DE69919029D1 - Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen - Google Patents

Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen

Info

Publication number
DE69919029D1
DE69919029D1 DE69919029T DE69919029T DE69919029D1 DE 69919029 D1 DE69919029 D1 DE 69919029D1 DE 69919029 T DE69919029 T DE 69919029T DE 69919029 T DE69919029 T DE 69919029T DE 69919029 D1 DE69919029 D1 DE 69919029D1
Authority
DE
Germany
Prior art keywords
components
biological fluid
processing chamber
stem cells
separated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919029T
Other languages
English (en)
Other versions
DE69919029T2 (de
Inventor
Claude Fell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosafe SA
Original Assignee
Biosafe SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosafe SA filed Critical Biosafe SA
Application granted granted Critical
Publication of DE69919029D1 publication Critical patent/DE69919029D1/de
Publication of DE69919029T2 publication Critical patent/DE69919029T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0485Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with a displaceable piston in the centrifuge chamber

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69919029T 1998-12-24 1999-12-24 Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen Expired - Lifetime DE69919029T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/IB98/02114 1998-12-24
IB9802114 1998-12-24
PCT/IB1999/002053 WO2000038762A1 (en) 1998-12-24 1999-12-24 Blood separation system particularly for concentrating hematopoietic stem cells

Publications (2)

Publication Number Publication Date
DE69919029D1 true DE69919029D1 (de) 2004-09-02
DE69919029T2 DE69919029T2 (de) 2005-09-08

Family

ID=11004802

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919029T Expired - Lifetime DE69919029T2 (de) 1998-12-24 1999-12-24 Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen

Country Status (11)

Country Link
US (1) US6733433B1 (de)
EP (1) EP1144026B1 (de)
JP (1) JP4514338B2 (de)
CN (1) CN1182882C (de)
AT (1) ATE271890T1 (de)
AU (1) AU1675600A (de)
DE (1) DE69919029T2 (de)
ES (1) ES2224726T3 (de)
HK (1) HK1041454B (de)
PT (1) PT1144026E (de)
WO (1) WO2000038762A1 (de)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10134913C2 (de) 2001-07-18 2003-06-26 Hiberna Ag Vorrichtung und Verfahren zur Blutpräparation
US7201848B2 (en) * 2001-12-05 2007-04-10 Gambro Bct, Inc. Methods and apparatus for separation of particles
US8062837B2 (en) 2002-02-14 2011-11-22 Stemcyte, Inc. Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20040256331A1 (en) * 2002-10-04 2004-12-23 Arking E. James System and method for fractionation of a centrifuged sample
JP5148873B2 (ja) 2003-06-27 2013-02-20 エチコン、インコーポレイテッド 臍帯組織由来の分娩後細胞、及びその作成及び使用方法
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
ITMI20031715A1 (it) 2003-09-05 2005-03-06 Dideco Spa Dispositivo di comando nella raccolta differenziata dei
US7060018B2 (en) 2003-09-11 2006-06-13 Cobe Cardiovascular, Inc. Centrifuge apparatus for processing blood
EP2476445B1 (de) * 2003-10-02 2013-10-23 Terumo Kabushiki Kaisha Filtereinheit
US7052451B2 (en) * 2004-04-14 2006-05-30 Wagner Development, Inc. Conical piston solids discharge centrifugal separator
US7261683B2 (en) 2004-04-14 2007-08-28 Wagner Development, Inc. Conical piston solids discharge and pumping centrifugal separator
MX2007011218A (es) * 2005-03-23 2007-10-17 Biosafe Sa Sistema integrado para colectar, procesar y transplantar subconjuntos de celulas, incluyendo celulas madre adultas para medicina regenerativa.
US7364657B2 (en) * 2005-03-31 2008-04-29 Abbott Cardiovascular Systems Inc. Integrated system for on-site cell acquisition, processing, and delivery
US8048619B2 (en) 2005-06-02 2011-11-01 Stemcyte, Inc. Method of treating a hematopoietic associated disease or disorder with plasma-depleted, but not erythrocyte-depleted cord blood compositions
US20100210441A1 (en) * 2005-06-22 2010-08-19 Caridianbct, Inc. Apparatus And Method For Separating Discrete Volumes Of A Composite Liquid
CA2612891A1 (en) * 2005-06-22 2007-01-04 Gambro Bct, Inc. Apparatus and method for separating discrete volumes of a composite liquid
US7618361B2 (en) * 2005-09-01 2009-11-17 Wagner Development, Inc. Gas driven solids discharge and pumping piston for a centrifugal separator
US7628749B2 (en) 2005-09-01 2009-12-08 Wagner Development Inc. Solids recovery using cross-flow microfilter and automatic piston discharge centrifuge
US20070119508A1 (en) * 2005-11-29 2007-05-31 West Richard L Fluid Flow Diversion Valve and Blood Collection System Employing Same
ES2642844T3 (es) 2005-12-16 2017-11-20 DePuy Synthes Products, Inc. Composiciones y métodos para inhibir una respuesta inmune adversa en el trasplante de histocompatibilidad que no coinciden
KR20190104428A (ko) 2005-12-29 2019-09-09 안트로제네시스 코포레이션 태반 줄기 세포 집단
US7998052B2 (en) * 2006-03-07 2011-08-16 Jacques Chammas Rotor defining a fluid separation chamber of varying volume
GB0608451D0 (en) * 2006-04-28 2006-06-07 Ge Healthcare Bio Sciences Ab Centrifugal separation system
WO2008051847A2 (en) * 2006-10-20 2008-05-02 Caridianbct Biotechnologies, Llc Methods for washing a red blood cell component and for removing prions therefrom
US20080108954A1 (en) * 2006-11-02 2008-05-08 Jean-Marie Mathias Flow Controllers
US20080108955A1 (en) * 2006-11-02 2008-05-08 Blickhan Bryan J Flow Controllers
SI2120977T1 (sl) 2007-02-12 2014-01-31 Anthrogenesis Coroporation Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic
WO2009045360A2 (en) 2007-09-28 2009-04-09 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
DE102007059841B3 (de) * 2007-12-12 2009-04-23 Ab Skf Biokompatibles Verbindungsmodul für einen Fluidbehälter
US20090218535A1 (en) * 2008-02-27 2009-09-03 Andres Pasko Flow controllers for fluid circuits
US7976796B1 (en) * 2008-07-03 2011-07-12 Emcyte Corp. Centrifuge tube for separating and aspirating biological components
KR20240052847A (ko) 2008-08-20 2024-04-23 셀룰래리티 인코포레이티드 개선된 세포 조성물 및 그의 제조 방법
DE102008047068B4 (de) 2008-09-12 2015-02-26 Walter Pobitschka Verfahren und Vorrichtung zur Trennung von Blut unter Einsatz einer Zentrifuge
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
US8475352B2 (en) 2008-12-29 2013-07-02 Wagner Development, Inc. Solids discharge centrifugal separator with disposable contact elements
JP2010193879A (ja) * 2009-01-27 2010-09-09 Jms Co Ltd 臍帯血造血幹細胞の増殖制御方法およびその用途
EP2435108B1 (de) 2009-05-29 2016-12-07 EndoCellutions, Inc. Vorrichtung und verfahren zur absaugung und trennung von komponenten verschiedener dichte aus einem physiologischen fluid mit zellen
WO2011005411A1 (en) * 2009-07-06 2011-01-13 Caridianbct, Inc. Apparatus and method for automatically loading washing solution in a multi-unit blood processor
DE102009040525B4 (de) * 2009-09-08 2015-02-05 Andreas Hettich Gmbh & Co. Kg Zentrifuge zum Trennen von Vollblut in Blutkomponenten, sowie fluidisch kommunizierende Behälter zum Einsetzen in die Zentrifuge, sowie Verfahren zur Gewinnung eines hochangereichten Thrombozytenkonzentrats aus Vollblut
JP2013507931A (ja) 2009-10-16 2013-03-07 ユニバーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー 再生医療用途のための接着性骨髄幹細胞の閉鎖系統分離システム
KR101049201B1 (ko) * 2009-10-29 2011-07-14 토자이홀딩스 주식회사 말초혈액 내의 조혈 줄기세포 및 중간엽 줄기세포의 추출을 위한 바이오 디바이스
US9034280B2 (en) 2009-12-16 2015-05-19 General Electric Corporation High-throughput methods and systems for processing biological materials
KR200458000Y1 (ko) * 2010-01-07 2012-01-16 (주)아모레퍼시픽 잔량확인이 가능한 에어리스펌프를 갖는 화장품용기
EP3284818B1 (de) 2010-01-26 2022-03-09 Celularity Inc. Behandlung von knochenbedingten karzinomen mit plazentastammzellen
TW201902496A (zh) 2010-04-07 2019-01-16 美商安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
EP2575925B1 (de) 2010-05-27 2014-10-15 Terumo BCT, Inc. Blutprozessor mit mehreren einheiten und temperaturmessung
WO2011156068A1 (en) 2010-06-07 2011-12-15 Caridianbct, Inc. Multi-unit blood processor with volume prediction
KR20190108599A (ko) 2010-07-13 2019-09-24 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
AU2011289658A1 (en) * 2010-08-09 2013-01-10 Kci Licensing, Inc. System and method for measuring pressure applied by a piezo-electric pump
US8469871B2 (en) 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US8556794B2 (en) 2010-11-19 2013-10-15 Kensey Nash Corporation Centrifuge
US8394006B2 (en) 2010-11-19 2013-03-12 Kensey Nash Corporation Centrifuge
US8870733B2 (en) 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US8317672B2 (en) 2010-11-19 2012-11-27 Kensey Nash Corporation Centrifuge method and apparatus
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN113559126A (zh) 2011-06-01 2021-10-29 人类起源公司 利用胎盘干细胞治疗疼痛
JP6034366B2 (ja) * 2012-03-13 2016-11-30 テルモ株式会社 血液成分分離装置、及び遠心分離器
US20130252227A1 (en) * 2012-03-20 2013-09-26 Fenwal, Inc. Apparatus and Method for Providing Cryopreserved ECP-Treated Mononuclear Cells
US9060724B2 (en) 2012-05-30 2015-06-23 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9022950B2 (en) 2012-05-30 2015-05-05 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
WO2014022275A1 (en) 2012-08-01 2014-02-06 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
EP3318295B1 (de) 2012-10-11 2021-04-14 Magnolia Medical Technologies, Inc. System zur abgabe eines fluids an einen patienten mit reduzierter kontamination
US9155495B2 (en) 2012-11-30 2015-10-13 Magnolia Medical Technologies, Inc. Syringe-based fluid diversion mechanism for bodily fluid sampling
US10772548B2 (en) 2012-12-04 2020-09-15 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
US10251590B2 (en) 2012-12-04 2019-04-09 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
US10603665B2 (en) 2013-01-29 2020-03-31 Endocellutions, Inc. Cell concentration devices and methods that include an insert defining a lumen and a cannula assembly
CN115137753A (zh) 2013-02-05 2022-10-04 细胞结构公司 来自胎盘的自然杀伤细胞
EP2970913B1 (de) * 2013-03-15 2018-08-22 LongBoat Explorers AB Zellen, verfahren und vorrichtungen für nabelschnurblutentnahme und isolierung von zellen
US9427503B2 (en) * 2013-03-15 2016-08-30 Corvivo Inc. Cardiotomy suction tube system with multiple tips
ES2424272B1 (es) * 2013-07-23 2014-01-29 Riera Nadeu, S.A. Supercentrífuga con dispositivo no intrusivo de extracción de sólido y procedimiento de extracción del mismo
CN103342748B (zh) * 2013-07-26 2015-04-08 中国人民解放军第三军医大学第一附属医院 天然软骨基质主要成分-ⅱ型胶原蛋白提取专用装置
CN106413904A (zh) 2014-01-31 2017-02-15 帝斯曼知识产权资产管理有限公司 脂肪组织离心装置和使用方法
WO2015160320A1 (en) * 2014-04-15 2015-10-22 Promedart Biyoteknoloji Ve Ozel Saglik Hizmetleri Sanayi Ticaret Limited Sirketi A separation system
EP3151970B1 (de) * 2014-06-04 2018-08-15 Biosafe S.A. System zur mehrfachverarbeitung und trennung von biologischen flüssigkeiten
TWI735418B (zh) 2014-11-05 2021-08-11 美商奇諾治療有限公司 用於轉導作用及細胞處理之方法
US10900874B2 (en) 2014-11-19 2021-01-26 The Regents Of The University Of Colorado, A Body Corporate Apparatus, method, and system for filter based cell capture and labeling with configurable laydown area
KR102443818B1 (ko) * 2014-12-19 2022-09-19 바이오세이프 쏘시에떼아노님 생물학적 유체의 순차적 처리
CN104474598B (zh) * 2015-01-05 2016-06-08 浙江保尔曼生物科技有限公司 血浆分离装置
MX2017013479A (es) * 2015-05-07 2017-12-07 Biosafe Sa Dispositivo, sistema y metodo para el procesamiento continuo y separacion de fluidos biologicos en componentes.
WO2016201406A1 (en) 2015-06-12 2016-12-15 Bullington Gregory J Devices and methods for syringe-based fluid transfer for bodily-fluid sampling
US10010282B2 (en) 2015-07-24 2018-07-03 Kurin, Inc. Blood sample optimization system and blood contaminant sequestration device and method
CN112401882A (zh) 2015-09-03 2021-02-26 木兰医药技术股份有限公司 用于维护样本容器的无菌性的设备和方法
KR20230107408A (ko) 2016-07-29 2023-07-14 주노 쎄러퓨티크스 인코퍼레이티드 항-cd19 항체에 대한 항-이디오타입 항체
CN106110750B (zh) * 2016-08-15 2018-10-16 鲁绍荣 一种高效血液回收机
WO2018049420A1 (en) 2016-09-12 2018-03-15 Juno Therapeutics, Inc. Perfusion bioreactor bag assemblies
EP3295972B1 (de) 2016-09-14 2020-11-25 Fenwal, Inc. Zellverarbeitungssytem und -verfahren mit fülloptionen
US11542473B2 (en) 2016-10-21 2023-01-03 Amniotics Ab Methods and compositions for generating hematopoietic cells
EP3329947B1 (de) 2016-12-01 2021-06-02 Fenwal, Inc. Füll- und endbearbeitungssysteme und -verfahren
CA3045338A1 (en) 2016-12-05 2018-06-14 Juno Therapeutics, Inc. Production of engineered cells for adoptive cell therapy
JP6309606B1 (ja) * 2016-12-21 2018-04-11 三井電気精機株式会社 遠心分離システム
US10827964B2 (en) 2017-02-10 2020-11-10 Kurin, Inc. Blood contaminant sequestration device with one-way air valve and air-permeable blood barrier with closure mechanism
US20200191774A1 (en) 2017-02-27 2020-06-18 Juno Therapeutics, Inc. Compositions, articles of manufacture and methods related to dosing in cell therapy
US10449555B2 (en) * 2017-05-16 2019-10-22 Robert Bret Carr Centrifugal separator with annular piston for solids extrusion
US10987672B2 (en) * 2017-06-08 2021-04-27 Emcyte Corp. Dual piston centrifuge tube
WO2019027850A1 (en) 2017-07-29 2019-02-07 Juno Therapeutics, Inc. CELL EXPANSION REAGENTS EXPRESSING RECOMBINANT RECEPTORS
GB201713252D0 (en) * 2017-08-18 2017-10-04 Biosafe Sa Piston movement
GB201713981D0 (en) * 2017-08-31 2017-10-18 Biosafe Sa Centrifugal separation chamber
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
WO2019055487A1 (en) 2017-09-12 2019-03-21 Magnolia Medical Technologies, Inc. FLUID CONTROL DEVICES AND METHODS OF USE
BR112020008340A2 (pt) 2017-11-01 2020-11-17 Juno Therapeutics Inc processo para gerar composições terapêuticas de células modificadas
US20210254000A1 (en) 2017-11-01 2021-08-19 Juno Therapeutics, Inc. Process for producing a t cell composition
JP2021502094A (ja) 2017-11-10 2021-01-28 ジュノー セラピューティクス インコーポレイテッド 閉鎖系極低温容器
GB201720405D0 (en) 2017-12-07 2018-01-24 Biosafe Sa A bioprocessing system
CN115553822A (zh) 2017-12-07 2023-01-03 木兰医药技术股份有限公司 流体控制装置及其使用方法
US20210207080A1 (en) 2017-12-08 2021-07-08 Juno Therapeutics, Inc. Serum-free media formulation for culturing cells and methods of use thereof
SG11202005272SA (en) 2017-12-08 2020-07-29 Juno Therapeutics Inc Process for producing a composition of engineered t cells
WO2019113559A2 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Phenotypic markers for cell therapy and related methods
JP6425793B2 (ja) * 2017-12-12 2018-11-21 三井電気精機株式会社 遠心分離装置
US11191880B2 (en) * 2018-05-16 2021-12-07 Fenwal, Inc. Fill and finish systems and methods for small volume processing
US11911553B2 (en) * 2018-07-06 2024-02-27 Fenwal, Inc. Systems and methods for concentrating cells with a syringe and a centrifuge
EA202190469A1 (ru) 2018-08-09 2021-06-28 Джуно Терапьютикс, Инк. Способы оценки интегрированных нуклеиновых кислот
KR20210057730A (ko) 2018-08-09 2021-05-21 주노 쎄러퓨티크스 인코퍼레이티드 조작 세포 및 이의 조성물 생성 방법
BR112021004261A2 (pt) 2018-09-11 2021-05-25 Juno Therapeutics Inc métodos para análise por espectrometria de massas de composições de células geneticamente modificadas
CN109321458B (zh) * 2018-10-17 2023-03-24 深圳市深研生物科技有限公司 一种制备细胞的方法
CN109225673B (zh) * 2018-10-24 2024-05-31 上海瑛泰医疗器械股份有限公司 一种血液离心分离机
SG11202104355SA (en) 2018-10-31 2021-05-28 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
CA3117419A1 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
JP2022512913A (ja) 2018-11-06 2022-02-07 ジュノー セラピューティクス インコーポレイテッド 遺伝子操作されたt細胞を作製するための方法
BR112021009420A2 (pt) 2018-11-16 2021-11-23 Juno Therapeutics Inc Métodos de dosagem de células t manipuladas para o tratamento de malignidades de células b
KR20210117260A (ko) 2018-11-30 2021-09-28 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 요법을 사용한 치료방법
MX2021006244A (es) 2018-11-30 2021-09-10 Juno Therapeutics Inc Metodos de dosificacion y tratamiento de canceres de celulas b en terapia celular adoptiva.
WO2020117610A1 (en) * 2018-12-08 2020-06-11 Min Wei Apparatus for manufacturing cell therapy product
EP3920801A1 (de) 2019-02-08 2021-12-15 Magnolia Medical Technologies, Inc. Vorrichtungen und verfahren zur sammlung und verteilung von körperflüssigkeiten
EP3938108B1 (de) 2019-03-11 2023-08-02 Magnolia Medical Technologies, Inc. Fluidsteuerungsvorrichtungen
KR20220034782A (ko) 2019-06-12 2022-03-18 주노 쎄러퓨티크스 인코퍼레이티드 세포 매개 세포 독성 요법 및 친생존 bcl2 패밀리 단백질 억제제의 병용 요법
CN110456033A (zh) * 2019-07-03 2019-11-15 深圳市深研生物科技有限公司 用于调整含有细胞的液体样品的密度和或体积的系统
US11478755B2 (en) 2019-08-15 2022-10-25 Fenwal, Inc. Small volume processing systems and methods
EP4017527A1 (de) 2019-08-22 2022-06-29 Juno Therapeutics, Inc. Kombinationstherapie aus einer t-zell-therapie und einem verstärker des zeste-homolog 2 (ezh2)-inhibitors und zugehörige verfahren
CN114600172A (zh) 2019-08-30 2022-06-07 朱诺治疗学股份有限公司 用于将细胞分类的机器学习方法
WO2021076042A2 (en) 2019-10-18 2021-04-22 Amniotics Ab Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof
US11559770B2 (en) 2019-10-24 2023-01-24 Fenwal, Inc. Small volume processing systems and methods with capacitive sensing
AU2020377043A1 (en) 2019-10-30 2022-06-02 Juno Therapeutics Gmbh Cell selection and/or stimulation devices and methods of use
CN115087868A (zh) 2019-11-05 2022-09-20 朱诺治疗学股份有限公司 确定治疗性t细胞组合物的属性的方法
CN115916817A (zh) 2019-12-06 2023-04-04 朱诺治疗学股份有限公司 针对bcma靶向结合结构域的抗独特型抗体及相关组合物和方法
KR20220122656A (ko) 2019-12-06 2022-09-02 주노 쎄러퓨티크스 인코퍼레이티드 Gprc5d-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법
EP4070097A1 (de) 2019-12-06 2022-10-12 Juno Therapeutics, Inc. Verfahren in zusammenhang mit toxizität und ansprechen bei einer zelltherapie zur behandlung von b-zell-malignitäten
US20230071910A1 (en) 2020-01-24 2023-03-09 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
KR20220146480A (ko) 2020-01-28 2022-11-01 주노 쎄러퓨티크스 인코퍼레이티드 T 세포 형질도입 방법
CN115768443A (zh) 2020-02-12 2023-03-07 朱诺治疗学股份有限公司 Cd19定向嵌合抗原受体t细胞组合物和方法及其用途
BR112022015968A2 (pt) 2020-02-12 2022-10-11 Juno Therapeutics Inc Composições de células t do receptor de antígeno quimérico direcionado a bcma e métodos e usos das mesmas
CN115916223A (zh) 2020-04-10 2023-04-04 朱诺治疗学股份有限公司 与用靶向b细胞成熟抗原的嵌合抗原受体工程化的细胞疗法相关的方法和用途
WO2021231661A2 (en) 2020-05-13 2021-11-18 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
US20230178239A1 (en) 2020-05-13 2023-06-08 Juno Therapeutics, Inc. Methods of identifying features associated with clinical response and uses thereof
WO2022029660A1 (en) 2020-08-05 2022-02-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
AU2022244229A1 (en) 2021-03-22 2023-09-14 Juno Therapeutics, Inc. Method to assess potency of viral vector particles
AU2022241654A1 (en) 2021-03-22 2023-09-28 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
BR112023019847A2 (pt) 2021-03-29 2023-11-07 Juno Therapeutics Inc Métodos para dosagem e tratamento com uma combinação de uma terapia com inibidor de ponto de verificação e uma terapia com célula t car
CN113318287A (zh) * 2021-05-31 2021-08-31 衷博瑞佳生物技术(上海)有限公司 一种带内核的活塞式生物液体分离杯及其分离方法
GB2605850B (en) 2021-07-06 2023-04-26 Cellularorigins Ltd Bioprocessing system
CN113943651B (zh) * 2021-11-17 2023-08-18 北京集美生物科技有限公司 一种干细胞提取离心抽取工艺
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2023250400A1 (en) 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells
WO2024032582A1 (en) * 2022-08-09 2024-02-15 Sino-Biocan (Shanghai) Biotech Ltd. Managing peripheral blood cells
WO2024124132A1 (en) 2022-12-09 2024-06-13 Juno Therapeutics, Inc. Machine learning methods for predicting cell phenotype using holographic imaging

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737096A (en) 1971-12-23 1973-06-05 Ibm Blood processing control apparatus
JPS59500340A (ja) * 1982-03-08 1984-03-01 モトロ−ラ・インコ−ポレ−テツド 集積回路のリ−ドフレ−ム
US4946434A (en) 1986-07-22 1990-08-07 Haemonetics Corporation Disposable manifold and valve
US5641622A (en) 1990-09-13 1997-06-24 Baxter International Inc. Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
JP2528058B2 (ja) * 1992-05-28 1996-08-28 川澄化学工業株式会社 血液成分分離装置
JP3184052B2 (ja) * 1994-08-17 2001-07-09 川澄化学工業株式会社 血液成分分離装置
AU6467796A (en) * 1996-04-24 1997-05-15 Claude Fell Cell separation system for biological fluids like blood
US6098646A (en) * 1997-02-19 2000-08-08 Ecolab Inc. Dispensing system with multi-port valve for distributing use dilution to a plurality of utilization points and position sensor for use thereon

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ATE271890T1 (de) 2004-08-15
EP1144026A1 (de) 2001-10-17
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CN1331610A (zh) 2002-01-16
HK1041454B (zh) 2004-12-31
CN1182882C (zh) 2005-01-05
JP4514338B2 (ja) 2010-07-28
WO2000038762A1 (en) 2000-07-06
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