ZA883442B - Beta-(fluoromethylene)-5-hydroxytryptophan and derivatives - Google Patents

Beta-(fluoromethylene)-5-hydroxytryptophan and derivatives

Info

Publication number
ZA883442B
ZA883442B ZA883442A ZA883442A ZA883442B ZA 883442 B ZA883442 B ZA 883442B ZA 883442 A ZA883442 A ZA 883442A ZA 883442 A ZA883442 A ZA 883442A ZA 883442 B ZA883442 B ZA 883442B
Authority
ZA
South Africa
Prior art keywords
fluoromethylene
hydroxytryptophan
beta
derivatives
Prior art date
Application number
ZA883442A
Other languages
English (en)
Inventor
A. Mcdonald Ian
G. Palfreyman Michael
Collard Jean-Noel
Original Assignee
Merrell Dow Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc. filed Critical Merrell Dow Pharmaceuticals Inc.
Publication of ZA883442B publication Critical patent/ZA883442B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA883442A 1987-05-21 1988-05-16 Beta-(fluoromethylene)-5-hydroxytryptophan and derivatives ZA883442B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,212 US4822812A (en) 1987-05-21 1987-05-21 β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition

Publications (1)

Publication Number Publication Date
ZA883442B true ZA883442B (en) 1988-11-16

Family

ID=21982670

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883442A ZA883442B (en) 1987-05-21 1988-05-16 Beta-(fluoromethylene)-5-hydroxytryptophan and derivatives

Country Status (17)

Country Link
US (1) US4822812A (xx)
EP (1) EP0291998A3 (xx)
JP (1) JP2520285B2 (xx)
KR (1) KR960016521B1 (xx)
CN (1) CN1031222A (xx)
AR (1) AR246952A1 (xx)
AU (1) AU605865B2 (xx)
CA (1) CA1310973C (xx)
DK (1) DK169330B1 (xx)
FI (1) FI90531C (xx)
HU (2) HU199790B (xx)
IL (1) IL86387A0 (xx)
NO (1) NO172576C (xx)
NZ (1) NZ224661A (xx)
PH (1) PH25384A (xx)
PT (1) PT87538B (xx)
ZA (1) ZA883442B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US6972014B2 (en) * 2003-01-04 2005-12-06 Endocare, Inc. Open system heat exchange catheters and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2513597B2 (de) * 1975-03-27 1977-06-02 L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel
US4183858A (en) * 1977-07-01 1980-01-15 Merrell Toraude Et Compagnie α-Vinyl tryptophanes
FR2499076A1 (fr) * 1981-02-02 1982-08-06 Panmedica Laboratoires Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
US4454158A (en) * 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
ZA855101B (en) * 1984-07-13 1986-05-28 Merrell Dow Pharma Fluoroallylaine derivatives

Also Published As

Publication number Publication date
KR880013891A (ko) 1988-12-22
AU605865B2 (en) 1991-01-24
IL86387A0 (en) 1988-11-15
EP0291998A2 (en) 1988-11-23
AU1634788A (en) 1988-11-24
NZ224661A (en) 1990-08-28
NO882240L (no) 1988-11-22
HUT50117A (en) 1989-12-28
FI90531C (fi) 1994-02-25
JP2520285B2 (ja) 1996-07-31
AR246952A1 (es) 1994-10-31
NO882240D0 (no) 1988-05-20
NO172576B (no) 1993-05-03
PH25384A (en) 1991-06-03
US4822812A (en) 1989-04-18
EP0291998A3 (en) 1989-01-25
FI882360A (fi) 1988-11-22
DK278388D0 (da) 1988-05-20
IL86387A (xx) 1992-12-01
KR960016521B1 (ko) 1996-12-14
PT87538B (pt) 1992-09-30
NO172576C (no) 1993-08-11
JPS63303965A (ja) 1988-12-12
FI882360A0 (fi) 1988-05-19
HUT47905A (en) 1989-04-28
CA1310973C (en) 1992-12-01
DK169330B1 (da) 1994-10-10
FI90531B (fi) 1993-11-15
HU199790B (en) 1990-03-28
PT87538A (pt) 1989-05-31
CN1031222A (zh) 1989-02-22
DK278388A (da) 1988-11-22

Similar Documents

Publication Publication Date Title
GB2210132B (en) Floodwashing process and floodwasher
EP0166451A3 (en) Para-phenylene sulfide block copolymers; process for the production of the same and use thereof
JPS6470497A (en) Dimethylsilyl substituted benzoylloride and its production
GB8419218D0 (en) Pivot bracket
ZA883442B (en) Beta-(fluoromethylene)-5-hydroxytryptophan and derivatives
EP0366795A4 (en) Multi-sensor and production thereof
ZA874505B (en) Substituted quinoxalinediones and quinolinediones
GB8903780D0 (en) Electrical heating arrangements
GB8814340D0 (en) Process
GB2215018B (en) Heaters
GB8803561D0 (en) Suppository
YU185187A (en) Flat heating object
GB8410258D0 (en) Arm supports and slings
GB2222310B (en) Electrical resistor adjustment process
JPS6425789A (en) Substituted amidephophonate and amidephosphate
GB8431607D0 (en) Warming/drying article
IL82372A0 (en) 2-vinylpenams and process
EP0329760A4 (en) Suppressive t lymphocyte cell lines and supernatant derivative thereof
GB8729679D0 (en) Heaters
GB8716511D0 (en) Heating installation
GB8403597D0 (en) Warming article
AU94358S (en) Arm sling
HU905915D0 (en) Oxiditing and desalkyling process
GB8615425D0 (en) Conductive article
GB8803747D0 (en) Electrical heating arrangements