CA2408315A1 - Aminoacyl-arnt synthetases - Google Patents
Aminoacyl-arnt synthetases Download PDFInfo
- Publication number
- CA2408315A1 CA2408315A1 CA002408315A CA2408315A CA2408315A1 CA 2408315 A1 CA2408315 A1 CA 2408315A1 CA 002408315 A CA002408315 A CA 002408315A CA 2408315 A CA2408315 A CA 2408315A CA 2408315 A1 CA2408315 A1 CA 2408315A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- polynucleotide
- atrs
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des aminoacyl-ARNt synthétases humaines (ATRS), ainsi que des polynucléotides permettant d'identifier ces ATRS et codant pour ces dernières. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes, et des antagonistes. L'invention concerne enfin des méthodes de diagnostic, de traitement ou de prévention de troubles associés à une expression aberrante d'ATRS.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20724800P | 2000-05-25 | 2000-05-25 | |
US60/207,248 | 2000-05-25 | ||
US20879100P | 2000-06-01 | 2000-06-01 | |
US60/208,791 | 2000-06-01 | ||
US21058500P | 2000-06-08 | 2000-06-08 | |
US60/210,585 | 2000-06-08 | ||
PCT/US2001/016808 WO2001090330A2 (fr) | 2000-05-25 | 2001-05-22 | Aminoacyl-arnt synthetases |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2408315A1 true CA2408315A1 (fr) | 2001-11-29 |
Family
ID=27395048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002408315A Abandoned CA2408315A1 (fr) | 2000-05-25 | 2001-05-22 | Aminoacyl-arnt synthetases |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1290148A2 (fr) |
JP (1) | JP2004510407A (fr) |
AU (1) | AU2001263404A1 (fr) |
CA (1) | CA2408315A1 (fr) |
WO (1) | WO2001090330A2 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2431493A1 (fr) * | 2000-12-15 | 2002-08-01 | Incyte Genomics, Inc. | Aminoacyl arnt synthetases |
AU2009257538A1 (en) | 2008-06-11 | 2009-12-17 | Atyr Pharma, Inc. | Thrombopoietic activity of tyrosyl-tRNA synthetase polypeptides |
EP3176261A1 (fr) | 2008-06-26 | 2017-06-07 | aTyr Pharma, Inc. | Compositions et procédés comprenant des glycyl-arnt synthétases ayant des activités biologiques non canoniques |
WO2010099477A2 (fr) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Motifs structuraux de polypeptides associés à une activité de signalisation cellulaire |
EP3255146B1 (fr) | 2009-03-16 | 2019-05-15 | Pangu Biopharma Limited | Compositions et procedes comprenant des variants d'epissage d'histidyl-arnt synthetase presentant des activites biologiques non canoniques |
ES2560674T3 (es) | 2009-03-31 | 2016-02-22 | Atyr Pharma, Inc. | Composiciones y procedimientos que comprenden aspartil-ARNt sintetasas con actividades biológicas no canónicas |
US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
CA2783731C (fr) | 2009-12-11 | 2018-03-27 | Atyr Pharma, Inc. | Aminoacyl-arnt synthetases destinees a moduler une inflammation |
WO2011072266A2 (fr) * | 2009-12-11 | 2011-06-16 | Atyr Pharma, Inc. | Aminoacyl-arnt synthétases destinées à moduler l'hématopoïèse |
AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
CN108165537A (zh) | 2010-04-27 | 2018-06-15 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CA2797362C (fr) | 2010-04-27 | 2020-12-08 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques d'isoleucyl arnt synthetases |
CA2797271C (fr) | 2010-04-28 | 2021-05-25 | Atyr Pharma, Inc. | Compositions therapeutiques, diagnostiques et d'anticorps a base de fragments de proteines d'aminoacyl-arnt synthetases |
AU2011248490B2 (en) | 2010-04-29 | 2016-11-10 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
US9034321B2 (en) | 2010-05-03 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
EP2566516B1 (fr) | 2010-05-03 | 2019-07-03 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à des fragments protéiques de séryle-arnt synthétases |
CA2797277C (fr) | 2010-05-03 | 2021-02-23 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps liees a des fragments proteiques d'arginyle-arnt synthetases |
EP2566496B1 (fr) | 2010-05-03 | 2018-02-28 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées des fragments protéiques de méthionyl-arnt-synthétases |
CA2798301C (fr) | 2010-05-04 | 2020-09-15 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, diagnostiques et a base d'anticorps liees a des fragments proteiques de glutamyl-prolyl-arnt-synthetases |
AU2011248101B2 (en) | 2010-05-04 | 2016-10-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
CA2799197C (fr) | 2010-05-14 | 2019-10-29 | Atyr Pharma, Inc. | Decouverte de compositions inedites de nature therapeutique, diagnostique et a base d'anticorps contenant des fragments proteiques de phenylalanyl-beta-arnt synthetases |
AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
JP6046607B2 (ja) | 2010-05-27 | 2016-12-21 | エータイアー ファーマ, インコーポレイテッド | グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
WO2011153277A2 (fr) | 2010-06-01 | 2011-12-08 | Atyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, diagnostiques, et d'anticorps associés à des fragments de protéine de lysyl-tarn synthétases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
AU2011289833C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Histidyl-tRNA synthetases |
US8969301B2 (en) | 2010-07-12 | 2015-03-03 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-tRNA synthetases |
AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
EP2608801B1 (fr) | 2010-08-25 | 2019-08-21 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, diagnostiques et d'anticorps associées à des fragments protéiniques des tyrosyl-arnt synthétases |
JP6039566B2 (ja) | 2010-10-06 | 2016-12-07 | エータイアー ファーマ, インコーポレイテッド | 治療用、診断用および抗体組成物に関連したトリプトファニルtRNA合成酵素のタンパク質フラグメントの革新的発見 |
WO2013022982A2 (fr) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Polypeptides tyrosyl-arnt synthétase pégylés |
US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
WO2013115926A2 (fr) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Conjugués aspartyl-arnt synthétase-fc |
NZ628126A (en) | 2012-02-16 | 2016-10-28 | Atyr Pharma Inc | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
DK3460054T3 (da) | 2013-03-15 | 2021-01-18 | Atyr Pharma Inc | Histidyl-tRNA-syntetase-Fc-konjugater |
CA3060514A1 (fr) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions et procedes pour le traitement d'inflammation pulmonaire |
CN109266734A (zh) * | 2018-09-25 | 2019-01-25 | 深圳市人民医院 | 自身免疫性疾病诊断试剂盒和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5759833A (en) * | 1994-05-27 | 1998-06-02 | Cubist Pharmaceuticals, Inc. | Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same |
-
2001
- 2001-05-22 AU AU2001263404A patent/AU2001263404A1/en not_active Abandoned
- 2001-05-22 JP JP2001587126A patent/JP2004510407A/ja active Pending
- 2001-05-22 CA CA002408315A patent/CA2408315A1/fr not_active Abandoned
- 2001-05-22 WO PCT/US2001/016808 patent/WO2001090330A2/fr not_active Application Discontinuation
- 2001-05-22 EP EP01937694A patent/EP1290148A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2001263404A1 (en) | 2001-12-03 |
EP1290148A2 (fr) | 2003-03-12 |
WO2001090330A2 (fr) | 2001-11-29 |
WO2001090330A3 (fr) | 2002-08-08 |
JP2004510407A (ja) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |