CN107375043A - A kind of application of composition containing small-micelle water and said composition in cosmetics - Google Patents
A kind of application of composition containing small-micelle water and said composition in cosmetics Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
A kind of application of composition containing small-micelle water and said composition in cosmetics, composition is with small-micelle water, radix glycyrrhizae, red yeast rice, Sparassis crispa, sturgeon caviar, micromolecule hyaluronic acid, nanogold are main component, for the main mechanism of skin water shortage, the effect of comprehensive replenishing water and preserving moisture is realized, and the effect of Synergistic is produced between each composition;Said composition can operate with the form cosmetics such as aqua, aerosol.
Description
Technical field
The invention belongs to the technical field of cosmetics, and in particular to a kind of composition containing small-micelle water and its change
Utilization in cosmetic.
Background technology
Skin is the important reservoir of human body, and its water stored accounts for the 18~20% of whole body total Water, the height of its water content
Low closely related with the health status of skin, therefore, " moisturizing " is an eternal theme in cosmetics.Cuticula is in skin
Played an important role in terms of barrier function, its water content is the determinant of skin elasticity and flexibility.If water content is less than
10%, epidermal barrier function obstacle is may result in, triggers various skin problems (such as dry, long spot, long acne, acne, sensitivity, hair
Hole is thick, dark yellow, wrinkle, relaxation etc.), or even various skin diseases.
Cuticula is made up of horn cell, and it contains keratin fiber, NMF (Natural
Moisturizing Factor, NMF) etc. composition, wherein NMF account for 10% or so of horn cell dry weight.Horn cell gap
In be filled with the lipid material being made up of compositions such as natural lipid, aliphatic radical sphingols, it is maintaining the barrier function, aqueous of skin
Measure, prevent from playing an important role in terms of water loss, and adhesion to horn cell and furfur play regulating and controlling effect.Cuticula
In cell membrane, the combined water of cellular content and intercellular lipid, that is, determine the water content of cuticula.And cell membrane and
Lipid components in space between cells, then constitute the barrier for preventing water loss.Therefore, the water absorbing capacity of cuticula and barrier work(
Stronger water retention can be made it have.
It is the basic reason of " skin dehydration " that stratum corneum barrier function is impaired, mainly there is two kinds of fundamental types.It is first, outside
Factor:Due to low temperature and envionmental humidity is relatively low or other external factor (such as ultraviolet, microorganism) cause skin normal
Absorption and barrier function suffer damage, and cause water content in skin histology to decline.Second, skin oneself factor:With
Age increases, the natural aging of skin, and skin histology, cell viability declines or other internal factor (such as hormone, endocrine, inflammation
Disease etc.) caused by damage make cuticula moisture reduce caused by dry skin.Therefore, be respectively for above-mentioned two aspects
Using different measures, good replenishing water and preserving moisture effect could be obtained.
Under field conditions (factors), water is present in the form of molecular cluster, typically by more than 13~16 or even individual moisture up to a hundred
Molecular cluster.And the aperture for being mainly responsible for the aquaporin that hydrone is transported inside and outside cell membrane is 2nm, most narrow place is only
For 0.28nm, water molecule cluster under natural conditions be able to not need to resolve into more because it is relatively large in diameter directly by aquaporin
Small water molecule cluster could enter aquaporin.On the micel diameter and cell membrane of small-micelle water in the present invention
The aperture of aquaporin is close, can easily pass through aquaporin and enter cell, improves absorption efficiency of the cell to moisture.Mesh
It is preceding scientific investigations showed that, as water molecule cluster diminishes, dissolubility, permeability, metabolic, diffusivity, the emulsibility of water are equal
It has been strengthened that, the absorption of moisture can be obviously promoted and improve the active function of water;Due to the fracture of hydrogen bond between hydrone, make small
Micel water has antioxidation, and the smaller oxidation resistance of water clusters is stronger.
Have in the market and largely claim the cosmetics with moisture-keeping efficacy, mainly using various NMFs in skin outer layer
Simple " diaphragm " is formed, mechanism of action is single, does not fully take into account the multiple factors for causing skin dehydration, can not realize complete
Face is protected, therefore does not have good moistening effect.
It is rich in mineral ion by what is prepared using the methods of externally-applied magnetic field, extra electric field, laser emission in the market
Small-micelle water apply in cosmetics.It is well known that mineral ion has a strong impact on thickened systems and cosmetic in cosmetics
The stability of product, therefore restrict its utilization in cosmetics.And the product of in the market is not ground deeply to cosmetic formulations
Study carefully, the stability of water clusters is poor, easily re-forms macromolecular mass water, the advantages of can not giving full play to small-micelle water.In view of
Replenishing water and preserving moisture class cosmetics are the main categories in cosmetics at present, and replenishing water and preserving moisture is the primary demand of skin care, therefore, Ren Mendou
Expectation can provide the product of comprehensive replenishing water and preserving moisture effect.
The content of the invention
The present invention provides a kind of new composition containing small-micelle water, the defects of to overcome prior art to exist.This
The purpose of invention is:First, using the characteristic of small-micelle water, (dissolubility, permeability, metabolic, diffusivity, emulsibility are strong
In common water), improve in composition the effect of each raw material composition extraction effect;And have using small-micelle water and maintain
Biomolecule (such as enzyme, protein, polysaccharide, flavones ingredient) architectural characteristic, in enhancing red yeast rice, the raw material such as Sparassis crispa enzyme with
And the activity of other biological molecule, increase the extraction effect of the species of functional component and raising functional component in composition;And energy
Large biological molecule (such as polysaccharide, protein, hyaluronic acid) is degraded into the composition of more small-molecular-weight, is more easily absorbed by the skin,
The effect of realizing replenishing water and preserving moisture.In addition, the combination not only makes each composition give full play to self-acting, and also achieve collaboration and increase
The effect of effect.Second, realizing comprehensive replenishing water and preserving moisture effect to skin, and said composition is applied in cosmetics.Small point
Son group water can promote hydrone to permeate, absorption of the enhancing skin to moisture;It can activate corneocyte, strengthen biology in skin
Enzymatic activity, promote the synthesis of the compositions such as skin collagen, natural lipid, NMF, improve moisture-retaining capacity in skin;In composition
Rich in a variety of aging ingredients (such as SOD, Co-Q10), can slowing down skin aging, improve the water holding capacity of skin;Composition
In a variety of anti-inflammatory biocidal efficacies compositions for containing can resist scytitis, kill microorganism, mitigate the skin problem resulted from,
Reduce moisture of skin loss;In addition, said composition can form diaphragm outside cuticula, strengthen the barrier function of skin, improve
Skin Cell resists the ability of environmental damage, realizes comprehensive replenishing water and preserving moisture.
The technical scheme is that:
A kind of composition containing small-micelle water is made up of following parts by weight of component:
Functional component:10~1000 parts of small-micelle water, 0.1~40 part of radix glycyrrhizae, 0.001~10 part of red yeast rice, Sparassis crispa
0.01~30 part, 0.01~20 part of sturgeon caviar, micromolecule hyaluronic acid 0.01~20,0.00001~10 part of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh;Weigh
The sturgeon caviar of parts by weight is stated, 1~50 part of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, immersion 0.1
~4h, it is 15~45 DEG C to control extraction temperature, and the ultrasonic extraction time is 10~60min, and supersonic frequency is 20~40KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate collected, filter residue is carried out to extraction 1~3 time, merging filtrate again.It is small
The dosage of micel water adds up to 10~1000 parts by weight.
4th, digest:The micromolecule hyaluronic acid of corresponding parts by weight is added toward above-mentioned filtrate, is uniformly mixed, 25~40
After incubating 30~120min at DEG C, the nanogold of corresponding parts by weight is added, is stirred, is cooled to room temperature, is produced containing small
The composition of micel water.
Preferably it is combined as:
Functional component:50~1000 parts of small-micelle water, 0.5~30 part of radix glycyrrhizae, 0.05~10 part of red yeast rice, Sparassis crispa 0.1
~25 parts, 0.1~20 part of sturgeon caviar, micromolecule hyaluronic acid 0.1~20,0.00005~5 part of nanogold;
What is be more highly preferred to is combined as:
Functional component:100~800 parts of small-micelle water, 1~25 part of radix glycyrrhizae, 0.1~10 part of red yeast rice, Sparassis crispa 1~20
Part, 0.5~15 part of sturgeon caviar, micromolecule hyaluronic acid 0.1~10,0.001~5 part of nanogold;
Another object of the present invention is a kind of application of composition containing small-micelle water in cosmetics:
Described cosmetics are aqua, aerosol form.
The ratio 0.001%~90% of cosmetics gross weight shared by a kind of described composition containing small-micelle water.
Preferable ratio is that said composition accounts for the 0.01~60% of cosmetics gross weight.
Preferred ratio is that said composition accounts for the 0.1~40% of cosmetics gross weight.
Small-micelle water:Small-micelle water of the invention signified be with deionized water, pure water, ultra-pure water etc. without mineral from
The water of son is raw material, is made through HTHP, mainly by 4~5 molecular water molecule clusters of moisture, its17O-NMR half
Peak width≤60Hz.Its dissolubility, permeability, metabolic, diffusivity, emulsibility are better than light water, and have quick moisturizing, promote
Enter functional component absorption, decorporation poison, activating cell, promote cell metabolism, it is anti-oxidant, biomolecular structure is maintained, is improved
Biomolecule (such as enzyme) activity etc. acts on.
Radix glycyrrhizae:Radix glycyrrhizae is a kind of perennial herb, is under the jurisdiction of pulse family Papillionoideae Glycyrrhiza, it mainly contains triterpene
Lei, Yellow ketone and polysaccharide compound, additionally containing compounds such as organic acid, amino acid, alkaloid, cumarins, have
Anti-oxidant, anti-aging, antiallergy, sterilization anti-inflammatory, nti-freckle, Bearberry Extract.
Red yeast rice:It is manufactured a kind of meter Qu through solid state fermentation of monascus using rice as primary raw material, its color is in crimson.
It is rich in Monacolin K classes material, monascorubin, γ-aminobutyric acid, phenols, flavones ingredient, ergosterol, Co-Q10
And other functional ingredient, also containing a large amount of polyunsaturated fatty acids, polysaccharide, protein, Amino acids.In addition, also contain in red yeast rice
There are a variety of enzymes, there is amylase, carbohydrase, pectase, maltose, cellulase, protease, dextrin enzyme etc..With killing
Bacterium anti-inflammatory, anti-oxidant, anti-aging, promoting blood circulation and removing blood stasis, skin whitening, moisturizing and other effects.
Sparassis crispa:Sparassis crispa (SparassisCrispa) contains substantial amounts of beta glucan, superoxide dismutase (SOD),
Vitamin C, vitamin E, flavonoids, phenols and a variety of biology enzyme constituents, there is sterilization anti-inflammatory, whitening and anti-aging, antioxygen
Change, promote collagen synthesis, promote the effect such as wound healing, replenishing water and preserving moisture.After processed by the invention, more small molecule can obtain
The glucan of amount, is more easily absorbed by the skin, and has the effect of stronger and can improve the stability of small-micelle water.
Sturgeon caviar:It is to make to obtain as raw material using the fish-egg of sturgeon, and main component is close by being formed with human body skin
Lipid (unrighted acid, sterol, phosphatide etc.), substantial amounts of protein, small molecule oligopeptides and polypeptide and several amino acids
(isoleucine, lysine, methionine, cystine, phenylalanine, tyrosine, threonine, tryptophan, valine, arginine, group
Propylhomoserin, alanine, asparatate, glutamic acid, glycine, proline and serine), glucose, fructose, sucrose and glycogen etc.
Carbohydrate content, vitamin A, D, B1、B2With H etc..It can provide nutrition for skin, moisten and dry the skin of aging, recover skin
Vigor.
Micromolecule hyaluronic acid:It is less than 10000Da hyaluronic acid for molecular weight, there is whitening, anti-inflammatory, moisturizing, enhancing
Skin barrier, promote wound healing, promote cell growth and other effects.After processed by the invention, the saturating of more small-molecular-weight can obtain
Bright matter is sour (< 5000Da), is more easily absorbed by the skin, and has the function that to strengthen subset water stability.
Nanogold:Refer to gold particle of the particle diameter in 1~100nm diameters, it has sterilization anti-inflammatory, promotes wound healing, be anti-
Aging, the propagation for promoting keratinocyte, enhancing subset water stability and other effects.
The present invention develops a kind of new composition with replenishing water and preserving moisture effect, and it is comprehensive that it uses mechanism and multiple to realize
Replenishing water and preserving moisture, the physicochemical property of small-micelle water is made full use of, and compounding composition is innovated, improve the steady of small-micelle water
It is qualitative, the formula combination with synergistic function is obtained, all kinds of cosmetics prepared by said composition are respectively provided with good benefit
The effect of water moisturizing.
Embodiment
Following example is described in detail to the new method of the present invention, but is not intended to limit the scope of the present invention.
Embodiment 1:
A kind of composition containing small-micelle water, is made up of following parts by weight of component:
Functional component:300 parts of small-micelle water, 10 parts of radix glycyrrhizae, 1 part of red yeast rice, 5 parts of Sparassis crispa, 10 parts, small point of sturgeon caviar
Sub- 2 parts of hyaluronic acid, 0.01 part of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh sizes;Claim
The sturgeon caviar of above-mentioned parts by weight is taken, 20 parts of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, soaks 2h,
35 DEG C of extraction temperature is controlled, the ultrasonic extraction time is 60min, supersonic frequency 20KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate is collected, filter residue is carried out to extraction 2 times, merging filtrate again.Small molecule
The dosage of group's water adds up to 300 parts by weight.
4th, digest:2 parts of micromolecule hyaluronic acids are added toward above-mentioned filtrate, is uniformly mixed, 60min is incubated at 30 DEG C
Afterwards, 0.01 part of nanogold is added, stirs, is cooled to room temperature, produces the composition containing small-micelle water.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, the obtained group containing small-micelle water
Compound, have the characteristics that good replenishing water and preserving moisture effect, safety, effect are comprehensive.
Embodiment 2:
A kind of composition containing small-micelle water, is made up of following parts by weight of component:
Functional component:400 parts of small-micelle water, 15 parts of radix glycyrrhizae, 1.5 parts of red yeast rice, 10 parts of Sparassis crispa, 8 parts of sturgeon caviar are small
3 parts of molecular weight hyaluronic acid, 1 part of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh sizes;Claim
The sturgeon caviar of above-mentioned parts by weight is taken, 30 parts of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, soaks 3h,
38 DEG C of extraction temperature is controlled, the ultrasonic extraction time is 30min, supersonic frequency 40KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate is collected, filter residue is carried out to extraction 3 times, merging filtrate again.Small molecule
The dosage of group's water adds up to 400 parts by weight.
4th, digest:3 parts of micromolecule hyaluronic acids are added toward above-mentioned filtrate, is uniformly mixed, 40min is incubated at 35 DEG C
Afterwards, 1 part of nanogold is added, stirs, is cooled to room temperature, produces the composition containing small-micelle water.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, the obtained group containing small-micelle water
Compound, have the characteristics that good replenishing water and preserving moisture effect, safety, effect are comprehensive.
Embodiment 3:
A kind of composition containing small-micelle water, is made up of following parts by weight of component:
Functional component:100 parts of small-micelle water, 3 parts of radix glycyrrhizae, 0.5 part of red yeast rice, 5 parts of Sparassis crispa, 5 parts, small point of sturgeon caviar
Sub- 1 part of hyaluronic acid, 0.1 part of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh;Weigh
The sturgeon caviar of parts by weight is stated, 10 parts of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, soaks 1h,
30 DEG C of extraction temperature is controlled, the ultrasonic extraction time is 45min, supersonic frequency 30KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate is collected, filter residue is carried out to extraction 2 times, merging filtrate again.Small molecule
The dosage of group's water adds up to 100 parts by weight.
4th, digest:1 part of micromolecule hyaluronic acid is added toward above-mentioned filtrate, is uniformly mixed, 90min is incubated at 30 DEG C
Afterwards, 0.1 part of nanogold is added, stirs, is cooled to room temperature, produces the composition containing small-micelle water.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, the obtained group containing small-micelle water
Compound, have the characteristics that good replenishing water and preserving moisture effect, safety, effect are comprehensive.
Embodiment 4:
A kind of composition containing small-micelle water, is made up of following parts by weight of component:
Functional component:800 parts of small-micelle water, 25 parts of radix glycyrrhizae, 5 parts of red yeast rice, 10 parts of Sparassis crispa, 5 parts, small point of sturgeon caviar
Sub- 8 parts of hyaluronic acid, 0.05 part of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh;Weigh
The sturgeon caviar of parts by weight is stated, 20 parts of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, soaks 4h,
39 DEG C of extraction temperature is controlled, the ultrasonic extraction time is 60min, supersonic frequency 40KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate is collected, filter residue is carried out to extraction 2 times, merging filtrate again.Small molecule
The dosage of group's water adds up to 800 parts by weight.
4th, digest:8 parts of micromolecule hyaluronic acids are added toward above-mentioned filtrate, is uniformly mixed, is incubated at 39 DEG C
After 120min, 0.05 part of nanogold is added, stirs, is cooled to room temperature, produces the composition containing small-micelle water.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, the obtained group containing small-micelle water
Compound, have the characteristics that good replenishing water and preserving moisture effect, safety, effect are comprehensive.
Embodiment 5:
A kind of composition containing small-micelle water, is made up of following parts by weight of component:
Functional component:600 parts of small-micelle water, 10 parts of radix glycyrrhizae, 5 parts of red yeast rice, 20 parts of Sparassis crispa, 15 parts of sturgeon caviar are small
10 parts of molecular weight hyaluronic acid, 5 parts of nanogold;
Its manufacture craft is:
1st, crush:The radix glycyrrhizae of above-mentioned parts by weight, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh;Weigh
The sturgeon caviar of parts by weight is stated, 45 parts of small-micelle water is added, homogenate is prepared into tissue refiner;
2nd, extract:The composition of step 1 is added in extraction kettle, small-micelle water is added, is uniformly mixed, soaks 4h,
37.5 DEG C of extraction temperature is controlled, the ultrasonic extraction time is 30min, supersonic frequency 20KHz;
3rd, filter:After the completion of to be extracted, filtering, filtrate is collected, filter residue is carried out to extraction 2 times, merging filtrate again.Small molecule
The dosage of group's water adds up to 600 parts by weight.
4th, digest:10 parts of micromolecule hyaluronic acids are added toward above-mentioned filtrate, is uniformly mixed, is incubated at 25 DEG C
After 120min, 5 parts of nanogold are added, stirs, is cooled to room temperature, produce the composition containing small-micelle water.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, the obtained group containing small-micelle water
Compound, have the characteristics that good replenishing water and preserving moisture effect, safety, effect are comprehensive.
Another object of the present invention is application of the said composition in cosmetics, is made below with embodiments of the invention 4
It is described in detail for example, but is not intended to limit the interest field of the present composition.
Embodiment 6:
A kind of toner containing said composition:
Wherein, the cosmetics described in embodiment 6 illustrate by taking embodiment 4 as an example, such as change the composition of embodiment 4
For any combination and content in the claims in the present invention, then other compositions in cosmetic formulations can be in claim protection
In the range of make the appropriate adjustments.
Carried out for difference of the measure present composition in terms of replenishing water and preserving moisture the effect of and between single Effect raw material
Following experimental study:
Following experiments use following laboratory sample:By embodiment 4 the effect of exemplified by material combination, by 25 portions of radix glycyrrhizaes, 5 parts
Red yeast rice, 10 parts of Sparassis crispas, 5 parts of sturgeon caviars, 8 parts of micromolecule hyaluronic acid, 0.05 part of nanogold and embodiment 4, are used respectively
Common deionized water and small-micelle water are extracted, and extract is made using the technique of embodiment 4.
1st, influence of the Water condition to each raw material functional component effect of extracting
Influence of the Water condition to each raw material functional component effect of extracting is assessed using DPPH methods.DPPH (1,1- hexichol
Base -2- trinitrophenyl-hydrazines) be a kind of stabilization the proton free radical centered on nitrogen, it has strong absorption at 517nm, freely
Base Scavenging activity is linearly related to the light absorption value at 517nm, is the typical case side for the in vitro anti-oxidation for assessing antioxidant content
Method.
Blank control is done with the ethanol of 300 μ L 50%, draws the samples to be tested of different volumes to 250 μ L, 120 μm of ol/L
In DPPH solution, supplied less than 300 μ l with 50% ethanol, react 30min at room temperature, light absorption value (A) is determined in 517nm,
Replace sample to add in the DPPH solution of same volume with 50% ethanol of same dose, determine DPPH maximum light absorption values (A0).Separately
Equivalent prepare liquid is taken to be added in 50% ethanol to eliminate influence (A of the sample to light absorption value in itselfSample).It is repeated 3 times, Scavenging activity
Power represented with clearance rate, be calculated as follows:
Experimental result is shown in Table 1:
Influence of the Water condition of table 1 to each raw material functional component effect of extracting
Note:The analog of embodiment 4:By radix glycyrrhizae, red yeast rice, Sparassis crispa, sturgeon caviar, micromolecule hyaluronic acid, nanogold list
Solely extract obtained extract to mix in proportion, make the content of each raw material same as Example 4.
As can be seen from Table 1, removing of the extract of the various raw materials extracted using common deionized water to DPPH is imitated
Fruit is below the extract being obtained by extraction using small-micelle water, the extraction effect of this explanation small-micelle water be better than it is common go from
Sub- water.Regardless of whether the analog of embodiment 4 is still obtained using common deionized water and the small-micelle water extraction composition of embodiment 4
The antioxidation activity of extract solution be better than above-mentioned each single raw material sum, the effect that Synergistic between this explanation raw material be present.
And the activity of the extract of embodiment 4 is advantageous to improve much stronger than the analog of embodiment 4, this explanation using the manufacture craft of the present invention
The effect of extracting of functional component in each raw material.For embodiment 4, using the effect of small-micelle water extraction much stronger than commonly going
Ionized water, this dissolubility, permeability, diffusivity, the emulsibility of explanation except small-micelle water in itself are better than common deionized water
Outside, biomolecular structure also is maintained with small-micelle water, it is relevant strengthens bioenzyme activity.As being rich in protease, starch in red yeast rice
The biology enzymes such as enzyme, sugar, Protein components on its degradable animal vegetable tissue cell, destroy its structure, promote functional component
Dissolution, improve effect of extracting.
2nd, the synthesis promotion rate of III collagen type:
The content of collagen has a significant impact to skin moisture content in skin, therefore can be by testing collagen egg in skin
White content assesses the effect of its replenishing water and preserving moisture.The human fibroblasts that will be cultivated in the DMEM culture mediums containing 10%FBS
24 orifice plates are inoculated in, after cell attachment, are carried out with the DMEM culture mediums containing 0.25%FBS and 250 μM of magnesium ascorbyl phosphate
Culture medium exchanges, and is separately added into the above-mentioned testing sample for extracting to obtain by small-micelle water.After culture three days, reclaim on culture medium
Clearly, centrifuge, III collagen type in measure gained supernatant.
The evaluation method of the biosynthesis ability of III collagen type is to use " the P of RIA-gnostP III (P of P III) in cell
The terminal peptide (- peptide of Procollagen type III for III collagen type secreted in measure kit " measure supernatant:
The referred to as P of P III) content.Calculation formula is as follows:
Promotion rate=(A-B)/B*100%
A:Add III collagen type growing amount after test sample
B:It is not added with III collagen type growing amount of test sample
It the results are shown in Table 2:
Synthesis promotion rate of the 2 different test samples of table to III collagen type
Test sample (extract) | Concentration (μ l) | Promotion rate (%) |
Radix glycyrrhizae | 50 | -7.5 |
Red yeast rice | 50 | 6.1 |
Sparassis crispa | 50 | 9.3 |
Sturgeon caviar | 50 | 10.3 |
Micromolecule hyaluronic acid | 50 | 6.7 |
Nanogold | 50 | -10.2 |
Embodiment 4 | 50 | 27.3 |
As can be seen from Table 2, the extract of various single raw materials is respectively provided with certain to III collagen type growing amount
Influence, have promotion also has suppression.And embodiment 4 has activation to the generation of III collagen type, its promotion rate is higher than
Each single raw material sum, illustrates after compounding, avoids side effect, and composition occurs collaboration and made the effect of in each single raw material
With, it is mutual to strengthen, promote secretion of the cell to III collagen type, improve III collagen type growing amount, thicken extracellular base
Matter, and then realize more preferable moistening effect.
3rd, moisturizing activity
The change of 40 volunteer's moisture content of skin is tested using universally acknowledged Corneometer- capacitance methods, to assess
The performance of keeping humidity of the above-mentioned testing sample for extracting to obtain by small-micelle water.
40 subjects are the age in 20~40 years old health, the female volunteers without skin medical history.Volunteer before testing
Need to be in advance into the test environment (temperature is 20 DEG C ± 1 DEG C, and relative humidity is 40%~60%) of constant temperature and humidity, rest 30min.
Several area identical points are defined in left forearm, as using area.The point of right forearm same position is tested as blank control
When, the corresponding region of left and right forearm is tested simultaneously.The dosage each put is 5mg/cm2.After 2h, 3h are smeared in observation, skin is aqueous
The change of amount, to represent the performance of keeping humidity of testing sample.
Moisturizing rate=(A-B)/B*100%
A:Skin moisture content after addition test sample.
B:It is not added with test sample skin moisture content.
It the results are shown in Table 3:
The moisturizing activity of 3 different test samples of table
Test sample (extract) | Moisturizing rate (%, 2h) | Moisturizing rate (%, 3h) |
Radix glycyrrhizae | 1.5 | 0.5 |
Red yeast rice | 7.8 | 5.1 |
Sparassis crispa | 9.2 | 6.3 |
Sturgeon caviar | 8.7 | 5.5 |
Micromolecule hyaluronic acid | 10.2 | 6.7 |
Nanogold | 0.5 | 0.1 |
Embodiment 4 | 47.3 | 39.1 |
As can be seen from Table 3, the moistening effect of each single raw material is different, wherein the effect of silk ball fungus extract compared with
It is good, radix glycyrrhizae and nanogold it is relatively low.And the moisturizing rate after 2h of embodiment 4 reaches 47.3%, higher than each single raw material sum, and protect
The wet duration is longer, the as shown by data after 3h, and the moisturizing rate of various single raw materials significantly decreases, and embodiment 4
Moisturizing rate declines and unobvious (dropping to 39.1% from 47.3%).This explanation is after compounding, composition the effect of various raw materials
Act synergistically, improve the moisturizing rate of product and extend moistening effect.
The preferred embodiments of the present invention have shown and described in described above, as previously described, it should be understood that the present invention is not office
Be limited to form disclosed herein, be not to be taken as the exclusion to other embodiment, and available for various other combinations, modification and
Environment, and can be changed in the scope of the invention is set forth herein by the technology or knowledge of above-mentioned teaching or association area
It is dynamic., then all should be appended by the present invention and the change and change that those skilled in the art are carried out do not depart from the spirit and scope of the present invention
In scope of the claims.
Claims (8)
- A kind of 1. composition containing small-micelle water, it is characterised in that described composition:By following parts by weight of component group Into:10~1000 parts of small-micelle water, 0.1~40 part of radix glycyrrhizae, 0.001~10 part of red yeast rice, 0.01~30 part of Sparassis crispa, sturgeon seed 0.01~20 part of sauce, micromolecule hyaluronic acid 0.01~20,0.00001~10 part of nanogold.
- A kind of 2. composition containing small-micelle water as claimed in claim 1, it is characterised in that described composition:By Following parts by weight of component composition:50~1000 parts of small-micelle water, 0.5~30 part of radix glycyrrhizae, 0.05~10 part of red yeast rice, Sparassis crispa 0.1~25 part, 0.1~20 part of sturgeon caviar, micromolecule hyaluronic acid 0.1~20,0.00005~5 part of nanogold.
- A kind of 3. composition containing small-micelle water as claimed in claim 2, it is characterised in that described composition:By Following parts by weight of component composition:100~800 parts of small-micelle water, 1~25 part of radix glycyrrhizae, 0.1~10 part of red yeast rice, Sparassis crispa 1~20 Part, 0.5~15 part of sturgeon caviar, micromolecule hyaluronic acid 0.1~10,0.001~5 part of nanogold.
- A kind of 4. application of composition containing small-micelle water in cosmetics as claimed in claim 3, it is characterised in that: Described cosmetics are aqua, aerosol form.
- A kind of 5. application of composition containing small-micelle water in cosmetics as claimed in claim 4, it is characterised in that: The 0.001%~90% of cosmetics gross weight shared by a kind of described composition containing small-micelle water.
- A kind of 6. application of composition containing small-micelle water in cosmetics as claimed in claim 5, it is characterised in that: The 0.01~60% of cosmetics gross weight shared by a kind of described composition containing small-micelle water.
- A kind of 7. application of composition containing small-micelle water in cosmetics as claimed in claim 6, it is characterised in that: The 0.1~40% of cosmetics gross weight shared by a kind of described composition containing small-micelle water.
- A kind of 8. manufacture craft of the composition containing small-micelle water, it is characterised in that:Crush:By the sweet of above-mentioned parts by weight Grass, red yeast rice, Sparassis crispa are ground into the particle powder of 10~20 mesh.The sturgeon caviar of above-mentioned parts by weight is weighed, adds 1~50 part Small-micelle water, homogenate is prepared into tissue refiner.Extraction:Composition after crushing is added in extraction kettle, adds small molecule Group's water, is uniformly mixed, and soaks 0.1~4h, and it is 15~45 DEG C to control extraction temperature, and the ultrasonic extraction time is 10~60min, Supersonic frequency is 20~40KHz;Filtering:After the completion of to be extracted, filtering, filtrate collected, filter residue is carried out to extraction 1~3 time again, closed And filtrate;The dosage of small-micelle water adds up to 10~1000 parts by weight;Enzymolysis:The small of corresponding parts by weight is added toward above-mentioned filtrate Molecular weight hyaluronic acid, it is uniformly mixed, after incubating 30~120min at 25~40 DEG C, adds nanogold, stir, it is cold But to room temperature, the composition containing small-micelle water is produced.
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