CN102869650A - 一种厄洛替尼碱的新晶型及其制备方法 - Google Patents

一种厄洛替尼碱的新晶型及其制备方法 Download PDF

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Publication number
CN102869650A
CN102869650A CN2011800207779A CN201180020777A CN102869650A CN 102869650 A CN102869650 A CN 102869650A CN 2011800207779 A CN2011800207779 A CN 2011800207779A CN 201180020777 A CN201180020777 A CN 201180020777A CN 102869650 A CN102869650 A CN 102869650A
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crystal formation
tarceva
tarceva alkali
scholar
yue
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CN102869650B (zh
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向科
徐敏
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Zhejiang Huahai Pharmaceutical Co Ltd
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Zhejiang Huahai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明提供一种抗肿瘤药物厄洛替尼碱的新晶型Form IV及其制备方法。本发明还提供了一种制备高纯度的盐酸厄洛替尼的方法。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201180020777.9A 2010-08-14 2011-08-12 一种厄洛替尼碱的新晶型及其制备方法 Active CN102869650B (zh)

Priority Applications (1)

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CN201180020777.9A CN102869650B (zh) 2010-08-14 2011-08-12 一种厄洛替尼碱的新晶型及其制备方法

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CN 201010258627 CN101914068A (zh) 2010-08-14 2010-08-14 一种厄洛替尼碱的新晶型及其制备方法
CN201010258627.9 2010-08-14
CN2010102586279 2010-08-14
CN201180020777.9A CN102869650B (zh) 2010-08-14 2011-08-12 一种厄洛替尼碱的新晶型及其制备方法
PCT/CN2011/078352 WO2012022240A1 (zh) 2010-08-14 2011-08-12 一种厄洛替尼碱的新晶型及其制备方法

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CN102869650A true CN102869650A (zh) 2013-01-09
CN102869650B CN102869650B (zh) 2015-06-17

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US (1) US8653264B2 (zh)
EP (1) EP2612855B1 (zh)
CN (2) CN101914068A (zh)
WO (1) WO2012022240A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101914068A (zh) 2010-08-14 2010-12-15 浙江华海药业股份有限公司 一种厄洛替尼碱的新晶型及其制备方法
CN103360325A (zh) * 2012-03-26 2013-10-23 重庆医药工业研究院有限责任公司 一种盐酸厄洛替尼晶型a的制备方法
CN103420924B (zh) * 2012-05-25 2016-08-31 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
WO2014118737A1 (en) 2013-01-31 2014-08-07 Ranbaxy Laboratories Limited Erlotinib salts
CN103145628B (zh) * 2013-03-18 2015-04-22 齐鲁制药有限公司 一种厄洛替尼一水合物晶型i的制备方法
CN104119284A (zh) * 2013-04-28 2014-10-29 广东东阳光药业有限公司 厄洛替尼新晶型及其制备方法
CN103450097A (zh) * 2013-08-08 2013-12-18 江南大学 一种高纯度a晶型盐酸埃罗替尼的制备方法
CN104230824B (zh) * 2014-09-03 2016-07-06 山东金城医药股份有限公司 厄洛替尼碱晶型Form V及其制备方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CN1414954A (zh) * 1999-11-11 2003-04-30 Osi药物公司 N－(3－乙炔基苯基氨基)－6,7－二(2－甲氧基乙氧基)－4－喹唑啉胺盐酸盐的稳定多晶形物及其制备方法和医药用途
WO2007060691A2 (en) * 2005-11-23 2007-05-31 Natco Pharma Limited A novel process for the preparation of erlotinib
WO2009024989A2 (en) * 2007-08-17 2009-02-26 Hetero Drugs Limited A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
CN101463013A (zh) * 2007-12-21 2009-06-24 上海百灵医药科技有限公司 一种盐酸厄洛替尼的制备方法
CN101547910A (zh) * 2006-07-28 2009-09-30 合成纤维有限公司 结晶埃罗替尼
CN101602734A (zh) * 2009-04-24 2009-12-16 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
CN101735157A (zh) * 2009-12-30 2010-06-16 上海北卡医药技术有限公司 一种盐酸埃罗替尼的制备方法
CN101735156A (zh) * 2008-11-20 2010-06-16 上海医药工业研究院 厄罗替尼盐酸盐的多晶型l、其制备方法及其应用
CN101914068A (zh) * 2010-08-14 2010-12-15 浙江华海药业股份有限公司 一种厄洛替尼碱的新晶型及其制备方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CN1414954A (zh) * 1999-11-11 2003-04-30 Osi药物公司 N－(3－乙炔基苯基氨基)－6,7－二(2－甲氧基乙氧基)－4－喹唑啉胺盐酸盐的稳定多晶形物及其制备方法和医药用途
WO2007060691A2 (en) * 2005-11-23 2007-05-31 Natco Pharma Limited A novel process for the preparation of erlotinib
CN101547910A (zh) * 2006-07-28 2009-09-30 合成纤维有限公司 结晶埃罗替尼
WO2009024989A2 (en) * 2007-08-17 2009-02-26 Hetero Drugs Limited A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
CN101463013A (zh) * 2007-12-21 2009-06-24 上海百灵医药科技有限公司 一种盐酸厄洛替尼的制备方法
CN101735156A (zh) * 2008-11-20 2010-06-16 上海医药工业研究院 厄罗替尼盐酸盐的多晶型l、其制备方法及其应用
CN101602734A (zh) * 2009-04-24 2009-12-16 浙江九洲药业股份有限公司 一种盐酸埃罗替尼晶型a的制备方法
CN101735157A (zh) * 2009-12-30 2010-06-16 上海北卡医药技术有限公司 一种盐酸埃罗替尼的制备方法
CN101914068A (zh) * 2010-08-14 2010-12-15 浙江华海药业股份有限公司 一种厄洛替尼碱的新晶型及其制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JEREMY KOLPAK,等: "Enhanced SAR Maps: Expanding the Data Rendering Capabilities of a Popular Medicinal Chemistry Too", 《J. CHEM. INF. MODEL. 》 *
李付刚,等: "喹唑啉类抗癌药物的合成研究进展", 《精细与专用化学品》 *
李铭东,等: "盐酸埃洛替尼的合成", 《中国医药工业杂志》 *
郑志刚: "厄洛替尼及其中间体的合成工艺研究", 《天津大学硕士学位论文》 *

Also Published As

Publication number Publication date
EP2612855B1 (en) 2015-07-29
CN101914068A (zh) 2010-12-15
CN102869650B (zh) 2015-06-17
WO2012022240A1 (zh) 2012-02-23
US8653264B2 (en) 2014-02-18
US20130137867A1 (en) 2013-05-30
EP2612855A4 (en) 2014-04-02
EP2612855A1 (en) 2013-07-10

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