CN102575278B - 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 - Google Patents

果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 Download PDF

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CN102575278B
CN102575278B CN201080033796.0A CN201080033796A CN102575278B CN 102575278 B CN102575278 B CN 102575278B CN 201080033796 A CN201080033796 A CN 201080033796A CN 102575278 B CN102575278 B CN 102575278B
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fructosyl
oxidase
sample
electrode
peptidyl oxidase
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CN102575278A (zh
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K.索德
K.伊克布库罗
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201080033796.0A 2009-08-03 2010-08-02 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 Active CN102575278B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09009968A EP2281900A1 (en) 2009-08-03 2009-08-03 Fructosyl peptidyl oxidase and sensor for assaying a glycated protein
EP09009968.0 2009-08-03
PCT/EP2010/004707 WO2011015325A1 (en) 2009-08-03 2010-08-02 Fructosyl peptidyl oxidase and sensor for assaying a glycated protein

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CN102575278A CN102575278A (zh) 2012-07-11
CN102575278B true CN102575278B (zh) 2014-02-19

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US (2) US8721853B2 (https=)
EP (2) EP2281900A1 (https=)
JP (1) JP5870027B2 (https=)
CN (1) CN102575278B (https=)
ES (1) ES2524723T3 (https=)
WO (1) WO2011015325A1 (https=)

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WO2012018094A1 (ja) * 2010-08-06 2012-02-09 キッコーマン株式会社 基質特異性が改変されたアマドリアーゼ
JP6282115B2 (ja) 2011-12-28 2018-02-21 キッコーマン株式会社 熱安定性が向上したアマドリアーゼ、その遺伝子および組換えｄｎａならびに熱安定性が向上したアマドリアーゼの製造法
WO2013162035A1 (ja) 2012-04-27 2013-10-31 キッコーマン株式会社 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
JP2014102144A (ja) * 2012-11-20 2014-06-05 Nipro Corp 糖化ヘモグロビン測定キットおよび糖化ヘモグロビン測定方法
ES2848705T3 (es) 2013-08-09 2021-08-11 Kikkoman Corp Amadoriasa modificada y método para producirla, agente para mejorar la resistencia a tensioactivos de la amadoriasa y composición para medir la HbA1c usando la misma
CN105683390B (zh) 2013-10-25 2021-02-26 龟甲万株式会社 使用作用于糖基化肽的阿马多里酶的HbA1c测定方法
JP6542671B2 (ja) * 2013-10-25 2019-07-10 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
EP3786291B1 (en) 2014-10-24 2023-10-18 Kikkoman Corporation Amadoriase having enhanced dehydrogenase activity
WO2016072520A1 (ja) 2014-11-07 2016-05-12 キッコーマン株式会社 アニオン性界面活性剤耐性が向上したアマドリアーゼ
EP3279323B1 (en) 2015-04-03 2023-03-08 Kikkoman Corporation Amadoriase having improved specific activity
KR102596402B1 (ko) 2016-04-22 2023-10-31 기꼬만 가부시키가이샤 HbA1c 디히드로게나아제
WO2018012607A1 (ja) 2016-07-13 2018-01-18 キッコーマン株式会社 反応促進剤
TWI668229B (zh) 2016-12-13 2019-08-11 財團法人工業技術研究院 重組蛋白質及其製造方法與應用
JP7157063B2 (ja) 2017-08-31 2022-10-19 キッコーマン株式会社 糖化ヘモグロビンオキシダーゼ改変体及び測定方法
EP3887398A4 (en) * 2018-11-29 2022-10-19 Polymer Technology Systems, Inc. SYSTEMS AND METHODS FOR ELECTROCHEMICAL DETECTION OF HEMOGLOBIN AT THE POINT OF SUPPLY
CN113075143B (zh) * 2021-03-31 2023-01-03 奥研生物科技(南京)有限公司 一种糖化血红蛋白检测试剂及其检测方法

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Publication number Publication date
US20120202235A1 (en) 2012-08-09
CN102575278A (zh) 2012-07-11
JP5870027B2 (ja) 2016-02-24
US8721853B2 (en) 2014-05-13
US8962271B2 (en) 2015-02-24
EP2281900A1 (en) 2011-02-09
HK1172930A1 (en) 2013-05-03
WO2011015325A1 (en) 2011-02-10
EP2462239A1 (en) 2012-06-13
ES2524723T3 (es) 2014-12-11
US20140227728A1 (en) 2014-08-14
JP2013500728A (ja) 2013-01-10
EP2462239B1 (en) 2014-09-17

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