DE69605062T2 - Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut - Google Patents

Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut

Info

Publication number
DE69605062T2
DE69605062T2 DE69605062T DE69605062T DE69605062T2 DE 69605062 T2 DE69605062 T2 DE 69605062T2 DE 69605062 T DE69605062 T DE 69605062T DE 69605062 T DE69605062 T DE 69605062T DE 69605062 T2 DE69605062 T2 DE 69605062T2
Authority
DE
Germany
Prior art keywords
pct
processing chamber
blood
centrifugal
separation device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69605062T
Other languages
English (en)
Other versions
DE69605062D1 (de
Inventor
Claude Fell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69605062D1 publication Critical patent/DE69605062D1/de
Application granted granted Critical
Publication of DE69605062T2 publication Critical patent/DE69605062T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • A61M1/0218Multiple bag systems for separating or storing blood components with filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3627Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B1/00Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles
    • B04B1/02Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles without inserted separating walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692Washing or rinsing blood or blood constituents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0485Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with a displaceable piston in the centrifuge chamber
DE69605062T 1996-04-24 1996-08-02 Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut Expired - Lifetime DE69605062T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9600373 1996-04-24
PCT/IB1996/000771 WO1997015399A1 (en) 1996-04-24 1996-08-02 Cell separation system for biological fluids like blood

Publications (2)

Publication Number Publication Date
DE69605062D1 DE69605062D1 (de) 1999-12-09
DE69605062T2 true DE69605062T2 (de) 2000-07-13

Family

ID=11004420

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69605062T Expired - Lifetime DE69605062T2 (de) 1996-04-24 1996-08-02 Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut

Country Status (6)

Country Link
US (1) US6123655A (de)
EP (1) EP0912250B1 (de)
AT (1) ATE186235T1 (de)
AU (1) AU6467796A (de)
DE (1) DE69605062T2 (de)
WO (1) WO1997015399A1 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038762A1 (en) 1998-12-24 2000-07-06 Biosafe S.A. Blood separation system particularly for concentrating hematopoietic stem cells
WO2000045931A1 (en) * 1999-02-06 2000-08-10 Frymate Limited Apparatus for separating solids from oil
DE19938287A1 (de) 1999-08-12 2001-03-15 Fresenius Ag Vorrichtung und Verfahren zur autologenen Transfusion von Blut
US6695951B1 (en) * 2000-07-18 2004-02-24 Jack G. Bitterly Saline/sewage water reclamation system
DE10136375A1 (de) * 2001-07-26 2003-02-13 Cellgenix Technologie Transfer Verfahren zur Anreicherung von Zellen
GB0118742D0 (en) * 2001-08-01 2001-09-26 Jeory James A coupling
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
DE60331794D1 (de) * 2002-04-16 2010-04-29 Caridianbct Inc Verfahren zur Verarbeitung von Blutkomponenten
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7179391B2 (en) * 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
ITMI20031715A1 (it) * 2003-09-05 2005-03-06 Dideco Spa Dispositivo di comando nella raccolta differenziata dei
US7060018B2 (en) * 2003-09-11 2006-06-13 Cobe Cardiovascular, Inc. Centrifuge apparatus for processing blood
EP1683579A1 (de) * 2005-01-25 2006-07-26 Jean-Denis Rochat Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren
US7442178B2 (en) 2005-03-09 2008-10-28 Jacques Chammas Automated system and method for blood components separation and processing
WO2006100651A1 (en) * 2005-03-23 2006-09-28 Biosafe S.A. Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine
US7364657B2 (en) * 2005-03-31 2008-04-29 Abbott Cardiovascular Systems Inc. Integrated system for on-site cell acquisition, processing, and delivery
US7694828B2 (en) * 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US7618361B2 (en) * 2005-09-01 2009-11-17 Wagner Development, Inc. Gas driven solids discharge and pumping piston for a centrifugal separator
US7998052B2 (en) * 2006-03-07 2011-08-16 Jacques Chammas Rotor defining a fluid separation chamber of varying volume
GB0608451D0 (en) * 2006-04-28 2006-06-07 Ge Healthcare Bio Sciences Ab Centrifugal separation system
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
EP2567692B1 (de) 2008-02-27 2016-04-06 Biomet Biologics, LLC Verwendung einer Vorrichtung zur Erzeugung Interleukin-1-rezeptorantagonistreicher Lösungen
WO2009111338A1 (en) * 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
AU2013204205B2 (en) * 2008-12-01 2015-09-24 Baxalta GmbH Apparatus and method for processing biological material
US8177072B2 (en) * 2008-12-04 2012-05-15 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
US8475352B2 (en) * 2008-12-29 2013-07-02 Wagner Development, Inc. Solids discharge centrifugal separator with disposable contact elements
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
WO2010138895A2 (en) 2009-05-29 2010-12-02 Neil Francis Duffy Apparatus and methods for aspirating and separating components of different densities from a physiological fluid containing cells
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US9034280B2 (en) 2009-12-16 2015-05-19 General Electric Corporation High-throughput methods and systems for processing biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US8394006B2 (en) 2010-11-19 2013-03-12 Kensey Nash Corporation Centrifuge
US8556794B2 (en) 2010-11-19 2013-10-15 Kensey Nash Corporation Centrifuge
US8469871B2 (en) 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US8870733B2 (en) 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US8317672B2 (en) 2010-11-19 2012-11-27 Kensey Nash Corporation Centrifuge method and apparatus
EP2691182B1 (de) 2011-03-29 2019-06-26 EMD Millipore Corporation Verfahren und vorrichtung zum zentrifugieren und filtrieren
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2014120797A1 (en) 2013-01-29 2014-08-07 Endocellutions, Inc. Cell concentration devices and methods
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
ES2424272B1 (es) * 2013-07-23 2014-01-29 Riera Nadeu, S.A. Supercentrífuga con dispositivo no intrusivo de extracción de sólido y procedimiento de extracción del mismo
WO2015117007A1 (en) 2014-01-31 2015-08-06 Dsm Ip Assets B.V. Adipose tissue centrifuge and method of use
KR101466762B1 (ko) * 2014-03-28 2014-11-28 이준석 원심 분리 장치, 원심 분리 방법, 및 원심 분리용 용기
US10906049B2 (en) 2014-06-04 2021-02-02 Biosafe S.A. System for multi-processing and separation of biological fluids
CN107109438B (zh) 2014-11-05 2021-09-03 朱诺治疗学股份有限公司 用于转导及细胞处理的方法
EP3233148B1 (de) * 2014-12-19 2019-04-17 Biosafe S.A. Sequenzielle verarbeitung von biologischen fluiden
CA2982894C (en) 2015-05-07 2023-06-27 Biosafe S.A. A device, system and method for the continuous processing and separation of biological fluids into components
GB201511039D0 (en) * 2015-06-23 2015-08-05 Karhiniemi Marko And Medigoo Oy And Karilahti Mika In-vitro-analyser
US20240018268A1 (en) 2016-07-29 2024-01-18 Juno Therapeutics, Inc. Anti-idiotypic antibodies against anti-cd19 antibodies
RU2755725C2 (ru) 2016-09-12 2021-09-20 Джуно Терапьютикс, Инк. Сборочные узлы перфузионных биореакторных мешков
MA46998A (fr) 2016-12-05 2019-10-09 Juno Therapeutics Inc Production de cellules modifiées pour une thérapie cellulaire adoptive
WO2018157171A2 (en) 2017-02-27 2018-08-30 Juno Therapeutics, Inc. Compositions, articles of manufacture and methods related to dosing in cell therapy
US10449555B2 (en) * 2017-05-16 2019-10-22 Robert Bret Carr Centrifugal separator with annular piston for solids extrusion
EP3634637A4 (de) * 2017-06-08 2021-03-03 Patrick Pennie Zweikolbenzentrifugenrohr
JP7337773B2 (ja) 2017-07-29 2023-09-04 ジュノー セラピューティクス インコーポレイテッド 組換え受容体を発現している細胞を増大させるための試薬
GB201713252D0 (en) * 2017-08-18 2017-10-04 Biosafe Sa Piston movement
KR20230092033A (ko) 2017-09-01 2023-06-23 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화
EP3679370A1 (de) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Verfahren zur identifizierung von zellulären attributen im zusammenhang mit den ergebnissen einer zelltherapie
CN111542596A (zh) 2017-11-01 2020-08-14 朱诺治疗学股份有限公司 产生工程化细胞的治疗性组合物的方法
BR112020008565A2 (pt) 2017-11-01 2020-10-20 Juno Therapeutics Inc processo para a produção de uma composição de célula t
MA50571A (fr) 2017-11-10 2020-09-16 Juno Therapeutics Inc Réservoirs cryogéniques à système fermé
CA3084445A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Process for producing a composition of engineered t cells
US20210207080A1 (en) 2017-12-08 2021-07-08 Juno Therapeutics, Inc. Serum-free media formulation for culturing cells and methods of use thereof
AU2018379094A1 (en) 2017-12-08 2020-06-25 Juno Therapeutics, Inc. Phenotypic markers for cell therapy and related methods
JP2021531842A (ja) 2018-07-09 2021-11-25 ハヌマン ペリカン,インコーポレイテッド 血液成分を分離するための装置および方法
JP2021531059A (ja) 2018-07-09 2021-11-18 ハヌマン ペリカン,インコーポレイテッド 血液を処理するための装置および方法
AU2019318560A1 (en) 2018-08-09 2021-02-25 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
MX2021001519A (es) 2018-08-09 2021-05-27 Juno Therapeutics Inc Metodos para valorar acidos nucleicos integrados.
CN113167796A (zh) 2018-09-11 2021-07-23 朱诺治疗学股份有限公司 对工程化细胞组合物进行质谱分析的方法
WO2020089343A1 (en) 2018-10-31 2020-05-07 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
KR20210113169A (ko) 2018-11-01 2021-09-15 주노 쎄러퓨티크스 인코퍼레이티드 Β세포 성숙 항원에 특이적인 키메라 항원 수용체를 이용한 치료 방법
JP2022512913A (ja) 2018-11-06 2022-02-07 ジュノー セラピューティクス インコーポレイテッド 遺伝子操作されたt細胞を作製するための方法
SG11202105084VA (en) 2018-11-16 2021-06-29 Juno Therapeutics Inc Methods of dosing engineered t cells for the treatment of b cell malignancies
AU2019387497A1 (en) 2018-11-30 2021-06-24 Juno Therapeutics, Inc. Methods for treatment using adoptive cell therapy
BR112021010120A2 (pt) 2018-11-30 2021-08-31 Juno Therapeutics, Inc. Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva
CN113366099A (zh) 2018-12-21 2021-09-07 奥克泰生物科技股份有限公司 用于模块化生物生产单元的转盘
KR20210108406A (ko) 2018-12-21 2021-09-02 론자 워커스빌 아이엔씨. 바이러스 벡터의 자동화된 생산
US20220088589A1 (en) 2019-01-21 2022-03-24 Eclipse Medcorp, Llc Methods, Systems and Apparatus for Separating Components of a Biological Sample
JP7427676B2 (ja) 2019-02-06 2024-02-05 ハヌマン ペリカン,インコーポレイテッド 多血小板血漿を濃縮するための装置および方法
SG11202108473XA (en) 2019-02-08 2021-09-29 Lonza Walkersville Inc Cell concentration methods and devices for use in automated bioreactors
MA56206A (fr) 2019-06-12 2022-04-20 Juno Therapeutics Inc Combinaison thérapeutique d'une thérapie cytotoxique à médiation cellulaire et d'un inhibiteur d'une protéine de la famille bcl2 pro-survie
CN114555112A (zh) 2019-08-22 2022-05-27 朱诺治疗学股份有限公司 T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法
US20220392613A1 (en) 2019-08-30 2022-12-08 Juno Therapeutics, Inc. Machine learning methods for classifying cells
CA3159380A1 (en) 2019-10-30 2021-05-06 Juno Therapeutics Gmbh Cell selection and/or stimulation devices and methods of use
CN115087868A (zh) 2019-11-05 2022-09-20 朱诺治疗学股份有限公司 确定治疗性t细胞组合物的属性的方法
US20230028050A1 (en) 2019-12-06 2023-01-26 Juno Therapeutics, Inc. Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods
JP2023504736A (ja) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Gprc5d標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法
CN115398231A (zh) 2019-12-06 2022-11-25 朱诺治疗学股份有限公司 与治疗b细胞恶性肿瘤的细胞疗法相关的毒性和反应的相关方法
BR112022014501A2 (pt) 2020-01-24 2022-09-20 Juno Therapeutics Inc Métodos para dosagem e tratamento de linfoma folicular e linfoma de zona marginal em terapia celular adotiva
US20230090117A1 (en) 2020-01-28 2023-03-23 Juno Therapeutics, Inc. Methods for t cell transduction
AU2021220875A1 (en) 2020-02-12 2022-09-29 Juno Therapeutics, Inc. CD19-directed chimeric antigen receptor T cell compositions and methods and uses thereof
KR20220152227A (ko) 2020-02-12 2022-11-15 주노 쎄러퓨티크스 인코퍼레이티드 Bcma-지시된 키메라 항원 수용체 t 세포 조성물 및 이의 방법 및 용도
BR112022020333A2 (pt) 2020-04-10 2022-11-22 Juno Therapeutics Inc Métodos e usos relacionados à terapia celular projetada com um receptor de antígeno quimérico que alveja o antígeno de maturação de células b
KR20230022868A (ko) 2020-05-13 2023-02-16 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
KR20230024283A (ko) 2020-05-13 2023-02-20 주노 쎄러퓨티크스 인코퍼레이티드 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도
US11738288B2 (en) 2020-06-29 2023-08-29 Jacques Chammas Automated system and method to isolate specific cells from blood or bone marrow
US20230324408A1 (en) 2020-08-05 2023-10-12 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
KR20230158573A (ko) 2021-03-22 2023-11-20 주노 쎄러퓨티크스 인코퍼레이티드 바이러스 벡터 입자의 효력을 평가하는 방법
JP2024511418A (ja) 2021-03-22 2024-03-13 ジュノー セラピューティクス インコーポレイテッド 治療用細胞組成物の効力を決定する方法
CN117858719A (zh) 2021-03-29 2024-04-09 朱诺治疗学股份有限公司 使用检查点抑制剂疗法和car t细胞疗法的组合进行给药和治疗的方法
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2023250400A1 (en) 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2661150A (en) * 1947-12-17 1953-12-01 Jr William G Abbott Centrifuge
US3239136A (en) * 1962-05-07 1966-03-08 George N Hein Centrifuge and centrifuge head for separating constituents of a liquid and a liner therefor
US3096283A (en) * 1959-06-24 1963-07-02 Becton Dickinson Co Container for blood and machine for separating precipitates from liquid blood constituents
UST955355I4 (de) * 1959-06-24 1900-01-01
US3104225A (en) * 1960-01-29 1963-09-17 Lourdes Instr Corp Continuous flow centrifuge rotor and liner element
US3456875A (en) * 1966-08-18 1969-07-22 George N Hein Air driven centrifuge
US3737096A (en) * 1971-12-23 1973-06-05 Ibm Blood processing control apparatus
US4142670A (en) * 1978-01-27 1979-03-06 Beckman Instruments, Inc. Chylomicron rotor
US4303193A (en) * 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
EP0027476B1 (de) * 1979-10-19 1983-12-07 Otto Wimmer Zentrifuge
JPS59500340A (ja) * 1982-03-08 1984-03-01 モトロ−ラ・インコ−ポレ−テツド 集積回路のリ−ドフレ−ム
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
US4889524A (en) * 1987-09-04 1989-12-26 Haemonetics Corporation Portable centrifuge apparatus
ZA948564B (en) * 1993-11-19 1995-07-26 Bristol Myers Squibb Co Liquid separation apparatus and method
US5733253A (en) * 1994-10-13 1998-03-31 Transfusion Technologies Corporation Fluid separation system
US5728040A (en) * 1996-09-09 1998-03-17 Schill Enterprises, Inc. Variable volume cell saver bowl

Also Published As

Publication number Publication date
DE69605062D1 (de) 1999-12-09
WO1997015399A1 (en) 1997-05-01
EP0912250A1 (de) 1999-05-06
EP0912250B1 (de) 1999-11-03
AU6467796A (en) 1997-05-15
ATE186235T1 (de) 1999-11-15
US6123655A (en) 2000-09-26

Similar Documents

Publication Publication Date Title
DE69605062D1 (de) Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut
ES2192344T3 (es) Dispositivo y aparato para realizar un analisis.
DE69612973T2 (de) Verbesserung an der behandlung von proben
ATE263962T1 (de) Vorrichtung zur abnahme und einleitung von flüssigkeitsproben
ATE392625T1 (de) Vorrichtung zur durchführung von analysen in biologischen flüssigkeiten und damit verbundenes verfahren
ATE180261T1 (de) Durch menschliche lymphozyten produzierte proteine, die für diese proteine kodierende dns und pharmazeutische und biologische verwendungen
DE69231516T2 (de) Prozess und apparat zur bestimmung von analyten in flüssigen proben
DE69919029D1 (de) Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen
DE69524035T2 (de) Blutsammelsystem
SE0200860D0 (sv) Microfluidic cell and method for sample handling
DE60142177D1 (de) Vorrichtung zur bearbeitung von mikroprobenmengen
DE69912785D1 (de) Vorrichtung zur filtration und extraktion und methode für ihre verwendung
ES549895A0 (es) Procedimiento para detectar y determinar un analito con pro-piedades de fijacion bioafines en una muestra liquida
BR0112385A (pt) Meio de coleta universal
EP0861968A3 (de) Vorrichtung im Bohrloch, die durch Ringraumdruck betätigt wird
ATE372389T1 (de) Regeneration von biosensoren
CN104483434B (zh) 一种用于100个以内细胞的蛋白质组自动化分析系统及方法
ATE318103T1 (de) Vorrichtung zur kontinuierlichen entnahme und analyse von flüssigkeiten
ATE217020T1 (de) Extraktionsverfahren von karotenen aus karoten- enthaltenden materialien
DE69129417D1 (de) Nachweis des syndecangehalts in biologischen materialien, wie geweben und körperflüssigkeiten, zur anzeige der bösartigen umwandlung von zellen
ES2123247T3 (es) Dispositivo de filtracion de fluidos biologicos y su aplicacion.
ES2126151T3 (es) Metodo para cuantificar bpi extracelular en fluidos corporales.
DE69714778D1 (de) Immunohistochemischer nachweis des proliferativen zustandes von karzinoma
WO2002075280A3 (de) Untersuchungsvorrichtung und verfahren zum untersuchen chemischer und/oder biologischer proben
Gangadhar Novel Micro fluidic Techniques for Point-of-Care Diagnostics

Legal Events

Date Code Title Description
8364 No opposition during term of opposition