CN1031222A - 用作单胺氧化酶抑制前药的β-(氟亚甲基)-5-羟基色氨酸及衍生物 - Google Patents
用作单胺氧化酶抑制前药的β-(氟亚甲基)-5-羟基色氨酸及衍生物 Download PDFInfo
- Publication number
- CN1031222A CN1031222A CN88103199A CN88103199A CN1031222A CN 1031222 A CN1031222 A CN 1031222A CN 88103199 A CN88103199 A CN 88103199A CN 88103199 A CN88103199 A CN 88103199A CN 1031222 A CN1031222 A CN 1031222A
- Authority
- CN
- China
- Prior art keywords
- acid
- compound
- formula
- formula compound
- methylene radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/053,212 US4822812A (en) | 1987-05-21 | 1987-05-21 | β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition |
| US053,212 | 1987-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1031222A true CN1031222A (zh) | 1989-02-22 |
Family
ID=21982670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN88103199A Pending CN1031222A (zh) | 1987-05-21 | 1988-05-20 | 用作单胺氧化酶抑制前药的β-(氟亚甲基)-5-羟基色氨酸及衍生物 |
Country Status (17)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100588398C (zh) * | 2002-05-09 | 2010-02-10 | 波利药物股份公司 | 用于治疗中枢神经系统紊乱的3-吲哚基丙酮酸的烯醇互变体基本纯的固体形式 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488188A (en) * | 1994-09-29 | 1996-01-30 | Merrell Dow Pharmaceuticals Inc. | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof |
| US6972014B2 (en) * | 2003-01-04 | 2005-12-06 | Endocare, Inc. | Open system heat exchange catheters and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2513597B2 (de) * | 1975-03-27 | 1977-06-02 | L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel | |
| US4183858A (en) * | 1977-07-01 | 1980-01-15 | Merrell Toraude Et Compagnie | α-Vinyl tryptophanes |
| FR2499076A1 (fr) * | 1981-02-02 | 1982-08-06 | Panmedica Laboratoires | Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant |
| US4454158A (en) * | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
| ZA855101B (en) * | 1984-07-13 | 1986-05-28 | Merrell Dow Pharma | Fluoroallylaine derivatives |
-
1987
- 1987-05-21 US US07/053,212 patent/US4822812A/en not_active Expired - Lifetime
-
1988
- 1988-05-15 IL IL86387A patent/IL86387A0/xx not_active IP Right Cessation
- 1988-05-16 ZA ZA883442A patent/ZA883442B/xx unknown
- 1988-05-16 AR AR88310862A patent/AR246952A1/es active
- 1988-05-16 CA CA000566913A patent/CA1310973C/en not_active Expired - Lifetime
- 1988-05-17 AU AU16347/88A patent/AU605865B2/en not_active Ceased
- 1988-05-17 NZ NZ224661A patent/NZ224661A/xx unknown
- 1988-05-18 PH PH36944A patent/PH25384A/en unknown
- 1988-05-19 FI FI882360A patent/FI90531C/fi not_active IP Right Cessation
- 1988-05-19 PT PT87538A patent/PT87538B/pt not_active IP Right Cessation
- 1988-05-19 KR KR1019880005872A patent/KR960016521B1/ko not_active Expired - Fee Related
- 1988-05-20 JP JP63122187A patent/JP2520285B2/ja not_active Expired - Lifetime
- 1988-05-20 EP EP88108125A patent/EP0291998A3/en not_active Withdrawn
- 1988-05-20 NO NO882240A patent/NO172576C/no not_active IP Right Cessation
- 1988-05-20 HU HU882617A patent/HU199790B/hu not_active IP Right Cessation
- 1988-05-20 CN CN88103199A patent/CN1031222A/zh active Pending
- 1988-05-20 HU HU89172A patent/HUT50117A/hu unknown
- 1988-05-20 DK DK278388A patent/DK169330B1/da not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100588398C (zh) * | 2002-05-09 | 2010-02-10 | 波利药物股份公司 | 用于治疗中枢神经系统紊乱的3-吲哚基丙酮酸的烯醇互变体基本纯的固体形式 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63303965A (ja) | 1988-12-12 |
| FI90531B (fi) | 1993-11-15 |
| FI882360L (fi) | 1988-11-22 |
| DK169330B1 (da) | 1994-10-10 |
| IL86387A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-12-01 |
| EP0291998A2 (en) | 1988-11-23 |
| ZA883442B (en) | 1988-11-16 |
| PH25384A (en) | 1991-06-03 |
| FI882360A0 (fi) | 1988-05-19 |
| HUT47905A (en) | 1989-04-28 |
| NO172576C (no) | 1993-08-11 |
| NO172576B (no) | 1993-05-03 |
| PT87538B (pt) | 1992-09-30 |
| NO882240L (no) | 1988-11-22 |
| US4822812A (en) | 1989-04-18 |
| AU1634788A (en) | 1988-11-24 |
| AR246952A1 (es) | 1994-10-31 |
| EP0291998A3 (en) | 1989-01-25 |
| DK278388D0 (da) | 1988-05-20 |
| HU199790B (en) | 1990-03-28 |
| KR880013891A (ko) | 1988-12-22 |
| DK278388A (da) | 1988-11-22 |
| PT87538A (pt) | 1989-05-31 |
| JP2520285B2 (ja) | 1996-07-31 |
| FI90531C (fi) | 1994-02-25 |
| CA1310973C (en) | 1992-12-01 |
| NO882240D0 (no) | 1988-05-20 |
| AU605865B2 (en) | 1991-01-24 |
| NZ224661A (en) | 1990-08-28 |
| HUT50117A (en) | 1989-12-28 |
| KR960016521B1 (ko) | 1996-12-14 |
| IL86387A0 (en) | 1988-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |