CN103025859A - 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用 - Google Patents

用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用 Download PDF

Info

Publication number
CN103025859A
CN103025859A CN2011800365325A CN201180036532A CN103025859A CN 103025859 A CN103025859 A CN 103025859A CN 2011800365325 A CN2011800365325 A CN 2011800365325A CN 201180036532 A CN201180036532 A CN 201180036532A CN 103025859 A CN103025859 A CN 103025859A
Authority
CN
China
Prior art keywords
particles
particle
sample
binding
freedom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800365325A
Other languages
English (en)
Chinese (zh)
Inventor
克里斯托弗·克努特松
奥斯曼·阿克基尔
傅浩军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arryx Inc
Original Assignee
Arryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arryx Inc filed Critical Arryx Inc
Publication of CN103025859A publication Critical patent/CN103025859A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • G03H1/0866—Digital holographic imaging, i.e. synthesizing holobjects from holograms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0216—Investigating a scatter or diffraction pattern from fluctuations of diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G01N21/453—Holographic interferometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/22—Processes or apparatus for obtaining an optical image from holograms
    • G03H1/2202—Reconstruction geometries or arrangements
    • G03H1/2205—Reconstruction geometries or arrangements using downstream optical component
    • G03H2001/221—Element having optical power, e.g. field lens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Computing Systems (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
CN2011800365325A 2010-05-25 2011-05-25 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用 Pending CN103025859A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34794610P 2010-05-25 2010-05-25
US34807210P 2010-05-25 2010-05-25
US61/347,946 2010-05-25
US61/348,072 2010-05-25
PCT/US2011/000930 WO2011149526A2 (en) 2010-05-25 2011-05-25 Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics

Publications (1)

Publication Number Publication Date
CN103025859A true CN103025859A (zh) 2013-04-03

Family

ID=45004244

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011800365325A Pending CN103025859A (zh) 2010-05-25 2011-05-25 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用
CN2011800365147A Pending CN103025886A (zh) 2010-05-25 2011-05-25 用于确定颗粒和/或细胞分散体的迁移率的全息波动显微装置和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800365147A Pending CN103025886A (zh) 2010-05-25 2011-05-25 用于确定颗粒和/或细胞分散体的迁移率的全息波动显微装置和方法

Country Status (5)

Country Link
US (2) US9176152B2 (https=)
EP (2) EP2576759A4 (https=)
JP (2) JP2013533469A (https=)
CN (2) CN103025859A (https=)
WO (2) WO2011149525A1 (https=)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104765165A (zh) * 2015-04-20 2015-07-08 三峡大学 一种微球快速光悬浮的方法及装置
CN105531578A (zh) * 2013-06-28 2016-04-27 丹麦技术大学 基于磁性粒子的集群动态的测量的生物传感器
CN107110764A (zh) * 2014-12-30 2017-08-29 原子能和替代能源委员会 利用位置控制对透明样本进行分析的系统及相关联的方法
CN107544232A (zh) * 2016-06-27 2018-01-05 诺基亚技术有限公司 全息成像装置及方法和全息显微系统及方法
CN108474725A (zh) * 2016-01-29 2018-08-31 希森美康株式会社 生物体试样拍摄装置及生物体试样拍摄方法
CN108489872A (zh) * 2018-03-23 2018-09-04 奥星制药设备（石家庄）有限公司 在线粒度监测方法和系统
CN108717119A (zh) * 2018-04-20 2018-10-30 南京红十字血液中心 酶联免疫检测的基于时间序列的随机质控加样方法
CN108931846A (zh) * 2018-07-08 2018-12-04 苏州美丽澄电子技术有限公司 一种光镊粒子植入到高精密陶瓷的方法及装置
CN109240064A (zh) * 2018-08-06 2019-01-18 浙江工业大学 基于am335x处理器的便携式数字全息显微系统
CN110100002A (zh) * 2016-10-31 2019-08-06 梅科诺有限公司 用于自动化生物细胞注射的改进感测
CN110140050A (zh) * 2016-11-02 2019-08-16 卢米克斯科技有限公司 用于研究生物细胞的方法和系统
CN111474106A (zh) * 2019-01-23 2020-07-31 香港科技大学 用于测定生物细胞或生物细胞样颗粒的机械性质的方法和系统
CN111474142A (zh) * 2020-05-21 2020-07-31 中南大学 一种利用近红外1550nm激光器检测微塑料浓度的方法
CN112014581A (zh) * 2017-07-14 2020-12-01 迈恩医疗解决方案有限公司 用于执行化学、生化和/或免疫化学分析的自动分析器和方法
CN112203756A (zh) * 2018-06-07 2021-01-08 威尔科股份公司 用于监控自动检查系统的用于引起部分填充有液体的容器的运动的驱动机构的方法和设备
CN112673255A (zh) * 2018-01-25 2021-04-16 Essenlix公司 并行测定样品中细胞和非细胞分析物
CN112867916A (zh) * 2018-08-17 2021-05-28 恩里奇疗法公司 选择和隔离颗粒和细胞的系统和方法及其用途
CN113939730A (zh) * 2019-05-13 2022-01-14 荷语布鲁塞尔自由大学 用于颗粒表征的方法和系统
CN114556258A (zh) * 2019-04-24 2022-05-27 班努生物科技公司 用于分选和富集感兴趣的靶细胞的定位辅助的阴性颗粒排斥（panr）
CN115753461A (zh) * 2022-12-02 2023-03-07 芜湖普菲斯特电液技术有限公司 一种易于拆卸的液压阀测试工装
CN116338169A (zh) * 2022-12-26 2023-06-27 北京科技大学 以微球反射镜作为探针的显微分析方法
TWI818596B (zh) * 2022-06-22 2023-10-11 嘉碩生醫電子股份有限公司 具有槽結構的剪切模式液相感測器、其製造方法及其使用方法

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO998997A0 (en) * 1997-10-24 1997-11-20 University Of Sydney, The Brillouin/erbium fibre laser current monitor using elliptically polarizing fibre
EP2387708B1 (en) 2009-01-16 2019-05-01 New York University Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy
CN103025859A (zh) * 2010-05-25 2013-04-03 阿尔利克斯公司 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用
US20140347672A1 (en) * 2011-07-29 2014-11-27 Ecole Polytechnique Federale De Lausanne (Epfl) Apparatus and method for quantitive phase tomography through linear scanning with coherent and non-coherent detection
US20130310270A1 (en) * 2012-05-21 2013-11-21 Vib Holographic Imaging for Analyzing Molecules
JP6120518B2 (ja) * 2012-10-10 2017-04-26 公益財団法人かずさＤｎａ研究所 簡易測定器具
WO2014179269A2 (en) * 2013-04-30 2014-11-06 Molecular Devices, Llc Apparatus and method for generating in-focus images using parallel imaging in a microscopy system
NL2010960C2 (en) * 2013-06-12 2014-12-15 Stichting Vu Vumc Molecular manipulation system and method.
US20140371047A1 (en) * 2013-06-18 2014-12-18 L.U.M. Gmbh Centrifuge rotor
ITRM20130128U1 (it) 2013-07-23 2015-01-24 Particle Measuring Systems S R L Dispositivo per il campionamento microbico dell'aria
EP3076182A4 (en) 2013-11-29 2017-08-09 Nikon Corporation Washing/drying device, screening device, washing/drying method, and screening method
JP6191426B2 (ja) * 2013-12-05 2017-09-06 株式会社島津製作所 粒度分布測定装置及びこれに用いられる表示処理装置並びに粒度分布測定方法
DE102014205535A1 (de) * 2014-03-25 2015-10-01 Siemens Aktiengesellschaft Vorrichtung und in-vitro Verfahren zur markierungsfreien Darstellung und Analyse von Zellen und Kristallen in einer biologischen Probe
FR3020682B1 (fr) * 2014-04-30 2016-05-27 Commissariat Energie Atomique Procede et systeme de detection d'au moins une particule dans un liquide corporel, et procede associe de diagnostic de la meningite
WO2016077472A1 (en) 2014-11-12 2016-05-19 New York University Colloidal fingerprints for soft materials using total holographic characterization
FR3030749B1 (fr) * 2014-12-19 2020-01-03 Commissariat A L'energie Atomique Et Aux Energies Alternatives Methode d'identification de particules biologiques par piles d'images holographiques defocalisees
CN104567682B (zh) * 2015-01-14 2017-08-08 天津大学 液态环境下微粒三维位置纳米级分辨力测量方法
WO2016125251A1 (ja) * 2015-02-03 2016-08-11 株式会社日立製作所 単一細胞解析用フローセルデバイス及び単一細胞解析装置
KR101765070B1 (ko) * 2015-02-25 2017-08-04 연세대학교 원주산학협력단 세포의 움직임 분석을 통한 세포 구별 방법 및 기구
FR3034196B1 (fr) * 2015-03-24 2019-05-31 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede d'analyse de particules
WO2017117462A1 (en) * 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Detection and signal processing system for particle assays
WO2017139279A2 (en) 2016-02-08 2017-08-17 New York University Holographic characterization of protein aggregates
JP2017146696A (ja) * 2016-02-16 2017-08-24 ソニー株式会社 画像処理装置、画像処理方法及び画像処理システム
FR3049347B1 (fr) * 2016-03-23 2018-04-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede d’observation d’un echantillon par calcul d’une image complexe
KR102026521B1 (ko) * 2016-05-26 2019-09-30 서울대학교산학협력단 비대칭 입자를 이용한 표적 물질 검출 키트 및 방법
EP3252455A1 (fr) * 2016-05-30 2017-12-06 Biomérieux Dispositif et procede d'acquisition d'une particule presente dans un echantillon
CN105890671B (zh) * 2016-06-15 2018-04-24 浙江大学 用于高温环镜颗粒场三维测量的探针
EP3260841B1 (en) * 2016-06-22 2024-03-13 Uponor Oyj Detecting microscopic objects in fluids
US12120407B2 (en) * 2017-02-08 2024-10-15 Essenlix Corporation Image-based assay using mark-assisted machine learning
ES2986358T3 (es) * 2017-02-10 2024-11-11 Amgen Inc Sistema de obtención de imágenes para contar y dimensionar partículas en recipientes llenos de fluido
DE102017104801B4 (de) 2017-03-08 2020-02-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Partikelanalyse
CN107144520B (zh) * 2017-06-06 2020-05-05 深圳小孚医疗科技有限公司 用于显微成像粒子分析的粒子成像室和聚焦系统
CN110998294A (zh) * 2017-08-10 2020-04-10 Jvc建伍株式会社 分析方法和分析装置
TWI667530B (zh) * 2017-09-28 2019-08-01 日商紐富來科技股份有限公司 Inspection method and inspection device
FR3073047B1 (fr) * 2017-11-02 2021-01-29 Commissariat Energie Atomique Procede optique d'estimation d'un volume representatif de particules presentes dans un echantillon
SE542103C2 (en) * 2017-11-09 2020-02-25 Hemocue Ab A microcuvette holder, an analysis apparatus comprising the holder and method for analysing a blood sample using the analysis apparatus
US11199506B2 (en) * 2018-02-21 2021-12-14 Applied Materials Israel Ltd. Generating a training set usable for examination of a semiconductor specimen
WO2019169871A1 (zh) * 2018-03-07 2019-09-12 广州博冠光电科技股份有限公司 基于光纤数字同轴全息显微的细胞活性检测装置及方法
JP6687656B2 (ja) 2018-03-19 2020-04-28 ファナック株式会社 検査装置およびその検査方法
EP3575773A1 (en) * 2018-05-28 2019-12-04 Universität für Bodenkultur Wien A method for determining a three-dimensional particle distribution in a medium
KR102309284B1 (ko) * 2018-08-03 2021-10-06 주식회사 엘지에너지솔루션 고분자 솔루션의 미용해물 측정법
JP7203532B2 (ja) 2018-08-10 2023-01-13 シスメックス株式会社 被検物質の検出方法
EP3837543A4 (en) * 2018-08-16 2022-11-16 Essenlix Corporation CELL ANALYSIS IN BODY FLUID, ESPECIALLY BLOOD
KR102118266B1 (ko) * 2018-10-25 2020-06-03 한국기초과학지원연구원 Tem 시료 지지 장치
WO2020097268A1 (en) * 2018-11-07 2020-05-14 Massachusetts Institute Of Technology Substrate-immobilized optical nanosensors
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
KR102880992B1 (ko) 2018-11-16 2025-11-03 파티클 머슈어링 시스템즈, 인크. 로봇 제어된 제조 장벽 시스템을 위한 입자 샘플링 시스템 및 방법
KR102779340B1 (ko) * 2018-11-16 2025-03-07 파티클 머슈어링 시스템즈, 인크. 슬러리 모니터 커플링 벌크 크기 분포 및 단일 입자 검출
DE102018220779A1 (de) * 2018-12-03 2020-06-04 Carl Zeiss Microscopy Gmbh Nachweisverfahren von induzierten Lichtsignalen in einer dreidimensionalen Region einer Probe
KR20220012292A (ko) * 2019-05-23 2022-02-03 브리스톨-마이어스 스큅 컴퍼니 세포 배양 배지를 모니터링하는 방법
CN110487207B (zh) * 2019-08-20 2021-05-25 大连海事大学 基于三维轮廓链码与亮斑周长比值的微塑料检测装置及方法
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
CN111999225A (zh) * 2019-12-19 2020-11-27 瑞芯智造(深圳)科技有限公司 一种微纳颗粒浓度的检测方法
US11060138B1 (en) 2020-01-17 2021-07-13 Element Biosciences, Inc. Nucleic acid sequencing systems
TWI829492B (zh) 2020-01-21 2024-01-11 美商粒子監測系統有限公司 撞擊器及用於對來自一流體流之生物顆粒取樣之方法
KR102325759B1 (ko) * 2020-02-21 2021-11-12 부산대학교 산학협력단 적혈구의 침강속도를 향상시키는 적혈구 침강 장치 및 방법
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay
JP7421968B2 (ja) * 2020-03-17 2024-01-25 リオン株式会社 粒子測定装置及び粒子測定方法
US12553814B2 (en) 2020-08-21 2026-02-17 Technische Universiteit Eindhoven Biosensor using particle motion
FR3114650A1 (fr) * 2020-09-25 2022-04-01 Biomerieux Procédé d'analyse d'un échantillon biologique avec analyse de conformité initiale
CN112712877B (zh) * 2020-12-07 2024-02-09 西安电子科技大学 大视场高通量高分辨病理切片分析仪
EP4321936A4 (en) * 2021-04-09 2024-09-18 FUJIFILM Corporation HOLOGRAPHY DEVICE AND CELL ASSESSMENT METHODS
WO2022224722A1 (ja) * 2021-04-21 2022-10-27 富士フイルム株式会社 評価値の取得方法
DE102021204041B3 (de) * 2021-04-22 2022-03-24 Siemens Healthcare Gmbh Ultraschallbasierte Charakterisierung von Partikeln in einer fluidgefüllten Hohlstruktur
KR102522160B1 (ko) * 2021-06-22 2023-04-14 포항공과대학교 산학협력단 광학적 관측을 통한 입자의 분석 방법 및 분석 시스템
AU2022316142A1 (en) 2021-07-21 2024-02-22 Element Biosciences, Inc. Optical systems for nucleic acid sequencing and methods thereof
US20230326047A1 (en) * 2022-04-08 2023-10-12 Honeywell International Inc. Methods, apparatuses, and computer program products for analyzing image data related to fluid samples
CN118068554A (zh) * 2022-11-22 2024-05-24 群创光电股份有限公司 取像系统及取像方法
EP4649301A2 (en) * 2023-01-13 2025-11-19 Ortho-Clinical Diagnostics, Inc. Image capturing and processing for immunoassays
CN118938628B (zh) * 2024-09-04 2025-10-10 上海大学 真实场景的实时全息采集与再现系统及方法
EP4725599A1 (en) * 2024-10-10 2026-04-15 Imec VZW A device and method for characterizing objects

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101573618A (zh) * 2006-09-15 2009-11-04 赫摩耐提克斯公司 通过光学操作与功能化表面有关的颗粒进行表面作图

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647544A (en) 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
JPS62145165A (ja) 1985-12-20 1987-06-29 Toshimitsu Musha 光の位相変調を利用した免疫反応の測定方法および装置
US5017009A (en) 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
US4900685A (en) 1987-01-29 1990-02-13 Cytosignet, Inc. Analyte detection in particulate-containing samples
US6610256B2 (en) 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
TW239881B (https=) 1992-12-22 1995-02-01 Sienna Biotech Inc
US5483055A (en) 1994-01-18 1996-01-09 Thompson; Timothy V. Method and apparatus for performing an automatic focus operation for a microscope
GB9326450D0 (en) 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
IL108335A (en) 1994-01-14 1999-04-11 Laser Ind Ltd Laser microscope adaptor apparatus with auto-focus
US5532814A (en) 1994-06-20 1996-07-02 Cha; Soyoung S. Holographic diffraction image velocimetry for three-dimensional three-component particle fields or solid objects
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5707799A (en) 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US6143247A (en) 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
JP3462006B2 (ja) 1996-05-20 2003-11-05 株式会社ミツトヨ オートフォーカス装置
AU5054198A (en) 1996-12-03 1998-06-29 Erkki Soini Biospecific, two photon excitation, fluorescence detection and device
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US6525821B1 (en) 1997-06-11 2003-02-25 Ut-Battelle, L.L.C. Acquisition and replay systems for direct-to-digital holography and holovision
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6251615B1 (en) 1998-02-20 2001-06-26 Cell Analytics, Inc. Cell analysis methods
US20020028471A1 (en) 1998-02-20 2002-03-07 Oberhardt Bruce J. Cell analysis methods and apparatus
US6740497B2 (en) * 1998-03-06 2004-05-25 The Regents Of The University Of California Method and apparatus for detecting cancerous cells using molecules that change electrophoretic mobility
US7095032B2 (en) 1998-03-20 2006-08-22 Montagu Jean I Focusing of microscopes and reading of microarrays
US6159749A (en) 1998-07-21 2000-12-12 Beckman Coulter, Inc. Highly sensitive bead-based multi-analyte assay system using optical tweezers
US6770488B1 (en) 1999-03-19 2004-08-03 The University Of Wyoming Practical method and apparatus for analyte detection with colloidal particles
US6086821A (en) 1999-03-29 2000-07-11 The United States Of America As Represented By The Secretary Of The Navy Ultrasonic force differentiation assay
GB9909308D0 (en) 1999-04-22 1999-06-16 Univ Cambridge Tech Measurement and use of molecular interactions
AU6075100A (en) 1999-07-07 2001-01-30 Ljl Biosystems, Inc. Light detection device
US6979574B1 (en) 1999-08-06 2005-12-27 Institut Fuer Diagnostik Forshung Gmbh Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
AU2001247302A1 (en) 2000-03-10 2001-09-24 Sensormatic Electronics Corporation Method and apparatus for object surveillance with a movable camera
JP4198990B2 (ja) 2000-10-18 2008-12-17 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 造血細胞のｅ−セレクチン／ｌ−セレクチンリガンドポリペプチドおよびその使用法
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
AU2002219971A1 (en) 2000-11-01 2002-05-15 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
US7033821B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
EP1348124B1 (en) 2000-12-22 2004-05-19 Cellomics, Inc. Identification of individual cells during kinetic assays
US6416190B1 (en) * 2001-04-27 2002-07-09 University Of Chicago Apparatus for using optical tweezers to manipulate materials
CA2724743C (fr) 2001-06-29 2014-11-25 Universite Libre De Bruxelles Procede et dispositif destines a l'obtention par microscopie d'images en trois dimensions d'un echantillon
DE10140699A1 (de) 2001-08-24 2003-03-13 Roche Diagnostics Gmbh Anordnung und Verfahren zur Untersuchung der Fließfähigkeit einer physiologischen Flüssigprobe
EP3252538B1 (en) 2001-12-04 2019-02-06 Ecole Polytechnique Federale De Lausanne (Epfl) Apparatus and method for digital holographic imaging
IL148664A0 (en) 2002-03-13 2002-09-12 Yeda Res & Dev Auto-focusing method and device
DK1486065T3 (en) 2002-03-15 2016-02-29 Nokia Technologies Oy PROCEDURE FOR CODING MOVEMENT IN A VIDEO SEQUENCE
US6961481B2 (en) 2002-07-05 2005-11-01 Lockheed Martin Corporation Method and apparatus for image processing using sub-pixel differencing
JP2004069397A (ja) 2002-08-02 2004-03-04 Nec Corp 分析チップおよび分析装置
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US6876474B2 (en) 2002-11-27 2005-04-05 Dalhousie University Method for tracking particles and life forms in three dimensions and in time
PL1631788T3 (pl) 2003-05-16 2007-08-31 Univ Bruxelles Cyfrowy mikroskop holograficzny do trójwymiarowego obrazowania i sposób jego stosowania
US7106502B1 (en) 2003-08-21 2006-09-12 The United States Of America As Represented By The Administrator Of National Aeronautics And Space Administration Operation of a Cartesian robotic system in a compact microscope imaging system with intelligent controls
DE10344924A1 (de) 2003-09-25 2005-05-04 Constantin Odefey Verfahren und Vorrichtung zum Nachweis sehr geringer Partikelmengen
WO2005066613A1 (en) 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US7542588B2 (en) 2004-04-30 2009-06-02 International Business Machines Corporation System and method for assuring high resolution imaging of distinctive characteristics of a moving object
US7518651B2 (en) 2004-05-28 2009-04-14 Aptina Imaging Corporation Multiple image autofocus
US7457472B2 (en) 2005-03-31 2008-11-25 Euclid Discoveries, Llc Apparatus and method for processing video data
US7436981B2 (en) 2005-01-28 2008-10-14 Euclid Discoveries, Llc Apparatus and method for processing video data
US7301133B2 (en) 2005-01-21 2007-11-27 Photon Dynamics, Inc. Tracking auto focus system
ITRM20050120A1 (it) 2005-03-16 2006-09-17 Consiglio Nazionale Ricerche Metodo olografico a ricostruzione numerica per ottenere un'immagine di un oggetto tridimensionale nella quale siano a fuoco anche punti situati al di fuori della profondita' di campo, e apparato olografico utilizzante tale metodo.
US7447334B1 (en) 2005-03-30 2008-11-04 Hrl Laboratories, Llc Motion recognition system
US7522749B2 (en) 2005-04-08 2009-04-21 Microsoft Corporation Simultaneous optical flow estimation and image segmentation
US7532214B2 (en) 2005-05-25 2009-05-12 Spectra Ab Automated medical image visualization using volume rendering with local histograms
EP1952091A1 (en) * 2005-10-17 2008-08-06 Arryx, Inc. Apparatus and method for detecting deformability of cells using spatially modulated optical force microscopy
US8149416B2 (en) * 2005-10-17 2012-04-03 Arryx, Inc. Apparatus and method for dynamic cellular probing and diagnostics using holographic optical forcing array
EP1963927B1 (en) * 2005-12-22 2020-01-15 Phase Holographic Imaging PHI AB Method and apparatus for analysis of a sample of cells
EP1863066A1 (en) 2006-05-29 2007-12-05 FEI Company Sample carrier and sample holder
WO2008034102A2 (en) * 2006-09-15 2008-03-20 Haemonetics Corporation Surface mapping by optical manipulation of particles in relation to a functionalized surface
US7498551B2 (en) 2006-10-06 2009-03-03 Los Alamos National Security, Llc Apparatus and method for tracking a molecule or particle in three dimensions
EP1953791A1 (en) 2007-02-05 2008-08-06 FEI Company Apparatus for observing a sample with a particle beam and an optical microscope
WO2009035623A1 (en) * 2007-09-11 2009-03-19 Arryx, Inc. Binding method and apparatus for sorting objects
WO2009059008A1 (en) 2007-10-30 2009-05-07 New York University Tracking and characterizing particles with holographic video microscopy
US8184298B2 (en) * 2008-05-21 2012-05-22 The Board Of Trustees Of The University Of Illinois Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
CN103025859A (zh) * 2010-05-25 2013-04-03 阿尔利克斯公司 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101573618A (zh) * 2006-09-15 2009-11-04 赫摩耐提克斯公司 通过光学操作与功能化表面有关的颗粒进行表面作图

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105531578A (zh) * 2013-06-28 2016-04-27 丹麦技术大学 基于磁性粒子的集群动态的测量的生物传感器
CN105531578B (zh) * 2013-06-28 2018-06-12 丹麦技术大学 生物传感器及其相关方法
CN107110764A (zh) * 2014-12-30 2017-08-29 原子能和替代能源委员会 利用位置控制对透明样本进行分析的系统及相关联的方法
CN107110764B (zh) * 2014-12-30 2020-06-09 原子能和替代能源委员会 利用位置控制对透明样本进行分析的系统及相关联的方法
CN104765165A (zh) * 2015-04-20 2015-07-08 三峡大学 一种微球快速光悬浮的方法及装置
CN108474725A (zh) * 2016-01-29 2018-08-31 希森美康株式会社 生物体试样拍摄装置及生物体试样拍摄方法
US11360017B2 (en) 2016-01-29 2022-06-14 Sysmex Corporation Biological sample imaging device and biological sample imaging method
CN107544232A (zh) * 2016-06-27 2018-01-05 诺基亚技术有限公司 全息成像装置及方法和全息显微系统及方法
CN110100002A (zh) * 2016-10-31 2019-08-06 梅科诺有限公司 用于自动化生物细胞注射的改进感测
CN110100002B (zh) * 2016-10-31 2023-08-18 梅科诺有限公司 用于自动化生物细胞注射的改进感测
US12403474B2 (en) 2016-11-02 2025-09-02 Lumicks Ca Holding B.V. Method and system for studying biological cells
US11207684B2 (en) 2016-11-02 2021-12-28 Lumicks Ca Holding B.V. Method and system for studying biological cells
CN110140050A (zh) * 2016-11-02 2019-08-16 卢米克斯科技有限公司 用于研究生物细胞的方法和系统
US12053778B2 (en) 2016-11-02 2024-08-06 Lumicks Ca Holding B.V. Method and system for studying biological cells
CN112014581A (zh) * 2017-07-14 2020-12-01 迈恩医疗解决方案有限公司 用于执行化学、生化和/或免疫化学分析的自动分析器和方法
CN112673255A (zh) * 2018-01-25 2021-04-16 Essenlix公司 并行测定样品中细胞和非细胞分析物
CN108489872A (zh) * 2018-03-23 2018-09-04 奥星制药设备（石家庄）有限公司 在线粒度监测方法和系统
CN108489872B (zh) * 2018-03-23 2022-03-04 奥星制药设备（石家庄）有限公司 在线粒度监测方法和系统
CN108717119A (zh) * 2018-04-20 2018-10-30 南京红十字血液中心 酶联免疫检测的基于时间序列的随机质控加样方法
CN112203756A (zh) * 2018-06-07 2021-01-08 威尔科股份公司 用于监控自动检查系统的用于引起部分填充有液体的容器的运动的驱动机构的方法和设备
CN108931846A (zh) * 2018-07-08 2018-12-04 苏州美丽澄电子技术有限公司 一种光镊粒子植入到高精密陶瓷的方法及装置
CN108931846B (zh) * 2018-07-08 2020-12-04 福州力佳达智能科技有限公司 一种光镊粒子植入到高精密陶瓷的方法及装置
CN109240064A (zh) * 2018-08-06 2019-01-18 浙江工业大学 基于am335x处理器的便携式数字全息显微系统
CN112867916A (zh) * 2018-08-17 2021-05-28 恩里奇疗法公司 选择和隔离颗粒和细胞的系统和方法及其用途
CN112867916B (zh) * 2018-08-17 2024-06-07 恩里奇生物系统有限公司 选择和隔离颗粒和细胞的系统和方法及其用途
CN111474106A (zh) * 2019-01-23 2020-07-31 香港科技大学 用于测定生物细胞或生物细胞样颗粒的机械性质的方法和系统
CN114556258A (zh) * 2019-04-24 2022-05-27 班努生物科技公司 用于分选和富集感兴趣的靶细胞的定位辅助的阴性颗粒排斥（panr）
CN113939730A (zh) * 2019-05-13 2022-01-14 荷语布鲁塞尔自由大学 用于颗粒表征的方法和系统
CN111474142A (zh) * 2020-05-21 2020-07-31 中南大学 一种利用近红外1550nm激光器检测微塑料浓度的方法
TWI818596B (zh) * 2022-06-22 2023-10-11 嘉碩生醫電子股份有限公司 具有槽結構的剪切模式液相感測器、其製造方法及其使用方法
CN115753461A (zh) * 2022-12-02 2023-03-07 芜湖普菲斯特电液技术有限公司 一种易于拆卸的液压阀测试工装
CN116338169A (zh) * 2022-12-26 2023-06-27 北京科技大学 以微球反射镜作为探针的显微分析方法
CN116338169B (zh) * 2022-12-26 2026-02-10 北京科技大学 以微球反射镜作为探针的显微分析方法

Also Published As

Publication number Publication date
WO2011149526A3 (en) 2012-03-15
CN103025886A (zh) 2013-04-03
US20130260396A1 (en) 2013-10-03
US20130274119A1 (en) 2013-10-17
EP2576759A4 (en) 2014-01-22
JP2013531787A (ja) 2013-08-08
EP2576805A1 (en) 2013-04-10
JP2013533469A (ja) 2013-08-22
EP2576759A2 (en) 2013-04-10
US9176152B2 (en) 2015-11-03
WO2011149525A1 (en) 2011-12-01
WO2011149526A2 (en) 2011-12-01

Similar Documents

Publication Publication Date Title
US9176152B2 (en) Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
JP5643825B2 (ja) 物質決定装置
JP6400630B2 (ja) 試料使用の極大化のためのシステム及び方法
JP2019168471A (ja) サンプルを代表する光を検出すること及び利用すること
US20080050830A1 (en) Detecting multiple types of leukocytes
US20120088230A1 (en) System And Method For Cell Analysis
US20110026009A1 (en) Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface
EP3394597B1 (en) Optical detection of a substance in fluid
CN105051538A (zh) 用于检测生物状况的系统和方法
JP2009509124A (ja) 大型のパラレルの免疫ベースのアレルギー試験および蛍光のエバネセント場励起のためのデバイス
CN101573618A (zh) 通过光学操作与功能化表面有关的颗粒进行表面作图
CA2651872A1 (en) Detecting multiple types of leukocytes
US20210356460A1 (en) Method for Analyzing Immunoglobulins and Other Analytes in an Immunoassay
JP2006292410A (ja) 分析装置およびそれに使用する分析デバイス
EP3030903B1 (en) Method for the analysis of immunoreactivity, and a device suitable for carrying out the method
KR20190087983A (ko) 항원의 정량 분석용 마이크로 칩 및 항원의 정량 분석용 디바이스, 및 이를 이용한 항원의 정량 분석 방법
HK1183686A (en) Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
Trueb Enabling and understanding nanoparticle surface binding assays with interferometric imaging
Brouwer Development of a single-molecule, real-time, label-free, mass-resolved immunoassay
HK1182743A (en) Holographic fluctuation microscopy apparatus and method for determining mobility of particle and/or cell dispersions
HK1135768A (en) Surface mapping by optical manipulation of particles in relation to a functionalized surface

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1183686

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130403

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1183686

Country of ref document: HK