CN102397393A - Compound propolis composition for treating sudden death syndrome in poultry, and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating sudden death syndrome in poultry, and a preparation method thereof, and relates to the field of animal medicines. The preparation method for the composition comprises the following steps of: (1), performing ultra micro grinding on all components in a formula and then screening with a 700-mesh sieve; (2) weighing 15 to 35 weight parts of propolis, 10 to 30 weight parts of atractylodes lancea, 15 to 35 weight parts of sanguisorba officinalis, and 10 to 35 weight parts of astragalus, and mixing for 5 to 10 minutes until a composition is uniform; (3), weighing 10 to 35 weight parts of prepared rehmannia root, 15 to 35 weight parts of indigowoad root, 10 to 35 weight parts of plantain herb, 15 to 45 weight parts of motherwort herb, and 15 to 45 weight parts of gardenia, and mixing for 5 to 10 minutes until a composition is uniform; and (4) mixing the composition which is obtained in the step (2) and the composition which is obtained in the step (3), and continuously mixing for 10 to 15 minutes until a mixture is uniform. The invention has the advantages that: the formula is reasonable, and the composition is easy to prepare, does not have toxic or side effect, and has high bioavailability due to ultra micro grinding, and a very obvious curative effect, and has a special effect of treating sudden death syndrome in poultry through clinical verification; pollution and medicinal residuals are avoided; and poultry do not have medicine resistance.

Description

A kind of compound bee-glue composition of treating the poultry SDS and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition of treating the poultry SDS and preparation method thereof.

Background technology

The poultry SDS is claimed the acute death syndrome again, though the cause of disease of primary disease is unclear, thinks relevant with factors such as nutrition, environment, acid-base balance, heredity and ontogeny mostly.Broiler is than other poultry susceptible diseases, and when primiparity hen was opened product at 20%-30%, its mortality rate was higher.This disease all can take place throughout the year, is one of principal disease of harm poultry husbandry.

This disease almost spreads all over all countries of raising chickens of the world, distributes very extensively.At present, prevent and treat this disease the most frequently used be in feedstuff, to add vitamin, electrolyte and Chinese medicine etc., Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.

Therefore researching and developing a kind of drug residue free of poultry SDS, generations that have no drug resistance, the significant specific medicament of clinical effectiveness of treating is one of this field scientific research technical staff urgency new problem to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment poultry SDS of drug residue and preparation method thereof.

For realizing above-mentioned purpose; The embodiment that the present invention adopted is following: a kind of compound bee-glue composition of treating the poultry SDS, by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Radix Sanguisorbae 15-35 part, Radix Astragali 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Isatidis 15-35 part, Herba Plantaginis 10-35 part, Herba Leonuri 15-45 part, Fructus Gardeniae 15-45 part.

Said various component optimum ratio amount is: 25 parts of propolis, 20 parts of Rhizoma Atractylodis, 25 parts of Radix Sanguisorbaes, 25 parts of the Radixs Astragali, 20 parts of Radix Rehmanniae Preparata, 25 parts of Radix Isatidis, 20 parts of Herba Plantaginiss, 30 parts of Herba Leonuris, 30 parts of Fructus Gardeniaes.

A kind of method for preparing of treating the compound bee-glue composition of poultry SDS, carry out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Radix Sanguisorbae 15-35 part, Radix Astragali 10-35 part by weight, mix 5-10 minute to even;

(3) take by weighing Radix Rehmanniae Preparata 10-35 part, Radix Isatidis 15-35 part, Herba Plantaginis 10-35 part, Herba Leonuri 15-45 part, Fructus Gardeniae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Rhizoma Atractylodis: hot, bitter, warm, return spleen, stomach, Liver Channel, the function that have drying damp and strengthening spleen, expelling wind and cold, makes eye bright; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Radix Sanguisorbae: bitter, sour, puckery, be slightly cold, return liver, large intestine channel, have the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, epistaxis, the yellow furunculosis of skin ulcer etc.

Radix Rehmanniae Preparata: liver, tepor, return liver, kidney channel, have the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow; Cure mainly that the hepatic and renal YIN deficiency, blood deficiency damage of essence, waist hip flaccidity are soft, dyspnea due to deficiency chronic cough, deficiency-heat night sweat etc.

Herba Plantaginis: sweet, cold, return liver, kidney, lung, small intestine meridian, have clearing away heat and promoting diuresis, eliminate the phlegm, removing heat from blood, antidotal function; Cure mainly that pyretic stranguria, short urination are red, diarrhea due to damp-heat, phlegm-heat cough, carbuncle sore tumefacting virus etc.

Herba Leonuri: bitter, hot, be slightly cold, return liver, pericardium, urinary bladder channel, have the function of promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema; Cure mainly edema oliguria, lochiorrhea, leukorrhagia etc.

Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to the cause of disease and the clinical symptoms and the pathological change of poultry SDS, bring into play the effect of treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, can also can drink water the curative effect highly significant by spice.The present invention is according to Chinese veterinarian's traditional theory; Optimize this nine flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; Treatment poultry SDS there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound bee-glue composition of treating the poultry SDS and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, 100 parts of Rhizoma Atractylodis, 150 parts of Radix Sanguisorbaes, 100 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(3) take by weighing 100 parts of Radix Rehmanniae Preparata, 150 parts of Radix Isatidis, 100 parts of Herba Plantaginiss, 150 parts of Herba Leonuris, 150 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition of treating the poultry SDS and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 250 parts of propolis, 100 parts of Rhizoma Atractylodis, 250 parts of Radix Sanguisorbaes, 250 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(3) take by weighing 150 parts of Radix Rehmanniae Preparata, 250 parts of Radix Isatidis, 250 parts of Herba Plantaginiss, 300 parts of Herba Leonuris, 300 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition of treating the poultry SDS and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 350 parts of propolis, 300 parts of Rhizoma Atractylodis, 350 parts of Radix Sanguisorbaes, 350 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(3) take by weighing 350 parts of Radix Rehmanniae Preparata, 350 parts of Radix Isatidis, 350 parts of Herba Plantaginiss, 450 parts of Herba Leonuris, 450 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 120kg feeds, drinking-water 200kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment poultry SDS:

Numbering	Group	Case fatality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	26.8	58.1	15.1
II	Sudden death is loose and is organized	11.4	78.5	10.1
					III	Chinese medicine composition group of the present invention	6.3	87.9	5.8

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with sudden death and compared difference extremely significantly (P＜0.01) aspect the cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment poultry SDS and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound bee-glue composition of treating the poultry SDS, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Radix Sanguisorbae 15-35 part, Radix Astragali 10-35 part, Radix Rehmanniae Preparata 10-35 part, Radix Isatidis 15-35 part, Herba Plantaginis 10-35 part, Herba Leonuri 15-45 part, Fructus Gardeniae 15-45 part.

2. the compound bee-glue composition of treatment poultry SDS according to claim 1 is characterized in that said various component optimum ratio amount is: 25 parts of propolis, 20 parts of Rhizoma Atractylodis, 25 parts of Radix Sanguisorbaes, 25 parts of the Radixs Astragali, 20 parts of Radix Rehmanniae Preparata, 25 parts of Radix Isatidis, 20 parts of Herba Plantaginiss, 30 parts of Herba Leonuris, 30 parts of Fructus Gardeniaes.

3. the method for preparing of the compound bee-glue composition of a treatment according to claim 1 and 2 poultry SDS is characterized in that carrying out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-35 part, Rhizoma Atractylodis 10-30 part, Radix Sanguisorbae 15-35 part, Radix Astragali 10-35 part by weight, mix 5-10 minute to even;

(3) take by weighing Radix Rehmanniae Preparata 10-35 part, Radix Isatidis 15-35 part, Herba Plantaginis 10-35 part, Herba Leonuri 15-45 part, Fructus Gardeniae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.