CN102438672A - 分离血液成分的一体式装置 - Google Patents
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Abstract
一种分离装置,包括第一浮体(20)、第二浮体(22)、第一阀(65)和第二阀(67)。第一浮体被安装到浮体导柱(18)并被可滑动地安装在分离腔(12)内。第二浮体被可滑动地安装到导柱并能够在第一位置和第二位置之间移动。第二浮体(22)在第一位置时关闭第一阀(65)而打开第二阀(67)。第二浮体在第二位置时打开第一阀而关闭第二阀。第二浮体的密度使得在使装置旋转合适的时间后,混合物的第一成分被隔离在第一浮体和第二浮体之间而混合物的第二成分被隔离在第二浮体和分离腔的与通口相对的端部之间。
Description
技术领域
本公开涉及无菌装置、系统,以及用于分离诸如血液的混合物的成分的方法。
背景技术
此部分的中的叙述仅提供与本公开相关的背景信息而不会构成现有技术。
全血包括各种不同的成分或者部分。例如,人类全血包括富血小板血浆(PRP)、贫血小板血浆(PPP)、红血球(RBCs),以及白血球(WBCs)。这些不同的血液成分具有多种临床和实验用途。常规的血液分离装置必须用单独的注射器装载,该单独的注射器装有从诸如患者的血管的源头抽出的全血。然后,分离装置被离心,并且不同的注射器被用以从装置中抽出所分离的成分以输送到希望的区域。用单独的注射器来装载和卸载分离装置是麻烦、费时且不经济的。另外,每次转移血液就增大污染的可能性。
因而,需要一种一体式分离装置,以及使用方法,该一体式分离装置可以用于从诸如患者的源头直接抽出血液,并可以被离心以根据密度分离全血的不同成分,并且该一体式分离装置可以用于将选择的成分施放在希望的区域。
发明内容
本教导提供一种具有用于根据密度分离混合物的成分的分离腔的装置。该装置包括通口、浮体导柱、第一浮体、第二浮体、通路、第一阀以及第二阀。通口提供分离腔的内部和外部之间的流体连通。第一浮体被固定地安装到浮体导柱并且被可滑动地安装在分离腔内。第二浮体被可滑动地安装到浮体导柱并且能够沿着浮体导柱在第一位置和第二位置之间移动。通路被限定在浮体导柱内,并且与通口流体连通。浮体导柱内的第一阀与通路以及分离腔的介于第一浮体和第二浮体之间的区域流体连通。浮体导柱内的第二阀与通路以及分离腔的介于第二浮体和分离腔的与通口相对的端部之间的区域流体连通。第二浮体在第一位置时关闭第一阀而打开第二阀。第二浮体在第二位置时打开第一阀而关闭第二阀。第二浮体的密度使得在使装置被旋转合适的时间后,混合物的第一成分被隔离在第一浮体和第二浮体之间,而混合物的第二成分被隔离在第二浮体和分离腔的与通口相对的端部之间。
本教导还提供一种用于将全血分离成不同成分的方法。该方法包括以下步骤:通过分离腔的通口将全血直接从患者抽入分离腔,分离腔具有被固定地安装到浮体导柱的第一浮体和被可滑动地安装到浮体导柱的第二浮体,浮体导柱具有第一阀和第二阀,当第二浮体在第一位置时,第一阀关闭而第二阀打开,全血被通过第二阀抽入分离腔,进入介于第二浮体和被可滑动地安装在分离腔中的柱塞之间的区域;使腔在离心机中转动足够的时间,使得第二浮体移动到第二位置,其中第二浮体与第一浮体间隔开以关闭第二阀而打开第一阀,并且根据密度分离全血的成分,使得红血球在通口和第一浮体之间,富血小板血浆在第一浮体和第二浮体之间,而贫血小板血浆在第二浮体和柱塞之间;将柱塞压到分离腔内的第一距离,以使第一浮体从第二位置移动到第一位置以迫使富血小板血浆通过第一阀并通过通口到达分离腔之外,以关闭第一阀而打开第二阀;通过附连到通口的施放器将富血小板血浆直接施放到所关注区域;将柱塞进一步压到分离腔内的大于第一距离的第二距离,以迫使贫血小板血浆通过第二阀并通过通口到达分离腔之外;以及通过附连到通口的施放器将贫血小板血浆直接施放到所关注区域。
本教导还提供一种用于将骨髓抽取物分离成不同成分的方法。该方法包括:通过分离腔的通口将骨髓抽取物直接从患者抽入分离腔,分离腔具有固定地安装到浮体导柱的第一浮体和可滑动地安装到导柱的第二浮体,浮体导柱具有第一阀和第二阀,当第二浮体在第一位置时,第一阀关闭而第二阀打开,骨髓抽取物被通过第二阀抽入分离腔,进入介于第二浮体和可滑动地安装在分离腔中的柱塞之间的区域;使腔在离心机中转动足够的时间,使得第二浮体移动到第二位置,其中第二浮体与第一浮体间隔开,以关闭第二阀而打开第一阀,并且根据密度分离骨髓抽取物的成分,使得红血球在通口和第一浮体之间,多能细胞在第一浮体和第二浮体之间,而骨髓浆在第二浮体和柱塞之间;将柱塞压到分离腔内的第一距离以使第一浮体从第二位置移动到第一位置以迫使多能细胞通过第一阀并通过通口到达分离腔之外,以关闭第一阀而打开第二阀;通过附连到通口的施放器将多能细胞直接施放到所关注区域;将柱塞进一步压到分离腔内的大于第一距离的第二距离,以迫使骨髓浆通过第二阀并通过通口到达分离腔之外;以及通过附连到通口的施放器将骨髓浆直接施放到所关注区域。
本教导还提供一种具有用于根据密度分离混合物的成分的分离腔的装置,包括通口、第一浮体、以及第二浮体。通口提供分离腔的外部与内部之间的流体连通。第一浮体被可滑动地安装在分离腔内。第二浮体被可滑动地安装在分离腔内。第二浮体的密度使得在使装置旋转合适的时间后混合物的第一成分被隔离在第一浮体和第二浮体之间,而混合物的第二成分被隔离在第二浮体和分离腔的与通口相对的端部之间。
本教导还提供一种用于将全血分离为不同成分的方法。该方法包括:通过通口将全血直接从患者抽入分离腔,分离腔具有被可滑动地安装在分离腔中的第一浮体和被可滑动地安装在分离腔中的第二浮体,全血被抽入分离腔中,进入介于第二浮体和被可滑动地安装在分离腔中的柱塞之间的区域;使腔在离心机中转动足够的时间,使得第二浮体移动到第二位置,其中第二浮体与第一浮体间隔开,并且根据密度分离全血的成分,使得红血球在通口和第一浮体之间,富血小板血浆在第一浮体和第二浮体之间,而贫血小板血浆在第二浮体和柱塞之间;将柱塞压到分离腔内的第一距离,以使第一浮体从第二位置移动到第一位置,以迫使富血小板血浆通过通口到达分离腔之外;通过附连到通口的施放器将富血小板血浆直接施放到所关注区域;将柱塞进一步压到分离腔内的大于第一距离的第二距离,以迫使贫血小板血浆通过通口到达分离腔之外;以及通过附连到通口的施放器将贫血小板血浆直接施放到所关注区域。
根据本文所提供的描述,另外的适用范围将变得明显。应该理解,描述和具体示例仅意在起到说明作用而并非意在限制本公开的范围。
附图说明
本文中描述的图仅为了说明目的而并非意在以任何方式限制本公开的范围。
图1A是根据本教导的、用于分离多成分混合物的成分的装置的透视图;
图1B是图1A的装置的柱塞的分解图;
图2A是图1A的装置的沿图1A的线2A-2A截取的透视截面图;
图2B是图1A的装置的截面图;
图3A是图1A的装置的浮体导柱的截面图;
图3B是图3A的浮体导柱的分解透视图;
图3C是可以用于图1A的装置的另外的浮体导柱的分解透视图;
图4是图1A的装置的截面图,该装置已装有全血并被旋转合适的时间以根据密度分离全血的不同成分,贫血小板血浆在第二浮体和柱塞基部之间,富血小板血浆在第二浮体和第一浮体之间,而红血球在第一浮体和入口/出口之间;
图4A是如在图4中示出的装置的顶部透视图,其中柱塞基部通过锁定片(locking tab)紧固在装置的末端处;
图5是图1A的装置的截面图,其示出柱塞正在被致动以将富血小板血浆从装置中排出;以及
图6是图1A的装置的截面图,其示出柱塞正在被进一步致动以将贫血小板血浆从装置中排出。
具体实施方式
以下描述实质上仅为示例性的且并非意在限制本公开、应用或者使用。
首先参照图1A、1B、2A和2B,以附图标记10示出根据本教导的用于分离多成分混合物的成分的装置。装置10是一体式装置,该一体式装置可以用于从诸如患者的源头直接抽取多成分混合物,并且可以被离心以根据密度分离混合物的不同成分,并且该一体式装置可以用于将混合物的所选择的成分直接施放在希望的区域,诸如受伤部位。
装置10大体上包括:分离腔12;通口14,用于将多成分混合物抽入到分离腔12中以及用于从分离腔12分发所分离的成分;柱塞16;以及浮体导柱18,其上安装有第一浮体20和第二浮体22。
分离腔12可以为具有任意合适的尺寸或形状的任意合适的容器的形式。例如在所有图中所示出的,分离腔12可以为圆柱形并可以形成注射器的本体。分离腔12包括纵轴A。
柱塞16可滑动地安装在分离腔12内。具体地,柱塞16包括柱塞基部24和柱塞柄部26。柱塞基部24座置在分离腔12内,而柱塞柄部26从柱塞基部24以及从分离腔12延伸。
柱塞柄部26可以以任意合适的方式可拆卸地附连在基部24上。例如在图1B中示出的,柱塞基部24可以包括从基部24的上表面延伸的两个相对的锁定凸缘27。柱塞柄部26可以包括锁定片29,一旦将锁定片29放置在凸缘27之间并将柱塞柄部26转动90°以使得锁定片29位于凸缘27的下方并在凸缘27和基部24的其余部分之间时,则锁定片29与凸缘27配合。柱塞16便于通过在分离腔12中产生真空来将多成分混合物吸入分离腔12,以及便于将所分离的成分从分离器12分发出去,如在本文中进一步描述的。注射器手柄23从分离腔12的外表面延伸以便于操作和处理装置10。
待分离的多成分混合物通过通口14被抽入分离腔12中以及从分离腔12分发。通口14可以为允许待分离的多成分混合物通过的任何合适的贯通通口,其中待分离的多成分混合物诸如为全血。例如,通口14可以包括鲁尔锁(Luerlock)15。通口14可以与各种装置相配合,例如延伸管口21(图1)。
延伸管口21可以为任意合适的连接器,诸如所示出的鲁尔延伸部。管口21包括第一端处的第一鲁尔锁连接器31和第二端处的第二鲁尔锁连接器33。第一鲁尔锁31与通口14的鲁尔锁15相配合。第二鲁尔锁33与针头25(图1)或者喷头(未示出)相配合。第二鲁尔锁33可以为在针头25被取下时关闭的鲁尔驱动型阀。如此处进一步地描述的,管口21便于在保持装置10无菌的同时将通口14用作抽入口和排出口。
针头25用于将混合物抽入分离腔12中。针头25和喷头便于将混合物的各种成分施放在诸如受伤部位的输送部位。
另外参照图3A和3B,浮体导柱18包括第一端28和与第一端28相对的第二端30。浮体导柱18具有大体上为圆柱体的形状。导柱18限定中央通路或通道32。通道32从第一端28沿着导柱18的纵轴B延伸。如所示出的,通道32从第一端28延伸并在刚要到达第二端30之前终止。
另外参照图3C,以附图标记18′示出根据本教导的另外的浮体导柱。浮体导柱18′的也包括在导柱18中的特征用相同的附图标记标示,但包括撇(′)符号。本文中提出的关于导柱18的一般特征的描述也适用于导柱18′。导柱18和导柱18′之间的主要差异在于通道32′延伸至第二端30′以提供从第一端28′到第二端30′完全延伸通过浮体导柱18′的管道。
导柱18还包括至少一个第一孔34和至少一个第二孔36。第一孔34接近于第一端28而第二孔36接近于第二端30。如所示出的,导柱18包括两个第一孔34和两个第二孔36。两个第一孔34和两个第二孔36关于导柱18的外部圆周以180°间隔进行定位。第一孔34中的每一个的开口和第二孔36中的每一个的开口分别位于环形凹部37A和37B中。
第一孔34和第二孔36各自在通道32和分离腔12之间提供流体连通。如在图3C中示出的,导柱18′包括在第二端30′处的第三孔39。第三孔39便于通道32′和分离腔12′之间的流体连通。
在第二孔36的相对侧并且靠近第二孔36,为导柱18内的环形凹部38A和38B。环形凹部38A和38B各自分别容纳O形环40A和40B。如此处进一步描述的,O形环40A和40B便于第二浮体22沿着浮体导柱18的纵轴B在第一端28和第二端30之间移动并限制混合物流过O形环40A和40B。O形环40A和40B可以由诸如聚合材料的任意合适的材料制成。浮体导柱18位于分离腔12内使得导柱18的纵轴B沿着分离腔12的纵轴A延伸。
第一浮体20通常被成形为如直圆柱。另外参照图4,第一浮体20包括下表面或第一表面42和与下表面42相对的上表面或第二表面44。圆形侧壁46在下表面42的外部圆周和上表面44的外部圆周之间延伸。上表面44具有半球形状并相对于第一浮体20的其余部分凹入。下表面42具有半球形状并相对于第一浮体20的其余部分凸出。
通孔48延伸过第一浮体20的轴向中心。浮体导柱18位于通孔48中并以任意合适的方式,诸如以示出的通过压入配合或者用合适的粘合剂,固定地安装到通孔48。浮体导柱18被安装到第一浮体20,使得导柱18的第一端28座置在第一浮体20内靠近下表面42,其中第一孔34在上表面44处。具体地,导柱18被定位成使得第一孔34的大部分凹入第一浮体20的通孔48内,其中仅第一孔34的小部分在第一浮体20的中央处略高于上表面44。另外,由于第一孔34被定位在凹部37A内,因此第一孔34与第一浮体20间隔开。因此,在第一孔34和第二浮体22之间有微小的间隙,多成分混合物可以穿过该微小的间隙以提供第一孔和位于第一浮体20与第二浮体22之间的区域间的流体连通。由于上表面44是凹形的,第一孔34在完全跨越上表面44延伸且垂直于侧壁46的平面的下方凹入并且不穿过该平面。
第一浮体20位于分离腔12中,使得下表面42面向通口14且上表面44面向柱塞16。第一浮体20的圆形侧壁46面向分离腔12的内部侧壁50。当装置10没有转动或者旋转时,侧壁46接触分离腔12的内部侧壁50以限制正在被分离的多成分混合物在侧壁46和内部侧壁50之间通过。
第二浮体22大体上被成形为直圆锥。第二浮体22包括下表面或第一表面52以及与下表面52相对的上表面或第二表面54。圆柱形侧壁56在下表面52和上表面54之间延伸并且围绕第二浮体22的外围。上表面54朝着侧壁56向下倾斜。下表面52具有半球形状并相对于第二浮体22的其余部分凸出。侧壁56包括围绕侧壁56延伸的环形凹部58。环形凹部58容纳围绕第二浮体22的圆柱形侧壁56延伸的O形环60。当装置10没有转动或者旋转时,侧壁56接触分离腔12的内部侧壁50以限制正在被分离的多成分混合物在侧壁56和内部侧壁50之间通过。O形环60可以由任何合适的材料制成,该合适的材料便于第二浮体22在分离腔12内移动并限制混合物在侧壁56和内部侧壁50之间通过。例如,O形环60可以由合适的聚合材料制成。
通孔62延伸通过第二浮体22的中央。浮体导柱18位于通孔62内。第二浮体22可滑动地安装到导柱18以允许第二浮体22沿着分离腔12的纵轴A和通孔48的纵轴B可滑动地移动。第二浮体22座置在O形环40A和40B上,其便于第二浮体22移动并限制多成分混合物流过O形环40A和40B。由于O形环40A和40B的存在,第二浮体22与浮体导柱18的外表面41略微地间隔开。
第二浮体22可以在第二浮体22接触第一浮体20的第一位置(图2A和2B)和第二浮体22与第一浮体20间隔开的第二位置(图4)之间可滑动地移动。在第一位置中,第二浮体22的下表面52与第一浮体20的上表面44齐平,以限制多成分混合物通过第一孔34并进入分离腔12中。当第二浮体22在第一位置时,在第二孔36和分离腔12之间有通路,以提供导柱18的通道32与分离腔12的在第二浮体22和柱塞16之间的部分间的流体连通。由于第二孔36和O形环40B两者与第二浮体22之间的间隙,提供通路。
在第二位置,第二浮体22与第一浮体20间隔开并靠近导柱18的第二端30。导柱18包括第二端30处的环形突出部64(图3A)以防止第二浮体22从导柱18滑落。由于第二浮体22与第一浮体20间隔开,第一孔34与第一浮体20之间的间隙允许在导柱18的通道32与分离腔12的在第一浮体20和第二浮体22之间的部分间的流体连通。在第二位置中,第二浮体22与O形环配合,以阻塞第二孔36与分离腔12之间的通路并限制第二孔36与分离腔12的在第二浮体22之上的区域间的流体连通。
因而,第一孔34提供分离腔12与浮体导柱18的通道32之间的第一阀65,第二孔36提供分离腔12与浮体导柱18的通道32之间的第二阀67,浮体导柱18的通道32最终与通口14流体连通。由第二浮体22的位置控制混合物通过第一孔34和第二孔36的流通。当第二浮体22在第一位置时,第二浮体22不阻塞混合物流过第二孔36,因而打开通道32与分离腔12的在第二浮体22之上的区域之间的第二阀67。在第一位置中,第二浮体22限制混合物流过第一孔34并进入分离腔12,因而关闭在通道32与分离腔12的在第一浮体20和第二浮体22之间的区域间的第一阀65。
当第二浮体22在第二位置时,第二浮体阻塞混合物流过第二孔36,因而关闭在通道32与分离腔12的在第二浮体22之上的区域之间的第二阀67。在第二位置中,第二浮体22未限制混合物通过第一孔34,从而打开在通道32与分离腔12的在第一浮体20和第二浮体22之间的区域间的第一阀65。
第一浮体20和第二浮体22可以由任意合适的材料制成,该合适的材料允许第一浮体20和第二浮体22在装置10在离心机中转动或者旋转适当的时间时在分离腔12中移动,并稳定在待隔离的多成分混合物的不同成分之间。例如,当装置10用于分离全血的成分时,浮体20和22可以由任何合适的高密度聚乙烯材料(HDPE)制成。由HDPE制成的浮体20和22将具有允许全血分离的密度,使得:红血球(RBC)在通口14和第一浮体20之间;当第二浮体22在第二位置时,富血小板血浆、白膜层或富细胞成分(统称“PRP”)在第一浮体20和第二浮体22之间;并且贫血小板血浆(PPP)在第二浮体22和柱塞基部24之间。
第一浮体20被设置成具有大于第二浮体22的密度。具体地,第一浮体20可以具有在大约1.070g/ml和大约1.095g/ml之间的密度,诸如1.075g/ml。第二浮体22可以具有在大约0.93g/ml和大约0.95g/ml之间的密度,诸如0.945g/ml。包括第一浮体20、第二浮体22和浮体导柱18的组件可以具有在大约1.02g/ml和大约1.09g/ml之间的整体密度,诸如1.045g/ml。
第一连接器66被安装在第一浮体20的下表面42处。第一连接器66与通道32流体连通并延伸超过第一浮体20的下表面42。第二连接器68被安装在通口14上。第二连接器68从通口14延伸到分离腔12内。软管或导管70连接到第一连接器66和第二连接器68,以提供通口14和浮体导柱18之间的流体连通。
装置10可以用于根据密度将任意液体混合物的大部分分离成其组成成分。特别参照图2和图4至图6,以下描述操作装置10从全血中分离RBC、PPP和PRP的步骤。
在第一浮体20接近于通口14并且第二浮体22在第一位置的情况下,全血被装入装置10的分离腔12中,如在图2A和2B中示出的。在第一位置中,第二浮体22与第一浮体20接触以阻塞血液通过第一孔34进入分离腔12,从而关闭由第一孔34限定的第一阀65,并允许血液通过第二孔36进入分离腔12,从而打开由第二孔36限定的第二阀67。在装填之前,柱塞16被定位成使得柱塞基部24座置在分离腔12中的深处,并远离分离腔12的与通口14相对的端部72(图1)。
在延伸管口21的第一鲁尔锁31耦合到通口14的鲁尔锁15且针头25耦合到延伸管口21的第二鲁尔锁33的情况下,针头25插入全血的源头,诸如患者的血管。然后,柱塞16被向外拉以使柱塞基部24朝着腔12的端部72移动。如图2B所示,拉拔柱塞16在分离腔12中产生真空,真空抽吸全血通过通口14、管70、导柱18的通道32、第二孔36并进入到第二浮体22和柱塞基部24之间的分离腔12中。
可以抽取任意合适量的全血,诸如30ml或者60ml。分离腔的大小根据待分离的全血的量而变化。例如,如果要分离30ml的全血,则分离腔12的尺寸可以设定为以容纳大约51ml的流体。如果要分离60ml的全血,则分离腔12的尺寸可以设定为以容纳大约94ml的流体。第一浮体20和第二浮体22的直径可以改变,以配合不同直径的腔12。浮体20和22的密度可以保持相同,而与第一浮体和第二浮体的直径无关。
在血液被装入分离腔12后,通过使柱塞柄部26转动90°使得锁定片29不再啮合凸缘27,柱塞柄部26可以从柱塞基部24去除,并且可以从管口21的第二鲁尔锁连接器33上去除针头25。如果鲁尔锁连接器33为鲁尔阀,则其将在去除针头25时关闭。也可以用适当的无菌盖74(图4)关闭鲁尔锁连接器33。
为了防止在装置10旋转时柱塞基部24移动并施加压力于腔12中的全血,柱塞基部24的密度可以被设置成小于血液的密度。合适的锁定装置也可以用于紧固柱塞基部24。例如并如图4和图4A所示,在柱塞基部24大体上被定为成与注射器手柄23共面的情况下,锁定片76可以被插入锁定凸缘27的下方,使得锁定片76靠在注射器手柄23上并限制柱塞基部24的移动。
在全血座置在第二浮体22和柱塞基部24之间的情况下,装置10准备好进行旋转以根据密度分离全血的成分。使用诸如离心机的合适的旋转装置使装置10旋转。
装置10可以旋转任意合适的时间以分离血液的不同成分。例如,装置10可以以大约3200rpm旋转大约12至大约15分钟。当装置10旋转时,分离腔12的内部侧壁50从分离腔12的纵轴A向外弯曲或膨胀,以在第一浮体20的侧壁46和内部侧壁50之间以及在第二浮体22的侧壁56和内部侧壁50之间提供间隙,以允许第一浮体20和第二浮体22在分离腔12内移动并允许全血移动通过第一浮体20和第二浮体22。
当装置10转动时,不同的血液成分根据密度分离。另外,第一浮体20和第二浮体22沿着分离腔12的纵轴A可滑动地移动,直到各浮体到达浮体20和浮体22中的每一个的密度与周围血液成分的密度接近或者匹配的位置。具体地并如图4所示,第一浮体20离开通口14移动到在RBC和PRP之间的位置。第二浮体22移动到第二位置,使得第二浮体22与第一浮体20间隔开,使PRP在第一浮体20和第二浮体22之间。PPP稳定在第二浮体22和柱塞基部24之间。在第二位置中,第二浮体22打开分离腔12和通道32之间的由第一孔34限定的第一阀65而关闭由第二孔36限定的第二阀67。
为了从分离腔12提取不同的血液成分,装置10被从转动装置去除,柱塞柄部26重新附连到柱塞基部24,延伸管口21被去除,并且诸如喷头或者新的无菌针头25A的合适的施放器被直接耦接到通口14的鲁尔锁15。因而,通口14既是吸入口又是排出口。
为了保持通口14无菌,装置装配有附连到通口14的延伸管口21。通口14与环境隔离直到离心后将延伸管口21去除时。因而,通口14仅暴露于环境一次,这提高了通口14的无菌性。
如图5所示,柱塞16被推入分离腔12以对PPP和第二浮体22施加压力。第二浮体22被朝着第一浮体20推回并被推到第一位置。O形环60的存在避免了在由柱塞16施加压力于PPP时PPP围绕第二浮体22流通。O形环60还利于第二浮体22响应于柱塞16的制动而移动。
当在第二浮体22和第一浮体20之间的间隙关闭时,第一浮体20和第二浮体22之间的PRP被迫使通过由第一孔34限定的第一阀65。PRP通过第一孔34、通道32和软管70以移动至通口14。PRP从通口14处通过针头25A从装置10中排出至希望的区域。
被隔离的PRP可以用于一般的伤口愈合以及便于大多数的外科手术的完成。更具体地,PRP可以用于治疗骨折、骨不连接(non-union)、骨质缺损、肌腱炎和足底筋膜炎。PRP还可以结合全关节置换术、胃旁路术和骨移植手术使用。
在第二浮体22在第一位置的情况下,由导柱18中的第二孔36限定的第二阀67打开。如图6中所示,由柱塞16施加的持续的压力使第二浮体22和柱塞基部24之间的PPP穿过第二孔36。PPP通过第二孔36、通道32和软管70移动至通口14。PPP从装置10通过附连在通口14上的任何合适的施放器从通口14排出并施放到希望的区域。
PPP可以用于各种合适的目的,诸如促进伤口闭合。PPP也可以用作血纤蛋白粘合剂、血纤蛋白粘合胶以及用于面部重建。
通常不从分离装置10提取RBC。然而,本领域的技术人员将会理解,装置10可以设置有在通口14和第一浮体20之间的第三阀,可以通过该第三阀从装置10提取RBC。
因而,装置10提供一体式血液分离装置。装置10可以被放进无菌包中的无菌区。在装置10处于无菌区中并从无菌包中移除后,装置10可以如以上描述的被无菌人员用于从诸如患者血管的源头直接抽取血液,在离心期间分离RBC、PPP和PRP血液成分,并且将成分直接输送到受伤部位以促进愈合。装置10省去了用单独的注射器或者其它装置从患者身上抽取全血,将抽取的血液转移到适于离心的装置中,并将分离出的血液成分施放在受伤部位的必要。因此,装置10还消除了在不同注射器或者装置之间转移期间或者从无菌区到有菌区转移期间被污染的任何可能性。
装置10还可以用于分离骨髓抽取物的成分。例如,可以使用任何合适的骨髓抽取装置获取骨髓抽取物,骨髓抽取装置诸如是在2008年9月15日提交并授予Biomet Biologics,LLC的标题为骨髓抽取针的美国专利申请No.12/210,372中描述的装置,该申请通过引用并入到本文中。具体地,装置10可以通过鲁尔锁15和内部抽取针的鲁尔锁之间的配合直接附连到美国专利申请No.12/210,372中描述的内部抽取针上。
为了获取骨髓抽取物以进行分离,包括内部抽取针的骨髓抽取装置被推入到骨皮层中并最终到骨髓腔中,从骨髓腔中抽取骨髓抽取物。骨髓抽取物以与如以上描述的将全血抽入到装置10中的方式同样的方式被抽入到装置10中。可以使用任意合适的量的骨髓抽取物,诸如大约300cc、大约60cc、或者少于60cc。在将骨髓抽取物从骨髓腔中提取出之后,将适当量的合适的抗凝剂添加到骨髓抽取物中。
装置10以与如上关于全血的分离描述的方式同样的方式被离心。离心使骨髓抽取物分离,使得骨髓浆被隔离在第二浮体22和柱塞基部24之间。骨髓抽取物的重质成分,诸如RBC,被隔离在第一浮体20和通口14之间。多能细胞在当第二浮体22处于第二位置时形成在第一浮体20和第二浮体22之间的间隙中被隔离在第一浮体20和第二浮体22之间。可以以与上面关于PRP和PPP所述的方式同样的方式从装置10中去除多能细胞和骨髓浆。
当使用装置10从骨髓抽取物中隔离多能细胞时,第一浮体20被设置成具有大于第二浮体22的密度。当装置10用于分离骨髓抽取物的成分时第一浮体20的密度和第二浮体22的密度与装置10用于分离全血时浮体20和浮体22的密度大体上相同。
装置10可以用于根据密度将大部分液体混合物隔离成其组成成分。为了采用装置10分离不同成分,第一浮体20和第二浮体22的密度可以改变以接近待隔离的具体成分的密度。从而,待隔离的第一成分和第二成分将通过第二浮体22分离,使得第一成分被隔离在第一浮体20和第二浮体22之间而第二成分被隔离在第二浮体22和柱塞基部24之间。
本发明的描述实质上仅为示例性的,因此,没有脱离本发明的要点的变化意在处于本发明的范围内。这样的变化不被认为脱离本发明的精神和范围。
Claims (33)
1.一种具有用于根据密度分离混合物的成分的分离腔的装置,包括:
通口,其提供所述分离腔的内部和外部之间的流体连通;
浮体导柱;
第一浮体,其被固定地安装到所述浮体导柱并且被可滑动地安装在所述分离腔内;
第二浮体,其被可滑动地安装到所述浮体导柱并且能够沿着所述浮体导柱在第一位置和第二位置之间移动;
在所述浮体导柱内限定的通路,其与所述通口流体连通;
所述浮体导柱内的第一阀,其与所述通路以及所述分离腔的介于所述第一浮体和所述第二浮体之间的区域流体连通;
所述浮体导柱内的第二阀,其与所述通路以及所述分离腔的介于所述第二浮体和所述分离腔的与所述通口相对的端部之间的区域流体连通;
其中,所述第二浮体在处于所述第一位置时关闭所述第一阀而打开所述第二阀;并且
其中,所述第二浮体在处于所述第二位置时打开所述第一阀而关闭所述第二阀;并且
其中,所述第二浮体的密度使得在使所述装置被旋转合适的时间后,所述混合物的第一成分被隔离在所述第一浮体和所述第二浮体之间,而所述混合物的第二成分被隔离在所述第二浮体和所述分离腔的与所述通口相对的所述端部之间。
2.根据权利要求1所述的装置,其中,所述通口提供通向所述分离腔的通道,用于将所述混合物置入所述分离腔以及从所述分离腔提取所分离的成分。
3.根据权利要求1所述的装置,还包括能够在所述分离腔内可滑动地移动的柱塞,所述柱塞包括可拆卸地附连到柱塞柄部的柱塞基部。
4.根据权利要求3所述的装置,还包括柱塞止挡件,其限制所述柱塞的移动。
5.根据权利要求1所述的装置,其中,所述第一浮体的密度介于大约1.070g/ml和大约1.095g/ml之间。
6.根据权利要求1所述的装置,其中,所述第一浮体的密度大于所述第二浮体的密度。
7.根据权利要求1所述的装置,其中,所述第二浮体的密度介于大约0.93g/ml和大约0.955g/ml之间。
8.根据权利要求1所述的装置,其中,所述第一浮体具有面向所述第二浮体的顶部表面,所述顶部表面是凹的;并且
其中,所述第一浮体具有与所述顶部表面相对的底部表面,所述底部表面是凸的。
9.根据权利要求1所述的装置,其中,所述装置包括注射器。
10.根据权利要求9所述的装置,其中,所述注射器通过延伸管口连接到所述通口。
11.根据权利要求9所述的装置,其中,所述注射器直接连接到所述通口。
12.根据权利要求1所述的装置,其中,所述混合物包括以下之一:全血、血浆、单核细胞、骨髓抽取物、脊髓液和脂肪。
13.根据权利要求1所述的装置,其中,所述第一浮体和所述第二浮体具有允许以下隔离的密度:富血小板血浆在所述第一浮体和所述第二浮体之间;红血球在所述第一浮体的与所述第二浮体相对的一侧;并且贫血小板血浆在所述第二浮体的与所述第一浮体相对的一侧。
14.根据权利要求1所述的装置,其中,所述第一浮体和所述第二浮体具有允许以下隔离的密度:多能细胞在所述第一浮体和所述第二浮体之间;红血球在所述第一浮体的与所述第二浮体相对的一侧;并且骨髓浆在所述第二浮体的与所述第一浮体相对的一侧。
15.根据权利要求1所述的装置,还包括软管,其将所述浮体导柱的所述通路连接到所述通口。
16.根据权利要求1所述的装置,还包括聚合物环,其围绕所述第二浮体的圆柱形侧壁延伸。
17.根据权利要求1所述的装置,还包括第一聚合物环和第二聚合物环,其各自围绕所述浮体导柱的外径延伸,所述第一聚合物环和所述第二聚合物环被定位在所述第二阀的相对侧。
18.一种用于将全血分离成不同成分的方法,包括:
通过分离腔的通口将所述全血直接从患者抽入所述分离腔,所述分离腔具有被固定地安装到浮体导柱的第一浮体和被可滑动地安装到所述浮体导柱的第二浮体,所述浮体导柱具有第一阀和第二阀,当所述第二浮体在第一位置时,所述第一阀关闭而所述第二阀打开,所述全血通过所述第二阀被抽入所述分离腔,进入介于所述第二浮体和被可滑动地安装在所述分离腔中的柱塞之间的区域;
使所述腔在离心机中转动足够的时间,使得所述第二浮体移动到第二位置,其中所述第二浮体与所述第一浮体间隔开以关闭所述第二阀而打开所述第一阀,并且根据密度分离所述全血的所述成分,使得红血球在所述通口和所述第一浮体之间,富血小板血浆在所述第一浮体和所述第二浮体之间,而贫血小板血浆在所述第二浮体和所述柱塞之间;
将所述柱塞压到所述分离腔内的第一距离,以使所述第一浮体从所述第二位置移动到所述第一位置以迫使所述富血小板血浆通过所述第一阀并通过所述通口到达所述分离腔之外,以关闭所述第一阀而打开所述第二阀;
通过附连到所述通口的施放器将所述富血小板血浆直接施放到所关注区域;
将所述柱塞进一步压到所述分离腔内的大于所述第一距离的第二距离,以迫使所述贫血小板血浆通过所述第二阀并通过所述通口到达所述分离腔之外;以及
通过附连到所述通口的施放器将所述贫血小板血浆直接施放到所关注区域。
19.根据权利要求18所述的方法,其中,使用通过延伸管口连接到所述通口的针头将所述全血通过所述通口抽入所述分离腔。
20.根据权利要求18所述的方法,其中,通过直接附连到所述通口的施放器来施放所述贫血小板血浆。
21.根据权利要求18所述的方法,还包括将所述全血抽入包括所述分离腔的注射器。
22.根据权利要求18所述的方法,还包括使所述分离腔转动,使得所述第一浮体和所述第二浮体沿着所述分离腔的纵轴移动。
23.根据权利要求18所述的方法,还包括在使所述分离腔在所述离心机中转动之前将柱塞柄部从所述柱塞的柱塞体移除,以及在所述腔在所述离心机中转动后将所述柱塞柄部重新附连到所述柱塞体。
24.根据权利要求18所述的方法,还包括通过附连到所述通口的喷头将所述富血小板血浆和所述贫血小板血浆直接施放到受伤部位。
25.根据权利要求18所述的方法,还包括在使所述腔转动之前限制所述柱塞的移动。
26.一种用于将骨髓抽取物分离成不同成分的方法,包括:
通过分离腔的通口将所述骨髓抽取物直接从患者抽入所述分离腔,所述分离腔具有固定地安装到浮体导柱的第一浮体和可滑动地安装到所述导柱的第二浮体,所述浮体导柱具有第一阀和第二阀,当所述第二浮体在第一位置时,所述第一阀关闭而所述第二阀打开,所述骨髓抽取物通过所述第二阀被抽入所述分离腔,进入介于所述第二浮体和可滑动地安装在所述分离腔中的柱塞之间的区域;
使所述腔在离心机中转动足够的时间,使得所述第二浮体移动到第二位置,其中所述第二浮体与所述第一浮体间隔开,以关闭所述第二阀而打开所述第一阀,并且根据密度分离所述骨髓抽取物的所述成分,使得红血球在所述通口和所述第一浮体之间,多能细胞在所述第一浮体和所述第二浮体之间,而骨髓浆在所述第二浮体和所述柱塞之间;
将所述柱塞压到所述分离腔内的第一距离以使所述第一浮体从所述第二位置移动到所述第一位置以迫使所述多能细胞通过所述第一阀并通过所述通口到达所述分离腔之外,以关闭所述第一阀而打开所述第二阀;
通过附连到所述通口的施放器将所述多能细胞直接施放到所关注区域;
将所述柱塞进一步压到所述分离腔内的大于所述第一距离的第二距离,以迫使所述骨髓浆通过所述第二阀并通过所述通口到达所述分离腔之外;以及
通过附连到所述通口的施放器将所述骨髓浆直接施放到所关注区域。
27.一种具有用于根据密度分离混合物的成分的分离腔的装置,包括:
通口,其提供所述混合物从所述腔的外部到所述腔的内部的流体连通;
第一浮体,其被可滑动地安装在所述分离腔内;以及
第二浮体,其被可滑动地安装在所述分离腔内;
其中,所述第二浮体的密度使得在使所述装置旋转合适的时间后所述混合物的第一成分被隔离在所述第一浮体和所述第二浮体之间,而所述混合物的第二成分被隔离在所述第二浮体和所述分离腔的与所述通口相对的端部之间;并且
其中,所述通口提供所述第一成分和所述第二成分从所述腔的所述内部到所述腔的所述外部的流体连通。
28.根据权利要求27所述的装置,其中,所述第一浮体连接到所述第二浮体。
29.根据权利要求28所述的装置,其中,所述第一浮体和所述第二浮体均被可滑动地安装到沿所述分离腔的纵轴延伸的浮体导柱。
30.根据权利要求27所述的装置,其中,所述第一浮体未被连接到所述第二浮体。
31.一种用于将全血分离为不同成分的方法,包括:
通过通口将所述全血直接从患者抽入分离腔,所述分离腔具有被可滑动地安装在所述分离腔中的第一浮体和被可滑动地安装在所述分离腔中的第二浮体,所述全血被抽入所述分离腔中,进入介于所述第二浮体和被可滑动地安装在所述分离腔中的柱塞之间的区域;
使所述腔在离心机中转动足够的时间,使得所述第二浮体移动到第二位置,其中所述第二浮体与所述第一浮体间隔开,并且根据密度分离所述全血的所述成分,使得红血球在所述通口和所述第一浮体之间,富血小板血浆在所述第一浮体和所述第二浮体之间,而贫血小板血浆在所述第二浮体和所述柱塞之间;
将所述柱塞压到所述分离腔内的第一距离,以使所述第一浮体从所述第二位置移动到所述第一位置,以迫使所述富血小板血浆通过所述通口到达所述分离腔之外;
通过附连到所述通口的施放器将所述富血小板血浆直接施放到所关注区域;
将所述柱塞进一步压到所述分离腔内的大于所述第一距离的第二距离,以迫使所述贫血小板血浆通过所述通口到达所述分离腔之外;以及
通过附连到所述通口的所述施放器将所述贫血小板血浆直接施放到所关注区域。
32.根据权利要求31所述的方法,还包括通过使用延伸管口附连到所述通口的针头将所述全血抽入所述分离腔。
33.根据权利要求31所述的方法,其中,使用直接附连到所述通口的所述施放器将所述贫血小板血浆施放到所述所关注区域。
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104474598A (zh) * | 2015-01-05 | 2015-04-01 | 浙江保尔曼生物科技有限公司 | 血浆分离装置 |
CN104541166A (zh) * | 2012-08-08 | 2015-04-22 | 皇家飞利浦有限公司 | 使用一滴血实现的血浆分离 |
CN106994396A (zh) * | 2017-05-23 | 2017-08-01 | 武汉朗克医疗器械有限公司 | Prp连续离心分离装置及分离方法 |
CN107735119A (zh) * | 2015-12-29 | 2018-02-23 | 热起源公司 | 细胞分离装置、系统和方法 |
CN108601868A (zh) * | 2016-01-21 | 2018-09-28 | 托朗塞爾股份有限公司 | 血液成分分离用装置 |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
WO2003099412A1 (en) | 2002-05-24 | 2003-12-04 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
WO2008100442A1 (en) * | 2007-02-09 | 2008-08-21 | Biomet Biologics, Inc. | Treatment of tissue defects with a therapeutic composition |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
EP2146794B1 (en) | 2007-04-12 | 2016-10-19 | Biomet Biologics, LLC | Buoy suspension fractionation system |
EP2229197B1 (en) | 2008-01-15 | 2012-11-07 | West Pharmaceutical Services, Inc. | Collet mechanism and method of molding cannula to a syringe barrel |
US8721603B2 (en) | 2008-01-15 | 2014-05-13 | West Pharmaceutical Services, Inc. | Syringe with co-molded hub and cannula |
US8753690B2 (en) * | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
EP2567692B1 (en) | 2008-02-27 | 2016-04-06 | Biomet Biologics, LLC | Use of a device for obtaining interleukin-1 receptor antagonist rich solutions |
EP2254991B1 (en) * | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
CN102149473B (zh) | 2008-07-21 | 2014-12-31 | 贝克顿·迪金森公司 | 密度相分离装置 |
US8177072B2 (en) * | 2008-12-04 | 2012-05-15 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
ES2897762T3 (es) | 2009-05-15 | 2022-03-02 | Becton Dickinson Co | Dispositivo de separación de fase de densidad |
US9272083B2 (en) | 2009-05-29 | 2016-03-01 | Endocellutions, Inc. | Apparatus and methods for aspirating and separating components of different densities from a physiological fluid containing cells |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
JP5844258B2 (ja) | 2009-08-27 | 2016-01-13 | バイオメット、バイオロジクス、リミテッド、ライアビリティー、カンパニーBiomet Biologics, Llc | インターロイキン−1受容体アンタゴニストの生産のための植込み型装置 |
US20110052561A1 (en) * | 2009-08-27 | 2011-03-03 | Biomet Biologics,LLC | Osteolysis treatment |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US9164079B2 (en) * | 2011-03-17 | 2015-10-20 | Greyledge Technologies Llc | Systems for autologous biological therapeutics |
US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
USD693002S1 (en) * | 2011-09-21 | 2013-11-05 | West Pharmaceutical Services, Inc. | Hub for medical container |
USD689188S1 (en) | 2012-07-19 | 2013-09-03 | West Pharmaceutical Services, Inc. | Syringe plunger rod |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
WO2014120797A1 (en) | 2013-01-29 | 2014-08-07 | Endocellutions, Inc. | Cell concentration devices and methods |
WO2014130426A1 (en) | 2013-02-21 | 2014-08-28 | Regenerative Sciences, Llc | Blood and marrow draw processing devices and methods |
US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9168528B2 (en) | 2013-04-02 | 2015-10-27 | Alliance Partners, Llc | Fluids concentration cup assembly with hourglass shape |
US10416046B2 (en) | 2013-04-11 | 2019-09-17 | Rarecyte, Inc. | Device, system, and method for selecting a target analyte |
US9519002B2 (en) | 2013-04-11 | 2016-12-13 | Rarecyte, Inc. | Device, system, and method for selecting a target analyte |
US9976115B2 (en) | 2013-08-06 | 2018-05-22 | Regenexx, LLC | Bone marrow adipose portion isolation device and methods |
JP6154904B2 (ja) * | 2013-08-22 | 2017-06-28 | 株式会社ジェイ・エム・エス | 血液成分分離用装置 |
EP3074507B1 (en) | 2013-11-26 | 2022-01-05 | Biomet Biologics, LLC | Methods of mediating macrophage phenotypes |
WO2015122921A1 (en) | 2014-02-14 | 2015-08-20 | Green Richard Dennis | Gas removal systems and methods |
US10874805B2 (en) | 2014-02-14 | 2020-12-29 | Ailnh, Llc | Gas removal apparatus and related methods |
GB2524004A (en) * | 2014-03-10 | 2015-09-16 | Stratec Biomedical Ag | Dispenser |
US9937445B2 (en) * | 2014-03-27 | 2018-04-10 | Biomet Biologics, Llc | System and method for separating a fraction |
US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
US10040064B1 (en) * | 2015-04-07 | 2018-08-07 | Cellmedix Holdings, Llc | Centrifuge tube assembly |
USD811585S1 (en) | 2015-08-13 | 2018-02-27 | Richard Green | Air removal device |
EP3165921A1 (en) | 2015-11-05 | 2017-05-10 | Dominik Olbrzymek | A kit for centrifugal separation of biological fluid components and a method for centrifugal separation of biological fluid components |
USD774181S1 (en) * | 2015-11-10 | 2016-12-13 | Richard Green | Air removal device |
USD818117S1 (en) | 2016-03-01 | 2018-05-15 | Ailnh, Llc | Air removal device |
USD826397S1 (en) | 2016-03-01 | 2018-08-21 | Ailnh, Llc | Air removal device |
AU2017204355B2 (en) | 2016-07-08 | 2021-09-09 | Mako Surgical Corp. | Scaffold for alloprosthetic composite implant |
WO2018227161A1 (en) * | 2017-06-08 | 2018-12-13 | Patrick Pennie | Dual piston centrifuge tube |
US11090646B2 (en) | 2017-07-27 | 2021-08-17 | Biomerieux, Inc. | Isolation tube |
CN107991136B (zh) * | 2017-11-30 | 2020-06-05 | 徐州果姿电子商务有限公司 | 一种食品加工棒骨品质检测装置 |
US11229722B2 (en) * | 2018-01-29 | 2022-01-25 | Omer Peled | System and method for harvesting autologous adipose tissue |
CN108837189B (zh) * | 2018-04-28 | 2020-12-18 | 青岛大学附属医院 | 一种外科穿刺引流自动排液装置 |
EP3820541A4 (en) * | 2018-07-09 | 2022-04-06 | Hanuman Pelican, Inc. | BLOOD PROCESSING APPARATUS AND METHODS |
WO2020013997A1 (en) | 2018-07-09 | 2020-01-16 | Hanuman Pelican, Inc. | Apparatus and methods for separating blood components |
US20220088589A1 (en) | 2019-01-21 | 2022-03-24 | Eclipse Medcorp, Llc | Methods, Systems and Apparatus for Separating Components of a Biological Sample |
US11559613B2 (en) | 2019-02-06 | 2023-01-24 | Hanuman Pelican, Inc. | Apparatus and methods for concentrating platelet-rich plasma |
KR20220091580A (ko) | 2019-10-31 | 2022-06-30 | 이클립스 메드코프 엘엘씨 | 샘플의 구성요소들을 분리하기 위한 시스템, 방법 및 장치 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5707876A (en) * | 1996-03-25 | 1998-01-13 | Stephen C. Wardlaw | Method and apparatus for harvesting constituent layers from a centrifuged material mixture |
US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US20060151384A1 (en) * | 2003-05-19 | 2006-07-13 | Ellsworth James R | Method and apparatus for separating fluid components |
US20060273050A1 (en) * | 2002-05-24 | 2006-12-07 | Higgins Joel C | Apparatus and method for separating and concentrating fluids containing multiple components |
Family Cites Families (507)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US593333A (en) | 1897-11-09 | Device for separating liquids of different | ||
US280820A (en) | 1883-07-10 | Milk-can | ||
US1468313A (en) | 1920-07-03 | 1923-09-18 | Firm Luftfahrzeugbau Schutte L | Process of producing a cold glue from blood |
GB229644A (en) | 1924-02-19 | 1925-10-08 | Robert Vogel | A method of producing a substance adapted to tampon wounds |
US2722257A (en) | 1953-02-12 | 1955-11-01 | Compule Corp | Sampling tube equipment |
SE169293C1 (zh) | 1958-03-13 | 1959-11-10 | ||
US3013557A (en) | 1959-04-13 | 1961-12-19 | Hazleton Lab Inc | Combination syringe, shipping container and centrifuge tube |
US3159159A (en) | 1960-06-01 | 1964-12-01 | Milton J Cohen | Fluid withdrawal device and container |
US3141846A (en) | 1962-04-05 | 1964-07-21 | Western States Machine Co | Load control unit for cyclical centrifugal installation |
DK113248B (da) | 1963-09-02 | 1969-03-03 | Pharmacia Ab | Fremgangsmåde til fremstilling af med en eller flere mono- eller dihydroxyalkylgrupper substitueret dekstran. |
US3300051A (en) | 1963-09-26 | 1967-01-24 | Internat Equipment Co | Filter tube for use in a centrifuge |
JPS497539B1 (zh) | 1966-04-13 | 1974-02-21 | ||
US3469369A (en) | 1966-12-29 | 1969-09-30 | Bell Telephone Labor Inc | Method for preparing and applying a viscous fluid |
US3441143A (en) | 1967-02-10 | 1969-04-29 | Marvel Eng Co | Plural element filter assembly |
US3545671A (en) | 1967-02-14 | 1970-12-08 | Eugene Ross Lab Inc | Apparatus for and method of collecting,storing,separating and dispensing blood and blood components |
US3409165A (en) | 1967-04-03 | 1968-11-05 | Olin Mathieson | Floating deck |
US3508653A (en) | 1967-11-17 | 1970-04-28 | Charles M Coleman | Method and apparatus for fluid handling and separation |
US3596652A (en) | 1968-10-14 | 1971-08-03 | Bio Science Labor | Fluid separatory device |
US3583627A (en) | 1969-09-04 | 1971-06-08 | Onslow H Wilson | Apparatus for the concentration of macromolecules and subcellular particles from dilute solutions |
US3654925A (en) | 1969-09-23 | 1972-04-11 | Becton Dickinson Co | Plasma separator system |
US3647070A (en) | 1970-06-11 | 1972-03-07 | Technicon Corp | Method and apparatus for the provision of fluid interface barriers |
US3741400A (en) | 1970-06-15 | 1973-06-26 | J Dick | Blood sample container |
US3661265A (en) | 1970-07-27 | 1972-05-09 | Contemporary Research And Dev | Serum separator type container |
USRE32089E (en) | 1970-08-25 | 1986-03-04 | Amicon Corporation | Blood fractionating process and apparatus for carrying out same |
US3723244A (en) | 1971-01-18 | 1973-03-27 | Atomic Energy Commission | Fibrous fibrin sheet and method for producing same |
US3706306A (en) | 1971-03-03 | 1972-12-19 | Harold J Berger | Combination blood sampling vacuum syringe centrifuge container and specimen cup |
US3706305A (en) | 1971-03-03 | 1972-12-19 | Harold J Berger | Combination blood sampling vacuum syringe centrifuge container and specimen cup |
DE2115032C3 (de) | 1971-03-29 | 1975-05-07 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Vorrichtung zum Trennen zweier Phasen bei der Flüssig-Flüssig-Extraktion in einer Zentrifuge |
US3814248A (en) | 1971-09-07 | 1974-06-04 | Corning Glass Works | Method and apparatus for fluid collection and/or partitioning |
US3965889A (en) | 1971-11-26 | 1976-06-29 | Commissariat A L'energie Atomique | Apparatus for the sampling of blood and the separation of plasma under anaerobic conditions |
US3849072A (en) | 1972-04-25 | 1974-11-19 | Becton Dickinson Co | Plasma separator |
US3779383A (en) | 1972-04-25 | 1973-12-18 | Becton Dickinson Co | Sealed assembly for separation of blood components and method |
US3785549A (en) | 1972-07-31 | 1974-01-15 | Haemonetics Corp | Centrifuge chuck for disposable, snap-in centrifuge rotor |
DE7239445U (de) | 1972-10-27 | 1973-08-02 | Merten Utz P | Einwegspritze, insbesondere zur Entnahme von Blutproben |
SE452109B (sv) | 1973-01-29 | 1987-11-16 | Pharmacia Ab | Rengoringsmedel for vetskande utvertes sarytor |
US4537767A (en) | 1973-01-29 | 1985-08-27 | Pharmacia Aktiebolag | Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method |
US3850369A (en) | 1973-03-08 | 1974-11-26 | Coulter Electronics | Centrifuge for preparing platelet rich plasma |
US3879295A (en) | 1973-08-17 | 1975-04-22 | Eastman Kodak Co | Vacutainer with positive separation barrier |
US4001122A (en) | 1973-08-22 | 1977-01-04 | Telan Corporation | Method and device for separating blood components |
US3896733A (en) | 1973-10-18 | 1975-07-29 | Pall Corp | Autotransfusion apparatus |
US3962085A (en) | 1973-12-19 | 1976-06-08 | Abbott Laboratories | Skimmer assembly |
US3897337A (en) | 1974-02-27 | 1975-07-29 | Becton Dickinson Co | Plasma separator assembly having interface-seeking piston with centrifugal valve |
US3935113A (en) | 1974-02-27 | 1976-01-27 | Becton, Dickinson And Company | Serum/plasma separator with centrifugal valve |
US3957654A (en) | 1974-02-27 | 1976-05-18 | Becton, Dickinson And Company | Plasma separator with barrier to eject sealant |
US3951801A (en) | 1974-02-27 | 1976-04-20 | Becton, Dickinson And Company | Serum/plasma separator-strut stop type |
US3897343A (en) | 1974-02-27 | 1975-07-29 | Becton Dickinson Co | Plasma separator-hydrostatic pressure type |
US3931010A (en) | 1974-02-27 | 1976-01-06 | Becton, Dickinson And Company | Serum/plasma separators with centrifugal valves |
US3909419A (en) | 1974-02-27 | 1975-09-30 | Becton Dickinson Co | Plasma separator with squeezed sealant |
US3887466A (en) * | 1974-02-27 | 1975-06-03 | Becton Dickinson Co | Serum/plasma separator cannula fluid by-pass type centrifugal valve cannula seal |
US3894952A (en) | 1974-02-27 | 1975-07-15 | Becton Dickinson Co | Serum/plasma separator assembly having interface-seeking piston |
US3941699A (en) | 1974-02-27 | 1976-03-02 | Becton, Dickinson And Company | Plasma separator with centrifugal valve |
US3945928A (en) | 1974-02-27 | 1976-03-23 | Becton, Dickinson And Company | Serum/plasma separators with centrifugal valves |
US3929646A (en) | 1974-07-22 | 1975-12-30 | Technicon Instr | Serum separator and fibrin filter |
US3931018A (en) | 1974-08-09 | 1976-01-06 | Becton, Dickinson And Company | Assembly for collection, separation and filtration of blood |
US4204537A (en) | 1974-08-15 | 1980-05-27 | Haemonetics Corporation | Process for pheresis procedure and disposable plasma |
US4059108A (en) | 1974-08-15 | 1977-11-22 | Haemonetics Corporation | Process for pheresis procedure and disposable pheresis bowl therefor |
DE2444524A1 (de) | 1974-09-18 | 1976-04-08 | Oeser Henning Dr | Verfahren und vorrichtung zur ausfaellung von human-blutplasma-bestandteilen |
US3982691A (en) | 1974-10-09 | 1976-09-28 | Schlutz Charles A | Centrifuge separation and washing device and method |
US3972812A (en) | 1975-05-08 | 1976-08-03 | Becton, Dickinson And Company | Blood serum separation filter disc |
US4020831A (en) | 1975-12-04 | 1977-05-03 | Technicon Instruments Corporation | Blood collecting syringe |
US4088582A (en) | 1976-01-16 | 1978-05-09 | Sherwood Medical Industries Inc. | Blood phase separation means |
US4055501A (en) | 1976-01-16 | 1977-10-25 | Sherwood Medical Industries Inc. | Fluid collection device with phase partitioning means |
US4027660A (en) | 1976-04-02 | 1977-06-07 | Wardlaw Stephen C | Material layer volume determination |
CA1074273A (en) | 1976-05-06 | 1980-03-25 | Sherwood Medical Industries Inc. | Phase separation device |
US4046699A (en) | 1976-11-01 | 1977-09-06 | Corning Glass Works | Access device for centrifugal separation assemblies |
IT1103118B (it) | 1977-01-10 | 1985-10-14 | Levine Robert A | Dispositiov e tecnica per migliorare la separazione degli strati di cellule in campioni di sangue centrifugati |
AT381466B (de) | 1977-03-16 | 1986-10-27 | Ballies Uwe | Trennroehrchen fuer zentrifugaltrennung |
US4189385A (en) | 1977-05-03 | 1980-02-19 | Greenspan Donald J | Method and apparatus for separating serum or plasma from the formed elements of the blood |
US5217426A (en) | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US4146172A (en) | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
US4187979A (en) | 1978-09-21 | 1980-02-12 | Baxter Travenol Laboratories, Inc. | Method and system for fractionating a quantity of blood into the components thereof |
US4303193A (en) | 1979-01-22 | 1981-12-01 | Haemonetics Corporation | Apparatus for separating blood into components thereof |
US4229298A (en) | 1979-02-05 | 1980-10-21 | The Western States Machine Company | Method and apparatus for determining the thickness of a charge wall formed in a centrifugal basket |
US4453927A (en) | 1979-02-07 | 1984-06-12 | Gesco International | Method and apparatus for microfiltration of blood |
AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
US4314823A (en) | 1979-03-05 | 1982-02-09 | Dionex Corporation | Combination apparatus and method for chromatographic separation and quantitative analysis of multiple ionic species |
JPS5917386B2 (ja) | 1979-03-23 | 1984-04-20 | テルモ株式会社 | 血液分離方法および装置 |
US4300717A (en) | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
NO146616C (no) | 1979-10-04 | 1982-11-03 | Ken Heimreid | Fremgangsmaate og anordning ved preparering til undersoekelse av ukoagulert blod. |
US4269718A (en) | 1980-05-05 | 1981-05-26 | The Institutes Of Medical Sciences | Process and device for centrifugal separation of platelets |
ES8300261A1 (es) | 1980-05-08 | 1982-11-16 | Terumo Corp | Aparato para separacion de la sangre |
JPS6053845B2 (ja) | 1980-06-19 | 1985-11-27 | キヤノン株式会社 | レンズ鏡胴ユニットの製造方法 |
US4332351A (en) | 1980-09-22 | 1982-06-01 | International Business Machines Corporation | Blood fraction extracting centrifuge |
DE3101752A1 (de) | 1981-01-21 | 1982-08-26 | Behringwerke Ag, 3550 Marburg | "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen" |
DE3101733C2 (de) | 1981-01-21 | 1982-10-14 | Uwe Dr.Med. 2300 Kiel Ballies | Trennelement in einem Trennröhrchen zur Zentrifugaltrennung |
US4424132A (en) | 1981-02-05 | 1984-01-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
US4417981A (en) | 1981-05-04 | 1983-11-29 | Becton, Dickinson And Company | Blood phase separator device |
US4322298A (en) | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
ATE13810T1 (de) | 1981-06-25 | 1985-07-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung. |
ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
US4735726A (en) | 1981-07-22 | 1988-04-05 | E. I. Du Pont De Nemours And Company | Plasmapheresis by reciprocatory pulsatile filtration |
GB2104401B (en) | 1981-08-25 | 1985-03-20 | Krauss Maffei Ag | Support plate for centrifuges |
US4416654A (en) | 1981-09-03 | 1983-11-22 | Haemonetics Corporation | Pheresis apparatus |
US4464167A (en) | 1981-09-03 | 1984-08-07 | Haemonetics Corporation | Pheresis apparatus |
DE3203775A1 (de) | 1982-02-04 | 1983-08-11 | Behringwerke Ag, 3550 Marburg | Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung |
DE3212412C2 (de) | 1982-04-02 | 1986-01-02 | Dr. Ruhland Nachf. GmbH, 8425 Neustadt | Gewebeverklebbare kollagene Wundauflage |
US4511662A (en) | 1982-06-18 | 1985-04-16 | Bio-Rad Laboratories, Inc. | Simultaneous assay for T and B lymphocyte populations and subpopulations |
US4443345A (en) | 1982-06-28 | 1984-04-17 | Wells John R | Serum preparator |
JPS5928766A (ja) | 1982-08-10 | 1984-02-15 | Sony Corp | 遅延回路 |
US4445550B1 (en) | 1982-08-20 | 1999-03-09 | Scholle Corp | Flexible walled container having membrane fitment for use with aseptic filling apparatus |
WO1984000905A1 (en) | 1982-08-24 | 1984-03-15 | Baxter Travenol Lab | Blood component collection systems and methods |
US4680025A (en) | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
US4722790A (en) | 1982-09-13 | 1988-02-02 | Cawley Leo P | On-line plasma modification means |
US4839058A (en) | 1982-09-13 | 1989-06-13 | Cawley Leo P | On-line plasma modification method |
EP0109374A1 (fr) | 1982-10-08 | 1984-05-23 | Antoon Soetens | Dispositif pour capter l'énergie solaire sur un toit ou analogue |
SE8206767D0 (sv) | 1982-11-26 | 1982-11-26 | Seroteknik Hb | Sett och anordning for satsvis centrifugalseparering av blod |
US5034135A (en) | 1982-12-13 | 1991-07-23 | William F. McLaughlin | Blood fractionation system and method |
US4632761A (en) | 1983-08-15 | 1986-12-30 | W. R. Grace & Co. | Centrifugal microconcentrator and methods for its use |
US4755301A (en) | 1983-08-15 | 1988-07-05 | W. R. Grace & Co. | Apparatus and method for centrifugal recovery of retentate |
US4672969A (en) | 1983-10-06 | 1987-06-16 | Sonomo Corporation | Laser healing method |
JPS60250014A (ja) | 1984-05-28 | 1985-12-10 | Mitsui Toatsu Chem Inc | 濃縮用樹脂 |
CH665565A5 (de) | 1983-10-22 | 1988-05-31 | Mitsui Toatsu Chemicals | Verfahren zur steuerung der konzentration einer eine makromolekulare verbindung enthaltenden waessrigen loesung oder emulsion. |
CA1244774A (en) | 1983-11-09 | 1988-11-15 | Thomas Jefferson University | Medium for storing blood platelets |
DE3410286C2 (de) | 1984-03-21 | 1986-01-23 | Fresenius AG, 6380 Bad Homburg | Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens |
AT379311B (de) | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
US4577514A (en) | 1984-04-09 | 1986-03-25 | Vanderbilt University | Method and apparatus for sampling liquid phase components from a liquid-semisolid fluid |
JPS6144825A (ja) | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
US4610656A (en) | 1984-08-21 | 1986-09-09 | Mehealus Partnership | Fully portable semi-automatic mechanical heart-lung substitution system and method |
US4776964A (en) | 1984-08-24 | 1988-10-11 | William F. McLaughlin | Closed hemapheresis system and method |
US4627879A (en) | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
US4928603A (en) | 1984-09-07 | 1990-05-29 | The Trustees Of Columbia University In The City Of New York | Method of preparing a cryoprecipitated suspension and use thereof |
US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US5053134A (en) | 1984-12-04 | 1991-10-01 | Becton Dickinson And Company | Lymphocyte collection tube |
US4917801A (en) | 1984-12-04 | 1990-04-17 | Becton Dickinson And Company | Lymphocyte collection tube |
US4639316A (en) | 1984-12-14 | 1987-01-27 | Becton, Dickinson And Company | Automatic liquid component separator |
US5372945A (en) | 1985-06-06 | 1994-12-13 | Alchas; Paul G. | Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product |
AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
SE448323B (sv) | 1985-08-27 | 1987-02-09 | Ersson Nils Olof | Forfarande och anordnig att separera serum eller plasma fran blod |
EP0587257B1 (en) | 1985-09-10 | 1998-06-10 | Vereniging Het Nederlands Kanker Instituut | Method and device for preventing imbalance during the separation and isolation of blood or bone marrow components |
US4724317A (en) | 1985-12-05 | 1988-02-09 | Baxter Travenol Laboratories, Inc. | Optical data collection apparatus and method used with moving members |
US4871462A (en) | 1985-12-23 | 1989-10-03 | Haemonetics Corporation | Enhanced separation of blood components |
US4755300A (en) | 1985-12-23 | 1988-07-05 | Haemonetics Corporation | Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear |
AU578554B2 (en) | 1986-01-24 | 1988-10-27 | Japanese Red Cross Society | Centrifugal method of separating blood components |
US5112490A (en) | 1986-02-19 | 1992-05-12 | Jon Turpen | Sample filtration, separation and dispensing device |
ES2004281A6 (es) | 1986-04-04 | 1988-12-16 | Univ Jefferson | Una superficie protesica implantable para implantacion en un paciente humano |
SE8601891D0 (sv) | 1986-04-24 | 1986-04-24 | Svante Jonsson | Maskin for plasmabytesbehandling och trombocytgivning |
DE3615558A1 (de) | 1986-05-09 | 1987-11-12 | Behringwerke Ag | Verfahren zur herstellung eines faktor v-konzentrats |
DE3622642A1 (de) | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
US4983158A (en) | 1986-07-22 | 1991-01-08 | Haemonetics Corporation | Plasmapheresis centrifuge bowl |
US4943273A (en) | 1986-07-22 | 1990-07-24 | Haemonetics Corporation | Disposable centrifuge bowl for blood processing |
US4714457A (en) | 1986-09-15 | 1987-12-22 | Robert Alterbaum | Method and apparatus for use in preparation of fibrinogen from a patient's blood |
DK475386D0 (da) | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
US4915847A (en) | 1987-08-04 | 1990-04-10 | Baxter International Inc. | Cryoglobulin separation |
US4929242A (en) | 1986-11-26 | 1990-05-29 | Baxter International Inc. | Solution and method for maintaining patency of a catheter |
CH673117A5 (zh) | 1986-12-10 | 1990-02-15 | Ajinomoto Kk | |
US4933291A (en) | 1986-12-22 | 1990-06-12 | Eastman Kodak Company | Centrifugable pipette tip and pipette therefor |
US5053127A (en) | 1987-01-13 | 1991-10-01 | William F. McLaughlin | Continuous centrifugation system and method for directly deriving intermediate density material from a suspension |
US5641414A (en) | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US4834890A (en) | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
US5370802A (en) | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US5104526A (en) | 1987-01-30 | 1992-04-14 | Baxter International Inc. | Centrifugation system having an interface detection system |
US4832851A (en) | 1987-02-02 | 1989-05-23 | W. R. Grace & Co. | Centrifugal force-enhanced filtration of fluids |
US4983157A (en) | 1987-03-23 | 1991-01-08 | Ceramics Process Systems Corp. | Centrifugation system using static layer |
US5030341A (en) | 1987-04-03 | 1991-07-09 | Andronic Technologies, Inc. | Apparatus for separating phases of blood |
US5019243A (en) | 1987-04-03 | 1991-05-28 | Mcewen James A | Apparatus for collecting blood |
IT1203461B (it) | 1987-04-08 | 1989-02-15 | Dideco Spa | Cella per la centrifugazione del sangue |
US4939081A (en) | 1987-05-27 | 1990-07-03 | The Netherlands Cancer Institute | Cell-separation |
US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
US4738655A (en) | 1987-06-17 | 1988-04-19 | Utah Bioresearch, Inc. | Apparatus and method for obtaining a rapid hematocrit |
DE3723092C1 (de) | 1987-07-13 | 1989-01-26 | Westfalia Separator Ag | Durchlaufzentrifuge zur industriellen Produktion von Proteinen aus menschlichem Blutplasma |
US5260420A (en) | 1987-07-30 | 1993-11-09 | Centre Regional De Transfusion Sanguine De Lille | Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof |
DE3726227A1 (de) | 1987-08-07 | 1989-02-16 | Krauss Maffei Ag | Vorrichtung zum ergebnisabhaengigen steuern einer filterzentrifuge |
US4877520A (en) | 1987-10-08 | 1989-10-31 | Becton, Dickinson And Company | Device for separating the components of a liquid sample having higher and lower specific gravities |
US4818386A (en) | 1987-10-08 | 1989-04-04 | Becton, Dickinson And Company | Device for separating the components of a liquid sample having higher and lower specific gravities |
US4844818A (en) | 1987-10-23 | 1989-07-04 | Becton Dickinson & Company | Method for separating the cellular components of blood samples |
US4957638A (en) | 1987-10-23 | 1990-09-18 | Becton Dickinson And Company | Method for separating the cellular components of blood samples |
US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
US4957637A (en) * | 1988-05-23 | 1990-09-18 | Sherwood Medical Company | Serum separator system for centrifuge with piercable membrane |
AT397203B (de) | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
DE68902698C5 (de) | 1988-06-23 | 2005-07-14 | Asahi Medical Co. Ltd. | Verfahren zur Trennung von Blut in Blutkomponenten und Einheit zur Trennung von Blutkomponenten. |
US5024613A (en) | 1988-07-18 | 1991-06-18 | Pfizer Hospital Products Group, Inc. | Blood recovery system and method |
US4874368A (en) | 1988-07-25 | 1989-10-17 | Micromedics, Inc. | Fibrin glue delivery system |
US4846780A (en) | 1988-08-10 | 1989-07-11 | Exxon Production Research Company | Centrifuge processor and liquid level control system |
US4902281A (en) | 1988-08-16 | 1990-02-20 | Corus Medical Corporation | Fibrinogen dispensing kit |
US4946601A (en) | 1988-08-22 | 1990-08-07 | Sherwood Medical Company | Blood serum separator tube |
JPH02129224A (ja) | 1988-11-10 | 1990-05-17 | Terumo Corp | フィブリンの製造法 |
JPH0271747U (zh) | 1988-11-22 | 1990-05-31 | ||
US4973168A (en) | 1989-01-13 | 1990-11-27 | Chan Kwan Ho | Vacuum mixing/bone cement cartridge and kit |
DE8900469U1 (de) | 1989-01-17 | 1990-05-23 | Espe Stiftung & Co Produktions- und Vertriebs KG, 8031 Seefeld | Vorrichtung zum Mischen und Ausbringen pastöser Massen |
US5002571A (en) | 1989-02-06 | 1991-03-26 | Donnell Jr Francis E O | Intraocular lens implant and method of locating and adhering within the posterior chamber |
SE8900586L (sv) | 1989-02-21 | 1990-08-22 | Pharmacia Ab | Komposition och foerfarande foer att foerhindra adhesion mellan kroppsvaevnader |
CA2011100C (en) | 1989-05-24 | 1996-06-11 | Stephen C. Wardlaw | Centrifuged material layer measurements taken in an evacuated tube |
US5226877A (en) | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
US5000970A (en) | 1989-06-30 | 1991-03-19 | Horizons International Foods, Inc. | Process for preparing reheatable french fried potatoes |
WO1991001383A1 (en) | 1989-07-14 | 1991-02-07 | Michigan State University | Method for diagnosing blood clotting disorders |
US5207638A (en) | 1989-08-24 | 1993-05-04 | Hemotrans, Inc. | Blood transfer apparatus |
US5316674A (en) | 1989-09-12 | 1994-05-31 | Pall Corporation | Device for processing blood for human transfusion |
US5100564A (en) | 1990-11-06 | 1992-03-31 | Pall Corporation | Blood collection and processing system |
US5152905A (en) | 1989-09-12 | 1992-10-06 | Pall Corporation | Method for processing blood for human transfusion |
US5258126A (en) | 1989-09-12 | 1993-11-02 | Pall Corporation | Method for obtaining platelets |
IL95641A0 (en) | 1989-09-15 | 1991-06-30 | Curative Tech Inc | Preparation of a platelet releasate product |
US5104375A (en) | 1989-10-16 | 1992-04-14 | Johnson & Johnson Medical, Inc. | Locking holder for a pair of syringes and method of use |
US5039401A (en) | 1990-05-16 | 1991-08-13 | Eastman Kodak Company | Blood collection and centrifugal separation device including a valve |
US5030215A (en) | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
US5318524A (en) | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
US5219328A (en) | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
NL9000090A (nl) | 1990-01-15 | 1991-08-01 | Harimex Ligos Bv | Werkwijze voor het bereiden van een fibrinogeenconcentraat uit bloedplasma, inrichting voor het uitvoeren van deze werkwijze en werkwijze voor het bereiden van fibrinogeen uit het concentraat. |
US5185001A (en) | 1990-01-18 | 1993-02-09 | The Research Foundation Of State University Of New York | Method of preparing autologous plasma fibrin and application apparatus therefor |
US5047004A (en) | 1990-02-07 | 1991-09-10 | Wells John R | Automatic decanting centrifuge |
US5178602A (en) | 1990-02-07 | 1993-01-12 | Wells John R | Automatic decanting centrifuge |
US5045048A (en) | 1990-03-29 | 1991-09-03 | Haemonetics Corporation | Rotary centrifuge bowl and seal for blood processing |
US5204537A (en) | 1990-03-30 | 1993-04-20 | Recognition Equipment Incorporated | Thickness sensor comprising a leaf spring means, and a light sensor |
DK119490D0 (da) | 1990-05-14 | 1990-05-14 | Unes As | Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion |
US5171456A (en) | 1990-06-14 | 1992-12-15 | Baxter International Inc. | Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple blood components |
US5156586A (en) | 1990-07-10 | 1992-10-20 | Bardyne | Orbital separator for orbitally separating a mixture |
FR2665378B1 (fr) | 1990-08-03 | 1992-10-09 | Guigan Jean | Dispositif pour separer par centrifugation deux phases d'un echantillon d'un liquide heterogene, utilisable notamment pour la separation du plasma du sang total. |
US5420250A (en) | 1990-08-06 | 1995-05-30 | Fibrin Corporation | Phase transfer process for producing native plasma protein concentrates |
US5641622A (en) | 1990-09-13 | 1997-06-24 | Baxter International Inc. | Continuous centrifugation process for the separation of biological components from heterogeneous cell populations |
US5173295A (en) | 1990-10-05 | 1992-12-22 | Advance Biofactures Of Curacao, N.V. | Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor |
US5112484A (en) | 1990-10-11 | 1992-05-12 | Zuk, Inc. | Filtration apparatus |
US5217627A (en) | 1990-11-06 | 1993-06-08 | Pall Corporation | System and method for processing biological fluid |
US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5955436A (en) | 1990-11-20 | 1999-09-21 | Alcon Laboratories, Inc. | Use of platelet derived growth factor to enhance wound healing |
US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US5234608A (en) | 1990-12-11 | 1993-08-10 | Baxter International Inc. | Systems and methods for processing cellular rich suspensions |
JPH0774772B2 (ja) | 1990-12-31 | 1995-08-09 | エイ. レビン ロバート | 血液サンプリング組立体、ターゲット細胞の採取方法およびターゲット成分の採取方法 |
US5137832A (en) | 1991-01-02 | 1992-08-11 | Becton Dickinson & Company | Quantification of fibrinogen in whole blood samples contained in a tube using a float to separate materials |
US5206023A (en) | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5156613A (en) | 1991-02-13 | 1992-10-20 | Interface Biomedical Laboratories Corp. | Collagen welding rod material for use in tissue welding |
US5762798A (en) | 1991-04-12 | 1998-06-09 | Minntech Corporation | Hollow fiber membranes and method of manufacture |
US5236604A (en) | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
US5269927A (en) | 1991-05-29 | 1993-12-14 | Sherwood Medical Company | Separation device for use in blood collection tubes |
US5203825A (en) | 1991-06-07 | 1993-04-20 | Becton, Dickinson And Company | Capillary tube assembly including a vented cap |
SE9101853D0 (sv) | 1991-06-17 | 1991-06-17 | Jonas Wadstroem | Improved tissue ashesive |
FR2679251B1 (fr) | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
DE4126341C1 (zh) | 1991-08-09 | 1993-01-28 | Fresenius Ag, 6380 Bad Homburg, De | |
US5251786A (en) | 1991-08-16 | 1993-10-12 | Helena Laboratories Corporation | Biological fluid collection and delivery apparatus and method |
BR9103724A (pt) | 1991-08-29 | 1993-03-30 | Univ Estadual Paulista Julio D | Cola de fibrina derivada de veneno de cobra e processo para sua preparacao |
WO1993005067A1 (en) | 1991-09-05 | 1993-03-18 | Baxter International, Inc. | Topical fibrinogen complex |
DE4129516C2 (de) | 1991-09-06 | 2000-03-09 | Fresenius Ag | Verfahren und Vorrichtung zum Trennen von Blut in seine Bestandteile |
EP0534178B1 (en) | 1991-09-27 | 2001-04-18 | Omrix Biopharmaceuticals S.A. | Improved tissue glue prepared by using cryoprecipitate |
WO1993007824A1 (en) | 1991-10-18 | 1993-04-29 | Baxter International Inc. | Bone marrow kit |
US5344752A (en) | 1991-10-30 | 1994-09-06 | Thomas Jefferson University | Plasma-based platelet concentrate preparations |
CA2074671A1 (en) | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
US5190057A (en) | 1991-12-13 | 1993-03-02 | Faezeh Sarfarazi | Sarfarazi method of closing a corneal incision |
US5833866A (en) | 1991-12-23 | 1998-11-10 | Baxter International Inc. | Blood collection systems and methods which derive instantaneous blood component yield information during blood processing |
US5690835A (en) | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
DE4202667C1 (zh) | 1992-01-29 | 1993-05-13 | Behringwerke Ag, 3550 Marburg, De | |
DE4204012A1 (de) | 1992-02-12 | 1993-08-19 | Ulrich Prof Dr Zimmermann | Mitogenfreie substanz, deren herstellung und verwendung |
JPH07507055A (ja) | 1992-02-26 | 1995-08-03 | アラーガン、インコーポレイテッド | 眼の創傷の治癒における血小板誘導化成長因子の使用 |
US5298016A (en) | 1992-03-02 | 1994-03-29 | Advanced Haemotechnologies | Apparatus for separating plasma and other wastes from blood |
SE9201413L (sv) | 1992-04-30 | 1993-10-31 | Stiftelsen Foer Medicinsk Tekn | Beredning och sätt för aferesframställning av trombocytkoncentrat med väsentligt förlängd hållbarhet |
US5271852A (en) | 1992-05-01 | 1993-12-21 | E. I. Du Pont De Nemours And Company | Centrifugal methods using a phase-separation tube |
US5403272A (en) | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
US5275585A (en) | 1992-06-03 | 1994-01-04 | Zimmer Patient Care | Autotransfusion system with portable detachable vacuum source |
FR2691911B1 (fr) | 1992-06-05 | 1994-11-25 | Delmas Olivier | Dispositif permettant l'obtention d'un surnageant de thrombocytes activés, procédé mettant en Óoeuvre le dispositif et surnageant obtenu. |
DK83092D0 (da) | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
US5443481A (en) | 1992-07-27 | 1995-08-22 | Lee; Benjamin I. | Methods and device for percutaneous sealing of arterial puncture sites |
WO1994006460A1 (en) | 1992-09-21 | 1994-03-31 | Vitaphore Corporation | Embolization plugs for blood vessels |
FR2696095B1 (fr) | 1992-09-30 | 1994-11-25 | Inoteb | Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application. |
US5354483A (en) | 1992-10-01 | 1994-10-11 | Andronic Technologies, Inc. | Double-ended tube for separating phases of blood |
CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
DE69328738T2 (de) | 1992-12-01 | 2000-12-07 | Haemonetics Corp., Braintree | Vorrichtung zur apherese von roten blutkörperchen |
US5520885A (en) | 1993-01-19 | 1996-05-28 | Thermogenesis Corporation | Fibrinogen processing apparatus, method and container |
US5370221A (en) | 1993-01-29 | 1994-12-06 | Biomet, Inc. | Flexible package for bone cement components |
US5395923A (en) | 1993-02-23 | 1995-03-07 | Haemacure-Biotech, Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out" |
US5290918A (en) | 1993-02-23 | 1994-03-01 | Haemacure Biotech Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation |
US5330974A (en) | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
US5614106A (en) | 1993-03-12 | 1997-03-25 | Baxter International Inc. | Method and apparatus for collection of platelets |
GB9307321D0 (en) | 1993-04-07 | 1993-06-02 | Knight Scient Ltd | Method of separating particles from a filter |
WO1994025086A1 (en) | 1993-04-27 | 1994-11-10 | Haemonetics Corporation | Apheresis apparatus and method |
US5409833A (en) | 1993-07-01 | 1995-04-25 | Baxter International Inc. | Microvessel cell isolation apparatus |
US5456885A (en) | 1993-07-12 | 1995-10-10 | Coleman; Charles M. | Fluid collection, separation and dispensing tube |
US6189704B1 (en) | 1993-07-12 | 2001-02-20 | Baxter International Inc. | Inline filter |
JPH07103969A (ja) | 1993-08-13 | 1995-04-21 | Niigata Kako Kk | 血液分離部材及び血液分離用採血管 |
US5916557A (en) | 1993-11-12 | 1999-06-29 | The Trustees Of Columbia University In The City Of New York | Methods of repairing connective tissues |
CA2131738C (en) | 1993-11-17 | 2001-09-04 | Lonny R. Kelley | Flow enhanced one-pass centrifuge separator |
ZA948564B (en) | 1993-11-19 | 1995-07-26 | Bristol Myers Squibb Co | Liquid separation apparatus and method |
US5411885A (en) | 1993-12-17 | 1995-05-02 | New York Blood Center, Inc. | Methods for tissue embedding and tissue culturing |
US5437598A (en) | 1994-01-21 | 1995-08-01 | Cobe Laboratories, Inc. | Automation of plasma sequestration |
PT744409E (pt) | 1994-02-23 | 2008-11-03 | Kyowa Hakko Kogyo Kk | Acelerador do crescimento das plaquetas |
US5545339A (en) | 1994-02-25 | 1996-08-13 | Pall Corporation | Method for processing biological fluid and treating separated component |
ATE241394T1 (de) | 1994-04-08 | 2003-06-15 | Atrix Lab Inc | Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung |
US5533518A (en) | 1994-04-22 | 1996-07-09 | Becton, Dickinson And Company | Blood collection assembly including mechanical phase separating insert |
US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5795751A (en) | 1994-06-09 | 1998-08-18 | Lockheed Martin Idaho Technologies Company | Biofilter for removal of nitrogen oxides from contaminated gases under aerobic conditions |
US5501371A (en) | 1994-07-07 | 1996-03-26 | Schwartz-Feldman; Jean | Mixing syringe |
US5648223A (en) | 1994-08-31 | 1997-07-15 | Activated Cell Therapy, Inc. | Methods for enriching breast tumor cells |
US5646004A (en) | 1994-08-31 | 1997-07-08 | Activated Cell Therapy, Inc. | Methods for enriching fetal cells from maternal body fluids |
US5474687A (en) | 1994-08-31 | 1995-12-12 | Activated Cell Therapy, Inc. | Methods for enriching CD34+ human hematopoietic progenitor cells |
US5840502A (en) | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US5577513A (en) | 1994-08-31 | 1996-11-26 | Activated Cell Therapy, Inc. | Centrifugation syringe, system and method |
US5663051A (en) | 1994-08-31 | 1997-09-02 | Activated Cell Therapy, Inc. | Separation apparatus and method |
US5575778A (en) | 1994-09-21 | 1996-11-19 | B. Braun Melsungen Ag | Blood-taking device |
US5588958A (en) | 1994-09-21 | 1996-12-31 | C. R. Bard, Inc. | Closed wound orthopaedic drainage and autotransfusion system |
US5645540A (en) | 1994-10-11 | 1997-07-08 | Stryker Corporation | Blood conservation system |
US5733253A (en) | 1994-10-13 | 1998-03-31 | Transfusion Technologies Corporation | Fluid separation system |
US5601711A (en) | 1994-10-31 | 1997-02-11 | Gelman Sciences Inc. | Selective separation filter device |
NZ298283A (en) | 1994-12-02 | 1999-01-28 | Bristol Myers Squibb Co | Preloaded reagent delivery capsule for blood plasma centrifuge |
MX9704017A (es) | 1994-12-02 | 1998-02-28 | Bristol Myers Squibb Co | Metodo y dispositivo para separar fibrina i del plasma sanguineo. |
US5733446A (en) | 1994-12-02 | 1998-03-31 | Bristol-Myers Squibb Company | Centrifuge with annular filter |
CA2182862C (en) | 1994-12-07 | 2006-10-03 | Richard D. Antanavich | Plasma concentrate and tissue sealant compositions |
US5585007A (en) | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
US5560830A (en) | 1994-12-13 | 1996-10-01 | Coleman; Charles M. | Separator float and tubular body for blood collection and separation and method of use thereof |
NO301562B1 (no) | 1994-12-21 | 1997-11-10 | Exxon Production Research Co | Anordning for måling |
US5510102A (en) | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US7011644B1 (en) | 1995-02-06 | 2006-03-14 | Andrew Mark S | Tissue liquefaction and aspiration for dental treatment |
US6676629B2 (en) | 1995-02-06 | 2004-01-13 | Mark S. Andrew | Tissue liquefaction and aspiration for dental treatment |
US5823986A (en) | 1995-02-08 | 1998-10-20 | Medtronic, Inc. | Perfusion system |
FR2731176B1 (fr) | 1995-03-02 | 1997-04-30 | Sidel Sa | Installation de fabrication de recipients par soufflage de preformes en matiere plastique |
US5733545A (en) | 1995-03-03 | 1998-03-31 | Quantic Biomedical Partners | Platelet glue wound sealant |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US5900245A (en) | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
US5716616A (en) | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
US5643192A (en) | 1995-04-06 | 1997-07-01 | Hamilton Civic Hospitals Research Development, Inc. | Autologous fibrin glue and methods for its preparation and use |
US5674173A (en) | 1995-04-18 | 1997-10-07 | Cobe Laboratories, Inc. | Apparatus for separating particles |
US6022306A (en) | 1995-04-18 | 2000-02-08 | Cobe Laboratories, Inc. | Method and apparatus for collecting hyperconcentrated platelets |
US6053856A (en) | 1995-04-18 | 2000-04-25 | Cobe Laboratories | Tubing set apparatus and method for separation of fluid components |
DE69638219D1 (de) | 1995-04-18 | 2010-08-26 | Caridianbct Inc | Teilchentrennverfahren |
USRE38730E1 (en) | 1995-05-05 | 2005-04-26 | Harvest Technologies Corporation | Automatic multiple-decanting centrifuge and method of treating physiological fluids |
US5707331A (en) | 1995-05-05 | 1998-01-13 | John R. Wells | Automatic multiple-decanting centrifuge |
EP0836487A1 (en) | 1995-06-06 | 1998-04-22 | Quantic Biomedical Partners | Device and method for concentrating plasma |
US6544727B1 (en) | 1995-06-07 | 2003-04-08 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
US5738644A (en) | 1995-06-07 | 1998-04-14 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
US5837150A (en) | 1995-06-07 | 1998-11-17 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods |
US20020192632A1 (en) | 1995-06-07 | 2002-12-19 | Hei Derek J. | Method and devices for the removal of psoralens from blood products |
US5958250A (en) | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
US5750025A (en) | 1995-06-07 | 1998-05-12 | Cobe Laboratories, Inc. | Disposable for an apheresis system with a contoured support |
US5632905A (en) | 1995-08-07 | 1997-05-27 | Haynes; John L. | Method and apparatus for separating formed and unformed components |
US6351659B1 (en) | 1995-09-28 | 2002-02-26 | Brainlab Med. Computersysteme Gmbh | Neuro-navigation system |
AU700988B2 (en) | 1995-10-03 | 1999-01-14 | Beckman Instruments, Inc. | Axial spin blood separation system and method |
US5643193A (en) | 1995-12-13 | 1997-07-01 | Haemonetics Corporation | Apparatus for collection washing and reinfusion of shed blood |
US5736033A (en) | 1995-12-13 | 1998-04-07 | Coleman; Charles M. | Separator float for blood collection tubes with water swellable material |
US5817519A (en) | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
US6025201A (en) | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US5733466A (en) | 1996-02-06 | 1998-03-31 | International Business Machines Corporation | Electrolytic method of depositing gold connectors on a printed circuit board |
US5865785A (en) | 1996-02-23 | 1999-02-02 | Baxter International Inc. | Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes |
US5834418A (en) | 1996-03-20 | 1998-11-10 | Theratechnologies, Inc. | Process for the preparation of platelet growth factors extract |
DE69605062T2 (de) | 1996-04-24 | 2000-07-13 | Claude Fell | Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut |
WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
DE29723807U1 (de) | 1996-04-30 | 1999-11-04 | Medtronic, Inc., Minneapolis, Minn. | Autologe Fibrin-Blutstillungsmittel |
US6099493A (en) | 1997-05-06 | 2000-08-08 | Sherwood Services, Ag | Continuous autotransfusion filtration system |
US6020196A (en) * | 1996-05-09 | 2000-02-01 | Baxter International Inc. | Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells |
JP2859845B2 (ja) | 1996-05-09 | 1999-02-24 | 照明 伊藤 | 血清分取補助装置 |
US5811151A (en) | 1996-05-31 | 1998-09-22 | Medtronic, Inc. | Method of modifying the surface of a medical device |
US5824084A (en) | 1996-07-03 | 1998-10-20 | The Cleveland Clinic Foundation | Method of preparing a composite bone graft |
JP3638614B2 (ja) | 1996-07-25 | 2005-04-13 | ジェンザイム・コーポレーション | 軟骨細胞培地組成および培養方法 |
WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
FR2757770B1 (fr) | 1996-12-30 | 1999-02-26 | Inoteb | Procede de preparation d'une colle biologique capable de coaguler par simple addition d'ions calcium |
US5879624A (en) | 1997-01-15 | 1999-03-09 | Boehringer Laboratories, Inc. | Method and apparatus for collecting and processing blood |
US5961210A (en) | 1997-01-24 | 1999-10-05 | Mccardel; Brian R. | Bone cement preparation device, and methods of constructing and utilizing same |
US5889584A (en) | 1997-03-10 | 1999-03-30 | Robert A. Levine | Assembly for rapid measurement of cell layers |
WO1998043720A1 (en) | 1997-04-03 | 1998-10-08 | Baxter International Inc. | Interface detection and control systems and methods |
WO1998048938A1 (en) | 1997-04-25 | 1998-11-05 | Washington State University Research Foundation | Semi-continuous, small volume centrifugal blood separator |
US5860937A (en) | 1997-04-30 | 1999-01-19 | Becton, Dickinson & Company | Evacuated sample collection tube with aqueous additive |
DE19718648A1 (de) | 1997-05-02 | 1998-11-05 | Merck Patent Gmbh | Verfahren und Vorrichtung zur Herstellung von steril verpacktem Knochenzement |
US6063624A (en) | 1997-06-09 | 2000-05-16 | Baxter International Inc. | Platelet suspensions and methods for resuspending platelets |
JP2002514960A (ja) | 1997-06-18 | 2002-05-21 | コヘージョン テクノロジーズ,インコーポレイテッド | トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法 |
US6979307B2 (en) * | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
IT1292410B1 (it) | 1997-06-24 | 1999-02-08 | Roberto Beretta | Contenitore di pronto impiego per ottenere colla di fibrina autologa |
US6007811A (en) | 1997-07-01 | 1999-12-28 | Sea Run Holdings, Inc. | Method of producing fibrin sealant from clotting factors in fish blood |
US5918622A (en) | 1997-07-01 | 1999-07-06 | Bermad | Separation valve |
US6200287B1 (en) | 1997-09-05 | 2001-03-13 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
US5938621A (en) | 1997-09-12 | 1999-08-17 | Becton Dickinson And Company | Collection container assembly |
US5955032A (en) | 1997-09-12 | 1999-09-21 | Becton Dickinson And Company | Collection container assembly |
US5934803A (en) | 1997-10-30 | 1999-08-10 | Physical Systems, Inc. | Apparatus and method for mixing multi-part reaction materials under vacuum |
EP1030676B1 (en) | 1997-10-30 | 2005-09-14 | The General Hospital Corporation | Bonding of cartilaginous matrices using isolated chondrocytes |
US7031775B2 (en) | 1997-11-07 | 2006-04-18 | Medtronic, Inc. | Method and system for myocardial infarction repair |
US5951160A (en) | 1997-11-20 | 1999-09-14 | Biomet, Inc. | Method and apparatus for packaging, mixing and delivering bone cement |
US6478808B2 (en) | 1997-12-17 | 2002-11-12 | Closys Corporation | Clotting cascade initiating apparatus and methods of use and methods of closing wounds |
US6051146A (en) | 1998-01-20 | 2000-04-18 | Cobe Laboratories, Inc. | Methods for separation of particles |
EP1062321B1 (en) | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
AU3006199A (en) | 1998-03-16 | 1999-10-11 | Medtronic, Inc. | Hemostatic system and components for extracorporeal circuit |
US5924972A (en) | 1998-03-24 | 1999-07-20 | Turvaville; L. Jackson | Portable D.C. powered centrifuge |
US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
EP1083956A4 (en) | 1998-06-01 | 2005-08-10 | Haemonetics Corp | BLOOD SAMPLING SYSTEM |
US6327491B1 (en) | 1998-07-06 | 2001-12-04 | Neutar, Llc | Customized surgical fixture |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
US6308747B1 (en) | 1998-10-01 | 2001-10-30 | Barry Farris | Needleless method and apparatus for transferring liquid from a container to an injecting device without ambient air contamination |
US6563953B2 (en) | 1998-11-30 | 2003-05-13 | Microsoft Corporation | Predictive image compression using a single variable length code for both the luminance and chrominance blocks for each macroblock |
US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
US6280400B1 (en) | 1998-12-05 | 2001-08-28 | Becton Dickinson And Company | Device and method for separating component of a liquid sample |
US6479298B1 (en) | 1998-12-05 | 2002-11-12 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
US6406671B1 (en) | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
US6516953B1 (en) | 1998-12-05 | 2003-02-11 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
US6153113A (en) | 1999-02-22 | 2000-11-28 | Cobe Laboratories, Inc. | Method for using ligands in particle separation |
US6294187B1 (en) | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US6322785B1 (en) | 1999-03-02 | 2001-11-27 | Natrex Technologies | Methods and compositions for bone graft implants |
US20050076396A1 (en) | 1999-03-10 | 2005-04-07 | Katz Adam J. | Adipose-derived stem cells and lattices |
US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
US20050153442A1 (en) | 1999-03-10 | 2005-07-14 | Adam Katz | Adipose-derived stem cells and lattices |
EP1165830B1 (en) | 1999-03-10 | 2017-07-12 | University of Pittsburgh of the Commonwealth System of Higher Education | Adipose-derived stem cells and lattices |
US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
US6296602B1 (en) | 1999-03-17 | 2001-10-02 | Transfusion Technologies Corporation | Method for collecting platelets and other blood components from whole blood |
EP1093390B1 (en) | 1999-04-12 | 2013-05-08 | Harvest Technologies Corporation | Method and apparatus for producing platelet rich plasma and/or platelet concentrate |
US6417004B1 (en) | 1999-04-29 | 2002-07-09 | Helena Laboratories Corporation | Enhancing clot detection in activated clotting time and other fibrin endpoint based tests |
EP1057534A1 (en) | 1999-06-03 | 2000-12-06 | Haemonetics Corporation | Centrifugation bowl with filter core |
US6629919B2 (en) | 1999-06-03 | 2003-10-07 | Haemonetics Corporation | Core for blood processing apparatus |
US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
US6316247B1 (en) | 1999-06-15 | 2001-11-13 | University Of Pittsburgh | System and method for refining liposuctioned adipose tissue |
US6716187B1 (en) | 1999-07-08 | 2004-04-06 | Implant Innovations, Inc. | Platelet concentration syringe kit |
EP1202758B1 (en) | 1999-07-08 | 2006-08-30 | Implant Innovations, Inc. | Platelet concentration syringe kit and method |
US6758978B1 (en) | 1999-08-06 | 2004-07-06 | Gl&V Management Hungary Kft. | Deep bed thickener/clarifiers with enhanced liquid removal |
US6294094B1 (en) | 1999-09-03 | 2001-09-25 | Baxter International Inc. | Systems and methods for sensing red blood cell hematocrit |
US6284142B1 (en) | 1999-09-03 | 2001-09-04 | Baxter International Inc. | Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing |
US6487992B1 (en) | 1999-11-22 | 2002-12-03 | Robert L. Hollis | Dog behavior monitoring and training apparatus |
US6803022B2 (en) | 1999-12-06 | 2004-10-12 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
US6471069B2 (en) | 1999-12-03 | 2002-10-29 | Becton Dickinson And Company | Device for separating components of a fluid sample |
US6409528B1 (en) | 1999-12-06 | 2002-06-25 | Becton, Dickinson And Company | Device and method for collecting, preparation and stabilizing a sample |
ITAL990010U1 (it) | 1999-12-14 | 2001-06-14 | Maria Cristina Sacchi | Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. |
KR100505445B1 (ko) | 1999-12-28 | 2005-08-04 | 주식회사 하이닉스반도체 | 반도체 소자의 강유전체 캐패시터 및 그 형성방법 |
US6286670B1 (en) | 2000-03-14 | 2001-09-11 | Biomet, Inc. | Method and apparatus for mixing a compound utilizing a gas permeable barrier |
US20020104808A1 (en) | 2000-06-30 | 2002-08-08 | Lou Blasetti | Method and apparatus for producing platelet rich plasma and/or platelet concentrate |
AU2001272085B2 (en) | 2000-04-28 | 2006-03-02 | Harvest Technologies Corporation | Blood components separator disk |
BR0112109A (pt) | 2000-06-29 | 2007-05-29 | Biosyntech Canada Inc | composição e método para a correção e regeneração de cartilagem e outros tecidos |
US6368498B1 (en) | 2000-08-30 | 2002-04-09 | Paul Guilmette | Liquid separator |
US7411006B2 (en) | 2000-10-23 | 2008-08-12 | Shanbrom Technologies, Llc | Enhanced production of blood clotting factors and fibrin fabric |
MXPA03004030A (es) | 2000-11-08 | 2004-02-12 | Octapharma Ag | Proceso para preparacion de antitrombina iii latente. |
US20020090711A1 (en) | 2000-11-20 | 2002-07-11 | Goran Karlsson | Process for preparing latent antithrombin III |
WO2002060925A1 (en) | 2001-01-30 | 2002-08-08 | Genzymes Corporation | Method of producing latent antithrombin iii |
US6911202B2 (en) | 2001-02-06 | 2005-06-28 | Abraham Amir | Cosmetic repair using cartilage producing cells and medical implants coated therewith |
US20030050709A1 (en) | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
US7195606B2 (en) | 2001-02-26 | 2007-03-27 | Erythrosave Ltd. | Syringe and a method for its utilization in analysis |
US6723131B2 (en) | 2001-02-28 | 2004-04-20 | The Cleveland Clinic Foundation | Composite bone marrow graft material with method and kit |
JP2005098704A (ja) | 2001-03-13 | 2005-04-14 | Hajime Ogata | 比重の異なる微粒子の分別法 |
EP1381410A2 (en) | 2001-04-09 | 2004-01-21 | Medtronic, Inc. | Methods of isolating blood components using a centrifuge and uses thereof |
WO2002098566A2 (en) | 2001-06-06 | 2002-12-12 | Perfusion Partners & Associates, Inc. | Centrifuge tube assembly |
US6623959B2 (en) | 2001-06-13 | 2003-09-23 | Ethicon, Inc. | Devices and methods for cell harvesting |
US6764531B2 (en) | 2001-07-06 | 2004-07-20 | J. S. Hogan | Method and apparatus for cleaning a gas |
WO2003007787A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Cartilage repair and regeneration device and method |
WO2003015800A1 (en) | 2001-08-09 | 2003-02-27 | Ivoclar Vivadent, Inc. | Tissue implants and methods for making and using same |
US7371409B2 (en) | 2001-09-06 | 2008-05-13 | Wright Medical Technology, Inc. | Bone graft substitute composition |
US20030054331A1 (en) | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
US6638503B2 (en) | 2001-11-28 | 2003-10-28 | Maharashtra Association For The Cultivation Of Science | Streptomyces megasporus sd5, process for the isolation thereof, novel fibrinolytic enzyme prepared therefrom, process for the production of said enzyme and method of treatment of thrombolytic disorders using said enzyme |
US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
CA2469370C (en) | 2001-12-07 | 2014-07-08 | Macropore Biosurgery, Inc. | Adipose-derived cell processing unit |
US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
CA2470031A1 (en) | 2001-12-20 | 2003-07-03 | Macropore, Inc. | Systems and methods for treating patients with collagen-rich material extracted from adipose tissue |
US8313742B2 (en) | 2002-03-29 | 2012-11-20 | Depuy Acromed, Inc. | Cell-containing bone graft material |
US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US7374678B2 (en) | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
US6905612B2 (en) | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20040182795A1 (en) | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
US7309468B2 (en) * | 2002-05-13 | 2007-12-18 | Becton, Dickinson And Company | Protease inhibitor sample collection system |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
WO2003099412A1 (en) | 2002-05-24 | 2003-12-04 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7304128B2 (en) | 2002-06-04 | 2007-12-04 | E.I. Du Pont De Nemours And Company | Carbon nanotube binding peptides |
US7176034B2 (en) | 2002-07-03 | 2007-02-13 | St. Joseph's Healthcare | Apparatus and method for filtering biological samples |
WO2004009207A1 (en) | 2002-07-18 | 2004-01-29 | Hanuman Llc | Plasma concentrating apparatus and method |
US7077827B2 (en) | 2002-08-30 | 2006-07-18 | Christian John Greenfield | Syringe for sequential delivery of different fluids |
WO2004026709A1 (en) | 2002-09-19 | 2004-04-01 | Harvest Technologies Corporation | Sterile disposable unit |
US20040120942A1 (en) | 2002-12-23 | 2004-06-24 | Mcginnis Daniel | Device and process for the preparation of autologous thrombin serum |
US20040182394A1 (en) | 2003-03-21 | 2004-09-23 | Alvey Jeffrey Arthur | Powered air purifying respirator system and self contained breathing apparatus |
JP4344528B2 (ja) | 2003-04-07 | 2009-10-14 | テルモ株式会社 | 医療用容器および医療用容器の製造方法 |
CA2525713A1 (en) | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
JP2005013783A (ja) | 2003-06-23 | 2005-01-20 | Moriai Seiki Kk | 液体遠心分離装置 |
CA2531623A1 (en) | 2003-07-09 | 2005-01-20 | Sdgi Holdings, Inc. | Isolation of bone marrow fraction rich in connective tissue growth components and the use thereof to promote connective tissue formation |
US7744869B2 (en) | 2003-08-20 | 2010-06-29 | Ebi, Llc | Methods of treatment using electromagnetic field stimulated mesenchymal stem cells |
US20050084962A1 (en) | 2003-08-20 | 2005-04-21 | Bruce Simon | Methods of treatment using electromagnetic field stimulated stem cells |
CN1878470A (zh) | 2003-09-17 | 2006-12-13 | 马克罗珀尔生物外科公司 | 在周围血管疾病和相关病症的治疗中使用再生细胞的方法 |
US20050145187A1 (en) | 2003-12-29 | 2005-07-07 | Gray James D. | Asset management of livestock in an open range using satellite communications |
US7354515B2 (en) | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
US20060051865A1 (en) | 2004-08-31 | 2006-03-09 | Higgins Joel C | Systems and methods for isolating stromal cells from adipose tissue and uses thereof |
SE0402500D0 (sv) | 2004-10-14 | 2004-10-14 | Astra Tech Ab | Method and apparatus for autotransfusion |
ITRM20040638A1 (it) | 2004-12-24 | 2005-03-24 | Advance Holdings Ltd | Gel piastrinico semisintetico e metodo per la sua preparazione. |
US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
EP2910258B1 (en) | 2005-02-07 | 2018-08-01 | Hanuman LLC | Platelet rich plasma concentrate apparatus |
US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
PL1848473T3 (pl) | 2005-02-07 | 2013-11-29 | Hanuman Llc | Urządzenie - koncentrator osocza |
US7766900B2 (en) | 2005-02-21 | 2010-08-03 | Biomet Manufacturing Corp. | Method and apparatus for application of a fluid |
US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
US7531355B2 (en) | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
US8048297B2 (en) | 2005-08-23 | 2011-11-01 | Biomet Biologics, Llc | Method and apparatus for collecting biological materials |
US7771590B2 (en) | 2005-08-23 | 2010-08-10 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
FR2890976B1 (fr) | 2005-09-20 | 2007-12-14 | Univ La Reunion | Kit pour preparer une composition comprenant des cellules adipocytaires et procede d'obtention de ladite composition |
WO2007127834A2 (en) | 2006-04-26 | 2007-11-08 | Medtronic, Inc. | Compositions and methods of preparation thereof |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
EP2520161B1 (en) | 2006-09-05 | 2019-09-18 | Maasland N.V. | A milking implement |
JP2008104789A (ja) * | 2006-10-27 | 2008-05-08 | Nipro Corp | 多血小板血漿分離方法及び多血小板血漿分離装置 |
US20080164204A1 (en) | 2007-01-08 | 2008-07-10 | Mehdi Hatamian | Valve for facilitating and maintaining separation of fluids and materials |
WO2008100442A1 (en) | 2007-02-09 | 2008-08-21 | Biomet Biologics, Inc. | Treatment of tissue defects with a therapeutic composition |
US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
EP2146794B1 (en) | 2007-04-12 | 2016-10-19 | Biomet Biologics, LLC | Buoy suspension fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US20080269762A1 (en) | 2007-04-25 | 2008-10-30 | Biomet Manufacturing Corp. | Method and device for repair of cartilage defects |
US20080268064A1 (en) | 2007-04-25 | 2008-10-30 | Biomet Biologics, Inc. | Method for treating cartilage defects |
US7901344B2 (en) | 2007-05-11 | 2011-03-08 | Biomet Biologics, Llc | Methods of reducing surgical complications in cancer patients |
WO2009021257A1 (de) | 2007-08-13 | 2009-02-19 | Greiner Bio-One Gmbh | Medizinische trenneinrichtung |
WO2009073232A1 (en) | 2007-12-07 | 2009-06-11 | Harvest Technologies Corporation | Floating disk for separating blood components |
US20090192528A1 (en) | 2008-01-29 | 2009-07-30 | Biomet Biologics, Inc. | Method and device for hernia repair |
EP2567692B1 (en) | 2008-02-27 | 2016-04-06 | Biomet Biologics, LLC | Use of a device for obtaining interleukin-1 receptor antagonist rich solutions |
US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
US8518272B2 (en) | 2008-04-04 | 2013-08-27 | Biomet Biologics, Llc | Sterile blood separating system |
US8182769B2 (en) | 2008-04-04 | 2012-05-22 | Biomet Biologics, Llc | Clean transportation system |
US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
US7850651B2 (en) | 2008-09-15 | 2010-12-14 | Biomet Biologics, Llc | Bone marrow aspiration needle |
US8177072B2 (en) * | 2008-12-04 | 2012-05-15 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
-
2009
- 2009-04-03 US US12/417,789 patent/US8313954B2/en active Active
-
2010
- 2010-04-05 EP EP10712677.3A patent/EP2413989B1/en active Active
- 2010-04-05 JP JP2012503768A patent/JP5639149B2/ja active Active
- 2010-04-05 CN CN201080019707.7A patent/CN102438672B/zh active Active
- 2010-04-05 WO PCT/US2010/029957 patent/WO2010115190A1/en active Application Filing
-
2012
- 2012-11-15 US US13/677,897 patent/US8992862B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5707876A (en) * | 1996-03-25 | 1998-01-13 | Stephen C. Wardlaw | Method and apparatus for harvesting constituent layers from a centrifuged material mixture |
US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US20060273050A1 (en) * | 2002-05-24 | 2006-12-07 | Higgins Joel C | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060151384A1 (en) * | 2003-05-19 | 2006-07-13 | Ellsworth James R | Method and apparatus for separating fluid components |
Cited By (10)
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CN104541166A (zh) * | 2012-08-08 | 2015-04-22 | 皇家飞利浦有限公司 | 使用一滴血实现的血浆分离 |
CN104541166B (zh) * | 2012-08-08 | 2017-06-13 | 皇家飞利浦有限公司 | 使用一滴血实现的血浆分离 |
CN104474598A (zh) * | 2015-01-05 | 2015-04-01 | 浙江保尔曼生物科技有限公司 | 血浆分离装置 |
CN104474598B (zh) * | 2015-01-05 | 2016-06-08 | 浙江保尔曼生物科技有限公司 | 血浆分离装置 |
CN107735119A (zh) * | 2015-12-29 | 2018-02-23 | 热起源公司 | 细胞分离装置、系统和方法 |
CN107735119B (zh) * | 2015-12-29 | 2021-01-01 | 热起源公司 | 细胞分离装置、系统和方法 |
CN108601868A (zh) * | 2016-01-21 | 2018-09-28 | 托朗塞爾股份有限公司 | 血液成分分离用装置 |
US11192121B2 (en) | 2016-01-21 | 2021-12-07 | Transell Co., Ltd. | Blood component separator with slider for sealing |
CN106994396A (zh) * | 2017-05-23 | 2017-08-01 | 武汉朗克医疗器械有限公司 | Prp连续离心分离装置及分离方法 |
CN106994396B (zh) * | 2017-05-23 | 2019-03-29 | 武汉朗克医疗器械有限公司 | Prp连续离心分离装置及分离方法 |
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CN102438672B (zh) | 2015-04-01 |
US8313954B2 (en) | 2012-11-20 |
EP2413989A1 (en) | 2012-02-08 |
EP2413989B1 (en) | 2015-01-21 |
US20100256595A1 (en) | 2010-10-07 |
US20130068676A1 (en) | 2013-03-21 |
WO2010115190A1 (en) | 2010-10-07 |
US8992862B2 (en) | 2015-03-31 |
JP2012522610A (ja) | 2012-09-27 |
JP5639149B2 (ja) | 2014-12-10 |
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