CN103202928B - Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic - Google Patents
Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic Download PDFInfo
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- CN103202928B CN103202928B CN201210197127.8A CN201210197127A CN103202928B CN 103202928 B CN103202928 B CN 103202928B CN 201210197127 A CN201210197127 A CN 201210197127A CN 103202928 B CN103202928 B CN 103202928B
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Abstract
The invention discloses a traditional Chinese medicine composition with an anti-aging function and application of the same in an anti-aging cosmetic. The traditional Chinese medicine composition is prepared through complex formulation of a wolfberry extract, an Arabian jasmine flower extract, a lotus plumule extract, a fleece-flower root extract, a Sichuan lovage rhizome extract, a weeping forsythia capsule extract and a pipewort flower extract. The traditional Chinese medicine provided by the invention can be used in an anti-aging and whitening formula and has the functions of inhibiting activity of tyrosinase, removing free radicals and whitening the skin.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and the application in cosmetics thereof, particularly relate to and a kind of there is the Chinese medicine composition of anti-senescence function and the application in cosmetics thereof.
Background technology
Along with Chinese society steps into aging gradually, anti-aging beauty-care skin-protection product is more and more subject to people's attention.It is generally acknowledged, the action effect of anti aging effect active substance comprises scavenging free radicals, improves cell proliferation rate, delays the degradation speed of extracellular matrix.Meanwhile, anti-aging cosmetics needs to select excellent skin-care agent, supplements enough nutrients, reach deep layer nutrition to skin.In addition, scattering and disappearing of moisture in skin to also be slowed down, protection skin.At present, the efficacy assessments of anti-aging cosmetics, mainly evaluates two aspects from in-vitro evaluation and human body and carries out.
At present, all there is larger defect in the management of China's cosmetics and technology, and the phenomenon of adding in violation of rules and regulations is very serious, causes many beauty treatment accidents for many years, even disfeatures, cause very large injury to consumer, has caused the great attention of country and consumer.Exploitation has good safety, stability, successful, the natural defying age additive that cost performance is good, has become one of main direction of studying of current medicine and cosmetic industry, has had extraordinary development prospect.Natural materials is applied to cosmetics can reach skin treating and skin protection double effects, and has diverse in function, the characteristic such as widely applicable, safe, thus day by day comes into one's own.
Summary of the invention
The present invention want technical solution problem to be to provide a kind of Chinese medicine composition being derived from the natural anti-senescence function high and effective to human safety.
Another technical problem to be solved by this invention is to provide the application of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
There is a Chinese medicine composition for anti-senescence function, it is characterized in that it comprises the component of following percentage by weight:
Above-mentioned Chinese medicine extract can be obtained by Conventional solvents extraction method, such as, after above-mentioned Chinese medicine can being pulverized, sieves, and soaks or after reflux, filter, concentratedly to obtain together with Extraction solvent.In order to avoid dissolvent residual, the Extraction solvent used in the present invention can adopt water, ethanol, ethanol water.In order to obtain optimum extraction effect, invention has been Extraction solvent, extracting the screening of the extracting factor such as pressure, liquid material mass ratio, extraction time, obtaining optimal extract process, be shown in Table 1.
Table 1
The application of above-mentioned Chinese medicine composition in preparation anti-aging cosmetics.
Relative to the total amount of cosmetics, the consumption of above-mentioned plant extract in anti-aging cosmetics of the present invention, in dry thing, be 0.05 ~ 20% (w/w), preferable amount is 0.5 ~ 10% (w/w).
Chinese medicine composition of the present invention is applied in anti-aging cosmetics, except above-mentioned required composition, suitably can coordinate the composition usually used in cosmetics as required, such as, other the matrix components such as antidotal agent, wetting agent, surfactant, alcohols, water.
The dosage form of anti-aging cosmetics is not particularly limited, and can be solution, suspension, emulsion, paste, powdery, spray etc.
Beneficial effect: the Chinese medicine composition with anti-senescence function of the present invention has the effect of check melanin cell, restraint of tyrosinase, free radical resisting.Can effectively generate by check melanin, desalination pigmentation, Glycerin etc.Compared with other antidotal agents, said composition from the synthesis of the comprehensive check melanin of different approaches, can remove harmful free radicals, has excellent anti-senescence function, meanwhile, said composition containing chemosynthesis material, does not have no side effect, skin irritation is little, stable in properties, safe and reliable.Except having anti-senescence function, because said composition contains plurality of Chinese active component, have the functions such as activating blood circulation to dissipate blood stasis, antiinflammatory be antibacterial, can promote skin metabolism, the nutrition improving skin, with healthy, has good skin effect.
Accompanying drawing explanation
Fig. 1 is the comparison diagram of anti-aging cream and control sample performance of keeping humidity;
Fig. 2 is the comparison diagram of anti-aging cream and control sample skin elasticity;
Fig. 3 is the comparison diagram of anti-aging cream and the change of control sample melanin content.
Detailed description of the invention
The present invention will be described in more detail to enumerate embodiment below, but technical scope of the present invention does not limit by these embodiments.All proportional quantities all by weight percentage below.
Embodiment 1 experimental technique and anti-senescence function evaluation
1, the preparation of sample
Chinese medicine crude drug, in oven dried overnight, is crossed 40 mesh sieves after pulverizing, is added 10 times of distilled water, heating and refluxing extraction 3 times, each 1 hour.Merge extractive liquid, sucking filtration.Filtrate reduced in volume, places.Except precipitation, supernatant, by D101 macroporous resin eluting, collects 70% ethanol elution, and reduced vacuum concentrates, and obtains Chinese medicine extract.Extract is made into the sample solution that concentration is 1%, tests below carrying out.
2, the mensuration of restraint of tyrosinase vigor
According to following table application of sample, do not add tryrosinase, 1% arbutin is contrasted as one group of sample.Solution is placed in 37 DEG C of water-bath constant temperature 10min; Add tryrosinase, after solution being placed in 37 DEG C of water-bath constant temperature 10min, under 475nm, measuring its absorbance, and compare with 1% arbutin.
Table 2
By the relative inhibition (I, be called for short suppression ratio, lower same) of formula (1) calculation sample to tryrosinase.
In formula: A
1, A
2, A
3, A
4be respectively the absorbance of 1 group ~ 4 groups of solution.
3, the mensuration of ultra-oxygen anion free radical scavenging action
Get the Tris-HCl buffer 4.5mL of 0.05mol/LpH=8.2, preheating 20min in 25 DEG C of water-baths.Add the pyrogallol solution of 1mL sample and 0.4mL 25mmol/L again, after mixing, in 25 DEG C of water-baths, react 5min, add the HCl 1.0mL cessation reaction of 8mol/L.Make reference with Tris-HCl buffer, survey absorbance at 299nm place.The solvent of blank 1mL sample carrys out alternative sample.Clearance rate (D) is calculated according to formula (2).
Clearance rate formula (%)=[1-(A
2/ A
1)] × 100% (2)
A in formula
1for the absorbance of blank; A
2for the absorbance of medicine.
4, the Scavenging activity of hydroxy radical is measured
2mmol/LFeSO is added successively in 25mL color comparison tube
43mL, 1mmol/LH
2o
23mL, shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, take out after 37 DEG C of heating in water bath 15min, survey its absorbance; Add certain density liquid to be measured respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance.Following formula is the clearance rate of liquid to be measured to carboxylic free radical (OH):
OH clearance rate (%)=[A
1-A
2-(A
1-A
3)]/A
1× 100% (3)
A in formula
1for not adding the absorbance of reaction system before medicine; A
2for the absorbance of system after medicine removing OH; A
3for the absorbance of system after blank removing OH.
5, experimental result
Anti-senescence function evaluation experimental is as follows.
Table 3 experimental result
Experiment shows, Chinese medicine composition of the present invention can restraint of tyrosinase be active effectively, has the function of scavenging free radicals simultaneously.
Embodiment 2 Chinese medicine composition
The Chinese medicine composition (I) with anti-senescence function is composed as follows:
The Chinese medicine composition (II) with anti-senescence function is composed as follows:
Embodiment 3 anti-aging cream
Table 4 provides the anti-aging cream formula containing Chinese medicine composition, and the consumption of each material represents with mass fraction.
Table 4
Preparation: by the dimethyl siloxane in formula table, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid, methyl hydroxybenzoate, propylparaben mixing, be heated to 80 DEG C, fusing stirs, as oil phase; By the 1,2-PD in formula table, traditional Chinese medicine extract composition, triethanolamine, deionized water mixing, be heated to 85 DEG C, stirring and dissolving is even, as aqueous phase.Oil phase and aqueous phase are added in emulsifying pot, stir, emulsifying homogeneous, after 6 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, be cooled to 38 DEG C, be anti-aging cream.
Embodiment 4 anti-aging cream human efficiency evaluation test
Test according to " cosmetics health specification " (version in 2007).Fructus Lycii protective skin cream is prepared by embodiment 3, choose Chinese medicine extraction composition I I, select 30 (10 male, 20 women) healthy, without the volunteer of cosmetic allergic contact dermatitis history, carry out the detection of anti-aging cream moisture retention, skin elasticity and dermal melanin.
Moisture retention testing result is shown in shown in Fig. 1 of accompanying drawing.
Skin elasticity testing result is shown in shown in Fig. 2 of accompanying drawing.
Dermal melanin content detection the results are shown in shown in Fig. 3 of accompanying drawing.
Testing result shows, anti-aging cream has the effect of moisturizing, whitening, enhancing skin elasticity, can delay skin aging, and to no skin irritation.
Claims (3)
1. there is a cosmetic composition for anti-senescence function, it is characterized in that it is made up of the component of following percentage by weight:
2. cosmetic composition according to claim 1, it is characterized in that this cosmetic composition is for preparing anti-aging cosmetics, its consumption counts 0.05 ~ 20% with dry thing percentage by weight.
3. cosmetic composition according to claim 1, it is characterized in that this cosmetic composition is for preparing anti-aging cosmetics, the dosage form of gained anti-aging cosmetics is: solution, suspension, emulsion, paste, powdery, spray.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210197127.8A CN103202928B (en) | 2012-06-15 | 2012-06-15 | Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic |
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| CN201210197127.8A CN103202928B (en) | 2012-06-15 | 2012-06-15 | Traditional Chinese medicine composition with anti-aging function and application of same in anti-aging cosmetic |
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| CN103202928A CN103202928A (en) | 2013-07-17 |
| CN103202928B true CN103202928B (en) | 2015-07-08 |
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| CN103564503B (en) * | 2013-10-29 | 2015-12-30 | 无限极（中国）有限公司 | Forsythia suspense extraction is preparing the application in the health food or cosmetics with uv-resistant A radiation and senile-resistant efficacy |
| CN103751071B (en) * | 2014-02-12 | 2016-08-24 | 云南省药物研究所 | A kind of zero fragrant seamless skin maintenance agent for men only and preparation method thereof |
| CN105232384A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Anti-aging lycium barbarum skin-care product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113778A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Preparation for treating senile diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113778A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Preparation for treating senile diseases |
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Address after: 510663 Guangzhou High-tech Industrial Development Zone, Guangzhou, Guangdong Province, 15 Kelin Road, Guangzhou Science City Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |