JP5744872B2 - 親和性成熟ヒト化抗ｃｅａモノクローナル抗体 - Google Patents

親和性成熟ヒト化抗ｃｅａモノクローナル抗体 Download PDF

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JP5744872B2
JP5744872B2 JP2012526072A JP2012526072A JP5744872B2 JP 5744872 B2 JP5744872 B2 JP 5744872B2 JP 2012526072 A JP2012526072 A JP 2012526072A JP 2012526072 A JP2012526072 A JP 2012526072A JP 5744872 B2 JP5744872 B2 JP 5744872B2
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antibody
seq
abm
cea
sequence
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JP2013502913A5 (enExample
JP2013502913A (ja
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トーマス ウー． ホーファー，
トーマス ウー． ホーファー，
ラルフ ホッセ，
ラルフ ホッセ，
エッケハルト メスナー，
エッケハルト メスナー，
パブロ ウマーニャ，
パブロ ウマーニャ，
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ロシュ グリクアート アーゲー
ロシュ グリクアート アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012526072A 2009-08-31 2010-08-27 親和性成熟ヒト化抗ｃｅａモノクローナル抗体 Expired - Fee Related JP5744872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23850509P 2009-08-31 2009-08-31
US61/238,505 2009-08-31
PCT/EP2010/062527 WO2011023787A1 (en) 2009-08-31 2010-08-27 Affinity-matured humanized anti cea monoclonal antibodies

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JP2013502913A JP2013502913A (ja) 2013-01-31
JP2013502913A5 JP2013502913A5 (enExample) 2013-04-18
JP5744872B2 true JP5744872B2 (ja) 2015-07-08

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JP2012526072A Expired - Fee Related JP5744872B2 (ja) 2009-08-31 2010-08-27 親和性成熟ヒト化抗ｃｅａモノクローナル抗体

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US (2) US9068008B2 (enExample)
EP (1) EP2473532B1 (enExample)
JP (1) JP5744872B2 (enExample)
KR (1) KR101528013B1 (enExample)
CN (1) CN102741293B (enExample)
AR (1) AR078111A1 (enExample)
AU (1) AU2010288469A1 (enExample)
BR (1) BR112012003983A2 (enExample)
CA (1) CA2770174A1 (enExample)
CL (1) CL2012000551A1 (enExample)
CO (1) CO6491105A2 (enExample)
CR (1) CR20120087A (enExample)
EC (1) ECSP12011698A (enExample)
IL (1) IL218038A0 (enExample)
MA (1) MA33536B1 (enExample)
MX (1) MX339608B (enExample)
PE (1) PE20121552A1 (enExample)
RU (1) RU2570554C2 (enExample)
SG (1) SG178567A1 (enExample)
TW (1) TW201121994A (enExample)
WO (1) WO2011023787A1 (enExample)
ZA (1) ZA201200954B (enExample)

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ZA201200954B (en) 2014-07-30
EP2473532A1 (en) 2012-07-11
CL2012000551A1 (es) 2012-10-12
CN102741293A (zh) 2012-10-17
AR078111A1 (es) 2011-10-12
MX339608B (es) 2016-05-31
EP2473532B1 (en) 2017-06-21
SG178567A1 (en) 2012-04-27
CO6491105A2 (es) 2012-07-31
MX2012002461A (es) 2012-03-14
WO2011023787A1 (en) 2011-03-03
JP2013502913A (ja) 2013-01-31
KR101528013B1 (ko) 2015-06-16
ECSP12011698A (es) 2012-03-30
MA33536B1 (fr) 2012-08-01
RU2570554C2 (ru) 2015-12-10
US9068008B2 (en) 2015-06-30
RU2012112340A (ru) 2013-10-10
CN102741293B (zh) 2015-04-01
US20110104148A1 (en) 2011-05-05
PE20121552A1 (es) 2012-11-26
CA2770174A1 (en) 2011-03-03
IL218038A0 (en) 2012-04-30
HK1176951A1 (en) 2013-08-09
KR20120060874A (ko) 2012-06-12
TW201121994A (en) 2011-07-01
US20160075795A1 (en) 2016-03-17
CR20120087A (es) 2012-03-22
AU2010288469A1 (en) 2012-03-01
BR112012003983A2 (pt) 2021-09-14

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