CN102985424B - 5,7-取代的-咪唑并[1,2-c]嘧啶 - Google Patents

5,7-取代的-咪唑并[1,2-c]嘧啶 Download PDF

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Publication number
CN102985424B
CN102985424B CN201180029128.5A CN201180029128A CN102985424B CN 102985424 B CN102985424 B CN 102985424B CN 201180029128 A CN201180029128 A CN 201180029128A CN 102985424 B CN102985424 B CN 102985424B
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China
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pyrazol
imidazo
alkyl
pyrimidin
methyl
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Expired - Fee Related
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CN201180029128.5A
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English (en)
Chinese (zh)
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CN102985424A (zh
Inventor
M.L.博伊斯
L.E.伯吉斯
R.D.格朗伯格
D.M.哈维
L.黄
T.克尔彻
C.F.克拉塞
E.莱尔德
E.塔尔顿
赵千
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Array Biopharma Inc
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Array Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180029128.5A 2010-04-14 2011-04-11 5,7-取代的-咪唑并[1,2-c]嘧啶 Expired - Fee Related CN102985424B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32418610P 2010-04-14 2010-04-14
US61/324,186 2010-04-14
PCT/US2011/031896 WO2011130146A1 (en) 2010-04-14 2011-04-11 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases

Publications (2)

Publication Number Publication Date
CN102985424A CN102985424A (zh) 2013-03-20
CN102985424B true CN102985424B (zh) 2015-03-11

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CN201180029128.5A Expired - Fee Related CN102985424B (zh) 2010-04-14 2011-04-11 5,7-取代的-咪唑并[1,2-c]嘧啶

Country Status (21)

Country Link
US (1) US8962596B2 (https=)
EP (1) EP2558468B1 (https=)
JP (2) JP2013523884A (https=)
KR (1) KR20130094710A (https=)
CN (1) CN102985424B (https=)
AR (1) AR081075A1 (https=)
AU (1) AU2011240808B2 (https=)
CA (1) CA2796388A1 (https=)
CL (1) CL2012002882A1 (https=)
CO (1) CO6630187A2 (https=)
CR (1) CR20120572A (https=)
MX (1) MX2012011941A (https=)
NZ (1) NZ603446A (https=)
PH (1) PH12012502046A1 (https=)
RU (1) RU2012148246A (https=)
SG (1) SG184870A1 (https=)
TW (1) TWI494314B (https=)
UA (1) UA109131C2 (https=)
UY (1) UY33328A (https=)
WO (1) WO2011130146A1 (https=)
ZA (1) ZA201208544B (https=)

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WO2014146249A1 (en) 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors
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UA109131C2 (ru) 2015-07-27
EP2558468A1 (en) 2013-02-20
CN102985424A (zh) 2013-03-20
TW201134827A (en) 2011-10-16
CA2796388A1 (en) 2011-10-20
JP2013523884A (ja) 2013-06-17
US20130131039A1 (en) 2013-05-23
TWI494314B (zh) 2015-08-01
UY33328A (es) 2012-10-31
PH12012502046A1 (en) 2017-07-26
EP2558468B1 (en) 2015-04-01
ZA201208544B (en) 2015-04-29
SG184870A1 (en) 2012-11-29
CL2012002882A1 (es) 2013-02-08
AR081075A1 (es) 2012-06-06
US8962596B2 (en) 2015-02-24
KR20130094710A (ko) 2013-08-26
AU2011240808A1 (en) 2012-11-29
CR20120572A (es) 2013-02-20
NZ603446A (en) 2014-05-30
RU2012148246A (ru) 2014-05-20
WO2011130146A1 (en) 2011-10-20
JP2015205905A (ja) 2015-11-19
CO6630187A2 (es) 2013-03-01
MX2012011941A (es) 2013-08-27
AU2011240808B2 (en) 2015-01-22

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