CN103097523B - 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 - Google Patents

与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 Download PDF

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CN103097523B
CN103097523B CN201180030490.4A CN201180030490A CN103097523B CN 103097523 B CN103097523 B CN 103097523B CN 201180030490 A CN201180030490 A CN 201180030490A CN 103097523 B CN103097523 B CN 103097523B
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aars
cell
polypeptide
sequence
polynucleotide
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CN103097523A (zh
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莱斯利·安·格林尼
凯尔·P·基昂格
洪非
阿兰·P·瓦瑟洛特
罗咏诗
杰弗里·D·沃特金斯
约翰·D·门德莱恩
谢丽尔·L·奎恩
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Pangu Biopharma Ltd
aTyr Pharma Inc
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aTyr Pharma Inc
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CN201180030490.4A 2010-04-29 2011-04-28 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 Active CN103097523B (zh)

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US32947710P 2010-04-29 2010-04-29
US32946510P 2010-04-29 2010-04-29
US61/329,465 2010-04-29
US61/329,477 2010-04-29
PCT/US2011/034388 WO2011139854A2 (fr) 2010-04-29 2011-04-28 Découverte innovante de compositions thérapeutiques, diagnostiques et à based'anticorps associées à des fragments protéiques d'asparaginyl-arnt-synthétases

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CN103097523A CN103097523A (zh) 2013-05-08
CN103097523B true CN103097523B (zh) 2016-09-28

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US (4) US8986680B2 (fr)
EP (1) EP2563912B1 (fr)
JP (1) JP6008838B2 (fr)
CN (1) CN103097523B (fr)
AU (1) AU2011248490B2 (fr)
CA (1) CA2797374C (fr)
WO (1) WO2011139854A2 (fr)

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CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6008837B2 (ja) 2010-04-28 2016-10-19 エータイアー ファーマ， インコーポレイテッド アラニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103118693B (zh) 2010-04-29 2017-05-03 Atyr 医药公司 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103097523B (zh) 2010-04-29 2016-09-28 Atyr医药公司 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
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CN103096909A (zh) 2010-05-04 2013-05-08 Atyr医药公司 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ， インコーポレイテッド フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011146410A2 (fr) 2010-05-17 2011-11-24 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic, et d'anticorps associées à des fragments protéiques de leucyl-arnt synthétases
AU2011258106B2 (en) 2010-05-27 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
EP2575857B1 (fr) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques, et d'anticorps associés à des fragments de protéine de lysyl-tarn synthétases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103118695B (zh) 2010-07-12 2016-08-03 Atyr医药公司 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
EA030418B1 (ru) 2010-07-12 2018-08-31 ЭйТИР ФАРМА, ИНК. ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS)
WO2012009289A2 (fr) 2010-07-12 2012-01-19 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et d'anticorps relatives à des fragments protéiques d'aspartyl-arnt synthétases
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
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KR101771068B1 (ko) * 2015-07-14 2017-08-24 재단법인 의약바이오컨버젼스연구단 케모카인 활성을 가지는 신규한 폴리펩타이드
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CN111343970A (zh) 2017-09-13 2020-06-26 北卡罗莱纳州立大学 微针贴片局部诱导脂肪组织褐变治疗肥胖症
JP7487220B2 (ja) * 2019-03-05 2024-05-20 ダウ グローバル テクノロジーズ エルエルシー カスパーゼ活性を誘導するためのポリエチレングリコール誘導体

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