CN103202784A - Preparation method of common bombax flower extract with whitening and anti-aging activities, and application thereof in cosmetics - Google Patents
Preparation method of common bombax flower extract with whitening and anti-aging activities, and application thereof in cosmetics Download PDFInfo
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- CN103202784A CN103202784A CN2012101140344A CN201210114034A CN103202784A CN 103202784 A CN103202784 A CN 103202784A CN 2012101140344 A CN2012101140344 A CN 2012101140344A CN 201210114034 A CN201210114034 A CN 201210114034A CN 103202784 A CN103202784 A CN 103202784A
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Abstract
The invention discloses a preparation method of a common bombax flower extract with whitening and anti-aging activities. The preparation method is characterized in that dried common bombax flowers are crushed and sieved; the common bombax flower is subjected to ethanol soaking extraction twice; extracted liquids obtained in the two times are combined; reduced-pressure concentration is carried out, such that a suspension liquid is obtained; the suspension liquid is sequentially extracted by using petroleum ether and ethyl acetate; reduced-pressure concentration is carried out, and ethyl acetate is recovered; and a paste is obtained by vacuum drying, such that the common bombax flower extract is obtained. With the method, the prepared common bombax flower extract has anti-free radical oxidation, tyrosinase activity inhibiting, and anti-ultraviolet radiation functions, and can be used in skin whitening and aging-preventing especially photoaging-preventing. The common bombax flower extract can be used as a cosmetic additive or a medicine active component, and can be applied in whitening and anti-aging cosmetics.
Description
Technical field
The present invention relates to the preparation method of Flos Bombacis Malabarici extract, this extract Pear Power and senile-resistant efficacy can be applied to the whitening anti-aging cosmetics, belong to field of fine chemical.
Background technology
The skin-whitening defying age is the theme of cosmetics, and the cosmetics with skin-whitening anti-senescence function are one of main flow cosmetics of consumer's favor.Modern scientific research proves that skin aging is a very complicated process, is subjected to influence of various factors, and wherein melanic generation and free radical cause that the degeneration of elastic fibers of skin is two big principal elements.
The color of human skin depends on melanic content and distribution, and is inhomogeneous in the human body deposition distribution when a large amount of melanin, will form freckle, chloasma.Tryrosinase extensively is present in the human body, is to produce melanic key enzyme.Melanic forming process is: the tyrosine in the human body skin melanocyte is oxidized generation DOPA and DOPA quinone under the catalytic action of tryrosinase, generate dopachrome, 5 through resetting laggard oxidation step, 6-dihydroxy indole, istain, final synthesis of melanin.At present the dominant mechanism of whitening agent cosmetics commonly used is that active or blocking-up tyrosine oxidation generates melanin by restraint of tyrosinase, thereby reduces melanic generation and reach the effect of skin-whitening.
Free radical is the key factor that causes skin aging, and air pollution, pressure, medicine etc. all can make health produce free radical, and ultraviolet is the main source of skin free radical.Free radical contains the part of molecule or the molecule of one or more unpaired electrons, has the tendency of pairing.Therefore most of free radicals are all very active, have the chemism of height.Under normal circumstances, the free radical in the human body is to be among the dynamic equilibrium of continuous generation and removing.But free-radical generating is too much or removed slowly, and it can cause the various damages of body by attacking life macromolecule material and various cell, accelerates the senescence process of body, shows old and feeble gradually variation, as age pigment deposit, skin is wrinkling etc.Therefore, when whitening, it is extremely important to strengthen free radical resisting.
Now, the skin-lightening cosmetic market development is very rapid, and the developmental research of whitening agent is also constantly released.In recent years, the whitening agent that uses in cosmetics mainly contains chemical compounds such as hydroquinone (hydroquinone), L-ascorbic acid (vitamin C), kojic acid and arbutin.But these whitening agents exist many defectives, and very big as the zest of hydroquinone, vitamin C is very unstable, and kojic acid is to light, heat and metal ion instability, and skin absorption is poor, the single and poor effect of arbutin effect etc.So exploitation has good safety, stability, inhibition is obvious, and the natural whiting agent that cost performance is good has become one of main direction of studying of current medicine and cosmetic industry, has extraordinary development prospect.
Flos Bombacis Malabarici common bombax flower is the dried floral of Bombacaceae plant kapok Bombax malabaricum (DC.) Merr, another name Flos Bombacis Malabarici, speckle sesame.Be distributed in provinces and regions such as southern Guangdong, Guangxi, Yunnan, Sichuan, Hainan, Fujian, Taiwan.Beginning is stated from clearly, and what restrains remonstrate with " the SHENGCAO property of medicine is wanted fully ".Nature and flavor are sweet, cold.Effect with clearing away heat-damp and promoting diuresis, detoxifcation and hemostasis.Cure mainly enteritis, have loose bowels, bleeding hemorrhoids, bacillary dysentery.Flos Bombacis Malabarici is usually used in Chinese medicine compound, and as golden aster five-flower tea granule, be used for having loose bowels due to the damp-heat in the large intestine, dysentery, have blood in stool, hemorrhoidal bleeding and liver-heat conjunctival congestion, the wind heat pharyngalgia, dispute is festered etc.
At present, research and the application to Flos Bombacis Malabarici deepens continuously.Studies show that Flos Bombacis Malabarici contains volatile ingredient such as hexadecanoic acid, ethyl palmitate, Ethyl linoleate etc.; Triterpenes components such as lupeol, lupin ketone etc.; Flavone compound such as aromadendrin, Quercetin, luteolin etc.But the application of Flos Bombacis Malabarici is mostly in industries such as food, medicine, health cares, and for its research in cosmetics also seldom, the research that especially is applied in the whitening anti-aging cosmetics does not appear in the newspapers as yet.Because the recyclability of plant, the development and use Flos Bombacis Malabarici is an important opportunity of present cosmetics scientific research and innovation to obtain better active component.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Flos Bombacis Malabarici extract of Pear Power activity of fighting against senium, this Flos Bombacis Malabarici extract has the effect of free radical resisting oxidation, restraint of tyrosinase activity and ultraviolet radiation resisting.
The preparation scheme of Flos Bombacis Malabarici extract of the present invention is as follows:
1. the Flos Bombacis Malabarici of drying is made powder, cross 40～80 mesh sieves;
2. the Flos Bombacis Malabarici powder is put into round-bottomed flask, add 5mL～30mL alcoholic solution (mass concentration of ethanol is between 30%～80% in the alcoholic solution) by every 1g Flos Bombacis Malabarici powder, adding heat soaking then under 40 ℃～80 ℃ conditions extracts twice, each 1h～3h that extracts, merge extracted twice liquid, obtain crude extract;
3. Flos Bombacis Malabarici ethanol crude extract concentrating under reduced pressure is reclaimed ethanol, obtain suspension;
4. use the petroleum ether extraction suspension, described petroleum ether mixed with suspension in 3: 1 by volume, 2: 1 or 1: 1, removed pigment and tannin, obtained refining liquid;
5. with the active substance in the ethyl acetate extraction refining liquid, described ethyl acetate was mixed with refining liquid in 3: 1 by volume, 2: 1 or 1: 1, and concentrating under reduced pressure becomes mastic with the activity extract vacuum drying after reclaiming ethyl acetate.
Another object of the present invention is that Flos Bombacis Malabarici extract is used for the whitening anti-aging cosmetics, makes stable in properties, respond well whitening anti-aging cosmetics.The dosage form of whitening anti-aging cosmetics is not particularly limited, and can be solution, emulsion, paste, powdery etc.
The invention has the beneficial effects as follows by the inhibitory action of tryrosinase, test, uv absorption, anti-hydroxy radical oxidation and the human trial of melanocyte are verified that Flos Bombacis Malabarici extract has skin-whitening and senile-resistant efficacy.
The specific embodiment
Below come by specific embodiment that the present invention is further illustrated, but these embodiment are not limitations of the present invention just in order to illustrate.
The preparation of the Flos Bombacis Malabarici extract of embodiment 1 Pear Power activity of fighting against senium
Accurately take by weighing dried Flos Bombacis Malabarici 50g under natural environment, be ground into particle mean size at 50 purpose powder; Be that 70% ethanol water mixes with Flos Bombacis Malabarici powder and 750mL mass concentration, and add in the round-bottomed flask, then with 80 ℃ of water-bath lixiviate 1.5h twice, merge extracted twice liquid, obtain crude extract; With the Flos Bombacis Malabarici ethanol crude extract concentrating under reduced pressure that obtains, reclaim ethanol, obtain suspension; Petroleum ether and suspension were extracted in 2: 1 by volume, combining extraction liquid, concentrating under reduced pressure reclaims petroleum ether, obtains refining liquid; It is colourless substantially that ethyl acetate and refining liquid were extracted to ethyl acetate layer in 2: 1 by volume, combining extraction liquid, and concentrating under reduced pressure reclaims ethyl acetate, and dry 18h in 50 ℃ vacuum drying oven obtains extractum with active component.
Embodiment 2 restraint of tyrosinase active testings
(1) material
1. solution preparation
(1) HCl (0.1mol/L): the hydrochloric acid solution of 0.862mL 36%～38% is dissolved in the 99.138mL water.
(2) L-tyrosine solution: 0.05g is dissolved among the HCl of 35mL 0.1mol/L, is settled to 100mL with PBS (0.1mol/L) buffer of pH6.8.
(3) (pH=6.8,0.1mol/L): 1. the 17.91g disodium hydrogen phosphate is dissolved in the deionized water PBS solution, is settled to 500mL with deionized water.2. 7.8g ten sodium dihydrogen phosphate dihydrates are dissolved in the deionized water, are settled to 500mL with deionized water.3. get the phosphate buffer solution that 92.6mL and 107.4mL are mixed with 200mLpH=6.8 respectively.
(4) tryrosinase: 100U/mL.
2. sample preparation
Above-mentioned Flos Bombacis Malabarici extract is dissolved in the dimethyl sulfoxine, is made into concentration and is 0.1% sample solution, carry out following test.Simultaneously with arbutin sample in contrast.
(2) instrument
The 10mL test tube, water-bath, agitator.
(3) test method
1. according to table 1 application of sample, do not add tryrosinase.Arbutin is compared as one group of sample.
Table 1
2. solution is placed 37 ℃ of water-bath constant temperature 10min.
3. adding tryrosinase, solution placed 37 ℃ of water-bath constant temperature 10min after, under 475nm, measure its absorbance, and compare with arbutin.
The tyrosinase activity suppression ratio calculates according to formula (1):
Tyrosinase activity suppression ratio=(blank absorbency value-sample absorbance)/blank absorbency value * 100 (1)
Embodiment 3 suppresses melanin synthetic test in the melanocyte
The density of B16 melanoma cell with 1 * 105/mL is inoculated in 96 orifice plates every hole 90 μ L, CO
2After hatching 24 hours in the incubator, every hole adds sample solution.Set up the blank group of culture medium and cell simultaneously.
After placing incubator to hatch 72 hours the culture plate, abandoning supernatant, PBS washing twice, every hole adds 0.5mL trypsin digestion cell 3min then, and every hole adds 2mL and keeps liquid and stop digestion.Behind the mixing, every kind of concentration is taken out 0.5mL and is done the cell counting.All the other cell suspension are with 2500r/min centrifugalize 5min, and abandoning supernatant adds NaOH solution in precipitation, and heating makes the melanin dissolving, selects the 490nm wavelength to measure absorbance under enzyme-linked immunosorbent assay instrument.By formula (2) calculation sample to the synthetic suppression ratio of melanin (I ').
The anti-hydroxy radical ability of embodiment 4 salicylic acid methods test active matter
(1) test principle
The OH oxidation salicylic acid that produces by the Fenton reaction in the system produces has 2 of special absorption to 510nm light, and 3-dicarboxyl benzoic acid is caught the clearance rate that the resulting product of OH is determined OH by measuring salicylic acid.Reaction equation is: H
2O
2+ Fe
2+→ OH+OH
-+ Fe
3+
(2) material
1. reagent: salicylic acid, FeSO
4, H
2O
2
2. sample: Flos Bombacis Malabarici extract extractum is soluble in water, be made into concentration and be 0.1% sample solution, and with the arbutin of same concentrations in contrast.
3. instrument: 25mL test tube, water-bath, ultraviolet spectrophotometer, 1mL, 5mL liquid-transfering gun.
(3) test method
In the 25mL color comparison tube, add 2mmol/L FeSO successively
43mL, 1mmol/L H
2O
23mL shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, and takes out behind 37 ℃ of heating in water bath 15min, surveys its absorbance A
oAdd certain density liquid 0.2mL to be measured, 0.4mL, 0.6mL, 0.8mL, 1.0mL then respectively, and then add distilled water 0.8mL, 0.6mL, 0.4mL, 0.2mL, 0mL respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance A
xAs stated above, add each liquid as shown in table 2, do not add salicylic acid, shake up, heating in water bath 15min, measured value A
XoCalculate free radical scavenging activity by formula (3).
The free clearance rate of hydroxyl (%)=A
o-(A
x-A
Xo)/A
o* 100 (3)
A
o---the light absorption value of blank
A
x---add the light absorption value of sample
A
Xo---do not add developer H
2O
2Solution background absorption value
Table 2
The test of embodiment 5 uvioresistant effect assessments
Test according to the light industry standard QB/T 2334-1997 of the People's Republic of China (PRC) (cosmetics middle-ultraviolet lamp absorbent qualitative determination-ultraviolet spectrophotometry).Sample extractum is dissolved in 95% ethanol, is made into concentration and is 0.1% sample solution, in 280～400nm scope, scan every 10nm then, determine the absorbance under each wavelength, and calculate mean light absorbency.
Table 3 has provided the whitening and skin-protecting effect assessment experimental result of Flos Bombacis Malabarici extract.
Table 3 whitening and skin-protecting effect assessment experimental result
Find by above every whitening and skin-protecting evaluation experimental, Flos Bombacis Malabarici extract of the present invention restraint of tyrosinase effectively is active melanic synthetic with inhibition, have the hydroxy radical of removing and anti-ultraviolet function simultaneously, these functions all are better than arbutin whitening agent commonly used at present.
The evaluation of whitening of embodiment 6 human bodies
(1) principle
Utilize three kinds of different wave lengths absorptions and reflection to measure the amount of melanin and haemachrome, determine the performance of skin color.
(2) specimen and object
Flos Bombacis Malabarici extract extractum is added in the emulsifiable paste of no whitening effect commonly used, as specimen by 3% addition.Select the age be the healthy volunteer of 18 years old～50 years old no dermatosis and allergies as tested object, volunteer's number 10 people, the men and women is 5 people respectively.
(3) test instrunment
Mexamter MX18 (CK Electronic GmH, Germany)
(4) test condition
Room temperature is below 20 ± 2 ℃, and relative humidity (RH) is below 50 ± 5%; Testee 30min before mensuration enters in the test environment quiet to be measured, and 10min exposes tested position before mensuration.
(5) method
According to test request, choose testee's facial left and right sides cheek and the preceding wrist of right arm and bend the suitable area in lateral areas as being tested the district.Before the makeup application, the probe of Mexamter MX18 is vertically placed on the skin, read melanin and the red pigment numerical value at tested position behind 3s～5s behind the value stabilization to be determined.Measure melanin and red pigment numerical value after instant after the makeup application, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks respectively according to standardization program; Each is tested the dark red pigment at position and is got mensuration 5 times, gets its meansigma methods.
(6) result of the test
Experimental result sees Table 4 and table 5.
The melanin value of table 4 use test sample different time
The red pigment value of table 5 use test sample different time
This test is represented the color of skin with dermal melanin and red pigment content, and the more few skin color of melanin and red pigment content is more shallow, and is namely more white.By table 4 and table 5 as can be seen, Flos Bombacis Malabarici extract adds in the emulsifiable paste of no whitening effect commonly used, has tangible whitening effect.
The preparation of embodiment 7 body whitening cr
Table 6 provides the body whitening cr prescription that contains Flos Bombacis Malabarici extract, and the consumption of each material is represented with mass fraction.
Table 6
The preparation method of body whitening cr: the A component is mixed, be heated to 75 ℃, thawing stirs, and adds the B component before the emulsifying.C component (except Flos Bombacis Malabarici extract) is mixed and heated to 75 ℃, in stirring down A component and B component is slowly added in the C component, homogenizing is handled, add Flos Bombacis Malabarici extract and D component when waiting to be cooled to 50 ℃, continue slowly to stir, be cooled to room temperature, can pack behind the ageing 24h, get final product.
The preparation of embodiment 8 whitening and skin-protecting breasts
Table 7 provides the whitening and skin-protecting breast prescription that contains Flos Bombacis Malabarici extract, and the consumption of each material is represented with mass fraction.
Table 7
The preparation method of whitening and skin-protecting breast: each material of A component (except Flos Bombacis Malabarici extract) is added to the water, is heated to 85 ℃ and makes its dissolving, make water.In addition the B component is mixed post-heating to 85 ℃ fusion, add the C component before the emulsifying, dispersed with stirring evenly makes oil phase.In stirring down B component and C component are slowly added in the A component, homogenizing is handled, and adds Flos Bombacis Malabarici extract and D component when waiting to be cooled to 50 ℃, continues slowly to stir, and is cooled to room temperature, can pack behind the ageing 24h, gets final product.
Claims (3)
1. the preparation method of the Flos Bombacis Malabarici extract of Pear Power activity of fighting against senium is characterized in that may further comprise the steps:
(1) Flos Bombacis Malabarici of drying is made powder, cross 40～80 mesh sieves;
(2) the Flos Bombacis Malabarici powder is put into round-bottomed flask, add 5mL～30mL alcoholic solution (mass concentration of ethanol is between 30%～80% in the alcoholic solution) by every 1g Flos Bombacis Malabarici powder, adding heat soaking then under 40 ℃～80 ℃ conditions extracts twice, each 1h～3h that extracts, merge extracted twice liquid, obtain crude extract;
(3) Flos Bombacis Malabarici ethanol crude extract concentrating under reduced pressure is reclaimed ethanol, obtain suspension;
(4) use the petroleum ether extraction suspension, described petroleum ether mixed with suspension in 3: 1 by volume, 2: 1 or 1: 1, removed pigment and tannin, obtained refining liquid;
(5) with the active substance in the ethyl acetate extraction refining liquid, described ethyl acetate was mixed with refining liquid in 3: 1 by volume, 2: 1 or 1: 1, and concentrating under reduced pressure becomes mastic with the activity extract vacuum drying after reclaiming ethyl acetate.
2. the whitening anti-aging cosmetics that contain Flos Bombacis Malabarici extract, it is characterized in that: these cosmetics comprise the Flos Bombacis Malabarici extract that obtains according to the described preparation method of claim 1, have the effect of free radical resisting oxidation, restraint of tyrosinase activity and ultraviolet radiation resisting.
3. the whitening anti-aging active cosmetic that contains Flos Bombacis Malabarici extract according to claim 2, it is characterized in that: the dosage form of described cosmetics is solution, emulsion, paste, powdery etc.
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Cited By (7)
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| CN106924109A (en) * | 2017-02-15 | 2017-07-07 | 玉林祺钟商贸有限公司 | A kind of whitening skin care product |
| CN107714570A (en) * | 2017-12-08 | 2018-02-23 | 张健 | One Plant Extracts, preparation method and its application in cosmetics |
| CN110763597A (en) * | 2019-07-31 | 2020-02-07 | 杭州曼迪生物科技有限公司 | Method for evaluating whitening effect of cosmetics based on transdermal absorption |
| CN111712305A (en) * | 2017-12-22 | 2020-09-25 | 科学发展实验室 | Kapok flower extract, and cosmetic, pharmaceutical or dermatological composition containing same |
| CN112156119A (en) * | 2020-11-09 | 2021-01-01 | 广东丸美生物技术股份有限公司 | Application of kapok alcohol extract and medicament for inhibiting propionibacterium acnes |
| CN114469815A (en) * | 2022-02-25 | 2022-05-13 | 广东丸美生物技术股份有限公司 | Common bombax flower extract and preparation method and application thereof |
| CN114931535A (en) * | 2022-06-29 | 2022-08-23 | 广东远宸医药生物科技有限公司 | Preparation method and application of kapok extract with moisturizing and relieving effects |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106924109A (en) * | 2017-02-15 | 2017-07-07 | 玉林祺钟商贸有限公司 | A kind of whitening skin care product |
| CN107714570A (en) * | 2017-12-08 | 2018-02-23 | 张健 | One Plant Extracts, preparation method and its application in cosmetics |
| CN107714570B (en) * | 2017-12-08 | 2020-05-19 | 玮格沃德贸易有限公司 | Plant extract, preparation method and application thereof in cosmetics |
| CN111712305A (en) * | 2017-12-22 | 2020-09-25 | 科学发展实验室 | Kapok flower extract, and cosmetic, pharmaceutical or dermatological composition containing same |
| CN111712305B (en) * | 2017-12-22 | 2023-08-04 | 科学发展实验室 | Kapok extract and cosmetic, pharmaceutical or dermatological composition containing same |
| CN110763597A (en) * | 2019-07-31 | 2020-02-07 | 杭州曼迪生物科技有限公司 | Method for evaluating whitening effect of cosmetics based on transdermal absorption |
| CN112156119A (en) * | 2020-11-09 | 2021-01-01 | 广东丸美生物技术股份有限公司 | Application of kapok alcohol extract and medicament for inhibiting propionibacterium acnes |
| CN112156119B (en) * | 2020-11-09 | 2023-04-28 | 广东丸美生物技术股份有限公司 | Application of kapok alcohol extract and medicament for inhibiting propionibacterium acnes |
| CN114469815A (en) * | 2022-02-25 | 2022-05-13 | 广东丸美生物技术股份有限公司 | Common bombax flower extract and preparation method and application thereof |
| CN114931535A (en) * | 2022-06-29 | 2022-08-23 | 广东远宸医药生物科技有限公司 | Preparation method and application of kapok extract with moisturizing and relieving effects |
| CN114931535B (en) * | 2022-06-29 | 2023-09-26 | 广东远宸医药生物科技有限公司 | Preparation method and application of kapok extract with moisturizing and relieving effects |
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Address after: 510663 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |