KR101528013B1 - 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 - Google Patents

친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 Download PDF

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KR101528013B1
KR101528013B1 KR1020127008265A KR20127008265A KR101528013B1 KR 101528013 B1 KR101528013 B1 KR 101528013B1 KR 1020127008265 A KR1020127008265 A KR 1020127008265A KR 20127008265 A KR20127008265 A KR 20127008265A KR 101528013 B1 KR101528013 B1 KR 101528013B1
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KR20120060874A (ko
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토마스 유 호퍼
랄프 호세
에케하드 모에스너
파블로 우마나
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로슈 글리카트 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127008265A 2009-08-31 2010-08-27 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체 Expired - Fee Related KR101528013B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23850509P 2009-08-31 2009-08-31
US61/238,505 2009-08-31
PCT/EP2010/062527 WO2011023787A1 (en) 2009-08-31 2010-08-27 Affinity-matured humanized anti cea monoclonal antibodies

Publications (2)

Publication Number Publication Date
KR20120060874A KR20120060874A (ko) 2012-06-12
KR101528013B1 true KR101528013B1 (ko) 2015-06-16

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KR1020127008265A Expired - Fee Related KR101528013B1 (ko) 2009-08-31 2010-08-27 친화성-성숙된 인간화된 항-ｃｅａ 단일클론 항체

Country Status (22)

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US (2) US9068008B2 (enExample)
EP (1) EP2473532B1 (enExample)
JP (1) JP5744872B2 (enExample)
KR (1) KR101528013B1 (enExample)
CN (1) CN102741293B (enExample)
AR (1) AR078111A1 (enExample)
AU (1) AU2010288469A1 (enExample)
BR (1) BR112012003983A2 (enExample)
CA (1) CA2770174A1 (enExample)
CL (1) CL2012000551A1 (enExample)
CO (1) CO6491105A2 (enExample)
CR (1) CR20120087A (enExample)
EC (1) ECSP12011698A (enExample)
IL (1) IL218038A0 (enExample)
MA (1) MA33536B1 (enExample)
MX (1) MX339608B (enExample)
PE (1) PE20121552A1 (enExample)
RU (1) RU2570554C2 (enExample)
SG (1) SG178567A1 (enExample)
TW (1) TW201121994A (enExample)
WO (1) WO2011023787A1 (enExample)
ZA (1) ZA201200954B (enExample)

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CN110845618A (zh) 2013-02-26 2020-02-28 罗切格利卡特公司 双特异性t细胞活化抗原结合分子
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RU2753902C2 (ru) 2014-11-20 2021-08-24 Ф.Хоффманн-Ля Рош Аг Комбинированная терапия на основе активирующих т-клетки биспецифических антигенсвязывающих молекул против cd3 и фолатного рецептора 1 (folr1) и антагонистов, связывающихся с осью pd-1
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Also Published As

Publication number Publication date
ZA201200954B (en) 2014-07-30
EP2473532A1 (en) 2012-07-11
CL2012000551A1 (es) 2012-10-12
CN102741293A (zh) 2012-10-17
AR078111A1 (es) 2011-10-12
MX339608B (es) 2016-05-31
EP2473532B1 (en) 2017-06-21
SG178567A1 (en) 2012-04-27
CO6491105A2 (es) 2012-07-31
MX2012002461A (es) 2012-03-14
WO2011023787A1 (en) 2011-03-03
JP2013502913A (ja) 2013-01-31
ECSP12011698A (es) 2012-03-30
MA33536B1 (fr) 2012-08-01
JP5744872B2 (ja) 2015-07-08
RU2570554C2 (ru) 2015-12-10
US9068008B2 (en) 2015-06-30
RU2012112340A (ru) 2013-10-10
CN102741293B (zh) 2015-04-01
US20110104148A1 (en) 2011-05-05
PE20121552A1 (es) 2012-11-26
CA2770174A1 (en) 2011-03-03
IL218038A0 (en) 2012-04-30
HK1176951A1 (en) 2013-08-09
KR20120060874A (ko) 2012-06-12
TW201121994A (en) 2011-07-01
US20160075795A1 (en) 2016-03-17
CR20120087A (es) 2012-03-22
AU2010288469A1 (en) 2012-03-01
BR112012003983A2 (pt) 2021-09-14

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