CN116763667A - Refreshing and mild infant physical sun-screening emulsion and preparation method thereof - Google Patents
Refreshing and mild infant physical sun-screening emulsion and preparation method thereof Download PDFInfo
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- CN116763667A CN116763667A CN202310865262.3A CN202310865262A CN116763667A CN 116763667 A CN116763667 A CN 116763667A CN 202310865262 A CN202310865262 A CN 202310865262A CN 116763667 A CN116763667 A CN 116763667A
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- percent
- aluminum hydroxide
- titanium dioxide
- mild
- mixed powder
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- 239000000839 emulsion Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims description 12
- 238000004945 emulsification Methods 0.000 title claims description 4
- 238000012216 screening Methods 0.000 title description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000011812 mixed powder Substances 0.000 claims abstract description 33
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000002002 slurry Substances 0.000 claims abstract description 25
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 16
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 16
- 239000011787 zinc oxide Substances 0.000 claims abstract description 15
- 239000004519 grease Substances 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 239000003755 preservative agent Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 229920005862 polyol Polymers 0.000 claims abstract description 5
- 150000003077 polyols Chemical class 0.000 claims abstract description 5
- JRFBNCLFYLUNCE-UHFFFAOYSA-N zinc;oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[O-2].[Ti+4].[Zn+2] JRFBNCLFYLUNCE-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 230000037072 sun protection Effects 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 18
- 239000008267 milk Substances 0.000 claims description 11
- 210000004080 milk Anatomy 0.000 claims description 11
- 235000013336 milk Nutrition 0.000 claims description 11
- 239000011268 mixed slurry Substances 0.000 claims description 8
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 6
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 6
- 229940036350 bisabolol Drugs 0.000 claims description 6
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 6
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 6
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 5
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 238000001354 calcination Methods 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 150000005846 sugar alcohols Polymers 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 238000000967 suction filtration Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 2
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 claims description 2
- 125000002138 bisabolol group Chemical group 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 2
- 229940102552 disteardimonium hectorite Drugs 0.000 claims description 2
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 claims description 2
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical group CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 claims description 2
- 229960003493 octyltriethoxysilane Drugs 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical group O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical class 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 229940057429 sorbitan isostearate Drugs 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- 229940008099 dimethicone Drugs 0.000 claims 1
- 229940062000 polyglyceryl-2 triisostearate Drugs 0.000 claims 1
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 abstract description 9
- 230000007794 irritation Effects 0.000 abstract description 4
- 239000012266 salt solution Substances 0.000 abstract description 3
- 238000002791 soaking Methods 0.000 abstract description 3
- 239000002480 mineral oil Substances 0.000 abstract description 2
- 235000010446 mineral oil Nutrition 0.000 abstract description 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 6
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000010954 inorganic particle Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides fresh and mild infant physical sun-proof emulsion, which comprises the following raw materials in percentage by weight: 35 to 45 percent of mixed powder slurry, 11 to 14 percent of grease, 10 to 15 percent of polyol, 0.15 to 0.5 percent of sensitivity-relieving agent, 2 to 3 percent of thickening agent, 2.5 to 3 percent of emulsifying agent, 1 to 1.5 percent of sodium chloride, 0.7 to 1.2 percent of preservative and the balance of deionized water; the mixed powder slurry comprises zinc oxide, titanium dioxide and aluminum hydroxide, and the aluminum hydroxide is coated on the surface of the titanium dioxide-zinc oxide agglomerate. The formula of the invention has fresh skin feel, no alcohol, no essence, no mineral oil, and mild and no irritation. The titanium dioxide and zinc oxide treated by the aluminum hydroxide are effectively waterproof and sweat-proof, the aluminum hydroxide is coated on the surface of the titanium dioxide-zinc oxide aggregate, and the aluminum hydroxide and the allergy-relieving agent act cooperatively, so that the sun-proof emulsion has excellent waterproof and sweat-proof performances, the SPF value is reduced by not more than 50% under the condition of water soaking, the emulsion is stable in high-temperature salt solution, the emulsion is not easy to be carried out by sweat, and the emulsion is fresh, not fake white and not greasy.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a refreshing and mild infant physical sun-proof emulsion and a preparation method thereof.
Background
With the development of social economy and the improvement of sun protection consciousness, people are increasingly aware that excessive ultraviolet irradiation not only damages the human immune system, but also accelerates skin aging, various skin diseases and even skin cancers are caused, so that the market share of sun protection products is increasing. More and more sun protection products are favored by consumers, and consumers also become more intelligent, and the selection of sun protection products from a single sun protection factor is changed into the selection of safer and more comfortable high-efficiency sun protection products. In particular to a more finely divided child sun-protection product, the great difference of the structure and the function of the skin of the child and the skin of the adult promotes the higher requirements on the safety and the efficacy of the sun-protection product, and the sun-protection product is a trend which is considered to be a safer pure physical sun-protection product, and the pure physical sun-protection product has a certain skill in the aspects of skin feel and sun-protection index and formula design.
Titanium dioxide and zinc oxide are excellent physical sunscreens, inorganic particles are uniformly coated on the surface of skin to form a uniform protective layer, and the protective layer can reflect, refract and scatter ultraviolet rays to shield the damage of the ultraviolet rays to the skin, so that the skin is milder and safer than chemical sunscreens, and the skin is not stimulated, but most of the skin is thick and white in use.
The children have high metabolism, sweat is easy to take out and the sweat amount is large, so the requirements on the waterproof sweat-proof effect and the refreshing effect of the sun-proof product are high, sweat is weak acid and contains a large amount of inorganic salts and organic components, the sun-proof product needs certain stability and the capability of resisting the corrosion and denaturation of weak acid salt solution, and certain absorbability and adhesiveness are also needed to prevent the sun-proof effect from being influenced by the sweat.
Disclosure of Invention
The invention aims to provide infant physical sun-proof emulsion which is fresh, high in safety, mild and free of stimulation and has sun-proof, waterproof and sweat-proof performances and a preparation method thereof.
In order to achieve the aim, the invention provides fresh and mild infant physical sun-proof emulsion, which comprises the following raw materials in percentage by weight: 35 to 45 percent of mixed powder slurry, 11 to 14 percent of grease, 10 to 15 percent of polyol, 0.15 to 0.5 percent of sensitivity-relieving agent, 2 to 3 percent of thickening agent, 2.5 to 3 percent of emulsifying agent, 1 to 1.5 percent of sodium chloride, 0.7 to 1.2 percent of preservative and the balance of deionized water;
the mixed powder slurry comprises zinc oxide, titanium dioxide and aluminum hydroxide, and the aluminum hydroxide is coated on the surface of the titanium dioxide-zinc oxide aggregate.
Further, the mixed powder slurry also comprises 20.492-37.995% of grease, 3-5% of emulsifying agent and 3-5% of adhesive, wherein the zinc oxide accounts for 38-54% of the total mass of the mixed powder slurry; the titanium dioxide accounts for 16-30% of the total mass of the mixed slurry; the aluminum hydroxide accounts for 0.005-0.01% of the total mass of the mixed slurry.
Further, the grease comprises a plurality of dioctyl carbonate, isononyl isononanoate and polydimethylsiloxane; the emulsifier in the refreshing and mild infant physical sun protection milk comprises one or more of sorbitan isostearate and polyglycerol-2 diisostearate.
Further, the sensitivity-relieving agent is bisabolol or tocopheryl acetate; the polyol is glycerol or butanediol.
Further, the thickener comprises a vinyl polydimethylsiloxane/polymethylsiloxane silsesquioxane cross-linked polymer or disteardimonium hectorite; the preservative is benzyl alcohol, phenoxyethanol, potassium sorbate, methylisothiazolinone, imidazolidinyl urea, DMDM hydantoin, sodium benzoate, bismethylol imidazolidinyl urea or quaternary ammonium salt-15.
Further, the preparation method of the mixed powder slurry comprises the following steps:
s1, adding titanium dioxide and zinc oxide into an emulsifier, and rapidly stirring for 5-10 hours under the water bath condition of 50-60 ℃ at the stirring speed of 1200-1600 r/min;
s2, adding the adhesive into absolute ethyl alcohol, and performing low-temperature ultrasonic dispersion for 20-30 min to form a dispersion liquid; putting aluminum hydroxide into the dispersion liquid, and performing low-temperature ultrasonic dispersion for 30-60 min to form aluminum hydroxide suspension;
s3, adding the aluminum hydroxide suspension into the emulsion obtained in the step S1, carrying out vacuum suction filtration, respectively washing with absolute ethyl alcohol and deionized water for 3-5 times, drying, and calcining for 2-3 hours at 300-400 ℃ to obtain prefabricated mixed powder;
and S4, adding the prefabricated mixed powder into grease, and uniformly stirring to obtain mixed powder slurry.
Further, the titanium dioxide is anatase titanium dioxide.
Further, the emulsifier in the mixed powder slurry is one or more of polyglycerol-2 triisostearate and polyglycerol-3 diisostearate; the binder is triethoxy octyl silane.
The invention also provides a preparation method of the sun-proof emulsion, which comprises the following steps:
s11, placing the emulsifying agent, the grease, the sensitivity-relieving agent, the thickening agent and the mixed powder slurry into an oil pan for stirring and mixing, and starting to homogenize for 6 minutes until the materials are fine;
s12, placing the polyalcohol, sodium chloride and water into a water pot, stirring and mixing uniformly, and slowly adding the polyalcohol, the sodium chloride and the water into an oil pot while stirring;
s13, adding a preservative into the oil pan, starting low-speed homogenizing emulsification for 6-10 min, and preparing white emulsion with fine appearance, wherein the white emulsion is fresh and mild physical sun-proof emulsion for infants.
Compared with the prior art, the invention has the advantages that:
the fresh and mild infant physical sun-proof emulsion has the effective waterproof and sweat-proof components of zinc oxide and titanium dioxide treated by aluminum hydroxide, and the formula has fresh skin feel, no alcohol, no essence and no mineral oil, and is mild and has no irritation.
The mixed powder slurry disclosed by the invention has the advantages that the aluminum hydroxide is coated on the surface of the titanium dioxide-zinc oxide aggregate, so that the sun-proof emulsion has excellent water resistance and sweat resistance, the SPF value is reduced by not more than 50% under the condition of water soaking, the mixed powder slurry is stable in high-temperature salt solution, and the mixed powder slurry is adhered to the surface layer of skin and is not easy to be carried out by sweat;
the formula has no tear, does not need makeup removal, and can be cleaned by warm water or bath lotion; contains bisabolol and tocopheryl acetate, and has effects of moistening skin of infants; the emulsion has the advantages of light and thin texture, easy spreading after being smeared, synergistic effect of bisabolol, tocopheryl acetate and mixed powder slurry, realization of the effect of no false white and no greasy, and suitability for infants and children.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be further described below.
Examples 1 to 5.
Table 1 formulations of examples 1-5 of mixed slurries:
table 2 formulation of examples 1-5 for fresh and mild physical infant sun milk:
comparative example 1.
Unlike example 1, the preparation method of the mixed slurry was as follows:
s1, adding titanium dioxide and zinc oxide into an emulsifier, and rapidly stirring for 5 hours under the water bath condition of 50 ℃ at the stirring speed of 1200r/min;
s2, adding a binding agent into the emulsion obtained in the step S1, carrying out vacuum suction filtration, respectively washing with absolute ethyl alcohol and deionized water for 3 times, drying, and calcining for 2 hours at 300 ℃ to obtain prefabricated mixed powder;
and S3, adding the prefabricated mixed powder into grease, and uniformly stirring to obtain mixed powder slurry.
Comparative example 2.
Unlike example 1, the preparation method of the mixed slurry was as follows:
ball milling titanium dioxide, zinc oxide and aluminum hydroxide, adding an emulsifying agent, a binding agent and grease, and uniformly stirring to obtain mixed powder slurry.
Comparative example 3.
Unlike example 1, the preparation method of the mixed slurry was as follows:
s1, adding titanium dioxide and zinc oxide into an emulsifier, and uniformly stirring at room temperature;
s2, adding the adhesive and aluminum hydroxide into deionized water, and performing low-temperature ultrasonic dispersion for 20-30 min to form a dispersion liquid;
s3, adding the dispersion liquid into the emulsion obtained in the step S1, vacuum filtering, drying, and calcining for 2-3 hours at 100-200 ℃ to obtain prefabricated mixed powder;
and S4, adding the prefabricated mixed powder into grease, and uniformly stirring to obtain mixed powder slurry.
To verify the effect of the present invention, the sunscreen products of examples 1 to 5 and comparative examples 1 to 3 were subjected to various performance tests as follows:
1. skin irritation test
The subjects were 80 individuals in total from 20 to 30 year old females, and were divided into 8 groups of 10 individuals each. Selecting qualified plaque test equipment, placing about 0.030g-0.040g of a test object in a plaque tester by a closed plaque test method, applying a hypoallergenic tape to the back of a subject by external application, removing the test object after 24 hours, observing skin reactions after 0.5, 24 and 48 hours respectively, and recording the results according to skin reaction grading standards in cosmetic safety technical Specification (2015 edition).
Table 3 skin irritation test results for examples 1-5, comparative examples 1-3:
2. water resistance measurement
(1) The subject: women with ages 26-55 years old 80, average age 39.2+ -9.1 years, are divided into 8 groups of 10 persons each.
(2) A test object; the sun protection emulsions of examples 1 to 5 and comparative examples 1 to 3.
(3) Light source: the xenon arc lamp of the sunlight simulator meets the measurement specification requirements in each performance index.
(4) The inspection method comprises the following steps: the test was carried out according to the specific requirements of cosmetic safety Specification (2015 edition). The subject took a prone position and used the sun-protection creams of examples 1 to 5 and comparative examples 1 to 3 on the back for pre-bath irradiation and post-bath irradiation, respectively.
The minimum erythema dose (MED value) of the subject's skin to ultraviolet irradiation was predicted 24 hours before the test, and the ultraviolet irradiation dose was adjusted based on the prediction result, for testing the test object. On the day of examination, the back of the subject is selected to be not less than 30cm 2 Is used in an amount of (2.00.+ -. 0.05) mg/cm 2 Uniformly coating the object to be detected or the reference substance in the area, and waiting for 15-30 minutes. The subjects were moderately active in water or moderately rotating for 20 minutes with water out resting for 20 minutes. And (5) putting the skin into water for moderate activity for 20 minutes, ending the activity in the water, and waiting for the skin to dry. Then the ultraviolet irradiation dose is selected according to the specification. After 24 hours, the experimental results were observed, and MED values in 3 cases were recorded, respectively.
(5) The SPF value calculation method after bath comprises the following steps: the SPF value of the test object or the reference object for protecting the single subject is expressed by the following formula:
the SPF value of the individual is required to be accurate to one digit after the decimal point, the arithmetic mean of the SPF values of all the subjects protected by the sample is calculated, and the integer part of the arithmetic mean is taken as the SPF value of the measured sample.
Table 4 results of measuring water resistance of examples 1 to 5 and comparative examples 1 to 3:
conclusion: the human body measurement results show that the measured value of the detected sample is not reduced by more than 50% after 40 minutes of bath.
3. Resistance to denaturation test
8 groups of products of each of examples 1-5 and comparative examples 1-3 were sampled, 30g of each group was added with a sodium chloride solution having a pH of 5-6, an acidic environment was produced from acetic acid, and after testing for 15d, 30d and 60d at 10℃and 25℃respectively, the products were observed for abnormal conditions such as oil-water separation, odor, delamination, flocculation and precipitation of solids, wherein the abnormal conditions were recorded as unacceptable, and the abnormal conditions were recorded as acceptable.
Table 5 results of the anti-denaturation assays for examples 1-5, comparative examples 1-3:
as can be seen from the above examples 1-5, the product using the formulation of the present invention can maintain very high water repellency and sweat resistance, and the SPF value is not reduced by more than 50% under the condition of water wetting, and is stable in high temperature saline solution, and can be adhered to the surface layer of skin and not easily carried out by sweat; the combination of the bisabolol and the tocopheryl acetate relieves the irritation of the titanium dioxide and the zinc oxide attached to the skin, has a certain moistening effect on the skin of infants, and is fresh and not greasy;
as can be seen from comparative examples 1 to 3, in the case of the mixed powder slurry without pretreatment of aluminum hydroxide and changing the preparation method of the mixed powder slurry, the SPF value of the sun-proof milk is reduced by more than 50% under the condition of water soaking, good waterproof and sweat-proof performances cannot be achieved, and the synergistic effect of unmodified titanium dioxide, zinc oxide, aluminum hydroxide, bisabolol and tocopheryl acetate cannot be optimized, and the effect of relieving the irritation is relatively poor.
The foregoing is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Any person skilled in the art will make any equivalent substitution or modification to the technical solution and technical content disclosed in the invention without departing from the scope of the technical solution of the invention, and the technical solution of the invention is not departing from the scope of the invention.
Claims (9)
1. The fresh and mild physical sun protection emulsion for infants is characterized by comprising the following raw materials in percentage by weight: 35 to 45 percent of mixed powder slurry, 11 to 14 percent of grease, 10 to 15 percent of polyol, 0.15 to 0.5 percent of sensitivity-relieving agent, 2 to 3 percent of thickening agent, 2.5 to 3 percent of emulsifying agent, 1 to 1.5 percent of sodium chloride, 0.7 to 1.2 percent of preservative and the balance of deionized water;
the mixed powder slurry comprises zinc oxide, titanium dioxide and aluminum hydroxide, and the aluminum hydroxide is coated on the surface of the titanium dioxide-zinc oxide aggregate.
2. The fresh and mild infant physical sun protection milk according to claim 1, wherein said mixed slip further comprises 20.492-37.995% by weight of grease, 3-5% by weight of emulsifier and 3-5% by weight of binder, said zinc oxide being 38-54% by weight of said mixed slip; the titanium dioxide accounts for 16-30% of the total mass of the mixed slurry; the aluminum hydroxide accounts for 0.005-0.01% of the total mass of the mixed slurry.
3. The fresh and mild infant physical sun milk according to any one of claims 1 or 2, wherein said grease comprises a plurality of dioctyl carbonate, isononyl isononanoate and polydimethylsiloxane; the emulsifier in the refreshing and mild infant physical sun protection milk comprises one or more of sorbitan isostearate and polyglycerol-2 diisostearate.
4. The refreshing and mild infant physical sun protection milk according to claim 1, wherein said sensitivity-soothing agent is bisabolol or tocopheryl acetate; the polyol is glycerol or butanediol.
5. The refreshing and mild infant physical sun protection milk according to claim 1, wherein said thickener comprises a vinyl dimethicone/polymethylsilicone silsesquioxane cross polymer or disteardimonium hectorite; the preservative is benzyl alcohol, phenoxyethanol, potassium sorbate, methylisothiazolinone, imidazolidinyl urea, DMDM hydantoin, sodium benzoate, bismethylol imidazolidinyl urea or quaternary ammonium salt-15.
6. The refreshing and mild infant physical sun protection milk according to claim 1, wherein said mixed powder slurry preparation method comprises the following steps:
s1, adding titanium dioxide and zinc oxide into an emulsifier, and rapidly stirring for 5-10 hours under the water bath condition of 50-60 ℃ at the stirring speed of 1200-1600 r/min;
s2, adding the adhesive into absolute ethyl alcohol, and performing low-temperature ultrasonic dispersion for 20-30 min to form a dispersion liquid; putting aluminum hydroxide into the dispersion liquid, and performing low-temperature ultrasonic dispersion for 30-60 min to form aluminum hydroxide suspension;
s3, adding the aluminum hydroxide suspension into the emulsion obtained in the step S1, carrying out vacuum suction filtration, respectively washing with absolute ethyl alcohol and deionized water for 3-5 times, drying, and calcining for 2-3 hours at 300-400 ℃ to obtain prefabricated mixed powder;
and S4, adding the prefabricated mixed powder into grease, and uniformly stirring to obtain mixed powder slurry.
7. The refreshing and mild infant physical sun protection milk according to claim 6, wherein said titanium dioxide is anatase titanium dioxide.
8. The refreshing and mild infant physical sun protection milk according to claim 6, wherein the emulsifier in the mixed powder slurry is one or more of polyglyceryl-2 triisostearate and polyglyceryl-3 diisostearate; the binder is triethoxy octyl silane.
9. A method for preparing the refreshing and mild infant physical sun-block according to any one of claims 1-5, which is characterized in that the preparation method of the sun-block comprises the following steps:
s11, placing the emulsifying agent, the grease, the sensitivity-relieving agent, the thickening agent and the mixed powder slurry into an oil pan for stirring and mixing, and starting to homogenize for 6 minutes until the materials are fine;
s12, placing the polyalcohol, sodium chloride and water into a water pot, stirring and mixing uniformly, and slowly adding the polyalcohol, the sodium chloride and the water into an oil pot while stirring;
s13, adding a preservative into the oil pan, starting low-speed homogenizing emulsification for 6-10 min, and preparing white emulsion with fine appearance, wherein the white emulsion is fresh and mild physical sun-proof emulsion for infants.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117427018A (en) * | 2023-12-22 | 2024-01-23 | 广州海龟爸爸生物科技有限公司 | Centella asiatica extract and transparent zinc oxide sun-screening composition and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117427018A (en) * | 2023-12-22 | 2024-01-23 | 广州海龟爸爸生物科技有限公司 | Centella asiatica extract and transparent zinc oxide sun-screening composition and application thereof |
| CN117427018B (en) * | 2023-12-22 | 2024-03-12 | 广州海龟爸爸生物科技有限公司 | Centella asiatica extract and transparent zinc oxide sun-screening composition and application thereof |
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