DE60127958D1 - Mikroarrays für durchführen von proteomanalyse - Google Patents

Mikroarrays für durchführen von proteomanalyse

Info

Publication number
DE60127958D1
DE60127958D1 DE60127958T DE60127958T DE60127958D1 DE 60127958 D1 DE60127958 D1 DE 60127958D1 DE 60127958 T DE60127958 T DE 60127958T DE 60127958 T DE60127958 T DE 60127958T DE 60127958 D1 DE60127958 D1 DE 60127958D1
Authority
DE
Germany
Prior art keywords
array
protein
peptidomimetic
analysis
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60127958T
Other languages
English (en)
Inventor
Deborah Charych
Eric Beausoleil
Ronald N Zuckermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Application granted granted Critical
Publication of DE60127958D1 publication Critical patent/DE60127958D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545Synthetic resin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
DE60127958T 2000-06-05 2001-06-04 Mikroarrays für durchführen von proteomanalyse Expired - Lifetime DE60127958D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20971100P 2000-06-05 2000-06-05
PCT/US2001/018066 WO2001094946A2 (en) 2000-06-05 2001-06-04 Microarrays for performing proteomic analyses

Publications (1)

Publication Number Publication Date
DE60127958D1 true DE60127958D1 (de) 2007-05-31

Family

ID=22779937

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60127958T Expired - Lifetime DE60127958D1 (de) 2000-06-05 2001-06-04 Mikroarrays für durchführen von proteomanalyse

Country Status (10)

Country Link
US (1) US20020055125A1 (de)
EP (1) EP1297338B1 (de)
JP (1) JP2003536073A (de)
AT (1) ATE360207T1 (de)
AU (1) AU2001268173A1 (de)
DE (1) DE60127958D1 (de)
DK (1) DK1297338T3 (de)
ES (1) ES2281424T3 (de)
PT (1) PT1297338E (de)
WO (1) WO2001094946A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
WO2002012893A2 (en) * 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
WO2003056337A1 (en) * 2001-12-21 2003-07-10 Biacore Ab Immobilization of binding agents
WO2003054543A2 (en) * 2001-12-21 2003-07-03 Sense Proteomic Limited Probe for mass spectrometry
GB2386372A (en) * 2002-03-13 2003-09-17 Amersham Biosciences Uk Ltd The use of organic solvents in the preparation of arrays
GB0205910D0 (en) * 2002-03-13 2002-04-24 Sense Proteomic Ltd Arrays and methods
WO2003078625A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
CN1671859A (zh) * 2002-07-11 2005-09-21 美国红十字会 从复杂混合物中鉴定出单一活性实体的方法
DE10233303A1 (de) * 2002-07-22 2004-02-12 Micronas Holding Gmbh Sensoroberfläche mit verbessertem Signal/Rausch-Verhältnis
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
CA2539890A1 (en) * 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
EP1406089A1 (de) * 2002-10-02 2004-04-07 Taiwan Unison Biotechnology Co. Ltd. Eine Methode zur selektiven Färbung wasserlöslicher Proteine unter Verwendung von Reaktivfarbstoffen
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US20060216775A1 (en) * 2003-06-17 2006-09-28 The Regents Of The University Of Califoenia Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
KR100518953B1 (ko) * 2003-09-19 2005-10-12 주식회사 제노포커스 포자 외막단백질을 이용한 목적단백질의 표면발현 방법
US7019288B2 (en) * 2003-09-30 2006-03-28 Sequenom, Inc. Methods of making substrates for mass spectrometry analysis and related devices
WO2005040163A1 (en) 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
JP4736439B2 (ja) * 2005-01-25 2011-07-27 東レ株式会社 核酸固定化担体
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
WO2006138647A2 (en) * 2005-06-16 2006-12-28 Gtc Biotherapeutics, Inc. Method of making recombinant human antibodies for use in biosensor technology
WO2007037706A2 (en) * 2005-09-27 2007-04-05 Bernd Helmut Adam Rehm Polymer particles and uses thereof
ES2897529T3 (es) 2005-12-01 2022-03-01 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
WO2008136058A1 (ja) * 2007-04-25 2008-11-13 Shimadzu Corporation レーザ脱離イオン化用サンプルプレート及び該サンプルプレートを用いた質量分析装置
EP3255146B1 (de) 2009-03-16 2019-05-15 Pangu Biopharma Limited Zusammensetzungen und verfahren mit histidyl-trna-synthetase-spleissvarianten mit nicht-kanonischen biologischen aktivitäten
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
KR20120034683A (ko) * 2009-05-29 2012-04-12 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 자가면역 t-세포의 분리 및 처리를 위한 펩토이드 리간드
BRPI1013012A2 (pt) * 2009-06-02 2016-10-18 Opko Health Inc identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas
TW201124726A (en) * 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ, インコーポレイテッド システイニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
CA2800557A1 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
EP2566515B1 (de) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
AU2011248230B2 (en) 2010-05-03 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ, インコーポレイテッド p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ, インコーポレイテッド フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9034598B2 (en) 2010-05-17 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ, インコーポレイテッド グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
CN103118695B (zh) 2010-07-12 2016-08-03 Atyr医药公司 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
CA2836836A1 (en) 2011-06-01 2012-12-06 Medical Prognosis Institute A/S Methods and devices for prognosis of cancer relapse
RU2659423C2 (ru) 2012-02-16 2018-07-02 ЭйТИР ФАРМА, ИНК. ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ
CA2868928A1 (en) * 2012-04-10 2013-10-17 The Trustees Of Princeton University Ultra-sensitive sensor
WO2014145036A1 (en) * 2013-03-15 2014-09-18 The Trustees Of Princeton University Rapid and sensitive analyte measurement assay
NZ709167A (en) 2012-11-27 2020-03-27 Univ Pontificia Catolica Chile Compositions and methods for diagnosing thyroid tumors
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
US9897602B2 (en) 2013-07-30 2018-02-20 The Chinese University Of Hong Kong Microarray substrate, microarray, microfluidic system and methods for preparing the same
US9799501B2 (en) 2013-08-07 2017-10-24 Citizen Finedevice Co., Ltd. Sample mounting plate
NZ717526A (en) * 2013-09-24 2020-03-27 Entopsis Llc Detectable arrays, systems for diagnosis, and methods of making and using the same
WO2016008048A1 (en) 2014-07-15 2016-01-21 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
CN108347916B (zh) 2015-10-14 2022-02-08 先时迈纳米生物科技股份有限公司 一种减少冰晶形成的组合物及其方法
IL299387A (en) * 2017-07-07 2023-02-01 Aviana Molecular Tech Llc Bioactive coating for an acoustic surface wave sensor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864085A (en) * 1973-10-31 1975-02-04 Princenton Biomedix Inc Glutathione reagent and test method
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5965695A (en) * 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
IL98150A0 (en) * 1990-05-17 1992-08-18 Adeza Biomedical Corp Highly reflective biogratings and method for theirhighly reflective biogratings and method production
DE4039677A1 (de) * 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5599695A (en) * 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
DE19741716A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
JP2002507617A (ja) * 1998-03-23 2002-03-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 化合物および化合物のライブラリの合成
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
AU5879400A (en) * 1999-06-29 2001-01-31 Chiron Corporation Arrays of biopolymeric agents and method for their production and use
US7148058B2 (en) * 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses

Also Published As

Publication number Publication date
EP1297338A2 (de) 2003-04-02
PT1297338E (pt) 2007-05-31
AU2001268173A1 (en) 2001-12-17
WO2001094946A2 (en) 2001-12-13
ATE360207T1 (de) 2007-05-15
DK1297338T3 (da) 2007-06-11
EP1297338B1 (de) 2007-04-18
ES2281424T3 (es) 2007-10-01
WO2001094946A9 (en) 2002-04-11
WO2001094946A3 (en) 2003-01-30
US20020055125A1 (en) 2002-05-09
JP2003536073A (ja) 2003-12-02

Similar Documents

Publication Publication Date Title
DE60127958D1 (de) Mikroarrays für durchführen von proteomanalyse
WO2004005319A3 (en) Microarrays on mirrored substrates for performing proteomic analyses
WO2004005477A3 (en) Protein microarrays on mirrored surfaces for performing proteomic analyses
Paulick et al. Cleavable hydrophilic linker for one-bead-one-compound sequencing of oligomer libraries by tandem mass spectrometry
Righetti et al. The proteome buccaneers: how to unearth your treasure chest via combinatorial peptide ligand libraries
Hugli Techniques in protein chemistry
DE69830497D1 (de) Bibliothek für die in vitro expression von peptiden oder proteinen
HUP0202532A2 (hu) Ko-stimulátor szignál-transzdukciós molekula (AILIM) elleni humán monoklonális antitest és gyógyászati alkalmazása
NO963371L (no) Hematopoietisk protein samt materialer og fremgangsmåter for fremstilling av det
ATE495252T1 (de) Neuartige phagenanzeigetechnologien
DE60335000D1 (de) In vitro peptid-expressionsbank
NO20014584D0 (no) Proteinisolering og -analyse
US20160054331A1 (en) Method for the detection and/or enrichment of analyte proteins and/or analyte peptides from a complex protein mixture
JPH1025299A (ja) 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法
ATE311443T1 (de) Methoden zur durchforstung (screenen) von proteinen
JP2009531679A5 (ja) 複合タンパク質混合物中の被分析タンパク質および/または被分析ペプチドを検出および/または濃縮するための方法
HUP0203537A2 (hu) Célmolekula transzgénikus állatban történő előállítására és tisztítására szolgáló eljárások
Wang et al. Proteomic studies of stem cells
DE69534920D1 (de) Src SH3 BINDENDE PEPTIDE UND VERFAHREN ZU IHRER ISOLIERUNG UND VERWENDUNG
ATE452994T1 (de) In situ protein mikroarray zusammenbau
NO20013563D0 (no) Fremgangsmåter og prövesett for sekvensering av polypeptider
ATE288589T1 (de) Verfahren zur analyse von proteinen
ATE306666T1 (de) Verfahren zur eiweissanalyse
Byeon et al. Affinity adsorbent based on combinatorial phage display peptides that bind α-cobratoxin
Gwynne et al. Advances in: proteomics

Legal Events

Date Code Title Description
8332 No legal effect for de