CN102861162B - Antiviral complex traditional Chinese medicine and preparation method and application thereof - Google Patents
Antiviral complex traditional Chinese medicine and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses an antiviral complex traditional Chinese medicine and a preparation method and application of the antiviral complex traditional Chinese medicine. The complex traditional Chinese medicine comprises isatis root, rheum officinale, astragalus mongholicus, folium isatidis, houttuynia cordata and polygonum cuspidatum. The antiviral complex traditional Chinese medicine and the preparation method provided by the invention are reasonable in prescription, and simple in preparation technology; as the clinical test shown, the traditional complex traditional Chinese medicine can be applied to preparing medicine for treating or preventing white spot syndrome of cray, hemorragic disease of grass carp, haematopoietic necrosis of crucian, koi herpes virus disease, channel catfish virus disease, iridovirus disease of siniperca chuatsi, and virosis of aquatic livestock; and the antiviral complex traditional Chinese medicine has high efficiency, is safe and has no toxic and side effect, and has a wide clinical application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of antiviral compound traditional Chinese medicament, also relate to a kind of preparation method of antiviral compound traditional Chinese medicament, also relate to the application of a kind of antiviral compound traditional Chinese medicament in preparation treatment or prevention aquatic animal viral disease medicine.
Technical background
Virus is one minimum in pathogenic microorganism, in cell, breeds, and its core is ribonucleic acid (RNA) or DNA (deoxyribonucleic acid) (DNA), and shell is protein, does not have cellularity.Virus parasite, in host cell, relies on host cell metabolic system and breeds and copy.Synthetic viral nucleic acid and protein under the hereditary information regulation and control that provide at viral gene, then in endochylema, be assembled into ripe infectious virus body, discharge and infect other cells from cell in every way, viral nucleic acid is integrated in cell sometimes, be difficult for eliminating therefore antiviral research slower development.
In recent years, along with culture fishery development, fisherman pursues high interests, and intensive culture makes viral disease sickness rate high, and constantly mutation of virus is propagated soon, popular wide, the development of serious harm culture fishery.The action pathway of the antiviral drugs of clinical practice is a lot, as direct inhibition or kill virus, viral interference absorption, stop virus penetrate cell, suppress viral organism synthetic, suppress virus and discharge or strengthen host anti-virus ability etc.But effectively Western medicine side effect is large for treatment virus both at home and abroad at present, and anti virus herb kind is few and effective percentage is low, and therefore, it is very necessary developing antiviral Chinese medicine new varieties application diseases prevention and treatment.
Summary of the invention
The object of this invention is to provide a kind of antiviral compound traditional Chinese medicament, mix and make by Radix Isatidis, Radix Et Rhizoma Rhei, the Radix Astragali, Rhizoma Polygoni Cuspidati, Folium Isatidis and Herba Houttuyniae, this herbal mixture antiviral spectrum is wide, can suppress the aquatic animal viral diseases such as Procambarus clarkii white spot syndrome, hemorrhagic disease of grass carp, Carassius auratus hemopoietic organ necrosis, Cyprinus carpio blister sore viral disease, effective percentage is high, the feature of safe without toxic side effect.
Another object of the present invention is the preparation method that has been to provide a kind of antiviral compound traditional Chinese medicament, and the method technique is simple, easy operating, is suitable for suitability for industrialized production.
A further object of the invention is to be to provide the application of a kind of antiviral compound traditional Chinese medicament powder in preparation treatment or prevention aquatic animal viral disease medicine.
Described aquatic animal viral disease is: hemorrhagic disease of grass carp, Cyprinus carpio blister sore viral disease, Ietalurus Punetaus virosis, crucian carp hemopoietic organ necrosis, Andrias davidianus Blanchard iridescent virus disease, Procambarus clarkii white spot syndrome.
In order to realize above object, the present invention adopts following technical measures:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
A kind of antiviral compound traditional Chinese medicament powder, by following raw materials in parts by weight formulated (better proportioning):
A kind of antiviral compound traditional Chinese medicament powder, by following raw materials in parts by weight formulated (best proportioning):
A preparation method for antiviral compound traditional Chinese medicament, the steps include:
Take in proportion the following traditional Chinese medicines that meets " Chinese Pharmacopoeia " specification:
Radix Isatidis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Astragali, Folium Isatidis, Herba Houttuyniae, after being dried, will make powdery after all the components mix homogeneously.An application for antiviral compound traditional Chinese medicament, its application process is:
1. for suffering from the Procambarus clarkii of white spot syndrome, by 1.0 grams/per kilogram shrimp body weight calculating dose, the mix fodder 5 days cure rates of throwing something and feeding continuously reach 90%.
2. for suffering from the Ctenopharyngodon idellus of hemorrhagic disease of grass carp, by 1.0 grams/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
3. for the Cyprinus carpio that suffers from Cyprinus carpio blister sore viral disease, by 1.0 grams/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
4. for the Ietalurus Punetaus of suffering from Ietalurus Punetaus virosis, by 1.0 grams/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
5. for the Carassius auratus that suffers from crucian carp hemopoietic organ necrosis, by 1.0 grams/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
6. for the Andrias davidianus Blanchard that suffers from Andrias davidianus Blanchard iridescent virus disease, by 1.0 grams/per kilogram fish body weight calculating dose, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Compared with prior art, the present invention has the following advantages:
Antiviral compound traditional Chinese medicament provided by the invention, compatibility is reasonable, preparation technology is simple, confirm through clinical experiment, the Chinese medicine composition the present invention relates to relatively other Aquatic product Chinese medicines is applicable to more Aquatic product virosiss, and be improved effect of aquatic animal autoimmunity, treat and prevent Procambarus clarkii guttate morphea syndrome, hemorrhagic disease of grass carp, Carassius auratus hemopoietic organ necrosis, Cyprinus carpio blister sore viral disease for preparation, crucian carp hemopoietic organ necrosis, the medicine of Andrias davidianus Blanchard iridescent virus disease, this herbal mixture efficiency is high, safe without toxic side effect, and cure rate reaches 90%.This drug use successful is better than other aquatic animal antiviral compound traditional Chinese medicaments.
Detailed description of the invention
Embodiment 1
A kind of antiviral compound traditional Chinese medicament, this medicine is prepared by following raw materials in parts by weight:
Herbal mixture embodiment consumption of the present invention following (weight portion)
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | |
| Radix Isatidis | 10 | 15 | 20 | 22 | 25 | 30 |
| Rhizoma Polygoni Cuspidati | 30 | 25 | 22 | 20 | 15 | 10 |
| Radix Et Rhizoma Rhei | 25 | 21 | 18 | 15 | 12 | 8 |
| The Radix Astragali | 25 | 21 | 18 | 15 | 12 | 8 |
| Folium Isatidis | 8 | 12 | 15 | 18 | 21 | 25 |
| Herba Houttuyniae | 8 | 12 | 15 | 18 | 21 | 25 |
Take by weight the above-mentioned Chinese medicine that meets " Chinese Pharmacopoeia " specification:
After all the components mix homogeneously is dry, make powdery.
Embodiment 7
Certain raiser, cultivation object: Procambarus clarkii, ill: white spot syndrome
Symptom: prawn head cuirass and uromere carapace are easy to be lifted and inadhesion corium, and can see obvious white macula on carapace.Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram shrimp body weight, the mix fodder 5 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 8
Certain raiser, cultivation object: Ctenopharyngodon idellus, ill: hemorrhagic disease of grass carp
Symptom: sick lymphogranuloma inguinale chamber, lower jaw, the gill cover, fin ray base portion performance hyperemia.By the strip off of sick fish skin skin, the demonstration point-like that muscle has or block congested, some whole-body muscles are congested phenomenon, and there is " the white gill " in gill portion anemia.The hyperemia of internal's intestinal, part is cerise because filling, mesentery and around fat, with significantly point-like hyperemia, but intestinal smooth is generally still intact, without situation appearance such as rotten or edema.There is canescence or contrafluxion in the liver,spleen,kidney of the sick fish of minority etc., misty wall and gallbladder are often full of the blood streak.
Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram fish body weight, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 9
Certain raiser, cultivation object: Cyprinus carpio, ill: Cyprinus carpio blister sore viral disease
Symptom: most sick fishes show as eyeball and skin of head depression.Infecting after generation, there is speckle in body surface, and it is overlapping that dorsal fin seems.Afterwards, body surface is secreted a large amount of mucus.
Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram fish body weight, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 10
Certain raiser, cultivation object: Ietalurus Punetaus, ill: Ietalurus Punetaus virosis
Symptom: most sick fishes show as disease fish and show as appetite and decline, not even food, the solely trip that peels off, bradykinesia, the sick fish of part has under Caudad, and head upwards, suspends in water, and occurs that intermittence rotation moves about, and sinks under water, dies of exhaustion and die.Sick flake is outstanding, epidermis blackout, and the gill turns white, fin ray and hemorrhage of muscle, abdominal part expands, the red and swollen evagination of the visible anus of the sick fish of part.Dissect disease fish and see and in body, have a large amount of faint yellow or pale red ascites, gastrointestinal tract inanition, does not have food, is full of flaxen mucus, the internal organs generation petechial hemorrhages such as the heart, liver,spleen,kidney in it.Often color is shallow takes on a red color for spleen, enlargement.
Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram fish body weight, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 11
Certain raiser, cultivation object: Carassius auratus, ill: crucian carp hemopoietic organ necrosis
Symptom: sick fish health is rubescent, lateral line scales is following and chest is particularly evident.Gill cover swelling, in the process of gill cover opening and closing (or in process of fish body jump), blood and slime can flow out from gill portion; After sick fish death, the gill cover has obvious bleeding, cuts off the gill cover and observes, and gill filament swelling also has a large amount of mucus; The microscopy gill filament turns white without color.Sick fin bar tip turns white, and tail fin is particularly evident, when serious as moth fin-shaped.After dissection, see liver hyperemia (some individual liver swelling), spleen, the congested enlargement of kidney; Inflammatory bowel, food are few.
Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram fish body weight, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Embodiment 12
Certain raiser, cultivation object: Andrias davidianus Blanchard, ill: Andrias davidianus Blanchard iridescent virus disease
Symptom: most sick fishes show as to cut open to examine finds that sick salamander abdominal part expands, and occurs white point, ecchymosis, ulcer, head and limb edema on skin; Hepatomegaly, is canescence or mottled hemorrhage; Spleen, renomegaly, congestion, mottled hemorrhage; Intestinal wall attenuation, is full of a large amount of containing blood or flaxen liquid in enteric cavity.Microscopy is mainly shown in body tissue's organ popularity edema, hemorrhage, degeneration, necrosis and inflammatory cell infiltration, particularly the damage of kidney, liver, gastrointestinal tract, spleen and integumentary musculature is comparatively serious, and sees circle or oval acidophilia's cytoplasmic inclusions at pathological tissues cell.Kidney shows as the vacuolar degeneration of exudative glomerulonephritis and renal tubular epithelial with downright bad; Hepatocyte popularity vacuolar degeneration and focal necrosis; Splenocyte necrosis, quantity reduces; Gastrointestinal tract is Catarrhal one hemorrhagic inflammation; Hydroderma, epidermis cell vacuolar degeneration, necrosis comes off, and forms stain infections.Electronic Speculum shows that obvious pathological changes occurs the cell of liver,spleen,kidney, mitochondrial swelling, ridge fracture, dissolve, dilatation of rough endoplasmic reticula, ribosomal particle comes off, nucleus Chromatin condensation, limit collection, and see the irido virus sample granule that lattice-like is arranged or is dispersed in some sick cell slurries.Take the medicine that embodiment 1-6 makes every day, calculate dose by 1.0 grams/per kilogram fish body weight, the mix fodder 6 days cure rates of throwing something and feeding continuously reach 90%.
Claims (1)
1. antiviral compound traditional Chinese medicament powder is treated or a prevention Procambarus clarkii white spot syndrome in preparation as unique effective ingredient simultaneously, hemorrhagic disease of grass carp, Cyprinus carpio blister sore viral disease, Ietalurus Punetaus virosis, the application in Andrias davidianus Blanchard irido virus medicine;
Described antiviral compound traditional Chinese medicament powder, formulated by following raw materials in parts by weight:
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| CN109602880B (en) * | 2019-01-09 | 2022-02-01 | 广西科学院 | Traditional Chinese medicine composition for resisting grouper iridovirus and application thereof |
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| CN115154558B (en) * | 2022-08-08 | 2023-04-18 | 吉林省水产科学研究院(吉林省渔业生态环境及水产品质量监督检测中心) | Compound medicine for breeding juvenile tilapia of Turkey |
| CN116942710A (en) * | 2023-06-16 | 2023-10-27 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine extract and application thereof in preparation of products for preventing, relieving or treating common fish virus diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641479A (en) * | 2012-05-15 | 2012-08-22 | 张治愈 | Drug composite for treating hepatitis c |
-
2012
- 2012-10-18 CN CN201210395658.8A patent/CN102861162B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641479A (en) * | 2012-05-15 | 2012-08-22 | 张治愈 | Drug composite for treating hepatitis c |
Non-Patent Citations (10)
| Title |
|---|
| 中草药在水产养殖中应用的研究进展;邢跃楠等;《中国水产》;20070405(第04期);64-66 * |
| 中草药防治畜禽病毒病的研究进展;张展等;《畜牧兽医杂志》;20080510;第27卷(第03期);43-44，46 * |
| 中草药防治鱼病研究进展;曹红峰等;《海洋科学》;20060409;第30卷(第04期);83-87 * |
| 中草药饲料添加剂现状及前景(Ⅱ);吴德峰;《中国中医药信息杂志》;201102;第8卷(第02期);33-34 * |
| 吴德峰.中草药饲料添加剂现状及前景(Ⅱ).《中国中医药信息杂志》.2011,第8卷(第02期), * |
| 张展等.中草药防治畜禽病毒病的研究进展.《畜牧兽医杂志》.2008,第27卷(第03期), * |
| 抗病毒中药及其活性成分研究进展;赵凤柱等;《实用中医药杂志》;20090615;第25卷(第6期);428-429 * |
| 曹红峰等.中草药防治鱼病研究进展.《海洋科学》.2006,第30卷(第04期), * |
| 赵凤柱等.抗病毒中药及其活性成分研究进展.《实用中医药杂志》.2009,第25卷(第6期), * |
| 邢跃楠等.中草药在水产养殖中应用的研究进展.《中国水产》.2007,(第04期), * |
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