CN103172496A - 一种γ-结晶山梨醇的制备方法 - Google Patents
一种γ-结晶山梨醇的制备方法 Download PDFInfo
- Publication number
- CN103172496A CN103172496A CN201210478583XA CN201210478583A CN103172496A CN 103172496 A CN103172496 A CN 103172496A CN 201210478583X A CN201210478583X A CN 201210478583XA CN 201210478583 A CN201210478583 A CN 201210478583A CN 103172496 A CN103172496 A CN 103172496A
- Authority
- CN
- China
- Prior art keywords
- sorbitol
- sorbyl alcohol
- preparation
- crystalline sorbitol
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 title claims abstract description 69
- 239000000600 sorbitol Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000013078 crystal Substances 0.000 claims abstract description 46
- 238000005507 spraying Methods 0.000 claims abstract description 16
- 238000001816 cooling Methods 0.000 claims abstract description 13
- 238000001704 evaporation Methods 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000007787 solid Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 4
- MEIRRNXMZYDVDW-MQQKCMAXSA-N (2E,4E)-2,4-hexadien-1-ol Chemical compound C\C=C\C=C\CO MEIRRNXMZYDVDW-MQQKCMAXSA-N 0.000 claims description 59
- 238000002425 crystallisation Methods 0.000 claims description 18
- 230000008025 crystallization Effects 0.000 claims description 17
- 238000009835 boiling Methods 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 8
- 230000008020 evaporation Effects 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 238000002844 melting Methods 0.000 abstract description 5
- 230000008018 melting Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 2
- 229930003268 Vitamin C Natural products 0.000 abstract 2
- 235000019154 vitamin C Nutrition 0.000 abstract 2
- 239000011718 vitamin C Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 52
- 235000010356 sorbitol Nutrition 0.000 description 49
- 238000000034 method Methods 0.000 description 18
- 230000015572 biosynthetic process Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004898 kneading Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- HIMQVZDNGULBFJ-HUNMEVQMSA-N (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO HIMQVZDNGULBFJ-HUNMEVQMSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- -1 scale remover Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201210478583.XA CN103172496B (zh) | 2012-11-22 | 2012-11-22 | 一种γ-结晶山梨醇的制备方法 |
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CN201210478583.XA CN103172496B (zh) | 2012-11-22 | 2012-11-22 | 一种γ-结晶山梨醇的制备方法 |
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CN103172496A true CN103172496A (zh) | 2013-06-26 |
CN103172496B CN103172496B (zh) | 2014-11-26 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104095184A (zh) * | 2014-07-15 | 2014-10-15 | 浙江华康药业股份有限公司 | 一种粒状复合糖醇及其制备方法 |
CN104478662A (zh) * | 2014-12-29 | 2015-04-01 | 临沂市鑫轮化工有限公司 | 一种γ-晶型固体山梨糖醇连续制备方法 |
CN109438188A (zh) * | 2018-11-16 | 2019-03-08 | 浙江华康药业股份有限公司 | 一种颗粒山梨醇及其制备方法 |
CN114404395A (zh) * | 2022-02-16 | 2022-04-29 | 天津信诚康达药业有限公司 | 一种耐潮山梨醇的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1481846A (en) * | 1972-10-13 | 1977-08-03 | Roquette Freres | Process for producing crystalline sorbitol |
GB2046743A (en) * | 1979-03-16 | 1980-11-19 | Roquette Freres | Compressible sorbitol |
CN1130617A (zh) * | 1994-12-28 | 1996-09-11 | (株)三养吉尼克斯 | 结晶山梨醇粉末的制备方法 |
CN1188097A (zh) * | 1998-02-19 | 1998-07-22 | 范志刚 | 一种r晶型山梨醇的制备方法 |
CN101547884A (zh) * | 2006-07-28 | 2009-09-30 | 诺克特兄弟 | 颗粒山梨醇及其制备方法 |
-
2012
- 2012-11-22 CN CN201210478583.XA patent/CN103172496B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1481846A (en) * | 1972-10-13 | 1977-08-03 | Roquette Freres | Process for producing crystalline sorbitol |
GB2046743A (en) * | 1979-03-16 | 1980-11-19 | Roquette Freres | Compressible sorbitol |
CN1130617A (zh) * | 1994-12-28 | 1996-09-11 | (株)三养吉尼克斯 | 结晶山梨醇粉末的制备方法 |
CN1188097A (zh) * | 1998-02-19 | 1998-07-22 | 范志刚 | 一种r晶型山梨醇的制备方法 |
CN101547884A (zh) * | 2006-07-28 | 2009-09-30 | 诺克特兄弟 | 颗粒山梨醇及其制备方法 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104095184A (zh) * | 2014-07-15 | 2014-10-15 | 浙江华康药业股份有限公司 | 一种粒状复合糖醇及其制备方法 |
CN104095184B (zh) * | 2014-07-15 | 2016-03-30 | 浙江华康药业股份有限公司 | 一种粒状复合糖醇及其制备方法 |
CN104478662A (zh) * | 2014-12-29 | 2015-04-01 | 临沂市鑫轮化工有限公司 | 一种γ-晶型固体山梨糖醇连续制备方法 |
CN104478662B (zh) * | 2014-12-29 | 2015-12-02 | 临沂市鑫轮化工有限公司 | 一种γ-晶型固体山梨糖醇连续制备方法 |
CN109438188A (zh) * | 2018-11-16 | 2019-03-08 | 浙江华康药业股份有限公司 | 一种颗粒山梨醇及其制备方法 |
CN114404395A (zh) * | 2022-02-16 | 2022-04-29 | 天津信诚康达药业有限公司 | 一种耐潮山梨醇的制备方法 |
CN114404395B (zh) * | 2022-02-16 | 2023-11-10 | 天津信诚康达药业有限公司 | 一种耐潮山梨醇的制备方法 |
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CN103172496B (zh) | 2014-11-26 |
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Inventor after: Xin Chengfu Inventor after: Jing Wenli Inventor after: Yu Li Inventor after: Ren Shangmei Inventor before: Ren Shangmei Inventor before: Xin Chengfu Inventor before: Jing Wenli Inventor before: Yu Li |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REN SHANGMEI XIN CHENGFU JING WENLI YU LI TO: XIN CHENGFU JING WENLI YU LI REN SHANGMEI |
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Denomination of invention: Preparation method of gamma-crystalline sorbitol Effective date of registration: 20180109 Granted publication date: 20141126 Pledgee: Yucheng Shandong rural commercial bank Limited by Share Ltd Pledgor: Shandong Lvjian Biological Technology Co., Ltd. Registration number: 2018370000010 |
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Effective date of registration: 20180428 Granted publication date: 20141126 |
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