CN102575295B - 可用于检测braf突变的方法、引物、探针和试剂盒 - Google Patents

可用于检测braf突变的方法、引物、探针和试剂盒 Download PDF

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CN102575295B
CN102575295B CN201080045765.7A CN201080045765A CN102575295B CN 102575295 B CN102575295 B CN 102575295B CN 201080045765 A CN201080045765 A CN 201080045765A CN 102575295 B CN102575295 B CN 102575295B
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braf
sample
primer
seq
mutation
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CN102575295A (zh
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C.斯蒂芬斯
K.达南伯格
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Response Genetics Inc
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Response Genetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201080045765.7A 2009-08-11 2010-08-10 可用于检测braf突变的方法、引物、探针和试剂盒 Expired - Fee Related CN102575295B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23305409P 2009-08-11 2009-08-11
US61/233,054 2009-08-11
US23707809P 2009-08-26 2009-08-26
US61/237,078 2009-08-26
US30179010P 2010-02-05 2010-02-05
US61/301,790 2010-02-05
PCT/US2010/044997 WO2011019704A2 (en) 2009-08-11 2010-08-10 Methods, primers, probes and kits useful for the detection of braf mutations

Publications (2)

Publication Number Publication Date
CN102575295A CN102575295A (zh) 2012-07-11
CN102575295B true CN102575295B (zh) 2016-02-17

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US (1) US20140248614A1 (cg-RX-API-DMAC7.html)
EP (1) EP2464751B1 (cg-RX-API-DMAC7.html)
JP (1) JP2013501523A (cg-RX-API-DMAC7.html)
KR (1) KR20120099630A (cg-RX-API-DMAC7.html)
CN (1) CN102575295B (cg-RX-API-DMAC7.html)
AR (1) AR077844A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010282632A1 (cg-RX-API-DMAC7.html)
CA (1) CA2770716A1 (cg-RX-API-DMAC7.html)
IL (1) IL218021A0 (cg-RX-API-DMAC7.html)
NZ (1) NZ598166A (cg-RX-API-DMAC7.html)
TW (1) TW201111517A (cg-RX-API-DMAC7.html)
WO (1) WO2011019704A2 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

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JP6153758B2 (ja) * 2012-04-20 2017-06-28 アークレイ株式会社 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
CN102816851A (zh) * 2012-08-29 2012-12-12 苏州旷远生物分子技术有限公司 用于检测braf基因v600e突变的引物、探针、试剂盒及方法
CN102876784B (zh) * 2012-09-13 2014-11-19 周宏灏 焦磷酸测序法检测B-raf基因多态性的试剂盒及方法
EP2711432A1 (en) * 2012-09-21 2014-03-26 Genomica S.A.U. Method for detection of BRAF and PI3K mutations
CA3077539C (en) 2012-12-27 2023-09-12 Quest Diagnostics Investments Incorporated Ddr2 mutations as targetable features of melanoma or basal cell carcinoma
CN103103269B (zh) * 2013-01-18 2015-07-15 陕西佰美基因股份有限公司 一种基于探针熔解技术准确检测braf基因突变的方法
WO2014152185A1 (en) * 2013-03-15 2014-09-25 Abbott Molecular Inc. Multiplex allele detection
KR101378920B1 (ko) * 2013-04-18 2014-03-27 주식회사 현일바이오 Ｂｒａｆ 돌연변이의 선택적 검출 방법 및 이를 이용한 키트
BR112016003058A2 (pt) * 2013-08-14 2017-11-21 Qiagen Mansfield Inc composições e métodos para análise multiplex de ácidos nucleicos nras e braf
CN104017887A (zh) * 2014-06-18 2014-09-03 广州好芝生物科技有限公司 人类braf基因突变检测引物对和探针及其试剂盒
KR102010225B1 (ko) * 2014-07-11 2019-10-22 익스프레션 패톨로지, 인크. 세린/트레오닌-단백질 키나제 수용체 B-raf(BRAF)에 대한 SRM/MRM 검정
CN105400900A (zh) * 2015-12-29 2016-03-16 杭州迪安生物技术有限公司 焦磷酸测序技术检测braf基因v600e微量突变试剂盒及其应用
CN105861691A (zh) * 2016-05-06 2016-08-17 北京晋祺生物科技有限公司 一种braf基因突变检测的引物组合物、试剂盒及方法
US12364776B2 (en) 2017-06-29 2025-07-22 Korea Advanced Institute Of Science And Technology Ganglioglioma-induced animal model and a method for diagnosing and treating ganglioglioma and related diseases
KR20190038464A (ko) * 2017-09-29 2019-04-08 (재)록원바이오융합연구재단 Ras/braf 돌연변이 검출용 조성물 및 이를 포함하는 키트
CN109161594A (zh) * 2018-08-17 2019-01-08 中山大学达安基因股份有限公司 一种检测braf基因突变的方法及其试剂盒
WO2022119423A1 (ko) * 2020-12-04 2022-06-09 주식회사 제노픽스 폐암 유전자 돌연변이 초고감도 선택적 증폭 방법 및 이를 위한 조성물

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101487051A (zh) * 2009-02-24 2009-07-22 广州益善生物技术有限公司 Braf基因突变的检测探针、液相芯片及其检测方法

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JP2004337120A (ja) * 2003-05-19 2004-12-02 Chang Gung Univ 膀胱癌再発検査方法
US7745125B2 (en) * 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization

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CN101487051A (zh) * 2009-02-24 2009-07-22 广州益善生物技术有限公司 Braf基因突变的检测探针、液相芯片及其检测方法

Non-Patent Citations (2)

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Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma;YANCOVITZ等;《Journal of Molecular Diagnostics》;20070430;第9卷(第2期);摘要、材料与方法 *
Real-time allele-specific amplification for sensitive detection of the BRAFmutation V600E;JARRY.A.等;《Materials and Method》;20041031;第18卷(第5期);第349-352页 *

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Publication number Publication date
KR20120099630A (ko) 2012-09-11
US20140248614A1 (en) 2014-09-04
CN102575295A (zh) 2012-07-11
NZ598166A (en) 2014-03-28
AU2010282632A1 (en) 2012-03-08
EP2464751B1 (en) 2017-05-24
WO2011019704A2 (en) 2011-02-17
HK1172931A1 (zh) 2013-05-03
IL218021A0 (en) 2012-04-30
TW201111517A (en) 2011-04-01
EP2464751A4 (en) 2013-07-03
AR077844A1 (es) 2011-09-28
WO2011019704A3 (en) 2011-07-07
EP2464751A2 (en) 2012-06-20
CA2770716A1 (en) 2011-02-17
JP2013501523A (ja) 2013-01-17

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