CN102655859A - 病毒感染的组合疗法治疗 - Google Patents

病毒感染的组合疗法治疗 Download PDF

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Publication number
CN102655859A
CN102655859A CN2010800567360A CN201080056736A CN102655859A CN 102655859 A CN102655859 A CN 102655859A CN 2010800567360 A CN2010800567360 A CN 2010800567360A CN 201080056736 A CN201080056736 A CN 201080056736A CN 102655859 A CN102655859 A CN 102655859A
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CN
China
Prior art keywords
hydroxy
antiviral agent
hydroxyl
agent
methyl
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Pending
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CN2010800567360A
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English (en)
Chinese (zh)
Inventor
W.J.吉尔福德
D.H.福尔兹
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Gemmus Pharma Inc
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Gemmus Pharma Inc
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Publication of CN102655859A publication Critical patent/CN102655859A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800567360A 2009-10-14 2010-10-13 病毒感染的组合疗法治疗 Pending CN102655859A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25156109P 2009-10-14 2009-10-14
US61/251,561 2009-10-14
PCT/US2010/052506 WO2011047048A1 (en) 2009-10-14 2010-10-13 Combination therapy treatment for viral infections

Publications (1)

Publication Number Publication Date
CN102655859A true CN102655859A (zh) 2012-09-05

Family

ID=43063744

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800567360A Pending CN102655859A (zh) 2009-10-14 2010-10-13 病毒感染的组合疗法治疗

Country Status (9)

Country Link
US (2) US20120190637A1 (enExample)
EP (1) EP2488168A1 (enExample)
JP (1) JP2013508282A (enExample)
KR (1) KR20120093955A (enExample)
CN (1) CN102655859A (enExample)
BR (1) BR112012008959A2 (enExample)
CA (1) CA2777384A1 (enExample)
NZ (1) NZ599128A (enExample)
WO (1) WO2011047048A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555276A (zh) * 2013-03-15 2016-05-04 格穆斯药业股份有限公司 作为治疗病毒性感染的药剂的贝前列素异构体
CN111184707A (zh) * 2020-02-20 2020-05-22 中山大学 托芬那酸或其药学上可接受的盐在制备预防和/或治疗新型冠状病毒炎症药物中的应用
CN111557939A (zh) * 2020-01-21 2020-08-21 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
TWI755105B (zh) * 2020-06-11 2022-02-11 長庚大學 抑制冠狀病毒感染與複製的方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2094273B1 (en) 2006-11-16 2013-03-06 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza A viral infection
WO2015109112A1 (en) * 2014-01-16 2015-07-23 Gemmus Pharma Inc. Combination treatment of antibiotic and gpcr agonist for viral/bacterial co-infections
EP3609502A1 (en) * 2017-04-12 2020-02-19 Vertex Pharmaceuticals Incorporated Combination therapies for treating influenza virus infection
EP4103192A4 (en) * 2020-02-12 2024-02-21 Cytoagents, Inc. COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTIONS
JP7715353B2 (ja) * 2020-04-30 2025-07-30 国立大学法人京都大学 Ｒｎａウイルス関連疾患の予防又は治療剤
CA3180351A1 (en) * 2020-04-30 2021-11-04 Minoryx Therapeutics S.L. Leriglitazone for treating lung inflammation and interstitial lung disease
US20240009214A1 (en) 2020-12-02 2024-01-11 Cipla Limited Method of Treating Viral Infection

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EP1975163A1 (en) * 2007-03-28 2008-10-01 Bayer Schering Pharma Aktiengesellschaft Novel 5-cyano-prostacyclin derivatives and their use as agents for the treatment of influenza a viral infection

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555276A (zh) * 2013-03-15 2016-05-04 格穆斯药业股份有限公司 作为治疗病毒性感染的药剂的贝前列素异构体
CN111557939A (zh) * 2020-01-21 2020-08-21 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
CN111557939B (zh) * 2020-01-21 2021-05-04 中国人民解放军军事科学院军事医学研究院 法匹拉韦在制备用于治疗冠状病毒感染的药物中的应用
WO2021147235A1 (zh) * 2020-01-21 2021-07-29 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
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CN111184707A (zh) * 2020-02-20 2020-05-22 中山大学 托芬那酸或其药学上可接受的盐在制备预防和/或治疗新型冠状病毒炎症药物中的应用
TWI755105B (zh) * 2020-06-11 2022-02-11 長庚大學 抑制冠狀病毒感染與複製的方法

Also Published As

Publication number Publication date
JP2013508282A (ja) 2013-03-07
WO2011047048A1 (en) 2011-04-21
KR20120093955A (ko) 2012-08-23
NZ599128A (en) 2014-02-28
AU2010306914A1 (en) 2012-04-19
CA2777384A1 (en) 2011-04-21
US20120190637A1 (en) 2012-07-26
EP2488168A1 (en) 2012-08-22
BR112012008959A2 (pt) 2019-09-24
US20150196578A1 (en) 2015-07-16

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