CN109172430A - A kind of rush penetrative composition containing small-micelle water and its application in cosmetics - Google Patents
A kind of rush penetrative composition containing small-micelle water and its application in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of rush penetrative composition containing small-micelle water, it is desirable to provide one kind has that rapid-action, effect is good, Small side effects, by changing keratoderma cell arrangement to be conducive to composition of the nutriment by cuticula；Technical points are, the composition mainly comprises the following components in parts by weight: double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae -0.1-3 parts of dicarboxylic ester, 3-21 parts of seawater, 0.3-2 parts, 0.1-1 parts of hydrolecithin of two (lauramide glutamine) Sodium lysinate；Belong to cosmetic technical field.
Description
Technical field
The invention discloses a kind of rush penetrative compositions, specifically, being a kind of rush osmotic composition containing small-micelle water
Object, the invention also discloses the cosmetics containing the rush penetrative composition, belong to cosmetic technical field.
Background technique
Cosmetics especially skin care item intersperse among human skin surface mainly in the method for smearing, to play cleaning, protect
It supports, the effect of beauty.But to avoid may causing dangerous exogenous molecule to body, keratoderma form one it is powerful
Barrier hinders the transdermal penetration of most of allogenic materials while protecting body.This makes to promote active constituent in cosmetics
Transdermal absorption become research hotspot.Reversible skin barrier is overcome currently, different types of permeation enhancers occurred and having shown
Potentiality, so that active constituent be helped to be carried through skin.
A kind of feature of ideal cosmetics permeation enhancers mainly includes following several respects: (1) should be with other cosmetics
Raw material is compatible；(2) physics and chemical property are stablized；It (3) should not sensitization, non-stimulated and nontoxic；(4) reaction should be reversible
's.For many years, many people endeavour the exploitation of permeation enhancers, permeation enhancers can be mainly divided into the saturating agent of chemical enhancement and natural rush
Bleeding agent two major classes.The saturating agent of chemical enhancement can act on keratoderma, changes cuticula physiology subregion or influences activity
Diffusion of the ingredient in cuticula.The common saturating agent of chemical enhancement at present mainly have ethyl alcohol or polyalcohol, fatty acid such as salicylic acid,
Mannitol, nitroglycerin etc.；Common natural permeation enhancers mainly have pennyroyal such as menthol, menthol, peppermint oil etc., cortex cinnamomi
Class, cloves class etc..
In addition, some researchers, which will promote permeable components, rationally assembles obtained corresponding rush penetrative composition, such as patent
In CN108210419A by one of capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide and its homologue or
Combination of the above is made permeation enhancers, the composition can Cucumber Extract, promote active material to infiltrate through skin, dimethyl sulfoxide and
Its homologue makes effective component be easier to the deep layer of skin permeation, improves the absorptivity of effective component；In patent CN102961282B
10 parts and 5 parts of Pogostemon cablin of Blumea balsamifera are made to have and promotees the chemosmotic composition of salbutamol sulfate.The composition is promoting
Significant effect in terms of the osmotic absorption of effective component also has certain effect in terms of nourishes rough skin, improvement skin quality, antibacterial anti-inflammatory.
Currently, the absorption in order to promote nutritional ingredient in cosmetics, often addition promotees osmotic absorption raw material in cosmetics.But mesh
It is not yet mature that preceding cosmetics promote the development of osmotic absorption raw materials market, is applied although having rush infiltration raw material, and type is more,
Quality is very different.Therefore, exploitation safety promotees infiltration raw material, and solution cosmetics nutritional ingredient accumulation skin surface, which does not absorb, to be caused
Series of problems, realize science, health skin nursing have become inexorable trend.
Summary of the invention
In order to solve the disadvantage that the prior art and shortcoming, the first purpose of the invention is to provide a kind of rush infiltration groups
Close object, the composition has many advantages, such as that rapid-action, effect is good, Small side effects, by changing keratoderma cell arrangement thus
Be conducive to nutriment and pass through cuticula.
For this purpose, technical solution provided by the invention is such that
A kind of rush penetrative composition, the composition mainly include the component of following parts by weight: double-diethoxy diethylene glycol (DEG) ring
0.1-3 parts of hexane 1,4- dicarboxylic ester, 3-21 parts of seawater, two 0.3-2 parts of (lauramide glutamine) Sodium lysinates, hydrogenation ovum
.1-1 parts of phosphatidase 0.Wherein, the seawater is the small-micelle water by ultrasonic treatment.
Further, above-mentioned a kind of rush penetrative composition further includes 0.5-1.5 parts of sodium bacillus subtilis lipopeptide.
Further, a kind of rush penetrative composition, the composition mainly include the component of following parts by weight: double-diethyl
0.5-2 parts of oxygroup diethylene glycol (DEG) hexamethylene 1,4- dicarboxylic ester, 5-15 parts of small-micelle water, two (lauramide glutamine) rely ammonia
Sour sodium 0.8-1.6 parts, 0.2-0.8 parts of hydrolecithin.
Further, above-mentioned a kind of rush penetrative composition, is composed of the following parts by weight: double-diethoxy
0.5-2 parts of base diethylene glycol (DEG) hexamethylene 1,4- dicarboxylic ester, 5-15 parts of small-micelle water, two (lauramide glutamine) lysines
0.8-1.6 parts of sodium, 0.2-0.8 parts of hydrolecithin, 0.7-1.2 parts of sodium bacillus subtilis lipopeptide.
Further, above-mentioned a kind of rush penetrative composition, the small-micelle water the preparation method is as follows:
1) 40-70g mineral composition will be added in every liter of seawater；
It 2) is 900-980W with ultrasonic power by the seawater that mineral composition is added, the pulse that ultrasonic temperature is 35-45 DEG C
It is ultrasonically treated 15-35min, wherein ultrasonic time/intermittent time is 1/3-3/4, can be prepared by small-micelle water；
Wherein, the mineral composition is by following parts by weight mineral composition: the Tourmaline weak base that partial size is 40-500 μm
Property 20-30 parts of stone, partial size be 0.1-0.5 μm 35-50 parts of sepiolite.
The last one technical solution provided by the invention is the application for promoting penetrative composition as skin-care product additive.Its
In, the skin care item are toner, essence, lotion, cream, facial mask, make-up remover, one of gel of washing one's face.
Compared with prior art, technical solution provided by the invention has following technological merit:
1, in the present invention, when double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester and small-micelle water interact
When, the permeance property of skin is improved by changing the effect of keratoderma cell arrangement；Two kinds of ingredients can promote lipoid
Lacuna expansion, extension in hypothallus structure, two (lauramide glutamine) Sodium lysinates and hydrolecithin pass through promotion
Adjacent lacuna fusion, ultimately forms netted lacuna system, permeation pathway is constituted, so that being conducive to nutritional ingredient passes through cutin
Layer.
2, when sodium bacillus subtilis lipopeptide is added in composition, nitrogen substance and water in skin surface keratin be can be improved
Binding ability, improve the aquation of cuticula, penetrated convenient for nutriment, to promote the Transdermal absorption of nutriment.
3, the present composition reversibly changes the barrier action of keratoderma and does not damage any competent cell, has
Help the skin penetration rate of both effectiveness ingredient or the increase of transdermal amount.And composition can be dissolved in water and oil, be added to cosmetics
Compatibility is more preferable when middle, has brilliant skin affinity, safe and non-stimulating.
Detailed description of the invention
Fig. 1 is residual condition comparison diagram of the VCE in different skin layer.
Specific embodiment
With reference to embodiment, claim of the invention is described in further detail, but do not constituted pair
Any restrictions of the invention, the modification of anyone limited times made in the claims in the present invention protection scope, still in this hair
Within bright claims.
It should be noted that raw material employed in technical solution provided by the invention, unless otherwise specified, by normal
The preparation of rule means is bought by commercial channel.Wherein, double-diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester buying is certainly
The long enterprise development Co., Ltd of upper marine rainbow, two (lauramide glutamine) Sodium lysinates buying right biotechnology from Guangzhou have
Limit company, hydrolecithin buying are purchased from Guangzhou Rong Dao Chemical Co., Ltd., seawater and sodium bacillus subtilis lipopeptide from Guangzhou hundred
Hao Bo Co., Ltd.
Embodiment 1
A kind of rush penetrative composition is grouped as by the group of following weight number: 0.1g is bis--diethoxy diethylene glycol (DEG) hexamethylene 1,
4- dicarboxylic ester, 3g small-micelle water, 2g bis- (lauramide glutamine) Sodium lysinate, 1g hydrolecithin.
Embodiment 2
A kind of rush penetrative composition is grouped as by the group of following weight number: 3g is bis--diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae-
Dicarboxylic ester, 21g small-micelle water, 0.3g bis- (lauramide glutamine) Sodium lysinate, 0.1g hydrolecithin.
Embodiment 3
A kind of rush penetrative composition is grouped as by the group of following weight number: 1.2g is bis--diethoxy diethylene glycol (DEG) hexamethylene 1,
4- dicarboxylic ester, 12g small-micelle water, 1.1g bis- (lauramide glutamine) Sodium lysinate, 0.4g hydrolecithin.
Embodiment 4
A kind of rush penetrative composition is grouped as by the group of following weight number: 0.5g is bis--diethoxy diethylene glycol (DEG) hexamethylene 1,
4- dicarboxylic ester, 5g small-micelle water, 1.6g bis- (lauramide glutamine) Sodium lysinate, 0.8g hydrolecithin, 0.5g
Sodium bacillus subtilis lipopeptide.
Embodiment 5
A kind of rush penetrative composition is grouped as by the group of following weight number: 2g is bis--diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae-
Dicarboxylic ester, 15g small-micelle water, 0.8g bis- (lauramide glutamine) Sodium lysinate, 0.2g hydrolecithin, 1.5g are withered
Careless bacterium lipopeptid sodium.
Wherein, the preparation method of embodiment 1-5 small molecular group water is as follows:
1) 40g mineral composition will be added in every liter of seawater；
2) the impulse ultrasound processing that be 900W with ultrasonic power by the seawater that mineral composition is added, ultrasonic temperature is 35 DEG C
15min, wherein ultrasonic time/interval time is 1/3, can be prepared by small-micelle water.
Wherein, the mineral composition is by following parts by weight mineral composition: the Tourmaline alkalescent stone that partial size is 40 μm
20 parts, partial size be 0.1 μm 35 parts of sepiolite.
Embodiment 6
A kind of rush penetrative composition is grouped as by the group of following weight number: 1g is bis--diethoxy diethylene glycol (DEG) hexamethylene Isosorbide-5-Nitrae-
Dicarboxylic ester, 12g small-micelle water, 1.3g bis- (lauramide glutamine) Sodium lysinate, 0.5g hydrolecithin, 0.7g are withered
Careless bacterium lipopeptid sodium.
Embodiment 7
A kind of rush penetrative composition is grouped as by the group of following weight number: 1.5g is bis--diethoxy diethylene glycol (DEG) hexamethylene 1,
4- dicarboxylic ester, 6g small-micelle water, 0.9g bis- (lauramide glutamine) Sodium lysinate, 0.6g hydrolecithin, 1.2g
Sodium bacillus subtilis lipopeptide.
Wherein, embodiment 6-7 small molecular group water the preparation method is as follows:
1) 70g mineral composition will be added in every liter of seawater；
2) the impulse ultrasound processing that be 980W with ultrasonic power by the seawater that mineral composition is added, ultrasonic temperature is 45 DEG C
35min, wherein ultrasonic time/interval time is 3/4, can be prepared by small-micelle water.
Wherein, the mineral composition is by following parts by weight mineral composition: the Tourmaline alkalescent stone that partial size is 500 μm
30 parts, partial size be 0.5 μm 50 parts of sepiolite.
Rush penetrative composition prepared by the present invention can be used as skin-care product additive and be added in the skin care item of various dosage forms,
Such as toner, essence, lotion, cream, facial mask, make-up remover, gel of washing one's face, promoting penetrative composition additive amount is gross mass
0.01-2%, preferably 0.8%.
In order to prove that effect of the invention, the application are also provided with following comparative example, with embodiment provided by the present application into
The comparison of row effect experiment:
Comparative example 1
A kind of composition is provided in comparative example 1, is grouped as by the group of following weight number: 1.2g is bis--diethoxy diethylene glycol (DEG)
Hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester, 12g seawater, 1.1g bis- (lauramide glutamine) Sodium lysinate, 0.4g hydrolecithin.
Comparative example 2
A kind of composition is provided in comparative example 2, is grouped as by the group of following weight number: 1.2g is bis--diethoxy diethylene glycol (DEG)
Hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester, 1.1g bis- (lauramide glutamine) Sodium lysinate, 0.4g hydrolecithin.
Comparative example 3
A kind of composition is provided in comparative example 3, is grouped as by the group of following weight number: 12g small-micelle water, 1.1g bis-
(lauramide glutamine) Sodium lysinate, 0.4g hydrolecithin.
Comparative example 4
A kind of composition is provided in comparative example 4, is grouped as by the group of following weight number: 1.2g is bis--diethoxy diethylene glycol (DEG)
Hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester, 12g small-micelle water, 0.4g hydrolecithin.
Comparative example 5
A kind of composition is provided in comparative example 5, is grouped as by the group of following weight number: 1.2g is bis--diethoxy diethylene glycol (DEG)
Hexamethylene Isosorbide-5-Nitrae-dicarboxylic ester, 12g small-micelle water, 1.1g bis- (lauramide glutamine) Sodium lysinate.
Comparative example 6
A kind of composition is provided in comparative example 6, is grouped as by the group of following weight number: 4g is bis--diethoxy diethylene glycol (DEG) ring
Hexane Isosorbide-5-Nitrae-dicarboxylic ester, 1g small-micelle water, 0.1g bis- (lauramide glutamine) Sodium lysinate, 2g hydrolecithin.
1. skin irritation test
Deionized water is added to be configured to the aqueous solution for being 2% containing mass fraction in the composition of embodiment 1-7.
1) materials and methods: choosing 35 volunteers, wherein male 10, meets subject and volunteers inclusion criteria by female 25,
Subject is without allergic dermatitis history, and excitant product is also not used in the previous moon.
Aqueous solution about 0.020~0.025ml that embodiment 1-7 is configured is applied to spot tester (Beijing science popularization instrument plant) cell
In, external application special adhesive tape is pasted on subject back, removes spot tester after 24 hours, light with wet paper handkerchief if any surplus products
It dabs, respectively at 0.5 hour, 24 hours, 48 hours, by dermoreaction classification in " cosmetics safety technical specification " (2015)
Its result of standard recording.Standard of perfection is shown in Table 1.
1 standard of perfection of table
| Grade | Standard of perfection |
| 0 | It is non-stimulated, without erythema |
| 1 | Slight erythema |
| 2 | Erythema |
| 3 | Erythema, papule, bubble |
| 4 | Serious attached edema, bulla |
2) enclosed type patch test result: 35 volunteers are made embodiment 1-7 0.5 hour, 24 hours, 48 hours
Rush penetrative composition do not show any adverse reaction, there are not the symptoms such as erythema, burn feeling, itch.Illustrate the present invention
It is non-stimulated to skin to promote penetrative composition.
2. promoting evaluation of permeating experiment
It is tested using Penetration enhancing effect of the adhesive tape stripping method to composition.Test method is as follows:
1) 20ml test solution is applied to position (application area: 1cm × 2cm) among forearm, wherein test solution be containing
The ethyl vitamin C (VCE, content 1%) and the ethyl without containing 3 composition of embodiment for having 0.8% embodiment, 3 composition
Vitamin C (VCE, content 1%).
2) it after 6 hours, is removed 20 times as position tape-stripping is smeared.
3) adhesive tape with cuticula is divided into 4 classifications.Respectively skin surface (adhesive tape 1-2), cuticula upper layer
(adhesive tape 3-8), cuticula middle layer (adhesive tape 9-14), cuticula bottom (adhesive tape 15-20).Cuticula in each adhesive tape
In VCE with 5mL EtOH Sonicate extract, and with HPLC method measurement the ascorbic content of ethyl.VCE is residual different skin layer
Condition of showing mercy is as shown in Figure 1.It will be seen from figure 1 that the VCE containing the present composition is in skin surface, angle by the infiltration of 6h
Matter layer upper layer, cuticula middle layer, cuticula bottom content than containing without containing the VCE content of the present composition in each skin layer
Amount is more, illustrates that the VCE containing the present composition more penetrates to the skin cuticula.The present composition seeps VCE
Saturating power is stronger.
3. promoting chemosmotic effect experiment
The preparation of the rush penetrative composition moisturizing emulsion of 1-7 containing embodiment:
According to mass percent, by 4% glycerol, 0.3% xanthan gum, the smooth stearate of 2% sorb, 3% sucrose coconut oil
Ester and appropriate amount of deionized water, which are mixed evenly, is heated to 85 DEG C up to water phases, by 7% caprylic/capric triglyceride, 5% white
Oil and 2% stearyl alcohol, which are mixed evenly, is heated to 85 DEG C up to oily phase, gained oil mutually is continued to stir under vacuum conditions, so
Water phase is added in backward oil phase, and continues to stir and emulsify, after emulsification, continues insulated and stirred 15min, is added after being cooled to 40 DEG C
0.001% lemon acid for adjusting pH adds 0.1% Phenoxyethanol, 0.8% promotees penetrative composition, stir to neutrality,
Up to moisturizing emulsion.
The preparation of the composition moisturizing emulsion of 1-6 containing comparative example:
The preparation of comparative example moisturizing emulsion and the preparation difference of embodiment 1-7 moisturizing emulsion are above-mentioned rush osmotic composition
Object changes the composition in comparative example 1-6 into, other preparation conditions and the same embodiment of method.
Moisture-keeping efficacy test
1) experimental method: the moisture content using capacitance method measurement human skin keratinocyte's layer is based on water and other substances
Difference in dielectric constant is significant, and according to the difference of keratoderma moisture content, the skin pricktest capacitance measured is different, and parameter can generation
Table skin moisture content.
2) test apparatus
Moisture content of skin tester Corneometer CM825
3) moisturizing test method: volunteer 65 that average age is 25~45 years old are chosen, wherein male volunteers 18
Name, female volunteers 47.13 groups are randomly divided into, every group 5, uses the guarantor of Examples 1 to 7 and comparative example 1-6 preparation respectively
Wet lotion.Subject smears moisturizing emulsion in face, smears twice, is used continuously 4 weeks sooner or later daily.During experiment, subject
Any other cosmetics cannot be smeared in Test sites.
Moisture content of skin, assessment were detected with moisture content of skin tester Corneometer CM825 at the 0th day and the 28th day
Use the water content situation of skin before and after moisturizing emulsion.Moisture-keeping efficacy test result is shown in Table 2.
2 moisture content of skin situation of change of table
Can be seen that moisturizing emulsion in Examples 1 to 7 from the experimental result of table 2 can significantly improve moisture content, and explanation adds
Add the skin care item of the present composition that there is good moisture-keeping efficacy, the present composition has the work for promoting moisturizing ingredient infiltration
With.After of the invention skin care item 28 days are used continuously, the moisture content of skin is all increased to 30% or more, embodiment 4-7's
Moisture content increases to 35% or more.After using moisturizing emulsion made from comparative example 1-6 composition, by 28 day time, water
Divide content growth rate between 5-13%, it is poorer than moisturizing emulsion moisture-retaining capacity made from embodiment.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (7)
1. a kind of rush penetrative composition, which is characterized in that the composition mainly includes the component of following parts by weight: double-diethoxy
0.1-3 parts of base diethylene glycol (DEG) hexamethylene 1,4- dicarboxylic ester, 3-21 parts of seawater, two (lauramide glutamine) Sodium lysinate 0.3-
2 parts, 0.1-1 parts of hydrolecithin；
Wherein, the seawater is the small-micelle water by ultrasonic treatment.
2. a kind of rush penetrative composition according to claim 1, which is characterized in that the composition further includes surfaction
0.5-1.5 parts of sodium.
3. a kind of rush penetrative composition according to claim 1, which is characterized in that the composition is main according to parts by weight
It include: double -0.5-2 parts of diethoxy diethylene glycol (DEG) hexamethylene 1,4- dicarboxylic ester, 5-15 parts of small-micelle water, two (lauramides
Glutamine) 0.8-1.6 parts of Sodium lysinate, 0.2-0.8 parts of hydrolecithin.
4. a kind of rush penetrative composition according to claim 2, which is characterized in that the composition is by following parts by weight
At being grouped as: double -0.5-2 parts of diethoxy diethylene glycol (DEG) hexamethylene 1,4- dicarboxylic ester, 5-15 parts of small-micelle water, two (laurels
Amide Gln) 0.8-1.6 parts of Sodium lysinate, 0.2-0.8 parts of hydrolecithin, 0.7-1.2 parts of sodium bacillus subtilis lipopeptide.
5. a kind of rush penetrative composition according to claim 1, which is characterized in that the preparation method of the small-micelle water
It is as follows:
1) 40-70g mineral composition will be added in every liter of seawater；
It 2) is 900-980W with ultrasonic power by the seawater that mineral composition is added, the impulse ultrasound that ultrasonic temperature is 35-45 DEG C
15-35min is handled, wherein ultrasonic time/intermittent time is 1/3-3/4, can be prepared by small-micelle water；
Wherein, the mineral composition is by following parts by weight mineral composition: the Tourmaline alkalescent stone that partial size is 40-500 μm
20-30 parts, partial size be 0.1-0.5 μm 35-50 parts of sepiolite.
6. a kind of application for promoting penetrative composition as skin-care product additive described in claim 1.
7. a kind of application for promoting penetrative composition as skin-care product additive according to claim 6, which is characterized in that institute
The skin care item stated are toner, essence, lotion, cream, facial mask, make-up remover, one of gel of washing one's face.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111450008A (en) * | 2020-04-30 | 2020-07-28 | 广州天玺生物科技有限公司 | Whitening cream and preparation method thereof |
| CN112245366A (en) * | 2020-11-24 | 2021-01-22 | 山东华熙海御生物医药有限公司 | Permeation-promoting composition containing hyaluronic acid and application of permeation-promoting composition in cosmetics |
| CN114369028A (en) * | 2022-01-14 | 2022-04-19 | 苏州科技大学 | Plasticizer with ether chain and modified asphalt thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450008A (en) * | 2020-04-30 | 2020-07-28 | 广州天玺生物科技有限公司 | Whitening cream and preparation method thereof |
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| CN114369028A (en) * | 2022-01-14 | 2022-04-19 | 苏州科技大学 | Plasticizer with ether chain and modified asphalt thereof |
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