CN102861162A - Antiviral complex traditional Chinese medicine and preparation method and application thereof - Google Patents
Antiviral complex traditional Chinese medicine and preparation method and application thereof Download PDFInfo
- Publication number
- CN102861162A CN102861162A CN2012103956588A CN201210395658A CN102861162A CN 102861162 A CN102861162 A CN 102861162A CN 2012103956588 A CN2012103956588 A CN 2012103956588A CN 201210395658 A CN201210395658 A CN 201210395658A CN 102861162 A CN102861162 A CN 102861162A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- antiviral compound
- compound traditional
- chinese medicament
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 56
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 230000017074 necrotic cell death Effects 0.000 claims abstract description 11
- 241000252230 Ctenopharyngodon idella Species 0.000 claims abstract description 9
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 7
- 241000701372 Iridovirus Species 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 9
- 241000252233 Cyprinus carpio Species 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- 241001253208 Andrias davidianus Species 0.000 claims description 7
- 208000032843 Hemorrhage Diseases 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 239000010231 banlangen Substances 0.000 claims description 7
- 230000002607 hemopoietic effect Effects 0.000 claims description 7
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 7
- 241000252498 Ictalurus punctatus Species 0.000 claims description 6
- 241000238030 Procambarus clarkii Species 0.000 claims description 6
- 241001609213 Carassius carassius Species 0.000 claims description 5
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 21
- 208000036142 Viral infection Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241001051708 Cyprinid herpesvirus 3 Species 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract 1
- 241000700723 Ictalurid herpesvirus 1 Species 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 241000264847 Siniperca chuatsi Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 241000251468 Actinopterygii Species 0.000 description 22
- 239000000203 mixture Substances 0.000 description 18
- 230000003612 virological effect Effects 0.000 description 14
- 230000037396 body weight Effects 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 206010028851 Necrosis Diseases 0.000 description 9
- 210000002816 gill Anatomy 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 208000031169 hemorrhagic disease Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 241000252229 Carassius auratus Species 0.000 description 4
- 230000007850 degeneration Effects 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 241000238557 Decapoda Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 2
- 230000002155 anti-virotic effect Effects 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000004943 gill filament Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 241000269333 Caudata Species 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000000185 Localized scleroderma Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010027982 Morphoea Diseases 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000010428 chromatin condensation Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 201000008160 exudative glomerulonephritis Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014987 limb edema Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000001581 lymphogranuloma venereum Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000008965 mitochondrial swelling Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an antiviral complex traditional Chinese medicine and a preparation method and application of the antiviral complex traditional Chinese medicine. The complex traditional Chinese medicine comprises isatis root, rheum officinale, astragalus mongholicus, folium isatidis, houttuynia cordata and polygonum cuspidatum. The antiviral complex traditional Chinese medicine and the preparation method provided by the invention are reasonable in prescription, and simple in preparation technology; as the clinical test shown, the traditional complex traditional Chinese medicine can be applied to preparing medicine for treating or preventing white spot syndrome of cray, hemorragic disease of grass carp, haematopoietic necrosis of crucian, koi herpes virus disease, channel catfish virus disease, iridovirus disease of siniperca chuatsi, and virosis of aquatic livestock; and the antiviral complex traditional Chinese medicine has high efficiency, is safe and has no toxic and side effect, and has a wide clinical application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of antiviral compound traditional Chinese medicament, also relate to a kind of preparation method of antiviral compound traditional Chinese medicament, also relate to the application of a kind of antiviral compound traditional Chinese medicament in preparation treatment or prevention aquatic animal viral disease medicine.
Technical background
Virus is a kind of of minimum in the pathogenic microorganism, breeds in cell, and its core is ribonucleic acid (RNA) or DNA (deoxyribonucleic acid) (DNA), and shell is protein, does not have cellularity.Virus parasite relies on the host cell metabolic system and breeds and copy in host cell.Synthetic viral nucleic acid and protein under the hereditary information regulation and control that viral gene provides, then in endochylema, be assembled into ripe infectious virus body, discharge from cell in every way and infect other cells, viral nucleic acid is integrated in cell sometimes, be difficult for eliminating, so the antiviral research slower development.
In recent years, along with the culture fishery development, the fisherman pursues high interests, and intensive culture is so that the viral disease sickness rate is high, and constantly mutation of virus is propagated soon, and is popular wide, the development of serious harm culture fishery.The action pathway of the antiviral drugs of clinical practice is a lot, as direct inhibition or kill virus, viral interference absorption, stop virus penetrate cell, suppress viral organism synthetic, suppress virus and discharge or strengthen host anti-virus ability etc.But effectively the Western medicine side effect is large for present treatment virus both at home and abroad, and the anti virus herb kind is few and effective percentage is low, and therefore, it is very necessary developing antiviral Chinese medicine new varieties application diseases prevention and treatment.
Summary of the invention
The purpose of this invention is to provide a kind of antiviral compound traditional Chinese medicament, made by Radix Isatidis, Radix Et Rhizoma Rhei, the Radix Astragali, Rhizoma Polygoni Cuspidati, Folium Isatidis and Herba Houttuyniae mixing, this herbal mixture antiviral spectrum is wide, can suppress the aquatic animal viral diseases such as Procambarus clarkii white spot syndrome, hemorrhagic disease of grass carp, Carassius auratus hemopoietic organ necrosis, Cyprinus carpio blister sore viral disease, effective percentage is high, the characteristics of safe without toxic side effect.
Another object of the present invention is the preparation method that has been to provide a kind of antiviral compound traditional Chinese medicament, and the method technique is simple, easy operating, is suitable for suitability for industrialized production.
A further object of the invention is to be to provide the application of a kind of antiviral compound traditional Chinese medicament powder in preparation treatment or prevention aquatic animal viral disease medicine.
Described aquatic animal viral disease is: hemorrhagic disease of grass carp, Cyprinus carpio blister sore viral disease, Ietalurus Punetaus virosis, crucian carp hemopoietic organ necrosis, Andrias davidianus Blanchard iridescent virus disease, Procambarus clarkii white spot syndrome.
In order to realize above purpose, the present invention adopts following technical measures:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, by following raw materials in parts by weight formulated (better proportioning):
A kind of antiviral compound traditional Chinese medicament powder, by following raw materials in parts by weight formulated (best proportioning):
A kind of preparation method of antiviral compound traditional Chinese medicament the steps include:
Take by weighing in proportion and meet " following traditional Chinese medicines of Chinese pharmacopoeia standard:
Radix Isatidis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Astragali, Folium Isatidis, Herba Houttuyniae after the drying, will be made powdery behind all the components mix homogeneously.A kind of application of antiviral compound traditional Chinese medicament, its application process is:
1. for the Procambarus clarkii that suffers from white spot syndrome, by 1.0 gram/per kilogram shrimp body weight calculating dose, the mix fodder 5 days cure rates of throwing something and feeding continuously reach 90%.
2. for the Ctenopharyngodon idellus of suffering from hemorrhagic disease of grass carp, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
3. for the Cyprinus carpio that suffers from Cyprinus carpio blister sore viral disease, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
4. for the Ietalurus Punetaus of suffering from the Ietalurus Punetaus virosis, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
5. for the Carassius auratus that suffers from crucian carp hemopoietic organ necrosis, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
6. for the Andrias davidianus Blanchard that suffers from the Andrias davidianus Blanchard iridescent virus disease, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Compared with prior art, the present invention has the following advantages:
Antiviral compound traditional Chinese medicament provided by the invention, compatibility is reasonable, preparation technology is simple, confirm through clinical experiment, the Chinese medicine composition that the present invention relates to relatively other Aquatic product Chinese medicines is applicable to more Aquatic product virosiss, and be improved the effect of aquatic animal autoimmunity, treat and prevent Procambarus clarkii guttate morphea syndrome, hemorrhagic disease of grass carp, Carassius auratus hemopoietic organ necrosis, Cyprinus carpio blister sore viral disease for preparation, crucian carp hemopoietic organ necrosis, the medicine of Andrias davidianus Blanchard iridescent virus disease, this herbal mixture efficient is high, safe without toxic side effect, and cure rate reaches 90%.This drug use successful is better than other aquatic animal antiviral compound traditional Chinese medicaments.
The specific embodiment
Embodiment 1
A kind of antiviral compound traditional Chinese medicament, this medicine is prepared by following raw materials in parts by weight:
Herbal mixture embodiment consumption of the present invention following (weight portion)
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | |
| Radix Isatidis | 10 | 15 | 20 | 22 | 25 | 30 |
| Rhizoma Polygoni Cuspidati | 30 | 25 | 22 | 20 | 15 | 10 |
| Radix Et Rhizoma Rhei | 25 | 21 | 18 | 15 | 12 | 8 |
| The Radix Astragali | 25 | 21 | 18 | 15 | 12 | 8 |
| Folium Isatidis | 8 | 12 | 15 | 18 | 21 | 25 |
| Herba Houttuyniae | 8 | 12 | 15 | 18 | 21 | 25 |
Take by weighing by weight and meet " the above-mentioned Chinese medicine of Chinese pharmacopoeia standard:
Get final product making powdery after all the components mix homogeneously drying.
Embodiment 7
Certain raiser, the cultivation object: Procambarus clarkii, ill: white spot syndrome
Symptom: prawn head cuirass and uromere carapace are easy to be lifted and inadhesion corium, and can see obvious white macula on carapace.Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram shrimp body weight calculating dose, the mix fodder 5 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 8
Certain raiser, the cultivation object: Ctenopharyngodon idellus, ill: hemorrhagic disease of grass carp
Symptom: sick lymphogranuloma inguinale chamber, lower jaw, the gill cover, fin ray base portion performance hyperemia.With the strip off of sick fish skin skin, the demonstration point-like that muscle has or block congested, the whole-body muscle that has is congested phenomenon, and " the white gill " appears in gill section anemia.Internal's intestinal is congested, and the part is cerise because filling, mesentery and fatty on every side, and with significantly point-like is congested, but intestinal smooth is generally still intact, without the appearance of the situations such as rotten or edema.Canescence or contrafluxion appear in the liver,spleen,kidney of the sick fish of minority etc., and misty wall and gallbladder often are full of the blood streak.
Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 9
Certain raiser, the cultivation object: Cyprinus carpio, ill: Cyprinus carpio blister sore viral disease
Symptom: most sick fishes show as eyeball and skin of head depression.As if after infecting generation, speckle appears in body surface, and dorsal fin is overlapping.Afterwards, body surface is secreted a large amount of mucus.
Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 10
Certain raiser, the cultivation object: Ietalurus Punetaus, ill: the Ietalurus Punetaus virosis
Symptom: most sick fishes show as the disease fish and show as appetite decline, and even food does not peel off and solely swims, bradykinesia, and the sick fish of part has under the Caudad, and head makes progress, and suspends in water, and the intermittence rotation occurs and moves about, and sinks under water, dies of exhaustion and die.Sick flake is outstanding, the epidermis blackout, and the gill turns white, fin ray and hemorrhage of muscle, abdominal part expands, the red and swollen evagination of the visible anus of the sick fish of part.Dissect the disease fish and see a large amount of faint yellow or pale red ascites are arranged in the body, gastrointestinal tract is hollow, does not have food, is full of flaxen mucus in it, the internal organs generation petechial hemorrhages such as the heart, liver,spleen,kidney.Often color is shallow takes on a red color enlargement for spleen.
Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 11
Certain raiser, the cultivation object: Carassius auratus, ill: crucian carp hemopoietic organ necrosis
Symptom: sick fish health is rubescent, and lateral line scales is following and chest is particularly evident.Gill cover swelling, in the process of gill cover opening and closing (or in process of fish body jump), blood and slime can flow out from gill section; After the sick fish death, the gill cover has obvious bleeding, cuts off the gill cover and observes, and gill filament swelling also has a large amount of mucus; The microscopy gill filament turns white without color.Sick fin bar tip turns white, and tail fin is particularly evident, when serious such as the moth fin-shaped.See liver congested (some individual liver swelling) after the dissection, spleen, the congested enlargement of kidney; Inflammatory bowel, food are few.
Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 12
Certain raiser, the cultivation object: Andrias davidianus Blanchard, ill: the Andrias davidianus Blanchard iridescent virus disease
Symptom: most sick fishes show as to cut open to examine finds that sick salamander abdominal part expands, and occurs white point, ecchymosis on the skin, ulcer, head and limb edema; Hepatomegaly is canescence or mottled hemorrhage; Spleen, renomegaly, congestion, mottled hemorrhage; The intestinal wall attenuation is full of in the enteric cavity and contains in a large number blood or flaxen liquid.Microscopy is mainly seen body tissue's organ popularity edema, hemorrhage, degeneration, necrosis and inflammatory cell infiltration, particularly the damage of kidney, liver, gastrointestinal tract, spleen and integumentary musculature is comparatively serious, and sees circle or oval acidophilia's cytoplasmic inclusions at the pathological tissues cell.Kidney shows as the vacuolar degeneration of exudative glomerulonephritis and renal tubular epithelial with downright bad; Hepatocyte popularity vacuolar degeneration and focal necrosis; Splenocyte is downright bad, and quantity reduces; Gastrointestinal tract is Catarrhal one hemorrhagic inflammation; Hydroderma, the epidermis cell vacuolar degeneration, necrosis comes off, and forms the stain infections.Electronic Speculum shows that obvious pathological changes occurs the cell of liver,spleen,kidney, mitochondrial swelling, ridge fracture, dissolving, dilatation of rough endoplasmic reticula, ribosomal particle comes off, the nucleus Chromatin condensation, the limit collection, and in some sick cell slurries, see the irido virus sample granule that lattice-like is arranged or is dispersed in.Take the medicine that embodiment 1-6 makes every day, by 1.0 gram/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Claims (10)
1. antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
Parts by weight of raw materials
Radix Isatidis 10-30
Rhizoma Polygoni Cuspidati 10-30
Radix Et Rhizoma Rhei 8-25
Radix Astragali 8-25
Folium Isatidis 8-25
Herba Houttuyniae 8-25.
2. a kind of antiviral compound traditional Chinese medicament powder according to claim 1 is characterized in that:
Parts by weight of raw materials
Radix Isatidis 15-25
Rhizoma Polygoni Cuspidati 15-25
Radix Et Rhizoma Rhei 12-21
Radix Astragali 12-21
Folium Isatidis 12-21
Herba Houttuyniae 12-21.
3. a kind of antiviral compound traditional Chinese medicament powder according to claim 1 is characterized in that:
Parts by weight of raw materials
Radix Isatidis 20-22
Rhizoma Polygoni Cuspidati 20-22
Radix Et Rhizoma Rhei 15-18
Radix Astragali 15-18
Folium Isatidis 15-18
Herba Houttuyniae 15-18.
4. a kind of antiviral compound traditional Chinese medicament powder according to claim 1 is characterized in that:
Parts by weight of raw materials
Radix Isatidis 20
Rhizoma Polygoni Cuspidati 20
Radix Et Rhizoma Rhei 15
The Radix Astragali 15
Folium Isatidis 15
Herba Houttuyniae 15.
5. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention Procambarus clarkii white spot syndrome medicine.
6. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention grass carp hemorrhage medicine.
7. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention Cyprinus carpio herpesvirus medicine.
8. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention Ietalurus Punetaus virus medicine.
9. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention crucian carp hemopoietic organ necrosis medicine.
10. the application of a kind of antiviral compound traditional Chinese medicament powder claimed in claim 1 in preparation treatment or prevention Andrias davidianus Blanchard irido virus medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210395658.8A CN102861162B (en) | 2012-10-18 | 2012-10-18 | Antiviral complex traditional Chinese medicine and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210395658.8A CN102861162B (en) | 2012-10-18 | 2012-10-18 | Antiviral complex traditional Chinese medicine and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102861162A true CN102861162A (en) | 2013-01-09 |
| CN102861162B CN102861162B (en) | 2014-11-12 |
Family
ID=47440477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210395658.8A Active CN102861162B (en) | 2012-10-18 | 2012-10-18 | Antiviral complex traditional Chinese medicine and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102861162B (en) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223114A (en) * | 2013-04-28 | 2013-07-31 | 赵道全 | Andrias davidianus rotten claw and rotten tail disease treatment traditional Chinese medicine and preparation method thereof |
| CN104258254A (en) * | 2014-09-29 | 2015-01-07 | 浙江海洋学院 | Fish medicine for treating pox diseases |
| CN104351571A (en) * | 2014-12-01 | 2015-02-18 | 山东新希望六和集团有限公司 | Feed for preventing fish infectious hematopoietic necrosis and preparation method thereof |
| CN104623011A (en) * | 2015-01-12 | 2015-05-20 | 武汉市天辰生物科技有限公司 | Preparation method and application of antiviral Chinese medicinal composition for aquatic products |
| CN105055847A (en) * | 2015-07-21 | 2015-11-18 | 梧州市景泰养鳖专业合作社 | Chinese herba preparation for treating herpes of Chinese softshell turtles and preparation method of Chinese herba preparation |
| CN105124201A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of spagrus macrocephalus |
| CN105124200A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of oplegnathidae |
| CN105146140A (en) * | 2015-08-10 | 2015-12-16 | 浙江省海洋开发研究院 | Artificial compound feed for preventing and treating haemorrhage of Japanese flounders |
| CN105816538A (en) * | 2016-05-19 | 2016-08-03 | 孙克林 | Composition for treating fulminant hemorrhagic disease of crucian carps |
| CN106616030A (en) * | 2016-12-08 | 2017-05-10 | 安徽省农业科学院水产研究所 | Compound Chinese herbal medicinal preparation for preventing and curing white spot disease of procambarus clarkia and method thereof |
| CN106857338A (en) * | 2017-04-17 | 2017-06-20 | 中国水产科学研究院长江水产研究所 | A kind of crucian carp Hematopoietic Necrosis disease Synthetical prevention method |
| CN107224509A (en) * | 2017-07-21 | 2017-10-03 | 句容市润泰生物科技有限公司 | Chinese medicine composition of anti-cray guttate morphea syndrome and its preparation method and application |
| CN107318727A (en) * | 2017-07-21 | 2017-11-07 | 句容市润泰生物科技有限公司 | A kind of method for integrated control of cray disease |
| CN107982361A (en) * | 2017-12-20 | 2018-05-04 | 深圳地天国际生物工程科技有限公司 | A kind of viral hemorrhagic disease rehabilitation agent and its preparation process for aquaculture |
| CN109602779A (en) * | 2019-01-09 | 2019-04-12 | 广西科学院 | A kind of Chinese medicine composition and its application in preparation prevention and treatment grouper irido virus medicine |
| CN109602880A (en) * | 2019-01-09 | 2019-04-12 | 广西科学院 | A kind of Chinese medicine composition of anti-grouper irido virus and its application |
| CN111419954A (en) * | 2020-05-19 | 2020-07-17 | 四川绿康大地科技有限公司 | Antiviral traditional Chinese medicine composition for shrimps and preparation method thereof |
| CN115154558A (en) * | 2022-08-08 | 2022-10-11 | 吉林省水产科学研究院(吉林省渔业生态环境及水产品质量监督检测中心) | Compound medicine for breeding juvenile tilapia of Turkey |
| CN116942710A (en) * | 2023-06-16 | 2023-10-27 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine extract and application thereof in preparation of products for preventing, relieving or treating common fish virus diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641479A (en) * | 2012-05-15 | 2012-08-22 | 张治愈 | Drug composite for treating hepatitis c |
-
2012
- 2012-10-18 CN CN201210395658.8A patent/CN102861162B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641479A (en) * | 2012-05-15 | 2012-08-22 | 张治愈 | Drug composite for treating hepatitis c |
Non-Patent Citations (5)
| Title |
|---|
| 吴德峰: "中草药饲料添加剂现状及前景(Ⅱ)", 《中国中医药信息杂志》 * |
| 张展等: "中草药防治畜禽病毒病的研究进展", 《畜牧兽医杂志》 * |
| 曹红峰等: "中草药防治鱼病研究进展", 《海洋科学》 * |
| 赵凤柱等: "抗病毒中药及其活性成分研究进展", 《实用中医药杂志》 * |
| 邢跃楠等: "中草药在水产养殖中应用的研究进展", 《中国水产》 * |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223114A (en) * | 2013-04-28 | 2013-07-31 | 赵道全 | Andrias davidianus rotten claw and rotten tail disease treatment traditional Chinese medicine and preparation method thereof |
| CN104258254A (en) * | 2014-09-29 | 2015-01-07 | 浙江海洋学院 | Fish medicine for treating pox diseases |
| CN104351571A (en) * | 2014-12-01 | 2015-02-18 | 山东新希望六和集团有限公司 | Feed for preventing fish infectious hematopoietic necrosis and preparation method thereof |
| CN104623011A (en) * | 2015-01-12 | 2015-05-20 | 武汉市天辰生物科技有限公司 | Preparation method and application of antiviral Chinese medicinal composition for aquatic products |
| CN105055847A (en) * | 2015-07-21 | 2015-11-18 | 梧州市景泰养鳖专业合作社 | Chinese herba preparation for treating herpes of Chinese softshell turtles and preparation method of Chinese herba preparation |
| CN105124201A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of spagrus macrocephalus |
| CN105124200A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of oplegnathidae |
| CN105146140A (en) * | 2015-08-10 | 2015-12-16 | 浙江省海洋开发研究院 | Artificial compound feed for preventing and treating haemorrhage of Japanese flounders |
| CN105816538A (en) * | 2016-05-19 | 2016-08-03 | 孙克林 | Composition for treating fulminant hemorrhagic disease of crucian carps |
| CN106616030A (en) * | 2016-12-08 | 2017-05-10 | 安徽省农业科学院水产研究所 | Compound Chinese herbal medicinal preparation for preventing and curing white spot disease of procambarus clarkia and method thereof |
| CN106857338A (en) * | 2017-04-17 | 2017-06-20 | 中国水产科学研究院长江水产研究所 | A kind of crucian carp Hematopoietic Necrosis disease Synthetical prevention method |
| CN107224509A (en) * | 2017-07-21 | 2017-10-03 | 句容市润泰生物科技有限公司 | Chinese medicine composition of anti-cray guttate morphea syndrome and its preparation method and application |
| CN107318727A (en) * | 2017-07-21 | 2017-11-07 | 句容市润泰生物科技有限公司 | A kind of method for integrated control of cray disease |
| CN107318727B (en) * | 2017-07-21 | 2021-12-17 | 句容市润泰生物科技有限公司 | Comprehensive control method for crayfish diseases |
| CN107982361A (en) * | 2017-12-20 | 2018-05-04 | 深圳地天国际生物工程科技有限公司 | A kind of viral hemorrhagic disease rehabilitation agent and its preparation process for aquaculture |
| CN109602779A (en) * | 2019-01-09 | 2019-04-12 | 广西科学院 | A kind of Chinese medicine composition and its application in preparation prevention and treatment grouper irido virus medicine |
| CN109602880A (en) * | 2019-01-09 | 2019-04-12 | 广西科学院 | A kind of Chinese medicine composition of anti-grouper irido virus and its application |
| CN109602880B (en) * | 2019-01-09 | 2022-02-01 | 广西科学院 | Traditional Chinese medicine composition for resisting grouper iridovirus and application thereof |
| CN109602779B (en) * | 2019-01-09 | 2022-02-01 | 广西科学院 | Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and treating grouper iridovirus disease |
| CN111419954A (en) * | 2020-05-19 | 2020-07-17 | 四川绿康大地科技有限公司 | Antiviral traditional Chinese medicine composition for shrimps and preparation method thereof |
| CN115154558A (en) * | 2022-08-08 | 2022-10-11 | 吉林省水产科学研究院(吉林省渔业生态环境及水产品质量监督检测中心) | Compound medicine for breeding juvenile tilapia of Turkey |
| CN115154558B (en) * | 2022-08-08 | 2023-04-18 | 吉林省水产科学研究院(吉林省渔业生态环境及水产品质量监督检测中心) | Compound medicine for breeding juvenile tilapia of Turkey |
| CN116942710A (en) * | 2023-06-16 | 2023-10-27 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine extract and application thereof in preparation of products for preventing, relieving or treating common fish virus diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102861162B (en) | 2014-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102861162B (en) | Antiviral complex traditional Chinese medicine and preparation method and application thereof | |
| CN103006792B (en) | A kind of herbal medicine for preventing and treating livestock and poultry intestinal canal diseases and preparation method thereof and feed | |
| CN104012798B (en) | Be used for the treatment of the feed of Gilt Uterus intimitis, Chinese medicine composition and preparation method | |
| CN103623071B (en) | A kind of Powerful insect repellent for veterinary use and preparation method thereof | |
| CN101773594B (en) | Composition for treating sheep diarrhea and preparation method thereof | |
| CN104352617A (en) | Sanhuang supper micropowder as well as preparing method and application thereof | |
| CN103316132A (en) | Compound medicine for preventing and treating fish liver-gall syndrome | |
| CN104383136A (en) | Compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes and preparation method thereof | |
| CN103202962A (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN112375708B (en) | Preparation for resisting white spot syndrome virus and Octopus iridovirus 1 and preparation method thereof | |
| CN104491154A (en) | Traditional Chinese medicine ultra-fine powder for treating hemorragic disease of grass carp | |
| CN103202908B (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN105497367A (en) | Composition for treating transmissible gastroenteritis of swine and preparation method of composition | |
| CN105267977A (en) | Dissolvable doxycycline powder and preparation method thereof | |
| CN103212007B (en) | Traditional Chinese medicine preparation for treating abdominal distension of giant salamanders and preparation method of preparation | |
| CN104187072A (en) | Anti-virus fish feed for preventing and treating pancreatic necrosis of salmons and trout | |
| CN102188494A (en) | Medicament for treating high fever of pigs with pure Chinese medicine | |
| CN104825700A (en) | Traditional Chinese medicine composition for resisting bacteria and diminishing inflammation | |
| CN103585313B (en) | Compound Chinese-western powder for treating fish disease | |
| CN101664434B (en) | Composite traditional Chinese medicine composition and preparation method and application thereof | |
| CN101209329A (en) | Chinese medicinal oral liquid with heat-clearing and detoxication, lung-heat-clearing and cough-relieving efficacy | |
| CN103055207B (en) | Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof | |
| CN102335416A (en) | Compound Chinese medicinal composition for treating hog cholera and preparation method thereof | |
| CN104758407A (en) | Traditional Chinese medicine composition for treating hemorrhagic enteritis in turkey and preparation method of traditional Chinese medicine composition | |
| CN104367670A (en) | Traditional Chinese medicine granules for preventing and treating piglet bacterial enteritis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191028 Address after: 610000 No. 588, Tianfu Road, Chengdu hi tech Zone, Sichuan, China Patentee after: TONGWEI Co.,Ltd. Address before: East Lake New Technology Development Zone Wu Da Yuan Road 430223 in Hubei Province, Wuhan City, No. 8 Patentee before: YANGTZE RIVER FISHERIES Research Institute CHINESE ACADEMY OF FISHERY SCIENCES |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231102 Address after: 610000 China (Sichuan) pilot Free Trade Zone, Chengdu, Sichuan Patentee after: Tongwei Agricultural Development Co.,Ltd. Address before: No. 588, middle section of Tianfu Avenue, high tech Zone, Chengdu, Sichuan 610000 Patentee before: TONGWEI Co.,Ltd. |
|
| TR01 | Transfer of patent right |