NO882240L - Fremgangsmaate for fremstilling av beta-(fluoralkylen)-5-hydroxy tryptofan og derivater som prolegemidler for mao-inhibering. - Google Patents

Fremgangsmaate for fremstilling av beta-(fluoralkylen)-5-hydroxy tryptofan og derivater som prolegemidler for mao-inhibering.

Info

Publication number
NO882240L
NO882240L NO882240A NO882240A NO882240L NO 882240 L NO882240 L NO 882240L NO 882240 A NO882240 A NO 882240A NO 882240 A NO882240 A NO 882240A NO 882240 L NO882240 L NO 882240L
Authority
NO
Norway
Prior art keywords
trytophane
fluoral
mao
practices
inhibition
Prior art date
Application number
NO882240A
Other languages
English (en)
Other versions
NO882240D0 (no
NO172576B (no
NO172576C (no
Inventor
Ian A Mcdonald
Michael G Palfreyman
Jean-Noel Collard
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO882240D0 publication Critical patent/NO882240D0/no
Publication of NO882240L publication Critical patent/NO882240L/no
Publication of NO172576B publication Critical patent/NO172576B/no
Publication of NO172576C publication Critical patent/NO172576C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO882240A 1987-05-21 1988-05-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive beta-(fluoralkylen)-5-hydroxytryptofan-derivater NO172576C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,212 US4822812A (en) 1987-05-21 1987-05-21 β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition

Publications (4)

Publication Number Publication Date
NO882240D0 NO882240D0 (no) 1988-05-20
NO882240L true NO882240L (no) 1988-11-22
NO172576B NO172576B (no) 1993-05-03
NO172576C NO172576C (no) 1993-08-11

Family

ID=21982670

Family Applications (1)

Application Number Title Priority Date Filing Date
NO882240A NO172576C (no) 1987-05-21 1988-05-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive beta-(fluoralkylen)-5-hydroxytryptofan-derivater

Country Status (17)

Country Link
US (1) US4822812A (no)
EP (1) EP0291998A3 (no)
JP (1) JP2520285B2 (no)
KR (1) KR960016521B1 (no)
CN (1) CN1031222A (no)
AR (1) AR246952A1 (no)
AU (1) AU605865B2 (no)
CA (1) CA1310973C (no)
DK (1) DK169330B1 (no)
FI (1) FI90531C (no)
HU (2) HU199790B (no)
IL (1) IL86387A0 (no)
NO (1) NO172576C (no)
NZ (1) NZ224661A (no)
PH (1) PH25384A (no)
PT (1) PT87538B (no)
ZA (1) ZA883442B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US6972014B2 (en) * 2003-01-04 2005-12-06 Endocare, Inc. Open system heat exchange catheters and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2513597B2 (de) * 1975-03-27 1977-06-02 L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel
US4183858A (en) * 1977-07-01 1980-01-15 Merrell Toraude Et Compagnie α-Vinyl tryptophanes
FR2499076A1 (fr) * 1981-02-02 1982-08-06 Panmedica Laboratoires Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant
US4454158A (en) * 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
ZA855101B (en) * 1984-07-13 1986-05-28 Merrell Dow Pharma Fluoroallylaine derivatives

Also Published As

Publication number Publication date
NO882240D0 (no) 1988-05-20
NO172576B (no) 1993-05-03
ZA883442B (en) 1988-11-16
KR960016521B1 (ko) 1996-12-14
AU605865B2 (en) 1991-01-24
FI882360A0 (fi) 1988-05-19
HUT47905A (en) 1989-04-28
JP2520285B2 (ja) 1996-07-31
IL86387A (no) 1992-12-01
NO172576C (no) 1993-08-11
NZ224661A (en) 1990-08-28
AU1634788A (en) 1988-11-24
US4822812A (en) 1989-04-18
PT87538B (pt) 1992-09-30
IL86387A0 (en) 1988-11-15
JPS63303965A (ja) 1988-12-12
CN1031222A (zh) 1989-02-22
AR246952A1 (es) 1994-10-31
DK278388D0 (da) 1988-05-20
HU199790B (en) 1990-03-28
FI882360A (fi) 1988-11-22
CA1310973C (en) 1992-12-01
DK278388A (da) 1988-11-22
FI90531B (fi) 1993-11-15
PT87538A (pt) 1989-05-31
EP0291998A2 (en) 1988-11-23
PH25384A (en) 1991-06-03
HUT50117A (en) 1989-12-28
DK169330B1 (da) 1994-10-10
KR880013891A (ko) 1988-12-22
EP0291998A3 (en) 1989-01-25
FI90531C (fi) 1994-02-25

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN NOVEMBER 2000