HUT50117A - Process for producing beta-/fluoro-methylene/-5-hydroxy-triptamine - Google Patents

Process for producing beta-/fluoro-methylene/-5-hydroxy-triptamine

Info

Publication number
HUT50117A
HUT50117A HU89172A HU17288A HUT50117A HU T50117 A HUT50117 A HU T50117A HU 89172 A HU89172 A HU 89172A HU 17288 A HU17288 A HU 17288A HU T50117 A HUT50117 A HU T50117A
Authority
HU
Hungary
Prior art keywords
triptamine
fluoro
methylene
hydroxy
producing beta
Prior art date
Application number
HU89172A
Other languages
English (en)
Inventor
Ian A Mcdonald
Michael G Palfreyman
Jean-Noel Collara
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of HUT50117A publication Critical patent/HUT50117A/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU89172A 1987-05-21 1988-05-20 Process for producing beta-/fluoro-methylene/-5-hydroxy-triptamine HUT50117A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,212 US4822812A (en) 1987-05-21 1987-05-21 β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition

Publications (1)

Publication Number Publication Date
HUT50117A true HUT50117A (en) 1989-12-28

Family

ID=21982670

Family Applications (2)

Application Number Title Priority Date Filing Date
HU882617A HU199790B (en) 1987-05-21 1988-05-20 Process for producing beta-/fluoromethylene/-5-hydroxy-tryptophan derivatives and pharmaceutical compositions comprising same
HU89172A HUT50117A (en) 1987-05-21 1988-05-20 Process for producing beta-/fluoro-methylene/-5-hydroxy-triptamine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU882617A HU199790B (en) 1987-05-21 1988-05-20 Process for producing beta-/fluoromethylene/-5-hydroxy-tryptophan derivatives and pharmaceutical compositions comprising same

Country Status (17)

Country Link
US (1) US4822812A (hu)
EP (1) EP0291998A3 (hu)
JP (1) JP2520285B2 (hu)
KR (1) KR960016521B1 (hu)
CN (1) CN1031222A (hu)
AR (1) AR246952A1 (hu)
AU (1) AU605865B2 (hu)
CA (1) CA1310973C (hu)
DK (1) DK169330B1 (hu)
FI (1) FI90531C (hu)
HU (2) HU199790B (hu)
IL (1) IL86387A0 (hu)
NO (1) NO172576C (hu)
NZ (1) NZ224661A (hu)
PH (1) PH25384A (hu)
PT (1) PT87538B (hu)
ZA (1) ZA883442B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US6972014B2 (en) * 2003-01-04 2005-12-06 Endocare, Inc. Open system heat exchange catheters and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2513597B2 (de) * 1975-03-27 1977-06-02 L-5-hydroxytryptophan-l-glutamatmonohydrat, verfahren zu seiner herstellung und arzneimittel
US4183858A (en) * 1977-07-01 1980-01-15 Merrell Toraude Et Compagnie α-Vinyl tryptophanes
FR2499076A1 (fr) * 1981-02-02 1982-08-06 Panmedica Laboratoires Nouveaux derives de l'acide ((indol-3 yl)-3 amino-2 propionyloxy)-2 acetique, procedes pour leur preparation et medicaments les contenant
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
US4454158A (en) * 1981-06-01 1984-06-12 Merrell Toraude Et Compagnie Allyl amine MAO inhibitors
ZA855101B (en) * 1984-07-13 1986-05-28 Merrell Dow Pharma Fluoroallylaine derivatives

Also Published As

Publication number Publication date
KR880013891A (ko) 1988-12-22
AU605865B2 (en) 1991-01-24
IL86387A0 (en) 1988-11-15
EP0291998A2 (en) 1988-11-23
AU1634788A (en) 1988-11-24
NZ224661A (en) 1990-08-28
NO882240L (no) 1988-11-22
FI90531C (fi) 1994-02-25
JP2520285B2 (ja) 1996-07-31
AR246952A1 (es) 1994-10-31
NO882240D0 (no) 1988-05-20
NO172576B (no) 1993-05-03
PH25384A (en) 1991-06-03
US4822812A (en) 1989-04-18
EP0291998A3 (en) 1989-01-25
FI882360A (fi) 1988-11-22
DK278388D0 (da) 1988-05-20
IL86387A (hu) 1992-12-01
KR960016521B1 (ko) 1996-12-14
PT87538B (pt) 1992-09-30
NO172576C (no) 1993-08-11
JPS63303965A (ja) 1988-12-12
FI882360A0 (fi) 1988-05-19
HUT47905A (en) 1989-04-28
CA1310973C (en) 1992-12-01
DK169330B1 (da) 1994-10-10
FI90531B (fi) 1993-11-15
HU199790B (en) 1990-03-28
ZA883442B (en) 1988-11-16
PT87538A (pt) 1989-05-31
CN1031222A (zh) 1989-02-22
DK278388A (da) 1988-11-22

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Legal Events

Date Code Title Description
DFC9 Refusal of application