CN107929121A - Skin care item for skin injury and inflammation reparation - Google Patents
Skin care item for skin injury and inflammation reparation Download PDFInfo
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- CN107929121A CN107929121A CN201711212904.0A CN201711212904A CN107929121A CN 107929121 A CN107929121 A CN 107929121A CN 201711212904 A CN201711212904 A CN 201711212904A CN 107929121 A CN107929121 A CN 107929121A
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- skin
- care item
- skin care
- polypeptides
- injury
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of skin care item for skin injury and inflammation reparation, the liquid fat of solid grease, 9.5~20wt%, the emulsifying agent of 1~5wt%, the moisturizer of 10~22wt% including 1~5wt%, the N15 polypeptides of 0.05~1wt%, the nasturtium extract of 0.1~1wt%, surplus is water.The present invention effectively facilitates skin healing, improves skin, play and reduce red swelling of the skin, itch, scurf by the way that nasturtium extract and N15 polypeptides with anti-inflammatory are combined, and slows down wrinkle and occurs and the effect of skin senescence.And the skin care item skin sense of the present invention is soft and moist, spreadability is good easily to be absorbed, and cold and hot excellent in stability, has preferable practicality.
Description
Technical field
The present invention relates to a kind of feature skin care item, in particular to a kind of skin care for being used for skin injury and inflammation reparation
Product.
Background technology
Skin is the organ for being covered in human body surface maximum, due to directly being contacted with external environment, is aoxidized, it is dry and
The stimulation of a variety of tension-causing factors such as ultraviolet, therefore be highly susceptible to damage.
Skin care item are smeared when skin has damage or skin has inflammation may aggravate the state of an illness, existing skin care item
Species is various, and in terms of its function concentrates on whitening, nutrition, anti-aging, it is medicine adornment to have part skin care item classification, its function includes anti-
Allergy, enhancing stratum corneum thickness etc., the active ingredient added in these above-mentioned skin care item are mostly nutritional agents, part skin care item
In order to reach the effect in its advertising, or even added with hormone, the health of user is harmful on the contrary.
A kind of promotion regenerated skin care item (publication number CN106137785A) of skin repair are disclosed in the prior art, are used
N15 polypeptides find that the skin care item formula also has larger room for improvement as main active ingredient by research.
The content of the invention
It is an object of the invention to provide a kind of better skin care item for being used for skin injury and inflammation reparation, meet
Alleviate scytitis while skin care item landscaping effect, reduce pruitus, furfur, general red, promotion Skin Cell reparative regeneration,
Reduce wrinkle of skin.
To achieve the above object, the skin care item for being used for skin injury and inflammation reparation designed by the present invention, including 1~
The solid grease of 5wt%, the liquid fat of 9.5~20wt%, the emulsifying agent of 1~5wt%, the moisturizer of 10~22wt%,
The N15 polypeptides of 0.05~1wt%, the nasturtium extract of 0.1~1wt%；Surplus is water.
Preferably, N15 polypeptides dosage in skin care item is 0.25~0.5wt%, and N15 polypeptides and nasturtium are extracted
The amount ratio of thing is 1:1~1.45.
Preferably, the nasturtium extract be nasturtium water or ethanol extract, its relative density be 1.01~
1.05。
Preferably, the moisturizer is selected from glycerine, propane diols, butanediol, glycine betaine, hyaluronic acid.
Preferably, the solid grease is atoleine, lanolin, gel.
Preferably, the liquid fat is different pungent to hydrogenate poly- certain herbaceous plants with big flowers alkene, isomery hexadecane, dimethyl silicone polymer, palmitic acid
At least one of ester, Vitwas E.
Preferably, the emulsifying agent is cetearyl alcohol acid alcohol, coco group glucoside, stearin, PEG-100 tristearin
At least one of sour fat, hydroxyethylacrylate, sodium acryloyldimethyl taurate copolymers.
N15 polypeptide sequences in the present invention are：Met-Pro-tyrosine-serine-threonine-glutamic acid-
Leu-Ile-phenylalanine-tyrosine-lle-Glu-methionine-asparatate-proline, should
Sequence is disclosed in Chinese patent application 201410123289.6.Nasturtium is Tropaeolaceae, nasturtium, is had clear
The oral medical value of thermal detoxification, also has researches show that the effect of its whitening spot-removing, and inventor is had found itself and N15 by studying
Polypeptide combination can strengthen repair function of the N15 polypeptides to skin.
Beneficial effects of the present invention：By the way that nasturtium extract and the N15 polypeptides with anti-inflammatory are combined, effectively facilitate
Skin healing, improves skin, plays and reduces red swelling of the skin, itch, scurf, slows down the work of wrinkle generation and skin senescence
With.And the skin care item skin sense of the present invention is soft and moist, spreadability is good easily to be absorbed, and cold and hot excellent in stability, has preferable practicality.
Brief description of the drawings
Fig. 1 compares figure for volunteer patients using the effect before and after skin care item of the present invention.
Embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
The N15 polypeptide sequences that following embodiments use for：Met-Pro-tyrosine-serine-threonine-paddy
Propylhomoserin-Leu-Ile-phenylalanine-tyrosine-lle-Glu-methionine-asparatate-dried meat ammonia
Acid, the sequence disclosed in Chinese patent application 201410123289.6, are not described in detail the polypeptide and preparation method thereof herein.
It should be noted that the principle active component of skin care item is the group of N15 polypeptides and nasturtium extract in the present invention
The skin care item such as compound, other moisturizer, grease, emulsifying agent basic ingredient is only the comfort level of increase user, and to skin
Skin reparation does not have substantial role, therefore does not do excessive change to these basic ingredients in following embodiments, this can not be used for
The limitation present invention.
Embodiment 1
For the skin care item 1 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.05wt% N15 polypeptides,
The nasturtium extract of 0.15wt%, surplus are water.
The nasturtium extract is prepared with the following method：
Nasturtium is taken, using the water immersion 2h of 10 times of weight after crushing, 85~95 DEG C is then heated in solvent, is returned
Stream 1.5~2h of extraction, solvent can use water or the ethanol of 75% (volume fraction), then be evaporated under reduced pressure (recycling ethanol),
Relative density is condensed at 25 DEG C for 1.01~1.05 extracting solution, extracting solution filters through the filter membrane that membrane aperture is 1 μm, room temperature
Preservation is spare.The extracting method is only for example, actually plant extraction process huge number, is the prior art.
Nasturtium extract is the same as embodiment 1 in following embodiments.
Embodiment 2
For the skin care item 2 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.25wt% N15 polypeptides,
The nasturtium extract of 0.25wt%, surplus are water.
Embodiment 3
For the skin care item 3 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.35wt% N15 polypeptides,
The nasturtium extract of 0.1wt%, surplus are water.
Embodiment 4
For the skin care item 4 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.35wt% N15 polypeptides,
The nasturtium extract of 0.35wt%, surplus are water.
Embodiment 5
For the skin care item 5 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.35wt% N15 polypeptides,
The nasturtium extract of 0.5wt%, surplus are water.
Embodiment 6
For the skin care item 6 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.5wt% N15 polypeptides,
The nasturtium extract of 0.5wt%, surplus are water.
Embodiment 7
For the skin care item 7 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.5wt% N15 polypeptides,
The nasturtium extract of 0.7wt%, surplus are water.
Embodiment 8
For the skin care item 8 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, 0.5wt% N15 polypeptides,
The nasturtium extract of 1wt%, surplus are water.
Embodiment 9
For the skin care item 8 of skin injury and inflammation reparation, component is：The lanolin of 2wt%, the poly dimethyl of 10wt%
Siloxanes, the cetearyl alcohol acid alcohol of 3wt%, the glycerine of 21wt%, 0.1wt% hyaluronic acids, N15 polypeptides, the 1wt% of 1wt%
Nasturtium extract, surplus is water.
Reference examples
Skin care item are compareed to use and the essentially identical formula of embodiment 1~9, difference lies in not adding nasturtium extract,
And the final concentration of the N15 polypeptides added takes graded, be respectively 0.05wt%, 0.1%wt, 0.25wt%,
0.5wt%, 0.8wt%, 1wt%, sequence notation are reference examples 1~6.
Special reference examples
Special control skin care item are hard using the lanolin of 2wt%, the dimethyl silicone polymer of 10wt%, the spermaceti of 3wt%
Resin acid alcohol, the glycerine of 21wt%, 0.1wt% hyaluronic acids, the N15 polypeptides of 0.5wt%, the azelaic acid of 10wt%, surplus is water.
Test example 1
Skin repair is tested, and chooses 170 subjects of 35~50 years old, and the skin of every subject all suffers from various degree
Scytitis, the red and swollen area of subjects skin is larger and has different degrees of itch, and subject is divided into 17 groups, every group 10
People corresponds to above-described embodiment 1~9, reference examples 1~6, special reference examples and blank control, carries out skin test, and medicine-feeding part is
The relatively thin scytitis position of the skins such as the four limbs or face of subject, 15 days by a definite date, blank control used commercially available vitamin E
Frost (gives the common skin care item smearing for being not added with N15 polypeptides) to the scytitis position of subject, and the results show is as follows, control
Example and blank is shown in Table 1, special reference examples and embodiment is shown in Table 2：
The using effect of the skin care item of 1. reference examples of table compares
It can see from the result in table, when the dosage of N15 polypeptides is more than 0.25wt%, the change of its concentration is brought
Difference on effect become smaller, the N15 polypeptide dosage difference on effect of 0.5wt% and 1wt% and special unobvious.In addition, with
In the comparison that blank skin care item use, the skin care item for adding N15 are 100% effective to subject, and use blank skin care item
It is, effective percentage≤50% still without any improvement using 15 days to have 5 people in 10 people.
The using effect of the skin care item of 2. embodiment of table compares
Upper table is the results show that special compared to the skin care item for comprising only N15 polypeptides merely, compound skin care item of the invention
Addition nasturtium extract has promotion effect to N15 polypeptides, better in terms of mitigating scytitis and promoting skin repair,
But nasturtium extract concentrations use maximum in embodiment 8,9, effect is preferable not as good as a small amount of additions on the contrary, it may be possible to drought gold
Itself do not removed containing some sensitizers also in lotus.
In addition, inventor has also attempted to add other products with antibacterial anti-inflammatory, and whether see can be combined with N15,
But it is many all undesirable, azelaic acid is with the addition of if special reference substance, azelaic acid has antibacterial anti-inflammatory, eliminates the work(of pathogen
Effect, excessively also has skin oil and fat certain effect, but is combined with N15 polypeptides, its effect is not notable.
Test example 2
Skin repair effect test：Embodiment skin care item 6 are selected to do clinical patients measures of effectiveness
Volunteer patients：Women, the age at 21 years old, with skin allergy inflammation, long acne, and red and swollen area is larger, makes on the face
After the skin care item 6,10 days prepared with embodiment 6, redness significantly reduces, and small pox disappears substantially.As shown in Figure 1.
Claims (7)
1. a kind of skin care item for skin injury and inflammation reparation, including the solid grease of 1~5wt%, 9.5~20wt%
Liquid fat, the emulsifying agent of 1~5wt%, the moisturizer of 10~22wt%, surplus are water；It is characterized in that：Further include 0.05~
The N15 polypeptides of 1wt%, the nasturtium extract of 0.1~1wt%.
2. the skin care item according to claim 1 for skin injury and inflammation reparation, it is characterised in that：The N15 is more
Peptide dosage in skin care item is 0.25~0.5wt%, and the amount ratio of N15 polypeptides and nasturtium extract is 1:1~1.45.
3. the skin care item according to claim 1 or 2 for skin injury and inflammation reparation, it is characterised in that：The drought
Lily feet extract is the water or ethanol extract of nasturtium, its relative density is 1.01~1.05.
4. the skin care item according to claim 1 for skin injury and inflammation reparation, it is characterised in that：The moisturizer
Selected from glycerine, propane diols, butanediol, glycine betaine, hyaluronic acid.
5. the skin care item according to claim 1 for skin injury and inflammation reparation, it is characterised in that：The solid oil
Fat is atoleine, lanolin, gel.
6. the skin care item according to claim 1 for skin injury and inflammation reparation, it is characterised in that：The liquid oil
Fat is at least one in the poly- certain herbaceous plants with big flowers alkene of hydrogenation, isomery hexadecane, dimethyl silicone polymer, isobutyl palmitate, Vitwas E
Kind.
7. the skin care item according to claim 1 for skin injury and inflammation reparation, it is characterised in that：The emulsifying agent
For cetearyl alcohol acid alcohol, coco group glucoside, stearin, PEG-100 stearates, hydroxyethylacrylate, propylene
At least one of acyl dimethyltaurine sodium copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711212904.0A CN107929121A (en) | 2017-11-28 | 2017-11-28 | Skin care item for skin injury and inflammation reparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711212904.0A CN107929121A (en) | 2017-11-28 | 2017-11-28 | Skin care item for skin injury and inflammation reparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107929121A true CN107929121A (en) | 2018-04-20 |
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ID=61950243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711212904.0A Pending CN107929121A (en) | 2017-11-28 | 2017-11-28 | Skin care item for skin injury and inflammation reparation |
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| Country | Link |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110051565A (en) * | 2019-05-08 | 2019-07-26 | 广东大鹏医药科技有限公司 | A kind of moisture-keeping crease-shedding eye cream and preparation method thereof containing trollflower ingredient |
| CN113101253A (en) * | 2020-01-10 | 2021-07-13 | 惠州绵俪生物科技有限公司 | Cosmetic composition for improving skin comprising mixed extract of edible flowers |
| WO2022029129A1 (en) * | 2020-08-05 | 2022-02-10 | Societe Industrielle Limousine D'application Biologique | Use of a cosmetic composition for mature skin in the form of a dry and soluble film comprising an extract of tropaeolum majus and an extract of lens esculenta |
| JP7465610B2 (en) | 2020-07-26 | 2024-04-11 | 武漢益承生物科技有限公司 | Use of Polypeptides in the Manufacture of Wound Care Medicaments - Patent application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106137785A (en) * | 2016-08-03 | 2016-11-23 | 夏献民 | A kind of skin care item promoting skin repair to regenerate |
-
2017
- 2017-11-28 CN CN201711212904.0A patent/CN107929121A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106137785A (en) * | 2016-08-03 | 2016-11-23 | 夏献民 | A kind of skin care item promoting skin repair to regenerate |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110051565A (en) * | 2019-05-08 | 2019-07-26 | 广东大鹏医药科技有限公司 | A kind of moisture-keeping crease-shedding eye cream and preparation method thereof containing trollflower ingredient |
| CN113101253A (en) * | 2020-01-10 | 2021-07-13 | 惠州绵俪生物科技有限公司 | Cosmetic composition for improving skin comprising mixed extract of edible flowers |
| JP7465610B2 (en) | 2020-07-26 | 2024-04-11 | 武漢益承生物科技有限公司 | Use of Polypeptides in the Manufacture of Wound Care Medicaments - Patent application |
| WO2022029129A1 (en) * | 2020-08-05 | 2022-02-10 | Societe Industrielle Limousine D'application Biologique | Use of a cosmetic composition for mature skin in the form of a dry and soluble film comprising an extract of tropaeolum majus and an extract of lens esculenta |
| FR3113247A1 (en) * | 2020-08-05 | 2022-02-11 | Societe Industrielle Limousine D'application Biologique | Use of a cosmetic composition for mature skin in the form of a dry and soluble film comprising an extract of Tropaeolum majus and an extract of Lens esculenta |
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Application publication date: 20180420 |