CN102575278B - 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 - Google Patents

果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 Download PDF

Info

Publication number
CN102575278B
CN102575278B CN201080033796.0A CN201080033796A CN102575278B CN 102575278 B CN102575278 B CN 102575278B CN 201080033796 A CN201080033796 A CN 201080033796A CN 102575278 B CN102575278 B CN 102575278B
Authority
CN
China
Prior art keywords
fructosyl
oxidase
sample
electrode
peptidyl oxidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080033796.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN102575278A (zh
Inventor
K.索德
K.伊克布库罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN102575278A publication Critical patent/CN102575278A/zh
Application granted granted Critical
Publication of CN102575278B publication Critical patent/CN102575278B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201080033796.0A 2009-08-03 2010-08-02 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器 Active CN102575278B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09009968A EP2281900A1 (en) 2009-08-03 2009-08-03 Fructosyl peptidyl oxidase and sensor for assaying a glycated protein
EP09009968.0 2009-08-03
PCT/EP2010/004707 WO2011015325A1 (en) 2009-08-03 2010-08-02 Fructosyl peptidyl oxidase and sensor for assaying a glycated protein

Publications (2)

Publication Number Publication Date
CN102575278A CN102575278A (zh) 2012-07-11
CN102575278B true CN102575278B (zh) 2014-02-19

Family

ID=41448516

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080033796.0A Active CN102575278B (zh) 2009-08-03 2010-08-02 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器

Country Status (6)

Country Link
US (2) US8721853B2 (https=)
EP (2) EP2281900A1 (https=)
JP (1) JP5870027B2 (https=)
CN (1) CN102575278B (https=)
ES (1) ES2524723T3 (https=)
WO (1) WO2011015325A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171338B (zh) 2008-10-10 2014-08-13 东洋纺织株式会社 具有果糖基缬氨酰基组氨酸氧化酶活性的蛋白质及其修饰产物以及其应用
WO2012018094A1 (ja) * 2010-08-06 2012-02-09 キッコーマン株式会社 基質特異性が改変されたアマドリアーゼ
US9708586B2 (en) 2010-08-06 2017-07-18 Kikkoman Corporation Amadoriase having altered substrate specificity
EP2808386B1 (en) 2011-12-28 2018-11-28 Kikkoman Corporation Amadoriase having improved thermal stability, gene and recombinant dna of same, and method for producing amadoriase having improved thermal stability
WO2013162035A1 (ja) 2012-04-27 2013-10-31 キッコーマン株式会社 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
JP2014102144A (ja) * 2012-11-20 2014-06-05 Nipro Corp 糖化ヘモグロビン測定キットおよび糖化ヘモグロビン測定方法
US10619183B2 (en) 2013-08-09 2020-04-14 Kikkoman Corporation Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same
EP3061829B1 (en) * 2013-10-25 2021-09-22 Kikkoman Corporation METHOD FOR MEASUREMENT OF HbA1c USING AMADORIASE THAT REACTS WITH GLYCATED PEPTIDE
JP6542671B2 (ja) * 2013-10-25 2019-07-10 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
CN107148475A (zh) 2014-10-24 2017-09-08 龟甲万株式会社 脱氢酶活性提高的阿马多里酶
US11198852B2 (en) 2014-11-07 2021-12-14 Kikkoman Corporation Amadoriase having enhanced anionic surfactant tolerance
US10934530B2 (en) 2015-04-03 2021-03-02 Kikkoman Corporation Amadoriase having improved specific activity
JP7471772B2 (ja) 2016-04-22 2024-04-22 キッコーマン株式会社 ＨｂＡ１ｃデヒドロゲナーゼ
WO2018012607A1 (ja) 2016-07-13 2018-01-18 キッコーマン株式会社 反応促進剤
US10533160B2 (en) 2016-12-13 2020-01-14 Industrial Technology Research Institute Recombinant protein, and preparation method and application thereof
WO2019045052A1 (ja) 2017-08-31 2019-03-07 キッコーマン株式会社 糖化ヘモグロビンオキシダーゼ改変体及び測定方法
US11693016B2 (en) * 2018-11-29 2023-07-04 Polymer Technology Systems, Inc. Systems and methods for electrochemical point-of-care detection of hemoglobin
CN113075143B (zh) * 2021-03-31 2023-01-03 奥研生物科技(南京)有限公司 一种糖化血红蛋白检测试剂及其检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291416A1 (en) * 2001-09-04 2003-03-12 Kikkoman Corporation Fructosyl peptide oxidase
CN1823166A (zh) * 2003-05-21 2006-08-23 旭化成制药株式会社 血红蛋白a1c的测定方法和用于此目的的酶及其生产方法
EP2020439A1 (en) * 2006-04-25 2009-02-04 Kikkoman Corporation Eukaryotic amadoriase having excellent thermal stability, gene and recombinant dna for the eukaryotic amadoriase, and process for production of eukaryotic amadoriase having excellent thermal stability

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826922A1 (de) 1988-08-09 1990-02-22 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen bestimmung eines analyten mittels enzymatischer oxidation
DE4003194A1 (de) * 1990-02-03 1991-08-08 Boehringer Mannheim Gmbh Verfahren und sensorelektrodensystem zur elektrochemischen bestimmung eines analyts oder einer oxidoreduktase sowie verwendung hierfuer geeigneter verbindungen
US5286362A (en) * 1990-02-03 1994-02-15 Boehringer Mannheim Gmbh Method and sensor electrode system for the electrochemical determination of an analyte or an oxidoreductase as well as the use of suitable compounds therefor
DE19521019A1 (de) 1995-06-13 1996-12-19 Boehringer Mannheim Gmbh Verfahren und Mittel zur gleichzeitigen kolorimetrischen und elektrochemischen Messung eines Analyten
DE19629656A1 (de) 1996-07-23 1998-01-29 Boehringer Mannheim Gmbh Diagnostischer Testträger mit mehrschichtigem Testfeld und Verfahren zur Bestimmung von Analyt mit dessen Hilfe
JP3842391B2 (ja) * 1997-08-05 2006-11-08 アークレイ株式会社 フルクトシルアミノ酸オキシダーゼをコードするｄｎａ
DE19753847A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit Kapillarkanal
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
JP3971702B2 (ja) 2000-07-14 2007-09-05 アークレイ株式会社 糖化ヘモグロビンの選択的測定方法
AU2003235973A1 (en) 2002-06-07 2003-12-22 Arkray, Inc. Method of assay by oxidation-reduction reaction with formazan
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
JP4227820B2 (ja) * 2003-03-12 2009-02-18 旭化成ファーマ株式会社 新規な酵素
TR201810169T4 (tr) * 2003-06-20 2018-08-27 Hoffmann La Roche Dar, homojen belirteç şeritlerinin üretilmesi için yöntem ve belirteç.
JP2005110657A (ja) 2003-09-18 2005-04-28 Kikkoman Corp α−糖化ジペプチドの製造法及びα−糖化ジペプチドの測定法
CN1957090A (zh) * 2004-03-17 2007-05-02 第一化学药品株式会社 糖蛋白的测定方法
JP2005261383A (ja) * 2004-03-22 2005-09-29 Asahi Kasei Pharma Kk キャリブレーション方法
JP4373260B2 (ja) 2004-03-29 2009-11-25 一則 片岡 高分子複合体
DE102004023662A1 (de) * 2004-05-06 2005-12-01 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Voltammetrischer Mikrofluidiksensor und Verfahren zum Nachweis von glykiertem Hämoglobin
JP4631028B2 (ja) * 2005-04-04 2011-02-16 独立行政法人産業技術総合研究所 バイオセンサー検出部
JP4889396B2 (ja) * 2005-07-27 2012-03-07 積水メディカル株式会社 ロイコ色素の安定化方法
WO2007072941A1 (ja) * 2005-12-22 2007-06-28 Kyowa Medex Co., Ltd. 糖化タンパク質の測定方法
WO2007094354A1 (ja) * 2006-02-14 2007-08-23 National Institute Of Advanced Industrial Science And Technology ヘモグロビンA1cセンサ
DE102006021401A1 (de) * 2006-05-08 2007-12-13 Henkel Kgaa Amadoriasen in Wasch- und Reinigungsmitteln
US9017536B2 (en) 2006-12-26 2015-04-28 Sekisui Chemical Co., Ltd. Hemoglobin measurement method and electrophoresis apparatus
JP4854651B2 (ja) * 2007-12-19 2012-01-18 積水化学工業株式会社 ヘモグロビン類の測定装置及びヘモグロビン類の測定方法
JP2008268197A (ja) * 2007-03-29 2008-11-06 Cci Corp タンパク質固定化膜、タンパク質の固定化方法およびバイオセンサ
CN101622532B (zh) 2007-04-27 2013-08-14 爱科来株式会社 分析芯片以及分析装置
JP5181576B2 (ja) * 2007-08-17 2013-04-10 ソニー株式会社 燃料電池の製造方法、燃料電池および電子機器
CN102171338B (zh) * 2008-10-10 2014-08-13 东洋纺织株式会社 具有果糖基缬氨酰基组氨酸氧化酶活性的蛋白质及其修饰产物以及其应用
JP5476021B2 (ja) * 2008-10-17 2014-04-23 東洋紡株式会社 フルクトシルアミノ酸オキシダーゼ改変体およびその利用
JP5465415B2 (ja) 2008-10-29 2014-04-09 東洋紡株式会社 フルクトシルアミノ酸測定用酵素、およびその利用法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291416A1 (en) * 2001-09-04 2003-03-12 Kikkoman Corporation Fructosyl peptide oxidase
CN1823166A (zh) * 2003-05-21 2006-08-23 旭化成制药株式会社 血红蛋白a1c的测定方法和用于此目的的酶及其生产方法
EP2020439A1 (en) * 2006-04-25 2009-02-04 Kikkoman Corporation Eukaryotic amadoriase having excellent thermal stability, gene and recombinant dna for the eukaryotic amadoriase, and process for production of eukaryotic amadoriase having excellent thermal stability

Also Published As

Publication number Publication date
JP2013500728A (ja) 2013-01-10
US20120202235A1 (en) 2012-08-09
JP5870027B2 (ja) 2016-02-24
US8962271B2 (en) 2015-02-24
HK1172930A1 (en) 2013-05-03
WO2011015325A1 (en) 2011-02-10
ES2524723T3 (es) 2014-12-11
US8721853B2 (en) 2014-05-13
EP2462239B1 (en) 2014-09-17
EP2462239A1 (en) 2012-06-13
EP2281900A1 (en) 2011-02-09
CN102575278A (zh) 2012-07-11
US20140227728A1 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
CN102575278B (zh) 果糖基肽基氧化酶和用于测定糖化蛋白质的传感器
CN102471763B (zh) 果糖基氨基酸氧化酶
US8673646B2 (en) Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
US8999140B2 (en) Glucose oxidase mutants, compositions, devices, kits and uses thereof
Kim et al. Construction of engineered fructosyl peptidyl oxidase for enzyme sensor applications under normal atmospheric conditions
EP2562250A1 (en) Glucose oxidase
EP3211079B1 (en) Amadoriase having enhanced dehydrogenase activity
EP3447132B1 (en) Hba1c dehydrogenase
WO2022072677A1 (en) Engineered stable lactate oxidoreductases, compositions, devices, kits and uses thereof
WO2020122231A1 (ja) エタノールアミンリン酸の定量方法、定量用のオキシドレダクターゼ、定量用組成物、定量用キット及び定量用センサー
HK1172930B (en) Fructosyl peptidyl oxidase and sensor for assaying a glycated protein
JP2001204494A (ja) 糖化ヘモグロビンの測定キット
TWI867923B (zh) 乳酸氧化酶變異體及其在乳酸檢測的用途
JP5036550B2 (ja) フルクトシルアミン酸化酵素
HK1171049B (en) Fructosyl amino acid oxidase

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1172930

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1172930

Country of ref document: HK