DE60127958D1 - Mikroarrays für durchführen von proteomanalyse - Google Patents
Mikroarrays für durchführen von proteomanalyseInfo
- Publication number
- DE60127958D1 DE60127958D1 DE60127958T DE60127958T DE60127958D1 DE 60127958 D1 DE60127958 D1 DE 60127958D1 DE 60127958 T DE60127958 T DE 60127958T DE 60127958 T DE60127958 T DE 60127958T DE 60127958 D1 DE60127958 D1 DE 60127958D1
- Authority
- DE
- Germany
- Prior art keywords
- array
- protein
- peptidomimetic
- analysis
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004458 analytical method Methods 0.000 title abstract 2
- 238000002493 microarray Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000816 peptidomimetic Substances 0.000 abstract 3
- 239000007787 solid Substances 0.000 abstract 2
- 238000003491 array Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 238000012916 structural analysis Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20971100P | 2000-06-05 | 2000-06-05 | |
PCT/US2001/018066 WO2001094946A2 (en) | 2000-06-05 | 2001-06-04 | Microarrays for performing proteomic analyses |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60127958D1 true DE60127958D1 (de) | 2007-05-31 |
Family
ID=22779937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60127958T Expired - Lifetime DE60127958D1 (de) | 2000-06-05 | 2001-06-04 | Mikroarrays für durchführen von proteomanalyse |
Country Status (10)
Country | Link |
---|---|
US (1) | US20020055125A1 (de) |
EP (1) | EP1297338B1 (de) |
JP (1) | JP2003536073A (de) |
AT (1) | ATE360207T1 (de) |
AU (1) | AU2001268173A1 (de) |
DE (1) | DE60127958D1 (de) |
DK (1) | DK1297338T3 (de) |
ES (1) | ES2281424T3 (de) |
PT (1) | PT1297338E (de) |
WO (1) | WO2001094946A2 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7153682B2 (en) * | 2000-06-05 | 2006-12-26 | Chiron Corporation | Microarrays on mirrored substrates for performing proteomic analyses |
US7148058B2 (en) | 2000-06-05 | 2006-12-12 | Chiron Corporation | Protein microarrays on mirrored surfaces for performing proteomic analyses |
WO2002012893A2 (en) * | 2000-08-03 | 2002-02-14 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
US20020102617A1 (en) * | 2000-08-03 | 2002-08-01 | Macbeath Gavin | Protein microarrays |
EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
WO2003056337A1 (en) * | 2001-12-21 | 2003-07-10 | Biacore Ab | Immobilization of binding agents |
WO2003054543A2 (en) * | 2001-12-21 | 2003-07-03 | Sense Proteomic Limited | Probe for mass spectrometry |
GB2386372A (en) * | 2002-03-13 | 2003-09-17 | Amersham Biosciences Uk Ltd | The use of organic solvents in the preparation of arrays |
GB0205910D0 (en) * | 2002-03-13 | 2002-04-24 | Sense Proteomic Ltd | Arrays and methods |
WO2003078625A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | An improved method for synthesising templated molecules |
US6791690B2 (en) * | 2002-04-30 | 2004-09-14 | Agilent Technologies, Inc. | Reading dry chemical arrays |
CN1671859A (zh) * | 2002-07-11 | 2005-09-21 | 美国红十字会 | 从复杂混合物中鉴定出单一活性实体的方法 |
DE10233303A1 (de) * | 2002-07-22 | 2004-02-12 | Micronas Holding Gmbh | Sensoroberfläche mit verbessertem Signal/Rausch-Verhältnis |
AU2003247266A1 (en) * | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
CA2539890A1 (en) * | 2002-09-27 | 2004-04-08 | Carlsberg A/S | Spatially encoded polymer matrix |
EP1406089A1 (de) * | 2002-10-02 | 2004-04-07 | Taiwan Unison Biotechnology Co. Ltd. | Eine Methode zur selektiven Färbung wasserlöslicher Proteine unter Verwendung von Reaktivfarbstoffen |
CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
DE60330406D1 (de) | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
US20060216775A1 (en) * | 2003-06-17 | 2006-09-28 | The Regents Of The University Of Califoenia | Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes |
DE602004023960D1 (de) | 2003-09-18 | 2009-12-17 | Nuevolution As | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
KR100518953B1 (ko) * | 2003-09-19 | 2005-10-12 | 주식회사 제노포커스 | 포자 외막단백질을 이용한 목적단백질의 표면발현 방법 |
US7019288B2 (en) * | 2003-09-30 | 2006-03-28 | Sequenom, Inc. | Methods of making substrates for mass spectrometry analysis and related devices |
WO2005040163A1 (en) | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd | Heterocyclic compounds that block the effects of advanced glycation end products (age) |
US20090239211A1 (en) * | 2004-02-17 | 2009-09-24 | Nuevolution A/S | Method For Enrichment Involving Elimination By Mismatch Hybridisation |
JP4736439B2 (ja) * | 2005-01-25 | 2011-07-27 | 東レ株式会社 | 核酸固定化担体 |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
WO2006138647A2 (en) * | 2005-06-16 | 2006-12-28 | Gtc Biotherapeutics, Inc. | Method of making recombinant human antibodies for use in biosensor technology |
WO2007037706A2 (en) * | 2005-09-27 | 2007-04-05 | Bernd Helmut Adam Rehm | Polymer particles and uses thereof |
ES2897529T3 (es) | 2005-12-01 | 2022-03-01 | Nuevolution As | Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes |
WO2008136058A1 (ja) * | 2007-04-25 | 2008-11-13 | Shimadzu Corporation | レーザ脱離イオン化用サンプルプレート及び該サンプルプレートを用いた質量分析装置 |
EP3255146B1 (de) | 2009-03-16 | 2019-05-15 | Pangu Biopharma Limited | Zusammensetzungen und verfahren mit histidyl-trna-synthetase-spleissvarianten mit nicht-kanonischen biologischen aktivitäten |
US20100310576A1 (en) | 2009-03-31 | 2010-12-09 | Adams Ryan A | COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES |
KR20120034683A (ko) * | 2009-05-29 | 2012-04-12 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 자가면역 t-세포의 분리 및 처리를 위한 펩토이드 리간드 |
BRPI1013012A2 (pt) * | 2009-06-02 | 2016-10-18 | Opko Health Inc | identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas |
TW201124726A (en) * | 2009-10-16 | 2011-07-16 | Univ Texas | Compositions and methods for producing coded peptoid libraries |
JP6066900B2 (ja) | 2010-04-26 | 2017-01-25 | エータイアー ファーマ, インコーポレイテッド | システイニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
CA2800557A1 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
EP2566515B1 (de) | 2010-05-03 | 2017-08-02 | aTyr Pharma, Inc. | Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen |
ES2623805T3 (es) | 2010-05-03 | 2017-07-12 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas |
AU2011248230B2 (en) | 2010-05-03 | 2016-10-06 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases |
JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ, インコーポレイテッド | フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
JP6046607B2 (ja) | 2010-05-27 | 2016-12-21 | エータイアー ファーマ, インコーポレイテッド | グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
US9029506B2 (en) | 2010-08-25 | 2015-05-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases |
CA2836836A1 (en) | 2011-06-01 | 2012-12-06 | Medical Prognosis Institute A/S | Methods and devices for prognosis of cancer relapse |
RU2659423C2 (ru) | 2012-02-16 | 2018-07-02 | ЭйТИР ФАРМА, ИНК. | ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ |
CA2868928A1 (en) * | 2012-04-10 | 2013-10-17 | The Trustees Of Princeton University | Ultra-sensitive sensor |
WO2014145036A1 (en) * | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Rapid and sensitive analyte measurement assay |
NZ709167A (en) | 2012-11-27 | 2020-03-27 | Univ Pontificia Catolica Chile | Compositions and methods for diagnosing thyroid tumors |
WO2014195032A1 (en) | 2013-06-07 | 2014-12-11 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients |
US9897602B2 (en) | 2013-07-30 | 2018-02-20 | The Chinese University Of Hong Kong | Microarray substrate, microarray, microfluidic system and methods for preparing the same |
US9799501B2 (en) | 2013-08-07 | 2017-10-24 | Citizen Finedevice Co., Ltd. | Sample mounting plate |
NZ717526A (en) * | 2013-09-24 | 2020-03-27 | Entopsis Llc | Detectable arrays, systems for diagnosis, and methods of making and using the same |
WO2016008048A1 (en) | 2014-07-15 | 2016-01-21 | Ontario Institute For Cancer Research | Methods and devices for predicting anthracycline treatment efficacy |
CN108347916B (zh) | 2015-10-14 | 2022-02-08 | 先时迈纳米生物科技股份有限公司 | 一种减少冰晶形成的组合物及其方法 |
IL299387A (en) * | 2017-07-07 | 2023-02-01 | Aviana Molecular Tech Llc | Bioactive coating for an acoustic surface wave sensor |
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US3864085A (en) * | 1973-10-31 | 1975-02-04 | Princenton Biomedix Inc | Glutathione reagent and test method |
US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
US5965695A (en) * | 1990-05-15 | 1999-10-12 | Chiron Corporation | Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such |
IL98150A0 (en) * | 1990-05-17 | 1992-08-18 | Adeza Biomedical Corp | Highly reflective biogratings and method for theirhighly reflective biogratings and method production |
DE4039677A1 (de) * | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | Universalbindefilm |
US5599695A (en) * | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US6306584B1 (en) * | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
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DE19741716A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung |
US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
JP2002507617A (ja) * | 1998-03-23 | 2002-03-12 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 化合物および化合物のライブラリの合成 |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
AU5879400A (en) * | 1999-06-29 | 2001-01-31 | Chiron Corporation | Arrays of biopolymeric agents and method for their production and use |
US7148058B2 (en) * | 2000-06-05 | 2006-12-12 | Chiron Corporation | Protein microarrays on mirrored surfaces for performing proteomic analyses |
US7153682B2 (en) * | 2000-06-05 | 2006-12-26 | Chiron Corporation | Microarrays on mirrored substrates for performing proteomic analyses |
-
2001
- 2001-06-04 PT PT01946078T patent/PT1297338E/pt unknown
- 2001-06-04 AT AT01946078T patent/ATE360207T1/de not_active IP Right Cessation
- 2001-06-04 JP JP2002502444A patent/JP2003536073A/ja not_active Withdrawn
- 2001-06-04 WO PCT/US2001/018066 patent/WO2001094946A2/en active IP Right Grant
- 2001-06-04 AU AU2001268173A patent/AU2001268173A1/en not_active Abandoned
- 2001-06-04 DE DE60127958T patent/DE60127958D1/de not_active Expired - Lifetime
- 2001-06-04 ES ES01946078T patent/ES2281424T3/es not_active Expired - Lifetime
- 2001-06-04 DK DK01946078T patent/DK1297338T3/da active
- 2001-06-04 US US09/874,091 patent/US20020055125A1/en not_active Abandoned
- 2001-06-04 EP EP01946078A patent/EP1297338B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1297338A2 (de) | 2003-04-02 |
PT1297338E (pt) | 2007-05-31 |
AU2001268173A1 (en) | 2001-12-17 |
WO2001094946A2 (en) | 2001-12-13 |
ATE360207T1 (de) | 2007-05-15 |
DK1297338T3 (da) | 2007-06-11 |
EP1297338B1 (de) | 2007-04-18 |
ES2281424T3 (es) | 2007-10-01 |
WO2001094946A9 (en) | 2002-04-11 |
WO2001094946A3 (en) | 2003-01-30 |
US20020055125A1 (en) | 2002-05-09 |
JP2003536073A (ja) | 2003-12-02 |
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