CN106924057A - The small-micelle water cosmetics for promoting water-soluble substances rapid transdermal to absorb - Google Patents
The small-micelle water cosmetics for promoting water-soluble substances rapid transdermal to absorb Download PDFInfo
- Publication number
- CN106924057A CN106924057A CN201611255157.4A CN201611255157A CN106924057A CN 106924057 A CN106924057 A CN 106924057A CN 201611255157 A CN201611255157 A CN 201611255157A CN 106924057 A CN106924057 A CN 106924057A
- Authority
- CN
- China
- Prior art keywords
- water
- small
- skin
- cosmetics
- micelle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to daily cosmetics field, a kind of small-micelle water cosmetics for promoting water-soluble substances rapid transdermal to absorb are disclosed.Contain substantial amounts of natural active matter in nature, apply has special-effect in cosmetics to anti-oxidant, anti-aging, sun-proof, whitening, sterilization, anti-inflammatory etc., but due to the special tectonic of skin, water-soluble substances is difficult quickly, sufficiently to be absorbed by skin through cuticula.Small-micelle water can increase the aquation of keratoderma, weaken its barrier action to water-soluble substances, and in small-micelle water, active material can keep molecular activity higher and readily penetrate through skin.Additionally, equally contain small-micelle water in tissue, the cosmetics prepared by small-micelle water, can active balance skin acid-base value, quickly supplement active water, moisten skin water.Experiment shows, relative to common deionized water, the cosmetics that small-micelle water is prepared can promote the rapid transdermal of water-soluble material to absorb.
Description
Technical field
The invention belongs to field of cosmetic manufacture, it is related to a kind of subset for promoting water-soluble substances rapid transdermal to absorb
Aquation cosmetic and its preparation.
Background technology
The active skull cap components for coming from plant, animal and marine algae at present are widely used in cosmetics, to new
The exploitation of cosmetics provides favourable condition, has boundless market application foreground.Some of them water-soluble active ingredient
Advantageous advantage is shown at aspects such as anti-oxidant, anti-aging, whitening, sun-proof, moisturizing, anti-inflammatory Shu Min, such as：1. marine alga
Composition enriches, and in addition to rich in vitamin, mineral matter, amino acid and carbohydrate, also contains polysaccharide, protein, unrighted acid, steroid
The various active material such as class and polyterpene.Research for many years shows that marine alga has cosmetology, anti-inflammation, antitumor, antiviral, anti-
Aging, a series of specific functions such as fat and enhancing body immunity that disappear of losing weight.At present, marine alga is widely used to food, medicine
And the aspect such as daily chemical industry；2. extract of magnolia sieboldii has and suppresses tyrosinase activity and reduce dermal melanin synthesis
Effect, and to the excitatory very small of skin；3. the main active Tea Polyphenols in green-tea extract, with powerful
Ability that is anti-oxidant and removing free radical, Tea Polyphenols can also absorb the ultraviolet of 200-400nm, there is light to protect to skin and make
With in addition, having to study confirms that green-tea extract also has certain skin whitening efficacy and anti-inflammation function；4. tinder
Certainly imperial ability of grass tool height, can resist atrocious weather and other growing environments, and its essential ingredient contains abundant mineral matter,
Have to skin it is crease-resistant, releive, calm, whitening and nourish protective effect.In addition, such as vitamin C, niacinamide, reproducibility
After the increasing water-soluble active ingredient such as glutathione is revealed, important work is played in skin nursing and beauty
With, and gradually penetrate into daily life in diversified form.
But because the outermost layer of human body skin is made up of dead keratinocyte and fibrosis albumen, water miscible work
Property nutritional ingredient transdermal penetration performance it is often poor, it is difficult to through cuticula reach skin corium, this turn into restriction its can send out
Wave the key factor of effect.Dividing for water-soluble substances can be improved with Thief zone, high diffusivity, solvent small-micelle water high
Sub- vigor, and promote horn cell to absorb more moisture, the aquation of skin is improved, bring it about and expand and change its cause
Close degree, reduces the osmotic resistance to water-soluble active ingredient, finally becomes the Transdermal absorption of active nutrient component in cosmetics
Must be more prone to.Research shows, when the water content of cuticula is up to more than 50%, the transmitance of function nutrition material in cosmetics
5-10 times can be increased, and absorption enhancement effect of the cuticula aquation to water-soluble substances is notable compared with liposoluble substance.
The content of the invention
Present invention aim at small-micelle water and water-soluble active ingredient preparing cosmetics are used, small-micelle water can be with
Strengthen the aquation of skin, improve the molecular activity of active component, and finally promote its rapid transdermal to absorb.
The product form of described cosmetics is the cosmetics such as thin skin water, moisture surge treatment formula, facial mask.Preferably, it is described
Cosmetics are thin skin water, and it includes small-micelle water, water-soluble active component, moisturizing active factors and other thin skin water
Matrix.
Small-micelle water containing active component of the invention is carried out into dermal penetration rate measure, using deionized water as
Control, uses the content of active component in ultraviolet specrophotometer determination sample.It was found that with subset water dissolves activity into
Percutaneous rate is divided to be significantly higher than deionized water group.
The thin skin water of small-micelle water containing sea lettuce active component of the invention is carried out into 3D skin models melanin to determine,
Using deionized water as control, as a result content and distribution using melanin in confocal fluorescent measurement microscope model find,
Relative to the thin skin water that deionized water makes, the water-treated skin of thin skin that small-micelle water makes, its melanin content and
Distribution is substantially reduced.
It follows that subset water energy improves water content of stratum corneum, strengthen the aquation of skin, improve sea lettuce activity
The molecular activity of composition, and finally promote its rapid transdermal to absorb.
Small-micelle water cosmetics physicochemical property containing water-soluble active ingredient of the invention is significantly better than with commonly going
Cosmetics obtained in ionized water, due to equally containing small-micelle water, small-micelle water cosmetics of the invention in tissue
The acid-base value of energy active balance skin, the sufficient active water of quick supplement makes the lasting water profit of skin, delicacy；Small-micelle water is high
Infiltration, high diffusivity, solvent property high, the molecular activity that can significantly improve water-soluble active ingredient in cosmetics are saturating with quick
Skin absorbs, for the nursing and maintenance of skin provide a kind of good environment.
Brief description of the drawings
The thin skin water that Fig. 1 is prepared with small-micelle water and deionized water respectively, different time points sea lettuce active component it is saturating
Skin absorptance compared with
The comparing figure of Fig. 2 series active component percutaneous rates in deionized water and small-micelle water
The thin skin water containing sea lettuce active component that Fig. 3 is prepared with small-micelle water and deionized water respectively, to 3D skin moulds
The influence of type melanin expression is compared.
Specific embodiment
Technical scheme is further illustrated below by way of specific embodiment, specific embodiment is not represented to this hair
The limitation of bright protection domain.Other people still fall within this hair according to some nonessential modifications and adjustment that theory of the present invention is made
Bright protection domain.
The a width of 50-100Hz of small-micelle water 17ONMR half-peaks used in embodiment.
Embodiment 1：Different water-soluble actives transdermal evaluation test methods and result
1st, sample preparation, weighs appropriate water-soluble active ingredient respectively, and small-micelle water and deionized water are dissolved in respectively
Table 1
| Composition | % concentration (by weight) |
| Sea lettuce extract | 3 |
| Extract of magnolia sieboldii | 3 |
| Green-tea extract | 3 |
| Edelweiss extract | 3 |
| Bulk kelp extract | 3 |
| Bladder-wrack extract | 3 |
2nd, water-soluble actives transdermal evaluation test method
The Sprague Dawley male rats 6 of body weight 200g or so are taken, after death electricity consumption palpus knife shaves mouse hair at cervical vertebra,
Skin of abdomen is cut, subcutaneous layer of fat, blood vessel and residue is removed, is cleaned with physiological saline, and check its integrality, use physiology
After saline rinse, freezen protective is standby in putting -20 DEG C of refrigerators.Transdermal test in vitro is carried out using improved horizontal Franz dispersers
Experiment.Rat skin is clipped between supply chamber and receiving chamber, towards supply chamber, effective infiltrating area is keratoderma
1.14cm2.4.5mL samples, receiving chamber 4.5mL phosphate buffers (PBS), and supply chamber and receiving chamber are added in supply chamber
Liquid level did not had the most upper limb of skin completely, and constant speed 300r/min is kept under constant temperature (32 ± 1 DEG C), was stirred continuously, in the 120th point
Clock pipettor draws the solution 0.1mL of receiving chamber as test fluid, determines water-soluble active thing with ultraviolet specrophotometer and contains
Amount.The transdermal experiment of each sample is repeated 3 times.
3rd, result of the test
Result with the active component percutaneous rate of subset water dissolves as shown in figure 1, in 120 minutes, be significantly higher than
Deionized water group.
Embodiment 2：Water-soluble active material and small-micelle water are used for thin skin water
Based on mass fraction 100%, thin skin water formula composition is as shown in table 2：
Table 2：Thin skin water formula (%)
| Marine alga sea lettuce extract | 3.0 | Small-micelle water | Surplus |
| Sodium Hyaluronate | 0.1 | Glycerine | 10.0 |
| 1,3 butylene glycol | 5.0 | Preservative | In right amount |
Embodiment 3：Small-micelle water promotes the absorption of marine alga sea lettuce extract
Using the thin skin water of embodiment 2 as sample, the small-micelle water in embodiment 2 is replaced according to identical with deionized water
The thin skin water for preparing of method as control, test method with embodiment 1, respectively at the 5th, 10,20,30,45,60,80,100,
The solution 0.1mL of receiving chamber is drawn as test fluid with pipettor within 120 minutes, while adding the PBS of equivalent, use ultraviolet spectrometry light
Degree meter determines water-soluble active thing content.The accumulation infiltration capacity Q of skin unit area is calculated as follows according to assay result：
Wherein, Q：Accumulation infiltration capacity；S：Effective diffusion area；V：Reception liquid volume in receiving chamber；Ci：1st time to last time
Sample concentration in reception liquid during sampling；Cn：Sample concentration in reception liquid during the sub-sampling.
Result is as shown in Fig. 2 the marine alga sea lettuce extract made of small-micelle water and the marine alga for spending ionized water making
The percutaneous rate of sea lettuce extract is respectively 6.01 μ g/ (cm2) and 4.91 μ g/ (cm min2·min)。
Embodiment 4：The thin skin water of marine alga sea lettuce extract and small-micelle water preparation is determined to black using 3D skin models
The influence of pigment.
The 3D skin models containing melanocyte are taken, the thin skin water containing sea lettuce extract is smeared in skin surface, to skin
Skin model carries out UVB irradiation, and treatment fixes the model for crossing sample treatment with 4% paraformaldehyde, carries out immuning tissue after terminating
Chemical analysis methods.With PBS 3 times, 5min/ times；0.2%TritonX-100 changes 5min thoroughly；PBS 3 times, using donkey
37 DEG C of incubator closings of serum；Primary antibody, slide is added to be put into wet box, 4 DEG C of overnight incubations.Next day PBS 3 times, adds life
The secondary antibody of thing elementization；37 DEG C of incubators are incubated 2h；Carry out PBS 3 times, 5min/ times after chromogenic reaction；Core is contaminated using DAPI
10min；PBS 3 times, 4 DEG C keep in dark place, and carry out Laser Scanning Confocal Microscope and take pictures, and analyze.
Using the thin skin water of embodiment 2 as sample, the small-micelle water in embodiment 2 is replaced according to identical with deionized water
The thin skin water for preparing of method as control, as a result as shown in figure 3, compared with deionized water group, what small-micelle water made contains
The thin skin water of marine alga sea lettuce extract can substantially reduce the melanin generation and distribution that UVB causes, it follows that, it is of the invention
Small-micelle water cosmetics containing sea lettuce active component are Thief zone, high diffusivity, solvent active water high, compared to commonly going
Ionized water, it can improve water content of stratum corneum, strengthen the aquation of skin and the molecular activity of active component, so as to promote
Sea lettuce active nutrient component fast strikethrough skin is absorbed.
Embodiment 5：Water-soluble active material and small-micelle water are used for moisture surge treatment formula
Based on mass fraction 100%, moisture surge treatment formula formula composition is as shown in table 3：
Table 3：Moisture surge treatment formula is formulated (%)
Claims (10)
1. a kind of cosmetic composition, its small molecule for containing water-soluble active ingredient and promoting active component rapid transdermal to absorb
Group's water.
2. cosmetic composition according to claim 1, it is characterised in that the water-soluble active ingredient is that marine alga is extracted
One or more in thing, extract of magnolia sieboldii, green-tea extract, edelweiss extract, vitamin C, niacinamide.
3. cosmetic composition according to claim 1, it is characterised in that the small-micelle water17ONMR half-peaks are a width of
50-100Hz。
4. cosmetic composition according to claim 1, it is characterised in that described cosmetics be thin skin water, cream or
Facial mask.
5. according to any described cosmetic compositions of claim 1-4, it is characterised in that the composition is anti-oxidant combination
Thing.
6. according to any described cosmetic compositions of claim 1-4, it is characterised in that the composition is combined for anti-aging
Thing.
7. according to any described cosmetic compositions of claim 1-4, it is characterised in that the composition be for whitening,
Composition that is sun-proof or suppressing cutaneous pigmentation.
8. according to any described cosmetic compositions of claim 1-4, it is characterised in that the composition is combined for moisturizing
Thing.
9. according to any described cosmetic compositions of claim 1-4, it is characterised in that the composition is anti-inflammatory Shu Min groups
Compound.
10. the cosmetic composition according to claim 1-4, it is characterised in that the composition is for improving skin
The molecular activity of cuticula aquation and water-soluble active ingredient, and finally promote the rapid transdermal of active component to absorb.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611255157.4A CN106924057B (en) | 2016-12-30 | 2016-12-30 | Small micelle water cosmetic for promoting rapid transdermal absorption of water-soluble substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611255157.4A CN106924057B (en) | 2016-12-30 | 2016-12-30 | Small micelle water cosmetic for promoting rapid transdermal absorption of water-soluble substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106924057A true CN106924057A (en) | 2017-07-07 |
| CN106924057B CN106924057B (en) | 2020-09-11 |
Family
ID=59444689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611255157.4A Active CN106924057B (en) | 2016-12-30 | 2016-12-30 | Small micelle water cosmetic for promoting rapid transdermal absorption of water-soluble substances |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106924057B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375043A (en) * | 2017-07-14 | 2017-11-24 | 高飞 | A kind of application of composition containing small-micelle water and said composition in cosmetics |
| CN109172430A (en) * | 2018-11-01 | 2019-01-11 | 广东芭薇生物科技股份有限公司 | A kind of rush penetrative composition containing small-micelle water and its application in cosmetics |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600044A (en) * | 2012-03-28 | 2012-07-25 | 中国科学院南海海洋研究所 | Mineral nutrient elements-enriched deep-sea small-molecular cluster water and preparation method and cosmetic applications thereof |
| CN103405347A (en) * | 2013-09-02 | 2013-11-27 | 李镇南 | Moisturizing liquid, mask and cosmetic adopting micro-cluster water and preparation method of micro-cluster water |
| CN105596224A (en) * | 2015-09-28 | 2016-05-25 | 北京森源华诚科技发展有限公司 | Preparation method of small molecule cluster water lotion |
| CN105596220A (en) * | 2015-09-06 | 2016-05-25 | 北京森源华诚科技发展有限公司 | Environment-friendly small molecular cluster water wet wipe |
| CN105832567A (en) * | 2016-05-19 | 2016-08-10 | 魏新 | Tourmaline energy membrane and preparation method thereof |
-
2016
- 2016-12-30 CN CN201611255157.4A patent/CN106924057B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600044A (en) * | 2012-03-28 | 2012-07-25 | 中国科学院南海海洋研究所 | Mineral nutrient elements-enriched deep-sea small-molecular cluster water and preparation method and cosmetic applications thereof |
| CN103405347A (en) * | 2013-09-02 | 2013-11-27 | 李镇南 | Moisturizing liquid, mask and cosmetic adopting micro-cluster water and preparation method of micro-cluster water |
| CN105596220A (en) * | 2015-09-06 | 2016-05-25 | 北京森源华诚科技发展有限公司 | Environment-friendly small molecular cluster water wet wipe |
| CN105596224A (en) * | 2015-09-28 | 2016-05-25 | 北京森源华诚科技发展有限公司 | Preparation method of small molecule cluster water lotion |
| CN105832567A (en) * | 2016-05-19 | 2016-08-10 | 魏新 | Tourmaline energy membrane and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 广州市颜肌生物科技有限公司: "《国产非特殊用途化妆品备案信息服务平台》", 8 October 2016 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375043A (en) * | 2017-07-14 | 2017-11-24 | 高飞 | A kind of application of composition containing small-micelle water and said composition in cosmetics |
| CN109172430A (en) * | 2018-11-01 | 2019-01-11 | 广东芭薇生物科技股份有限公司 | A kind of rush penetrative composition containing small-micelle water and its application in cosmetics |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106924057B (en) | 2020-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104958247B (en) | A kind of body lotion containing nostoc sphaeroids kutz extractive and preparation method thereof | |
| CN103767972B (en) | A kind of ternary moisturizing lock water composition and the application in cosmetics thereof | |
| CN108969433A (en) | Double-colored facial treatment mask and preparation method thereof with whitening, moisturizing and Shu Min effect | |
| CN110200875A (en) | A kind of antiallergic whitening mask and preparation method thereof | |
| CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
| CN105411991B (en) | It is a kind of based on deep layer maintenance, the skin spray of long-acting moisturizing and preparation method thereof | |
| CN107157880A (en) | A kind of HERBA DENDROBII moisturizing sleep mask and preparation method thereof | |
| CN107811938A (en) | A kind of natural tea pasta film and preparation method thereof | |
| CN106344429B (en) | A kind of needle mushroom Essence and preparation method thereof | |
| CN108524406A (en) | A kind of Golden flower facial mask and preparation method thereof | |
| CN105434239A (en) | Application of skin whitening composition containing natural plant source to cosmetics | |
| CN102421412A (en) | Composition containing chamaecyparis obtusa polysaccharides to be externally applied to the skin | |
| CN106580732A (en) | Emulsion and preparation method thereof | |
| CN108392459A (en) | A kind of sea cucumber peptide anti-oxidant face mask | |
| US20150182443A1 (en) | Traditional chinese medicine extract composition with whitening skin-care function adn its preparation method | |
| CN107536721B (en) | Composition for external skin preparation and use thereof | |
| CN107929121A (en) | Skin care item for skin injury and inflammation reparation | |
| CN106924057A (en) | The small-micelle water cosmetics for promoting water-soluble substances rapid transdermal to absorb | |
| CN104771340A (en) | Novel facial mask for resisting aging and filling fine wrinkles | |
| CN108014059A (en) | A kind of skin whitening, moisturizing lotion and preparation method thereof | |
| CN104188859A (en) | Anti-wrinkle skin-tendering emulsion containing natural component extracts and preparation method thereof | |
| CN103222936A (en) | Skin external use composition comprising lotus seed extract | |
| CN103006477A (en) | Camellia oil emollient cream | |
| CN110236974A (en) | A kind of toner and preparation method thereof containing glycine betaine salicylic acid ionic liquid | |
| CN105832648A (en) | Skin-nourishing anti-aging peony seed oil face mask and manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211230 Address after: No.23, Xianke 2nd Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province, 510890 Patentee after: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee after: Guangdong Danzi Group Co., Ltd Address before: No.23 Xianke Er Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province 510800 Patentee before: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee before: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT Patentee before: GUANGDONG DANZ GROUP Co.,Ltd. |