CN102741293B - 亲和力成熟的人源化抗cea单克隆抗体 - Google Patents

亲和力成熟的人源化抗cea单克隆抗体 Download PDF

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Publication number
CN102741293B
CN102741293B CN201080048622.1A CN201080048622A CN102741293B CN 102741293 B CN102741293 B CN 102741293B CN 201080048622 A CN201080048622 A CN 201080048622A CN 102741293 B CN102741293 B CN 102741293B
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China
Prior art keywords
antibody
antigen binding
binding molecules
cell
cea
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Expired - Fee Related
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CN201080048622.1A
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English (en)
Chinese (zh)
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CN102741293A (zh
Inventor
T.U.霍弗
R.霍斯
E.莫斯纳
P.乌马纳
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Roche Glycart AG
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Roche Glycart AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080048622.1A 2009-08-31 2010-08-27 亲和力成熟的人源化抗cea单克隆抗体 Expired - Fee Related CN102741293B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23850509P 2009-08-31 2009-08-31
US61/238,505 2009-08-31
PCT/EP2010/062527 WO2011023787A1 (en) 2009-08-31 2010-08-27 Affinity-matured humanized anti cea monoclonal antibodies

Publications (2)

Publication Number Publication Date
CN102741293A CN102741293A (zh) 2012-10-17
CN102741293B true CN102741293B (zh) 2015-04-01

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ID=42985489

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CN201080048622.1A Expired - Fee Related CN102741293B (zh) 2009-08-31 2010-08-27 亲和力成熟的人源化抗cea单克隆抗体

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Country Link
US (2) US9068008B2 (enExample)
EP (1) EP2473532B1 (enExample)
JP (1) JP5744872B2 (enExample)
KR (1) KR101528013B1 (enExample)
CN (1) CN102741293B (enExample)
AR (1) AR078111A1 (enExample)
AU (1) AU2010288469A1 (enExample)
BR (1) BR112012003983A2 (enExample)
CA (1) CA2770174A1 (enExample)
CL (1) CL2012000551A1 (enExample)
CO (1) CO6491105A2 (enExample)
CR (1) CR20120087A (enExample)
EC (1) ECSP12011698A (enExample)
IL (1) IL218038A0 (enExample)
MA (1) MA33536B1 (enExample)
MX (1) MX339608B (enExample)
PE (1) PE20121552A1 (enExample)
RU (1) RU2570554C2 (enExample)
SG (1) SG178567A1 (enExample)
TW (1) TW201121994A (enExample)
WO (1) WO2011023787A1 (enExample)
ZA (1) ZA201200954B (enExample)

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BR112015007120A2 (pt) 2012-10-08 2017-12-12 Roche Glycart Ag anticorpo biespecífico, composição farmacêutica, uso, célula hospedeira e método de produção de um anticorpo
UA119320C2 (uk) 2013-02-26 2019-06-10 Рош Глікарт Аг Активуюча т-клітини біспецифічна антигензв'язувальна молекула
CN110845618A (zh) 2013-02-26 2020-02-28 罗切格利卡特公司 双特异性t细胞活化抗原结合分子
WO2014131711A1 (en) 2013-02-26 2014-09-04 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
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RU2753902C2 (ru) 2014-11-20 2021-08-24 Ф.Хоффманн-Ля Рош Аг Комбинированная терапия на основе активирующих т-клетки биспецифических антигенсвязывающих молекул против cd3 и фолатного рецептора 1 (folr1) и антагонистов, связывающихся с осью pd-1
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Also Published As

Publication number Publication date
ZA201200954B (en) 2014-07-30
EP2473532A1 (en) 2012-07-11
CL2012000551A1 (es) 2012-10-12
CN102741293A (zh) 2012-10-17
AR078111A1 (es) 2011-10-12
MX339608B (es) 2016-05-31
EP2473532B1 (en) 2017-06-21
SG178567A1 (en) 2012-04-27
CO6491105A2 (es) 2012-07-31
MX2012002461A (es) 2012-03-14
WO2011023787A1 (en) 2011-03-03
JP2013502913A (ja) 2013-01-31
KR101528013B1 (ko) 2015-06-16
ECSP12011698A (es) 2012-03-30
MA33536B1 (fr) 2012-08-01
JP5744872B2 (ja) 2015-07-08
RU2570554C2 (ru) 2015-12-10
US9068008B2 (en) 2015-06-30
RU2012112340A (ru) 2013-10-10
US20110104148A1 (en) 2011-05-05
PE20121552A1 (es) 2012-11-26
CA2770174A1 (en) 2011-03-03
IL218038A0 (en) 2012-04-30
HK1176951A1 (en) 2013-08-09
KR20120060874A (ko) 2012-06-12
TW201121994A (en) 2011-07-01
US20160075795A1 (en) 2016-03-17
CR20120087A (es) 2012-03-22
AU2010288469A1 (en) 2012-03-01
BR112012003983A2 (pt) 2021-09-14

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