AR246952A1 - Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion. - Google Patents

Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion.

Info

Publication number
AR246952A1
AR246952A1 AR88310862A AR31086288A AR246952A1 AR 246952 A1 AR246952 A1 AR 246952A1 AR 88310862 A AR88310862 A AR 88310862A AR 31086288 A AR31086288 A AR 31086288A AR 246952 A1 AR246952 A1 AR 246952A1
Authority
AR
Argentina
Prior art keywords
beta
metoximetio
formula
treatment
substituted
Prior art date
Application number
AR88310862A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of AR246952A1 publication Critical patent/AR246952A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PREPARACION DE BETA-FLUORMETILEN-5-HIDROXITRIPTOFANO Y SUS DERIVADOS, UTILES COMO INHIBIDORES DE LA MONOAMINA OXIDASA Y EN EL TRATAMIENTO DE LA DEPRESION, DE FORMULA (I), DONDE R1 ES HIDROGENO OALQUILO Y R2 ES HIDROGENO O HCO-, QUE COMPRENDE LAS ETAPAS DE: A) HACER REACCIONAR UN 5-HIDROXI-3- BROMOFLUORACETILINDOL, BLOQUEADO DE FORMULA (II), DONDE B1 ES UN GRUPO PROTECTOR DE HIDROXI AROMATICO COMO ALQUILO, TETRAHIDROPIRANILO, METOXIMETILO, METOXIETOXIMETILO, T-BUTILO, BENCILO O TRIFENILMETILO Y B2 ES UN GRUPO PROTECTOR DE AMINA HETEROCICLICA COMO P-TOLUENSULFONILO, BENCENSULFONILO, BENCILOXICARBONILO SUSTITUIDO O NO, T-BUBILOXICARBONILO, T AMILOXICARBONILO, ISOPROPILOXICARBONILO, 2- (P.BIFENIL)ISOPROPILOXICARBONILO, ALILOXICARBONILO, CICLOPENTILOXICARBONILO, CICLOHEXILOXICARBONILO, ADAMANTILOXICARBONILO, CON UN ESTER APROPIADO DE UN ACIDO ISOCIANOACETICO; B) SOMETER EL DERIVADO DE OXAZOLIDINA OBTENIDO A UNA ELIMINACION REDUCTIVA CON ZN LUEGO DEL TRATAMIENTO CON ACIDO TRIFLUOROACETICO OBTENIENDOSE UN COMPUESTO DE FORMULA (III), DONDE Y ES ALQUILO, C) ELIMINACION DE LOS GRUPOS PROTECTORES Y CONVERSION DEL ESTER EN EL ACIDO CARBOXILICO; D)CONVERSION DE LOSCOMPUESTOS OBTENIDOS EN C)CON BETA- (FLUOROMETILEN)-5-HIDROXITRIPTOFANO POR TRATAMIENTO CON ACIDO PROTICO Y LUEGO OXIDO DE PROPILENO, SIENDO LUEGO DICHO BETA-FLUOROMETILEN-5- HIDROXITRIPTOFANO HECHO REACCIONAR PARA OBTENER ESTERES DERIVADOS ALFA-N- SUSTITUIDOS Y 5-OH-SUSTITUIDOS.
AR88310862A 1987-05-21 1988-05-16 Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion. AR246952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,212 US4822812A (en) 1987-05-21 1987-05-21 β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition

Publications (1)

Publication Number Publication Date
AR246952A1 true AR246952A1 (es) 1994-10-31

Family

ID=21982670

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310862A AR246952A1 (es) 1987-05-21 1988-05-16 Procedimiento para preparar beta-fluormetilen-5-hidroxitriptofano y sus derivados, utiles como inhibidores de la monoamino oxidasa y en el tratamiento de la depresion.

Country Status (17)

Country Link
US (1) US4822812A (es)
EP (1) EP0291998A3 (es)
JP (1) JP2520285B2 (es)
KR (1) KR960016521B1 (es)
CN (1) CN1031222A (es)
AR (1) AR246952A1 (es)
AU (1) AU605865B2 (es)
CA (1) CA1310973C (es)
DK (1) DK169330B1 (es)
FI (1) FI90531C (es)
HU (2) HU199790B (es)
IL (1) IL86387A0 (es)
NO (1) NO172576C (es)
NZ (1) NZ224661A (es)
PH (1) PH25384A (es)
PT (1) PT87538B (es)
ZA (1) ZA883442B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US6972014B2 (en) * 2003-01-04 2005-12-06 Endocare, Inc. Open system heat exchange catheters and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2513597B2 (de) * 1975-03-27 1977-06-02 L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel
US4183858A (en) * 1977-07-01 1980-01-15 Merrell Toraude Et Compagnie α-Vinyl tryptophanes
FR2499076A1 (fr) * 1981-02-02 1982-08-06 Panmedica Laboratoires Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
US4454158A (en) * 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
ZA855101B (en) * 1984-07-13 1986-05-28 Merrell Dow Pharma Fluoroallylaine derivatives

Also Published As

Publication number Publication date
KR880013891A (ko) 1988-12-22
AU605865B2 (en) 1991-01-24
IL86387A0 (en) 1988-11-15
EP0291998A2 (en) 1988-11-23
AU1634788A (en) 1988-11-24
NZ224661A (en) 1990-08-28
NO882240L (no) 1988-11-22
HUT50117A (en) 1989-12-28
FI90531C (fi) 1994-02-25
JP2520285B2 (ja) 1996-07-31
NO882240D0 (no) 1988-05-20
NO172576B (no) 1993-05-03
PH25384A (en) 1991-06-03
US4822812A (en) 1989-04-18
EP0291998A3 (en) 1989-01-25
FI882360A (fi) 1988-11-22
DK278388D0 (da) 1988-05-20
IL86387A (es) 1992-12-01
KR960016521B1 (ko) 1996-12-14
PT87538B (pt) 1992-09-30
NO172576C (no) 1993-08-11
JPS63303965A (ja) 1988-12-12
FI882360A0 (fi) 1988-05-19
HUT47905A (en) 1989-04-28
CA1310973C (en) 1992-12-01
DK169330B1 (da) 1994-10-10
FI90531B (fi) 1993-11-15
HU199790B (en) 1990-03-28
ZA883442B (en) 1988-11-16
PT87538A (pt) 1989-05-31
CN1031222A (zh) 1989-02-22
DK278388A (da) 1988-11-22

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