CN106265119B - Polypeptide firming and moisturizing mask and preparation method thereof - Google Patents
Polypeptide firming and moisturizing mask and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention discloses a polypeptide firming and moisturizing mask and a preparation method thereof, the mask is rich in beautifying polypeptide components and mainly comprises the following components: acetyl hexapeptide-3, tridecapeptide-1, carnosine, aloe barbadensis, milk yeast, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, yellow collagen, stearic acid, laureth-3, phenoxyethanol, methylparaben, and ethylparaben. The total weight percentage of the three cosmetic polypeptides of acetyl hexapeptide-3, tridecapeptide-1 and carnosine is 15-30%. The three beauty polypeptides of the facial mask are important nutritional ingredients of the skin and are main functional ingredients of the product. Research shows that acetyl hexapeptide-3, tridecapeptide-1 and carnosine have strong skin-tightening and water-locking functions, can effectively improve the facial skin relaxation, and can effectively supplement amino acids and other nutritional ingredients required by epidermal cells.
Description
Technical Field
The invention relates to the field of facial masks, and particularly relates to a polypeptide firming and moisturizing facial mask and a preparation method thereof.
Background
Skin aging is a continuous and progressive physiological process that directly affects the appearance and function of skin. With the improvement of the life quality of people, the anti-aging, skin-tightening and youth-regaining become topics concerned by consumers.
After the mask is applied to the face, the skin can be temporarily isolated from the outside, substances in the mask can tightly wrap the skin to separate the skin from the outside air, on one hand, water slowly permeates into the horny layer of the epidermis, cells of the horny layer can 'drink saturated water' in a moist environment, and deep cells absorb enough water, so that the skin can be soft and the elasticity is increased; meanwhile, the skin surface is also warmed, and capillary vessel expansion is promoted, so that external dust, chemical pollutants and microorganisms infected in pores are favorably removed, and waste generated by metabolism of epidermal cells and excessive accumulated grease substances are favorably discharged.
Polypeptides are composed of amino acids (50 amino acids are hereinafter referred to as polypeptides, 50 amino acids or more are referred to as proteins), are intermediate hydrolysates of proteins, and are also components of human cells. Numerous studies have shown that protein is not completely hydrolysed to amino acids after ingestion, and is mostly absorbed in the form of peptides, and it has been found that polypeptides are absorbed more rapidly than amino acids of the same composition.
The polypeptide is mainly endogenous polypeptide or other natural polypeptide, has clear structure and definite action mechanism, has quality control level close to that of the traditional small molecular chemical substance and activity close to that of protein, and integrates the advantages of the traditional chemical substance and the protein.
Cosmetic polypeptides are a class of polypeptides having cosmetic efficacy. Is a condensate composed of a plurality of amino acids (at present, the common cosmetic polypeptide is a condensate of 2 to 10 amino acids), but the functions of the cosmetic polypeptide are completely different because of different amino acid types and sequences.
The beauty polypeptide has no harm to human body, obvious effect and clear action mechanism, is applied abroad for more than twenty years, and a plurality of large-brand products are added (such as Yashilandai, Xiangnai, Dior, lanko and the like), but the cosmetic polypeptide is just started in China, the market application amount is very small, and a plurality of products are fried; however, with the gradual enhancement of the general control of the national food and drug administration, the market must be regulated gradually.
Disclosure of Invention
The invention comprehensively considers various factors causing skin water shortage and relaxation, and aims to provide a polypeptide firming and moisturizing mask. The polypeptide firming and moisturizing mask takes a plurality of beauty polypeptides as main active ingredients, plays a synergistic role, promotes the proliferation of new cells, delays the phenomena of cell aging and skin relaxation, and finally enables the skin to regain the new growth. The invention also aims to provide a preparation method of the polypeptide firming and moisturizing mask.
In order to achieve the purpose, the invention adopts the following technical scheme:
the polypeptide firming and moisturizing mask comprises the following components in percentage by weight:
preferably, the composition comprises the following components in percentage by mass:
preferably, the composition comprises the following components in percentage by mass:
preferably, the total weight percentage of the three cosmetic polypeptides of acetyl hexapeptide-3, tridecapeptide-1 and carnosine is 15-30%.
Preferably, the purity of the three cosmetic polypeptides of acetyl hexapeptide-3, tridecapeptide-1 and carnosine is 95-99%.
In order to achieve the second object, the invention adopts the following technical scheme:
a preparation method of a polypeptide firming and moisturizing mask comprises the following steps:
1) adding water, aloe vera, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, collagen, stearic acid, laureth-3, phenoxyethanol, methylparaben and ethylparaben into a reaction tank, starting stirring, heating to 75-80 ℃, and stirring and dispersing uniformly;
2) starting cooling circulating water, stirring and cooling, adding milk yeast into the reaction tank when the temperature is reduced to 40-45 ℃, homogenizing for 1 minute, and stirring and dissolving completely;
3) and continuously stirring and cooling to the temperature lower than 37 ℃, adding the acetyl hexapeptide-3, the tridecapeptide-1 and the carnosine into the reaction tank, homogenizing for 2-3 minutes, and completely stirring and dissolving to finish the process.
The mask provided by the invention has the effects of tightening the skin, keeping moisture and replenishing water.
Specifically, the facial mask disclosed by the invention has the effects of efficiently moisturizing, nourishing skin, promoting skin metabolism, improving skin sagging, brightening and firming skin, moisturizing and smoothing skin, and improving skin mildness.
In the present invention, three cosmetic polypeptides are the main additives. Wherein:
acetyl hexapeptide-3 is a kind of cosmetic polypeptide synthesized by solid phase synthesis method, and is characterized by high purity, no irritation to human body and clear cosmetic mechanism, and acetyl hexapeptide-3 is a skin conditioner and humectant, and can obviously reduce wrinkle produced by facial expression muscle contraction[1]。
The tridecapeptide-1 is a cosmetic polypeptide synthesized by a solid-phase synthesis method, and is characterized by high purity, no stimulation to human body and clear cosmetic mechanism, and the tridecapeptide-1 is a skin conditioner and has good whitening and anti-wrinkle effects[2]。
Carnosine is a kind of beautifying polypeptide synthesized by solid phase synthesis method, and features high purity, no irritation to human body, clear beautifying mechanism and capacity of promoting skin regenerationThe proliferation of collagen, elastic fiber and hyaluronic acid can increase water content of skin and increase skin thickness, thereby remarkably inhibiting skin thinning and elasticity decrease[3,4]。
The components used in the invention belong to the existing products and can be purchased in the market.
The invention has the following advantages:
1) the skin-care product has high content of polypeptide components, contains natural extracts of aloe barbadensis and the like in the formula, can effectively replenish water, preserve moisture, supply nutrition to skin, promote skin metabolism, improve skin sagging and drooping, lighten and tighten skin, moisten and smooth skin, is rich in elasticity, and improve skin mildness.
2) The polypeptide firming and moisturizing mask is safe, stable and easy to absorb, and the face is clean and non-sticky after use; and the preparation method is simple, the process is stable, and the method can be popularized and applied.
3) The polypeptide firming and moisturizing mask can form a fine film on the surface of a cortex, so that the polypeptide firming and moisturizing mask has an obvious firming effect and is more obvious in effect compared with other products. After being continuously used for 7 days, the skin is obviously tender, smooth and compact.
Drawings
FIG. 1 shows changes in the L value of the tested site during the use of the polypeptide firming and moisturizing mask
FIG. 2, change of skin moisture content during use of polypeptide firming and moisturizing mask
Detailed Description
The following table 1 shows the weight percentages of the components of the skin firming and moisturizing mask of the present invention in examples 1 to 3
The preparation method of the polypeptide firming and moisturizing mask comprises the following steps: adding water, aloe vera, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, xanthan gum, stearic acid, laureth-3, phenoxyethanol, methylparaben and ethylparaben into a reaction tank, starting stirring, heating to 75-80 ℃, and stirring and dispersing uniformly;
starting cooling circulating water, stirring and cooling, adding milk yeast into the reaction tank when the temperature is reduced to 40-45 ℃, homogenizing for 1 minute, and stirring and dissolving completely; and continuously stirring and cooling to the temperature lower than 37 ℃, adding acetyl hexapeptide-3, tridecapeptide-1 and carnosine into the reaction tank, homogenizing for 2-3 minutes, and completely stirring and dissolving to finish the process.
The following table 2 shows the weight percentages of the components of the skin firming and moisturizing mask of the present invention in examples 4 to 6
The preparation method of the polypeptide firming and moisturizing mask comprises the following steps: adding water, aloe vera, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, xanthan gum, stearic acid, laureth-3, phenoxyethanol, methylparaben and ethylparaben into a reaction tank, starting stirring, heating to 70-75 ℃, and stirring and dispersing uniformly;
starting cooling circulating water, stirring and cooling, adding milk yeast into the reaction tank when the temperature is reduced to 40-42 ℃, homogenizing for 1 minute, and stirring and dissolving completely; and continuously stirring and cooling to the temperature lower than 37 ℃, adding acetyl hexapeptide-3, tridecapeptide-1 and carnosine into the reaction tank, homogenizing for 2-3 minutes, and completely stirring and dissolving to finish the process.
The following Table 3 shows the weight percentages of the components of the skin firming and moisturizing facial mask of the invention in examples 7 to 9
The preparation method of the polypeptide firming and moisturizing mask comprises the following steps: adding water, aloe vera, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, xanthan gum, stearic acid, laureth-3, phenoxyethanol, methylparaben and ethylparaben into a reaction tank, starting stirring, heating to 75-78 ℃, and stirring and dispersing uniformly;
starting cooling circulating water, stirring and cooling, adding milk yeast into the reaction tank when the temperature is reduced to 40-42 ℃, homogenizing for 1 minute, and stirring and dissolving completely; and continuously stirring and cooling to the temperature lower than 37 ℃, adding acetyl hexapeptide-3, tridecapeptide-1 and carnosine into the reaction tank, homogenizing for 2-3 minutes, and completely stirring and dissolving to finish the process.
The product performance evaluation test of the invention is as follows:
first, example 9 skin tightening efficacy verification:
90 volunteers with similar facial skin relaxation degree are selected and divided into 9 groups of 10 persons, and the product is attached to the face once a day for 14 days.
Firming effect description (table 4):
it is obvious that: the skin is tight and elastic, and the loose feeling disappears;
moderate improvement: the skin is compact, and the loose feeling is relieved;
no effect is seen: basically no difference exists before the use.
TABLE 4 skin firming effect test results
As a result: in 90 cases, the product of the invention has obvious effect accounting for 83 percent, the moderate improvement accounting for 14 percent, the total effective rate accounting for 97 percent, and no adverse reaction occurs in all the subjects.
Second, whitening effect evaluation was performed on example 9
The polypeptide firming and moisturizing mask provided in example 9 was selected for this experiment.
Selecting 30 healthy women with the age of 23-50 years, measuring and recording the color of facial skin, then issuing a tested facial mask, and continuously tightening the skin of the tested subject to replenish the facial mask sample with the polypeptide. After continuously using 7d, 14d, 21d and 30d, each efficacy index is measured. Meanwhile, the volunteers are asked to feel and whether or not there is allergy after using the test sample, and the comparison before and after the volunteers are recorded. The change of skin color was measured using a Lab colorimetric system spectrophotometer 1d before use of the mask and 7d, 14d, 21d, and 30d after use, and the change was measured 3 times in succession, and the average value was taken. The data processing adopts the sps statistical software to carry out pairing t test, and has significance when P is less than 0.05.
The change of skin chromaticity L of the tested part before and after the test is as follows: the larger the skin color L value, the lighter the skin color. At 7d after the product was used, the skin color L values tended to increase, and were significantly greater than the pre-test level (P <0.05) from 14d (see fig. 1, data in table 5), with the L values tending to increase with time.
TABLE 5 Change in the value of the L of the tested site during use of the polypeptide firming and moisturizing mask
In conclusion, the mask product has the effects of whitening skin and brightening skin.
Third, the skin moisturizing effect evaluation was performed on example 9.
Selecting 20 healthy women aged 20-40 years, measuring the water content of the skin, then delivering a tested mask, and continuously using a polypeptide skin-tightening and water-replenishing mask sample by a tested subject. After 1d, 3d and 7d of the test piece are used, each efficacy index is measured. After the tested facial masks 1d, 3d and 7d are used, a skin moisture tester is used for testing the moisture content of the skin, the change value of the moisture content of the skin is recorded, the continuous testing is carried out for 3 times, and the average value is taken. The data processing adopts the sps statistical software to carry out pairing t test, and the significance is shown when P is less than 0.05.
The change of the water content of the tested part before and after the test is as follows: the larger the value tested, the higher the moisture content. The moisture content of the skin tends to increase 1d after the product is used, and is obviously higher than the level before the test (P <0.05) from 3d (see figure 2, data in table 6), and the moisture content tends to increase gradually along with the prolonging of the service time of the product.
TABLE 6 variation of skin Water content during use of polypeptide firming and hydrating mask
Fourth, polypeptide firming and moisturizing mask stability test result
The sensory and physicochemical properties of the prepared polypeptide firming and moisturizing mask containing 10% acetyl hexapeptide-3, 10% tridecapeptide-1 and 10% carnosine were tested according to the light industry standard QB/T2872 of the people's republic of China, and the results are shown in Table 7. From table 7, the detection results of the color, turbidity, cold and heat resistance tests and the pH value of the polypeptide firming and moisturizing mask all meet the sensory and physicochemical index regulations of the light industry standard QB/T2872 of the people's republic of China, and the quality index of the polypeptide firming and moisturizing mask is basically not affected by adding the three types of the polypeptide firming and moisturizing mask.
TABLE 7 stability test results of polypeptide firming and moisturizing mask
| Item | Results |
| Appearance of the product | Homogeneous liquid, free of impurities |
| Heat resistance test | Keeping the temperature at (40 +/-1) DEG C for 24h, and no obvious character difference exists between the room temperature and the room temperature before the test |
| Cold resistance test | Keeping the temperature at (5 +/-1) DEG C for 24h, and no obvious character difference exists between the room temperature and the room temperature before the test |
| pH | About 7.0 |
The polypeptide firming and moisturizing mask products prepared in the examples 1, 3, 5, 7 and 9 are compared with the existing firming and moisturizing mask products in the experiment, wherein the experiment conditions are as follows: 60 volunteers aged 20-45 years were used 1 time per day for 28 consecutive days. The results of the experiment are shown in the following table (table 8):
TABLE 8 comparison of polypeptide firming and moisturizing mask with existing firming and moisturizing mask
For the sake of space saving, the present invention only illustrates some embodiments and experimental results thereof, and actually, other technical solutions of the present invention can achieve similar or identical effects.
Reference to the literature
[1] Application and latest progress of stauntonvine in facial masks [ J ] daily chemical science, 2012, 35 (11): 35-38.
[2]Papini A M.Cosmetics towards peptide-based cosmeceutics[J].ChimicaOggi/Che- mistry Today,2010,28(6):3-4
[3] Use of a biologically active polypeptide in cosmetology in medicine [ c ] proceedings of the 10 th society of cosmetology in southeast asia, 2006: 14-17
[4] Leyankun, Yao Jingong, Huangyadong and the like, the basis and the application of the bioactive polypeptide skin care product fJ1, daily chemical industry, 2002, 32 (5): 41-43.
Claims (1)
1. A polypeptide firming and moisturizing mask is characterized by comprising the following components in percentage by weight
The preparation method of the mask comprises the following steps:
1) adding water, aloe vera, butanediol, glycerol, sodium hyaluronate, squalane, tocopherol, collagen, stearic acid, laureth-3, phenoxyethanol, methylparaben and ethylparaben into a reaction tank, starting stirring, heating to 75-80 ℃, and stirring and dispersing uniformly;
2) starting cooling circulating water, stirring and cooling, adding milk yeast into the reaction tank when the temperature is reduced to 40-45 ℃, homogenizing for 1 minute, and stirring and dissolving completely;
3) and continuously stirring and cooling to the temperature lower than 37 ℃, adding acetyl hexapeptide-3, tridecapeptide-1 and carnosine into the reaction tank, homogenizing for 2-3 minutes, and stirring and dissolving completely.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951366A (en) * | 2006-11-03 | 2007-04-25 | 南风化工集团股份有限公司 | A skin moisture-keeping wrinkle-resisting essence and production method thereof |
| CN101721340A (en) * | 2009-10-23 | 2010-06-09 | 无限极（中国）有限公司 | Cosmetic composition for delaying skin aging |
| CN104042464A (en) * | 2014-05-31 | 2014-09-17 | 青岛博泓海洋生物技术有限公司 | Whitening skin-care essence liquid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1951366A (en) * | 2006-11-03 | 2007-04-25 | 南风化工集团股份有限公司 | A skin moisture-keeping wrinkle-resisting essence and production method thereof |
| CN101721340A (en) * | 2009-10-23 | 2010-06-09 | 无限极（中国）有限公司 | Cosmetic composition for delaying skin aging |
| CN104042464A (en) * | 2014-05-31 | 2014-09-17 | 青岛博泓海洋生物技术有限公司 | Whitening skin-care essence liquid |
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| Title |
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| Cucumber (广源良) 丝瓜弹力紧緻緻面膜;佚名;《http://www.cosdna.com/chs/cosmetic_0d59169973.html》;20141221;第1页表格 * |
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