CN102428175A - 包含具有非经典生物活性的组氨酰-tRNA合成酶剪接变异体的组合物及方法 - Google Patents

包含具有非经典生物活性的组氨酰-tRNA合成酶剪接变异体的组合物及方法 Download PDF

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CN102428175A
CN102428175A CN201080020335XA CN201080020335A CN102428175A CN 102428175 A CN102428175 A CN 102428175A CN 201080020335X A CN201080020335X A CN 201080020335XA CN 201080020335 A CN201080020335 A CN 201080020335A CN 102428175 A CN102428175 A CN 102428175A
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hrs
polypeptide
cell
binding
cells
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周洁
刘静芬
许志雯
罗咏诗
克瑞斯蒂·海伦·派尔
莱斯利·安·格林
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Pangu Biopharma Ltd
aTyr Pharma Inc
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Pangu Biopharma Ltd
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Priority to CN201510024397.2A priority Critical patent/CN104830812B/zh
Priority to CN201710679673.8A priority patent/CN107574157A/zh
Publication of CN102428175A publication Critical patent/CN102428175A/zh
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CN201080020335XA 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰-tRNA合成酶剪接变异体的组合物及方法 Pending CN102428175A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510024397.2A CN104830812B (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法
CN201710679673.8A CN107574157A (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16063009P 2009-03-16 2009-03-16
US61/160,630 2009-03-16
US23974709P 2009-09-03 2009-09-03
US61/239,747 2009-09-03
PCT/US2010/027525 WO2010107825A2 (en) 2009-03-16 2010-03-16 Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities

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CN201510024397.2A Division CN104830812B (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法
CN201710679673.8A Division CN107574157A (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法

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CN102428175A true CN102428175A (zh) 2012-04-25

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CN201080020335XA Pending CN102428175A (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰-tRNA合成酶剪接变异体的组合物及方法
CN201510024397.2A Active CN104830812B (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法
CN201710679673.8A Pending CN107574157A (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法

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CN201710679673.8A Pending CN107574157A (zh) 2009-03-16 2010-03-16 包含具有非经典生物活性的组氨酰‑tRNA合成酶剪接变异体的组合物及方法

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US (7) US8404242B2 (enExample)
EP (2) EP3255146B1 (enExample)
JP (4) JP5730280B2 (enExample)
CN (3) CN102428175A (enExample)
AU (1) AU2010226726B8 (enExample)
CA (1) CA2755784C (enExample)
DK (2) DK3255146T3 (enExample)
ES (2) ES2742251T3 (enExample)
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US8404471B2 (en) 2008-06-26 2013-03-26 Atyr Pharma, Inc. Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities
WO2010099477A2 (en) 2009-02-27 2010-09-02 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
US8404242B2 (en) 2009-03-16 2013-03-26 Atyr Pharma, Inc. Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
US20100310576A1 (en) * 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
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WO2011097031A2 (en) * 2010-02-04 2011-08-11 The Scripps Research Institute Monomeric forms of human aminoacyl-trna synthetases having non-canonical biological activities
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JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ， インコーポレイテッド システイニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
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JP6008837B2 (ja) 2010-04-28 2016-10-19 エータイアー ファーマ， インコーポレイテッド アラニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
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CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
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