CN102432511B - 表面两亲聚合物和低聚物及其应用 - Google Patents

表面两亲聚合物和低聚物及其应用 Download PDF

Info

Publication number
CN102432511B
CN102432511B CN201110256264.XA CN201110256264A CN102432511B CN 102432511 B CN102432511 B CN 102432511B CN 201110256264 A CN201110256264 A CN 201110256264A CN 102432511 B CN102432511 B CN 102432511B
Authority
CN
China
Prior art keywords
polar
group
groups
oligomers
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201110256264.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN102432511A (zh
Inventor
W·F·德格拉多
刘大慧
G·N·特
M·L·克雷恩
苑晶
崔成旭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CN102432511A publication Critical patent/CN102432511A/zh
Application granted granted Critical
Publication of CN102432511B publication Critical patent/CN102432511B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • C07C323/42Y being a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • C07C323/44X or Y being nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30Low-molecular-weight compounds
    • C08G18/32Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C08G18/3225Polyamines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/028Polyamidoamines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/02Polyureas
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
CN201110256264.XA 2003-03-17 2004-03-17 表面两亲聚合物和低聚物及其应用 Expired - Fee Related CN102432511B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45547903P 2003-03-17 2003-03-17
US60/455,479 2003-03-17
US53063003P 2003-12-19 2003-12-19
US60/530,630 2003-12-19
US53698004P 2004-01-20 2004-01-20
US60/536,980 2004-01-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN 200480013245 Division CN1905867A (zh) 2003-03-17 2004-03-17 表面两亲聚合物和低聚物及其应用

Publications (2)

Publication Number Publication Date
CN102432511A CN102432511A (zh) 2012-05-02
CN102432511B true CN102432511B (zh) 2016-06-08

Family

ID=33033151

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201110256264.XA Expired - Fee Related CN102432511B (zh) 2003-03-17 2004-03-17 表面两亲聚合物和低聚物及其应用

Country Status (8)

Country Link
US (4) US9241917B2 (https=)
EP (5) EP2471526A3 (https=)
JP (4) JP2006521355A (https=)
KR (1) KR101241176B1 (https=)
CN (1) CN102432511B (https=)
AU (2) AU2004222272B2 (https=)
CA (1) CA2519023C (https=)
WO (1) WO2004082634A2 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289524A1 (en) * 2001-03-08 2011-03-02 The Trustees Of The University Of Pennsylvania Facially amphiphillic polymers as anti-infective agents
EP2471526A3 (en) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Facially amphiphillic polymers and oligomers and uses thereof
CN1922133A (zh) 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
AU2005254574B2 (en) 2004-06-15 2012-02-02 Polymedix, Inc. Polycationic compounds and uses thereof
US20060241052A1 (en) 2005-02-25 2006-10-26 Degrado William F Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
DE102008027133A1 (de) * 2008-05-30 2009-12-03 Ls Medcap Gmbh Vollsynthetisches Albumin-Analogon
RU2530899C2 (ru) * 2008-07-28 2014-10-20 Селлсьютикс Корпорейшн Противомалярийные соединения
TWI478915B (zh) * 2008-10-27 2015-04-01 Cellceutix Corp 宿主防禦之合成模擬物及其用途
CA2746421A1 (en) * 2008-12-10 2010-06-17 Polymedix, Inc. Antimicrobial molecules for treating multi-drug resistant and extensively drug resistant strains of mycobacterium
US9481719B2 (en) 2009-06-03 2016-11-01 Basf Se Recombinant production of peptides
MX2012007662A (es) * 2010-01-07 2012-08-23 Polymedix Inc Compuestos anti-heparina.
SG188281A1 (en) * 2010-08-23 2013-04-30 Univ California Compositions and uses of materials with high antimicrobial activity and low toxicity
EP2709619B1 (en) 2011-05-16 2017-10-11 Cellceutix Corporation Compounds for use in treatment of mucositis
CA2937128A1 (en) * 2011-05-19 2012-11-22 Eugene J. Oliva Heparin-based compostions and methods for the inhibition of metastasis
AU2012352621A1 (en) 2011-12-13 2014-07-24 Cellceutix Corporation Cyclic compounds and methods of making and using the same
MX2014008763A (es) * 2012-01-18 2015-04-13 Cellceutix Corp Compuestos y metodos para tratar infecciones por candidosis y aspergillus.
CN103373938B (zh) * 2012-04-17 2016-03-30 天津理工大学 一种4-乙氧基-1,3-苯二甲酰胺类化合物及其制备和应用
EP2986625B1 (en) * 2014-03-14 2020-03-11 Bio-rad Laboratories, Inc. Mixed mode ligands
CN108289926A (zh) 2015-10-14 2018-07-17 西北大学 用于生长因子递送和骨再生的纳米纤维糊剂
CN107390307A (zh) * 2016-05-16 2017-11-24 惠和株式会社 液晶显示装置用光学片、液晶显示装置用背光单元及液晶显示装置用光学片的制造方法
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
WO2019067676A1 (en) 2017-09-28 2019-04-04 The Regents Of The University Of California HYDROGELS OF POLYIONIC POLYPEPTIDE COMPLEXES AND USES THEREOF
JP7560884B2 (ja) 2019-01-24 2024-10-03 ノースウエスタン ユニバーシティ 超分子ikvavマトリックス内の動力学は、ヒトipsc由来のニューロンの機能的成熟と再生を増強する
US12214076B2 (en) 2019-02-18 2025-02-04 Northwestern University Drug delivery vehicles for atherosclerosis nanomedicine
CN111407764B (zh) * 2020-03-27 2021-09-10 广州中医药大学(广州中医药研究院) 一种杂萜衍生物在制备抗非酒精性脂肪性肝炎及肝纤维化的药物中的应用
US12090206B2 (en) 2020-04-23 2024-09-17 The Regents Of The University Of California Compositions comprising tri- and penta-block synthetic copolypeptide hydrogels
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections
US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
CA3225407A1 (en) 2021-07-29 2023-02-02 Shelby Chi YUAN Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (tgf-.beta.1) mimetic epitope

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049413A1 (en) * 1996-06-24 1997-12-31 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
WO2001051456A2 (en) * 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
WO2002100295A2 (en) * 2001-03-08 2002-12-19 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH479557A (de) 1961-09-11 1969-10-15 Wander Ag Dr A Verfahren zur Herstellung neuer mehrbasischer Verbindungen
CH525898A (de) 1961-09-11 1972-07-31 Wander Ag Dr A Verfahren zur Herstellung mehrbasischer Verbindungen
GB1033777A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Bis-anilide derivatives
CH475331A (de) * 1965-07-05 1969-07-15 Ciba Geigy Verfahren zum Härten von Gelatine
US3484407A (en) * 1967-01-13 1969-12-16 Monsanto Co Linear condensation polymers containing carbonamide and heterocyclic linkages
GB1324087A (en) 1969-07-18 1973-07-18 Commw Scient Ind Res Org Copolymers and veterinary compositions treated therewith
US4118232A (en) * 1971-04-07 1978-10-03 Ciba-Geigy Ag Photographic material containing sulphonic acid group containing disazo dyestuffs
US3829563A (en) * 1972-11-30 1974-08-13 Hoffmann La Roche Emollient cleansing compositions
US4038416A (en) * 1975-09-11 1977-07-26 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition and method of the use thereof
JPS5285133A (en) * 1976-01-05 1977-07-15 Chugai Pharmaceut Co Ltd Bis-(benzamide)-benzene derivatives
DE2616479C2 (de) 1976-04-14 1986-12-04 Brickl, Rolf, Dr., 7951 Warthausen Substituierte Fluoracylresorcine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel und Kosmetika
US4392848A (en) * 1979-06-25 1983-07-12 The Procter & Gamble Company Catheterization
US4343788A (en) * 1979-06-29 1982-08-10 The Procter & Gamble Company Antimicrobial polymer compositions
US4252951A (en) * 1979-10-09 1981-02-24 Eli Lilly And Company Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid
JPS5928521B2 (ja) 1980-03-04 1984-07-13 兼商株式会社 殺線虫組成物
FR2527618A1 (fr) * 1982-05-25 1983-12-02 Thomson Csf Polymeres contenant des heterocycles et des noyaux aromatiques et materiaux organiques conducteurs formes a partir de ces polymeres
US4515910A (en) * 1983-01-26 1985-05-07 Rawls Henry R Interpolymeric resin for treatment of teeth
JPS59177558U (ja) 1983-05-14 1984-11-27 ヤンマーディーゼル株式会社 農用トラクタ−のパワ−ステアリング装置
DE3533612A1 (de) 1985-09-20 1987-04-02 Johannes Reinmueller Neuartige verwendung von taurolin
CA1290490C (en) 1985-11-20 1991-10-08 Masakazu Uekita Amphiphilic high polymer and process for producing the same
JPS6322067A (ja) 1986-03-10 1988-01-29 Nippon Soda Co Ltd ピロ−ル誘導体のlb膜およびその製造方法
JPS62224090A (ja) 1986-03-26 1987-10-02 Polyplastics Co 高分子圧電材料
JPH0739457B2 (ja) * 1986-05-14 1995-05-01 タキロン株式会社 両親媒性セグメントポリウレタン
US4826829A (en) * 1986-07-23 1989-05-02 Fmc Corporation 2-Substituted ethynyl thiophene pesticides
US4847353A (en) * 1986-11-20 1989-07-11 Nippon Steel Chemical Co., Ltd. Resins of low thermal expansivity
US6040251A (en) * 1988-03-14 2000-03-21 Nextec Applications Inc. Garments of barrier webs
US6083602A (en) * 1988-03-14 2000-07-04 Nextec Applications, Inc. Incontinent garments
US5912116A (en) * 1988-03-14 1999-06-15 Nextec Applications, Inc. Methods of measuring analytes with barrier webs
US5874164A (en) * 1988-03-14 1999-02-23 Nextec Applications, Inc. Barrier webs having bioactive surfaces
US5856245A (en) * 1988-03-14 1999-01-05 Nextec Applications, Inc. Articles of barrier webs
JPH0229436A (ja) 1988-07-19 1990-01-31 Ricoh Co Ltd 導電性ピロール類重合膜の光化学的製造方法
JP2597160B2 (ja) * 1988-09-02 1997-04-02 富士写真フイルム株式会社 電子写真感光体
US4943624A (en) * 1988-10-28 1990-07-24 Lehigh University Supramolecular surfactants: amphiphilic polymers designed to disrupt lipid membranes
US5071648A (en) * 1989-04-06 1991-12-10 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
US5073564A (en) * 1990-07-06 1991-12-17 Fmc Corporation Ethynylbenzothiophene pesticides
US5219965A (en) * 1990-11-27 1993-06-15 Bausch & Lomb Incorporated Surface modification of polymer objects
EP0489660B1 (fr) 1990-12-06 1994-11-02 Roussel-Uclaf Utilisation de thiazolylalkoxy acrylates pour la fabrication de compositions insecticides et/ou acaricides
US5648070A (en) * 1991-12-04 1997-07-15 Cobe Laboratories, Inc. Biocompatible anion exchange materials
US5424063A (en) * 1992-01-09 1995-06-13 The Dow Chemical Company Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
US5262476A (en) * 1992-03-10 1993-11-16 The Dow Chemical Company Polycarbonate/polyester blends modified with poly(phenylene ether)
DE19709075A1 (de) * 1997-03-06 1998-09-10 Huels Chemische Werke Ag Verfahren zur Herstellung antimikrobieller Kunststoffe
US5847047A (en) * 1993-06-22 1998-12-08 E. I. Du Pont De Nemours And Company Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type
US5520910A (en) * 1993-07-14 1996-05-28 Nippon Chemical Industrial Antimicrobial polymer, contact lens and contact lens-care articles
WO1995019974A2 (en) 1994-01-24 1995-07-27 Harris Stephen J Calixarene-based compounds having antibacterial, antifungal, anticancer-hiv activity
ATE198119T1 (de) 1994-09-01 2001-01-15 Novo Nordisk As Eine grundlegende proteinzusammensetzung zur abtötung oder inhibierung mikrobieller zellen
GB9419206D0 (en) 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
WO1997029160A1 (en) 1996-02-09 1997-08-14 Surface Solutions Laboratories, Inc. Water-based hydrophilic coating compositions and articles prepared therefrom
FR2753094B1 (fr) 1996-09-06 1998-10-16 Oreal Composition de teinture d'oxydation pour fibres keratiniques comprenant un polymere amphiphile anionique
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
WO1998017625A1 (en) 1996-10-22 1998-04-30 Daiichi Pharmaceutical Co., Ltd. Novel remedies for infectious diseases
US6107397A (en) * 1997-03-24 2000-08-22 Basf Aktiengesellschaft Aqueous copolymer dispersions of water-soluble monomers with N-vinyl groups and hydrophobic monomers
US6217886B1 (en) 1997-07-14 2001-04-17 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
DE19735715A1 (de) 1997-08-18 1999-02-25 Huels Chemische Werke Ag Amphiphile Polymere auf Basis von Polyestern mit einkondensierten acetalischen Gruppen, die bei Raumtemperatur flüssig sind, sowie ihr Einsatz in Wasch- und Reinigungsmitteln
US5994340A (en) * 1997-08-29 1999-11-30 Synphar Laboratories, Inc. Azetidinone derivatives as β-lactamase inhibitors
JPH11152329A (ja) 1997-11-21 1999-06-08 Hitachi Chem Co Ltd ポリアミド又はその誘導体の製造法
JP2002507557A (ja) 1998-03-26 2002-03-12 デパートメント オブ ジ アーミー, ユー.エス. ガバメント 抗生物質抵抗性感染の処置のための置換芳香族化合物
CA2234410C (en) * 1998-05-01 2002-07-16 Jih Ru Hwu Novel phloroglucide derivatives and their pharmaceutical use
US6399629B1 (en) * 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
US6686345B2 (en) * 1998-07-16 2004-02-03 Research Development Foundation DNA-cleaving antitumor agents
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
AR024237A1 (es) 1998-12-21 2002-09-25 Novartis Ag Copolimeros en bloque anfifilicos, procedimiento y precursores para su preparacion, y articulo moldeado obtenible a partir de los mismos
ES2223464T3 (es) * 1999-02-01 2005-03-01 Eisai Co., Ltd. Compuestos adyuvantes inmunologicos.
US6166172A (en) * 1999-02-10 2000-12-26 Carnegie Mellon University Method of forming poly-(3-substituted) thiophenes
DE19908184A1 (de) * 1999-02-25 2000-08-31 Basf Ag Verfahren zur Herstellung wässriger Dispersionen von Copolymerisaten aus hydrophilen und hydrophoben Monomeren sowie daraus erhältliche Copolymerisate und deren Anwendungen
DE19921902A1 (de) 1999-05-12 2000-11-16 Creavis Tech & Innovation Gmbh Mikrobizide Copolymere
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
JP2001133975A (ja) 1999-08-23 2001-05-18 Toray Ind Inc ポジ型感光性樹脂前駆体組成物
AU2831901A (en) 2000-01-28 2001-08-07 Novo Nordisk A/S Propionic acid derivatives and their use in the treatment of diabetes and obesity
US6768009B1 (en) 2000-03-24 2004-07-27 The Regents Of The University Of California N-halamine vinyl compounds and their polymeric biocides
WO2002095044A2 (en) 2001-05-21 2002-11-28 Molecular Electronics Corporation Lipase catalyzed esterification, transesterification, and hydrolysis of arylthiols and aryl-thioesters
JP2002363261A (ja) 2001-06-06 2002-12-18 Sumitomo Bakelite Co Ltd 難燃性エポキシ樹脂組成物、半導体封止材料及び半導体装置
CN1170816C (zh) 2001-07-19 2004-10-13 温州师范学院 N、n'-二取代苯胺基芳香二甲酰胺及其衍生物、制备方法和用途
US20030073712A1 (en) 2001-07-23 2003-04-17 Bing Wang Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
US20030130454A1 (en) * 2001-11-07 2003-07-10 Mitsubishi Rayon Co., Ltd. Process for producing amphipathic polymers
JP2003165805A (ja) 2001-11-28 2003-06-10 Mitsubishi Rayon Co Ltd 両親媒性重合体の製造方法
CA2487454A1 (en) * 2002-05-28 2003-12-04 The Trustees Of The University Of Pennsylvania Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers
EP1513622A4 (en) * 2002-06-13 2005-09-14 Univ Pennsylvania METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR STIMULATING BIOMEMBRANES USING ROUGH GRAIN MODELS
CA2494695C (en) 2002-08-02 2011-04-05 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US7378479B2 (en) * 2002-09-13 2008-05-27 Lubrizol Advanced Materials, Inc. Multi-purpose polymers, methods and compositions
US7141519B2 (en) 2002-09-20 2006-11-28 Kimberly-Clark Worldwide, Inc. Ion triggerable, cationic polymers, a method of making same and items using same
JP3836420B2 (ja) 2002-11-18 2006-10-25 孝志 澤口 両親媒性メタクリレート及びその重合体
EP2471526A3 (en) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Facially amphiphillic polymers and oligomers and uses thereof
JP2004323688A (ja) 2003-04-25 2004-11-18 Mitsubishi Rayon Co Ltd 両親媒性重合体およびその製造方法
US7332623B2 (en) * 2003-06-30 2008-02-19 Kaohsiung Medical University Aryl-substituted acyclic enediyne compounds
US20050004211A1 (en) * 2003-06-30 2005-01-06 Kaohsiung Medical University Pharmaceutical compositions comprising aryl-substituted acyclic enediyne compounds
US7781498B2 (en) * 2003-07-03 2010-08-24 Mallard Creek Polymers, Inc. Cationic latex as a carrier for bioactive ingredients and methods for making and using the same
ITMI20031790A1 (it) * 2003-09-19 2005-03-20 Consiglio Nazionale Ricerche Antagonistici abiotici dell'eparina.
US20070173752A1 (en) * 2003-11-28 2007-07-26 Troels Schonfeldt Integrated package
CN1922133A (zh) * 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
AU2005254574B2 (en) 2004-06-15 2012-02-02 Polymedix, Inc. Polycationic compounds and uses thereof
JP5027659B2 (ja) 2004-07-23 2012-09-19 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗菌コポリマーおよびその使用
EP2404895A1 (en) 2004-10-04 2012-01-11 Regents of the University of Minnesota Calixarene-based peptide conformation mimetics, methods of use, and methods of making
US20060241052A1 (en) * 2005-02-25 2006-10-26 Degrado William F Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049413A1 (en) * 1996-06-24 1997-12-31 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
WO2001051456A2 (en) * 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
WO2002100295A2 (en) * 2001-03-08 2002-12-19 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
De novo design of biomimetic antimicrobial polymers;Gregory N. Tew, et al.;《Proceedings of the national academy of sciences of USA》;20020416;第99卷(第8期);5110-5114 *

Also Published As

Publication number Publication date
CA2519023A1 (en) 2004-09-30
EP1608313A2 (en) 2005-12-28
KR20060015479A (ko) 2006-02-17
WO2004082634A2 (en) 2004-09-30
KR101241176B1 (ko) 2013-03-13
US20080176807A1 (en) 2008-07-24
JP5898668B2 (ja) 2016-04-06
CA2519023C (en) 2014-05-20
AU2011201236A1 (en) 2011-04-07
EP2471524A3 (en) 2012-12-12
CN102432511A (zh) 2012-05-02
US20060041023A1 (en) 2006-02-23
EP1608313A4 (en) 2009-05-06
AU2004222272B2 (en) 2010-12-23
JP2014148499A (ja) 2014-08-21
US20130023561A1 (en) 2013-01-24
WO2004082634A3 (en) 2005-11-10
AU2011201236B2 (en) 2013-12-12
AU2004222272A1 (en) 2004-09-30
US9241917B2 (en) 2016-01-26
JP2012021012A (ja) 2012-02-02
JP2006521355A (ja) 2006-09-21
US8455490B2 (en) 2013-06-04
JP2014208641A (ja) 2014-11-06
EP2471525A2 (en) 2012-07-04
US8236800B2 (en) 2012-08-07
EP2471525A3 (en) 2012-12-12
EP2471527A3 (en) 2012-12-12
US20160151314A1 (en) 2016-06-02
EP2471526A3 (en) 2012-12-12
EP2471527A2 (en) 2012-07-04
EP2471526A2 (en) 2012-07-04
EP2471524A2 (en) 2012-07-04

Similar Documents

Publication Publication Date Title
CN102432511B (zh) 表面两亲聚合物和低聚物及其应用
US8716530B2 (en) Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
CN101027066B (zh) 两亲聚降冰片烯衍生物及其使用方法
AU2013263761B2 (en) Facially amphiphilic polymers and oligomers and uses thereof
TWI484951B (zh) 面部兩性聚合物和寡聚物及其用途
CN1905867A (zh) 表面两亲聚合物和低聚物及其应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160608

Termination date: 20170317