manipulation of cultured cells |
| EP1461592B1 (en) * | 2001-12-05 | 2019-04-10 | The J. David Gladstone Institutes | Robotic microscopy systems |
| US7560269B2 (en) * | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
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- 2013-03-13 EP EP13159032.5A patent/EP2639292B2/de active Active
- 2013-03-14 JP JP2013051999A patent/JP6189611B2/ja active Active
- 2013-03-14 CN CN201310177906.6A patent/CN103308497B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CH706326A2 (de) | 2013-09-30 |
| US20130280748A1 (en) | 2013-10-24 |
| EP2639292B1 (de) | 2017-11-29 |
| JP2013190428A (ja) | 2013-09-26 |
| CN103308497A (zh) | 2013-09-18 |
| EP2639292A1 (de) | 2013-09-18 |
| US10527550B2 (en) | 2020-01-07 |
| JP6189611B2 (ja) | 2017-08-30 |
| EP2639292B2 (de) | 2020-11-25 |
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