CN102625797B - 作为激酶抑制剂的取代杂环化合物及其使用方法 - Google Patents

作为激酶抑制剂的取代杂环化合物及其使用方法 Download PDF

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CN102625797B
CN102625797B CN201080027836.0A CN201080027836A CN102625797B CN 102625797 B CN102625797 B CN 102625797B CN 201080027836 A CN201080027836 A CN 201080027836A CN 102625797 B CN102625797 B CN 102625797B
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cancer
compound
compounds
preparation
amino
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CN102625797A (zh
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张大为
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Jiangsu Medolution Ltd
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MEDOLUTION Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080027836.0A 2009-06-25 2010-06-24 作为激酶抑制剂的取代杂环化合物及其使用方法 Active CN102625797B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26952509P 2009-06-25 2009-06-25
US61/269,525 2009-06-25
PCT/US2010/039877 WO2010151710A2 (en) 2009-06-25 2010-06-24 Substituted heterocyclic compounds as kinases inhibitors and method of use thereof

Publications (2)

Publication Number Publication Date
CN102625797A CN102625797A (zh) 2012-08-01
CN102625797B true CN102625797B (zh) 2014-03-26

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Country Link
US (1) US8748453B2 (https=)
EP (1) EP2445885A4 (https=)
JP (1) JP2012531433A (https=)
CN (1) CN102625797B (https=)
WO (1) WO2010151710A2 (https=)

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EP2340244A4 (en) 2008-10-14 2012-07-25 Ning Xi COMPOUNDS AND APPLICATION PROCEDURES
ES2578990T3 (es) 2009-03-21 2016-08-03 Sunshine Lake Pharma Co., Ltd. Derivados de amino éster, sales de los mismos y métodos de uso
US20110195066A1 (en) * 2010-02-05 2011-08-11 Auspex Pharmaceuticals, Inc. Quinoline inhibitors of tyrosine kinase
CN102649778A (zh) * 2011-02-23 2012-08-29 苏州波锐生物医药科技有限公司 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途
CN102731485B (zh) * 2011-04-02 2016-06-15 齐鲁制药有限公司 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途
CN102838539A (zh) * 2011-06-21 2012-12-26 苏州迈泰生物技术有限公司 喹啉烯酰胺衍生物及其在制备抗恶性肿瘤药物中的用途
CN103073539B (zh) * 2011-10-26 2016-05-11 齐鲁制药有限公司 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途
CN102603734A (zh) * 2012-01-19 2012-07-25 盛世泰科生物医药技术(苏州)有限公司 一种蛋白激酶抑制剂及其应用
CN104350049B (zh) * 2012-05-07 2016-07-13 苏州韬略生物科技有限公司 作为激酶抑制剂的取代氨基喹唑啉
WO2013173254A1 (en) * 2012-05-14 2013-11-21 Dawei Zhang Bicyclic compounds as kinases inhibitors
JP2016505015A (ja) 2013-01-09 2016-02-18 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化モメロチニブ（ｍｏｍｅｌｏｔｉｎｉｂ）
CN103965114B (zh) * 2013-01-28 2016-01-06 苏州泽璟生物制药有限公司 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物
CN103254142B (zh) * 2013-04-26 2015-10-28 浙江工业大学 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用
CN103254141B (zh) * 2013-04-26 2016-02-24 浙江工业大学 4-[4-(2-二丙氨基乙酰氨基)苯胺基]-6-取代喹唑啉类化合物及制备和应用
CN104513200B (zh) * 2013-09-26 2017-05-03 江苏苏中药业集团股份有限公司 取代丁烯酰胺的马来酸盐及其晶型
WO2016023217A1 (zh) * 2014-08-15 2016-02-18 安润医药科技（苏州）有限公司 喹唑啉衍生物、其制备方法、药物组合物和应用
CN104529800B (zh) * 2014-12-08 2017-01-25 重庆威鹏药业有限公司 反式‑4‑二甲基氨基巴豆酸及盐的制备方法
CN105175331B (zh) * 2015-08-14 2019-04-26 江苏苏中药业集团股份有限公司 一种egfr类分子靶向抗肿瘤药物的制备方法
WO2019165003A1 (en) * 2018-02-20 2019-08-29 Dawei Zhang Substituted quinolines useful as kinase inhibitors
CN110357854A (zh) * 2018-03-26 2019-10-22 江苏创诺制药有限公司 一种来那替尼的制备方法
WO2021009568A1 (en) 2019-07-17 2021-01-21 2692372 Ontario, Inc. Benzenesulfonamide derivatives and uses thereof
CN112574173B (zh) * 2019-09-27 2022-03-08 江苏苏中药业集团股份有限公司 一种杂环化合物及其制备方法与应用
CN112843060B (zh) * 2019-11-27 2022-07-22 苏中药业集团股份有限公司 一种取代丁烯酰胺药物组合物及其制备方法
CN112843059A (zh) * 2019-11-27 2021-05-28 江苏苏中药业集团股份有限公司 一种取代丁烯酰胺的应用
CN113493414B (zh) * 2020-03-19 2024-09-27 苏中药业集团股份有限公司 一种氘代取代丁烯酰胺及其制备方法与应用
CN113493413B (zh) * 2020-03-19 2024-03-26 苏中药业集团股份有限公司 一种取代丁烯酰胺-n-氧化物及其制备方法与应用
CN113679720B (zh) * 2020-05-19 2024-09-27 苏中药业集团股份有限公司 一种取代丁烯酰胺联合铂类化合物的药物组合物及其用途
CN111617081B (zh) * 2020-06-09 2021-04-09 江苏苏中药业集团股份有限公司 一种取代丁烯酰胺联合mTOR抑制剂的药物组合物及其用途
CN111875539B (zh) * 2020-07-15 2022-06-21 苏中药业集团股份有限公司 一种egfr类分子靶向抗肿瘤药物的制备方法
CN114380745A (zh) * 2020-10-19 2022-04-22 江苏苏中药业集团股份有限公司 一种取代丁烯酰胺颗粒混合物及晶型ii制备方法与应用
GB2617477A (en) 2020-11-20 2023-10-11 2692372 Ontario Inc Benzenesulfonamide derivatives and uses thereof
KR20230156767A (ko) * 2021-03-19 2023-11-14 베이징 사이텍-엠큐 파마슈티컬즈 리미티드 퀴나졸린계 화합물, 조성물 및 퀴나졸린계 화합물의 적용
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Also Published As

Publication number Publication date
EP2445885A2 (en) 2012-05-02
US20120101116A1 (en) 2012-04-26
WO2010151710A2 (en) 2010-12-29
JP2012531433A (ja) 2012-12-10
CN102625797A (zh) 2012-08-01
WO2010151710A3 (en) 2011-05-12
EP2445885A4 (en) 2012-11-28
US8748453B2 (en) 2014-06-10

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