CN108338955A - A kind of cosmetics and preparation method thereof - Google Patents

A kind of cosmetics and preparation method thereof Download PDF

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Publication number
CN108338955A
CN108338955A CN201810497911.8A CN201810497911A CN108338955A CN 108338955 A CN108338955 A CN 108338955A CN 201810497911 A CN201810497911 A CN 201810497911A CN 108338955 A CN108338955 A CN 108338955A
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parts
root
cosmetics
filtrate
raw material
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CN201810497911.8A
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Inventor
陈忠
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Yunnan Zhong Dan Hong Pharmaceutical Co Ltd
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Yunnan Zhong Dan Hong Pharmaceutical Co Ltd
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Priority to CN201810497911.8A priority Critical patent/CN108338955A/en
Publication of CN108338955A publication Critical patent/CN108338955A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to cosmetic technical fields, and in particular to a kind of cosmetics and preparation method thereof；Including following raw material:Centella, kuh-seng, Radix Notoginseng, Fructus Aesculi, worm beach wormwood, Radix Angelicae Sinensis, the fleece-flower root, the root of bidentate achyranthes, blackspiked lovegrass herb with root；Preparation method includes the following steps：1) it takes formula content of starting materials to add water to cook twice, filters and collect filtrate；2) magma that relative density is 1.23~1.28 when filtrate obtained by step 1) being concentrated into 70~80 DEG C；3) chitosan is added into magma obtained by step 2), the chitosan containing 1.4~1.7g in every 1000mL magmas, heat preservation is made to stand, filter and collect filtrate；4) filtrate obtained by step 3) is concentrated, makes to contain 2.5~3.2g active ingredients in every milliliter of extracting solution；5) extracting solution obtained by step 4) is configured to required State of cosmetics；The present invention is not added with chemical synthesis additive, be it is a kind of be originated from natural, safe, the good anti aging effect of effect composition.

Description

A kind of cosmetics and preparation method thereof
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of cosmetics and preparation method thereof.
Background technology
" scar " is the detrimental effect of the factors such as physics, biology, chemistry in human skin soft tissue, leads to skin soft tissue Major injury and completely self-confident normal cannot repair, the i.e. influence appearance for turning to be left by fibrous tissue replacement reparation influences work(again The local symptom of energy.The function and effect of scar repairing activity substance include removing free radical, improve cell proliferation rate, are delayed thin The degradation speed of extracellular matrix.Meanwhile anti-aging cosmetics need to select excellent skin-care agent, enough to skin supplement Nutrient reaches deep layer nutrition.In addition, also to slow down the loss of moisture in skin, skin is protected.
Currently, the management of China's cosmetics and technology have prodigious defect, the phenomenon that addition, is very serious in violation of rules and regulations, more Many beauty accidents are caused over year, prodigious injury is caused to consumer, have caused country and the great attention of consumer. Exploitation has extraordinary hair with good safety, stability, natural anti-aging cosmetics with obvious effects, cost performance is good Exhibition foreground.Natural materials can reach skin treating and skin care double effects applied to cosmetics, and with vdiverse in function, applicable The characteristics such as wide, safe, thus by attention increasingly.
Invention content
A kind of cosmetics of present invention proposition and preparation method thereof, the present invention is not added with chemical synthesis additive, is an introduces a collection From the composition of natural, the safe good anti aging effect of effect.
In order to achieve the above object, the present invention is achieved through the following technical solutions：
A kind of cosmetics, including following raw material:Centella, kuh-seng, Radix Notoginseng, Fructus Aesculi, worm beach wormwood, Radix Angelicae Sinensis, the fleece-flower root, ox Knee, blackspiked lovegrass herb with root.
Preferably, including following component raw material：5~10 parts of centella, 8~10 parts of kuh-seng, 6~8 parts of Radix Notoginseng, Fructus Aesculi 2~6 parts, 4~7 parts of worm beach wormwood, 4~7 parts of Radix Angelicae Sinensis, 2~4 parts of the fleece-flower root, 4~6 parts of the root of bidentate achyranthes, 3~5 parts of blackspiked lovegrass herb with root.
Preferably, including following component raw material：8 parts of centella, 9 parts of kuh-seng, 7 parts of Radix Notoginseng, 5 parts of Fructus Aesculi, worm beach wormwood 5 Part, 5 parts of Radix Angelicae Sinensis, 3 parts of the fleece-flower root, 5 parts of the root of bidentate achyranthes, 4 parts of blackspiked lovegrass herb with root.
A kind of preparation method of cosmetics, includes the following steps：
1) it takes formula content of starting materials to add water to cook twice, filters and collect filtrate；
2) magma that relative density is 1.23~1.28 when filtrate obtained by step 1) being concentrated into 70~80 DEG C；
3) chitosan is added into magma obtained by step 2), makes the chitosan containing 1.4~1.7g in every 1000mL magmas, keep the temperature It stands, filters and collect filtrate；
4) filtrate obtained by step 3) is concentrated, makes to contain 2.5~3.2g active ingredients in every milliliter of extracting solution；
5) extracting solution obtained by step 4) is configured to required State of cosmetics.
Preferably, in the step 1), it is 5~7 times of raw material weights, second of decoction water to decoct water consumption for the first time Amount is 3~5 times of raw material weights.
Preferably, the step 5) State of cosmetics is Essence, skin care condensation, lotion.
Compared with prior art, the present invention at least has the advantages that：
The present invention's there are anti-senescence function cosmetics to have inhibition melanocyte, inhibition white horse with a black mane propylhomoserin enzyme, Green Tea Extract Effect.Melanin production can effectively be inhibited, skin obfuscation can be alleviated, chloasma, wrinkle increase, insomnia and dreamful sleep, hectic fever night sweat, Moisturizing etc..Meanwhile the composition is free of chemical synthesis substance, has no toxic side effect, skin irritation is small, and property is stablized, peace It is complete reliable.Other than with anti-senescence function, since the composition contains there are many important component, have the function of it is anti-inflammatory antibacterial etc., It can promote skin metabolism, improve nutrition and the health of skin, there is good skin effect.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Embodiment 1
Raw material takes according to following weight (gram) proportioning：
Centella 35g, kuh-seng 15g, Radix Notoginseng 5g, Fructus Aesculi 20g, worm beach wormwood 3g, Radix Angelicae Sinensis 15g, fleece-flower root 10g, root of bidentate achyranthes 20g, Blackspiked lovegrass herb with root 10g.
Above-mentioned raw materials are dipped in 215 kilograms of water and are decocted 90 minutes, filtrate is collected by filtration.Gained filter residue is dipped in 129,000 It is decocted 50 minutes in gram water, filtrate is collected by filtration, merge gained filtrate twice.Gained filtrate, which is concentrated into 70 DEG C of relative densities, is 1.23 magma.Chitosan is added into magma, makes chitosan containing 1.4g in every 1000mL magmas, is sufficiently stirred, heat preservation is stood, It filters and collects filtrate.Gained filtrate is concentrated, makes to contain 2.5g active ingredients in every milliliter of extracting solution.Gained finished product can root It is used according to needing to be made Essence dosage form.
Embodiment 2
Raw material takes according to following weight (gram) proportioning：
Centella 35g, kuh-seng 15g, Radix Notoginseng 5g, Fructus Aesculi 20g, worm beach wormwood 3g, Radix Angelicae Sinensis 15g, fleece-flower root 10g, root of bidentate achyranthes 20g, Blackspiked lovegrass herb with root 10g.
Above-mentioned raw materials are dipped in 215 kilograms of water and are decocted 90 minutes, filtrate is collected by filtration.Gained filter residue is dipped in 129,000 It is decocted 50 minutes in gram water, filtrate is collected by filtration, merge gained filtrate twice.Gained filtrate, which is concentrated into 70 DEG C of relative densities, is 1.23 magma.Chitosan is added into magma, makes chitosan containing 1.4g in every 1000mL magmas, is sufficiently stirred, heat preservation is stood, It filters and collects filtrate.Gained filtrate is concentrated, makes to contain 2.5g active ingredients in every milliliter of extracting solution.Gained finished product can root It is used according to needing to be made Essence dosage form.
Embodiment 3
Raw material takes according to following weight (gram) proportioning：
Centella 30g, kuh-seng 15g, Radix Notoginseng 8g, Fructus Aesculi 20g, worm beach wormwood 2g, Radix Angelicae Sinensis 12g, fleece-flower root 5g, root of bidentate achyranthes 22g, dew Water plant 12g.
Above-mentioned raw materials are dipped in 539 kilograms of water and are decocted 100 minutes, filtrate is collected by filtration.Gained filter residue is dipped in 385,000 It is decocted 60 minutes in gram water, filtrate is collected by filtration, merge gained filtrate twice.Gained filtrate, which is concentrated into 80 DEG C of relative densities, is 1.28 magma.Chitosan is added into magma, makes chitosan containing 1.7g in every 1000mL magmas, is sufficiently stirred, heat preservation is stood, It filters and collects filtrate.Gained filtrate is concentrated, makes to contain 3.2g active ingredients in every milliliter of extracting solution.Gained finished product can be made It is used for beauty essence, skin care condensation, lotion.
Experimental analysis
One, anti-aging effects are tested
After magma is prepared Following the procedure of Example 1, processing is dried, flour is made, the distillation of 10 weight is added Water, heating and refluxing extraction 3 times, 1 hour every time.Merging filtrate filters.Filtrate decompression concentrates, and places, and removes precipitation, supernatant It is eluted by D101 macroreticular resins, collects 70% ethanol eluate, reduced vacuum concentration obtains Chinese medical extract.By extract It is made into a concentration of 1% sample solution, carries out experiment below.
1, inhibit the measurement of tyrosinase vigor
It is loaded according to following table (table 1), is compared 1% ursin as one group of sample.Solution is placed in 37 DEG C of water-baths After middle constant temperature 10min, its absorbance value is measured under 475nm, and be compared with 1% ursin.
Composition (the unit of 1 reaction solution of table：ml)
Relative inhibition of the sample to tyrosinase is calculated by formula (1).
Inhibiting rate=(A3-A4)/(A1-A2)
In formula：A1、A2、A3、A4Respectively 1 group to 4 groups of absorbance.
2 measurement result of table
2, the measurement of ultra-oxygen anion free radical scavenging effect
4.5 milliliters of Tris-HCl buffer solutions for taking 0.05mol/LpH=8.2,20min is preheated in 25 DEG C of water-baths, The neck benzenetriol solution of 1mL samples and 0.4mL25mmol/L is added, after mixing, 5min is reacted in 25 DEG C of water-baths, is added The HCl1.0mL of 8mol/L terminates reaction.Make reference with Tris-HCl buffer solutions, absorbance value is surveyed at 299nm.Blank control Sample is substituted with the solvent of 1mL samples.Clearance rate (D) is calculated according to formula (2).
Clearance rate (%)=[1- (A2/A1)] × 100% formula (2)
A in formula1For the absorbance value of blank control；A2For the absorbance value of drug.
3 measurement result of table
3, the Scavenging activity of hydroxy radical is measured
2mmol/LFeSO is sequentially added in 25mL colorimetric cylinders43mL, 1mmol/LH2O23mL shakes up, and is subsequently added into 6mmol/L salicylic acid 3mL, shake up, and are taken out after 37 DEG C of heating water bath 15min, measure absorbance；It is separately added into certain density Prepare liquid shakes up, and continues heating water bath 15min, takes out and measures its absorbance.Following formula (3) is prepare liquid to carboxylic free radical (OH) Clearance rate：
OH clearance rates (%)=[A1-A2-(A1-A3)]/A1× 100% formula (3)
A in formula1For the absorbance value of reaction system before non-dosing product；A2The absorbance value of system after OH is removed for drug；A3 For system absorbance value after blank control clearance rate OH.
4 measurement result of table
Test group A1 A2 A3 OH clearance rates (%)
1 0.523 0.033 0.518 92.7%
2 0.52 0.041 0.524 92.9%
3 0.498 0.032 0.491 92.2%
4 0.536 0.022 0.531 95.0%
5 0.551 0.032 0.558 95.5%
6 0.518 0.039 0.523 93.4%
Although reference be made herein to invention has been described for multiple explanatory embodiments of the invention, however, it is to be understood that Those skilled in the art can be designed that a lot of other modification and implementations, these modifications and implementations will be fallen in this Shen It please be within disclosed scope and spirit.It more specifically, within the scope of the present disclosure and claims, can be to master The building block and/or layout for inscribing composite configuration carry out a variety of variations and modifications.In addition to what is carried out to building block and/or layout Outside modification and improvement, to those skilled in the art, other purposes also will be apparent.

Claims (6)

1. a kind of cosmetics, it is characterised in that:Including following raw material:Centella, kuh-seng, Radix Notoginseng, Fructus Aesculi, worm beach wormwood, Radix Angelicae Sinensis, what The tuber of multiflower knotweed, the root of bidentate achyranthes, blackspiked lovegrass herb with root.
2. a kind of cosmetics according to claim 1, it is characterised in that:Including following component raw material：Centella 5~10 Part, 8~10 parts of kuh-seng, 6~8 parts of Radix Notoginseng, 2~6 parts of Fructus Aesculi, 4~7 parts of worm beach wormwood, 4~7 parts of Radix Angelicae Sinensis, 2~4 parts of the fleece-flower root, ox 4~6 parts of knee, 3~5 parts of blackspiked lovegrass herb with root.
3. a kind of cosmetics according to claim 1, it is characterised in that:Including following component raw material：8 parts of centella, hardship 9 parts of ginseng, 7 parts of Radix Notoginseng, 5 parts of Fructus Aesculi, 5 parts of worm beach wormwood, 5 parts of Radix Angelicae Sinensis, 3 parts of the fleece-flower root, 5 parts of the root of bidentate achyranthes, 4 parts of blackspiked lovegrass herb with root.
4. according to a kind of preparation method of cosmetics described in any one of claim 1-3, it is characterised in that：Including walking as follows Suddenly：
1) it takes formula content of starting materials to add water to cook twice, filters and collect filtrate；
2) magma that relative density is 1.23~1.28 when filtrate obtained by step 1) being concentrated into 70~80 DEG C；
3) chitosan is added into magma obtained by step 2), keeps the chitosan containing 1.4~1.7g in every 1000mL magmas, heat preservation quiet It sets, filter and collects filtrate；
4) filtrate obtained by step 3) is concentrated, makes to contain 2.5~3.2g active ingredients in every milliliter of extracting solution；
5) extracting solution obtained by step 4) is configured to required State of cosmetics.
5. a kind of preparation method of cosmetics according to claim 4, it is characterised in that：In the step 1), for the first time Decoction water consumption is 5~7 times of raw material weights, and it is 3~5 times of raw material weights that second, which decocts water consumption,.
6. a kind of preparation method of cosmetics according to claim 4, it is characterised in that：Step 5) the State of cosmetics For Essence, skin care condensation, lotion.
CN201810497911.8A 2018-05-23 2018-05-23 A kind of cosmetics and preparation method thereof Pending CN108338955A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111920735A (en) * 2020-08-21 2020-11-13 广东盛普生命科技有限公司 Plant-derived anti-aging composition and application thereof

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CN105380853A (en) * 2015-11-28 2016-03-09 铜仁市金农绿色农业科技有限公司 Cosmetic and preparation method thereof
CN107536777A (en) * 2017-09-12 2018-01-05 安徽天马生物科技有限公司 A kind of bright face of pseudo-ginseng is compacted Face-protecting mask

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CN105326780A (en) * 2015-11-28 2016-02-17 铜仁市金农绿色农业科技有限公司 Skin aging resistant cosmetic and preparation method thereof
CN105326714A (en) * 2015-11-28 2016-02-17 铜仁市金农绿色农业科技有限公司 Skin aging-resistant cosmetics and preparation method thereof
CN105380853A (en) * 2015-11-28 2016-03-09 铜仁市金农绿色农业科技有限公司 Cosmetic and preparation method thereof
CN107536777A (en) * 2017-09-12 2018-01-05 安徽天马生物科技有限公司 A kind of bright face of pseudo-ginseng is compacted Face-protecting mask

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111920735A (en) * 2020-08-21 2020-11-13 广东盛普生命科技有限公司 Plant-derived anti-aging composition and application thereof
CN111920735B (en) * 2020-08-21 2022-02-08 广东盛普生命科技有限公司 Plant-derived anti-aging composition and application thereof

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Application publication date: 20180731